Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PXDC1 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PXDC1 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Pxdc1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PXDC1 mRNA | CTD | PMID:26290441 and PMID:31511937 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PXDC1 mRNA | CTD | PMID:20106945 more ... | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Pxdc1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PXDC1 mRNA | CTD | PMID:26377647 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PXDC1 mRNA | CTD | PMID:31511937 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Pxdc1 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of PXDC1 mRNA | CTD | PMID:28973697 | 5-aza-2'-deoxycytidine | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | Decitabine results in increased expression of PXDC1 mRNA | CTD | PMID:19194470 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of PXDC1 mRNA | CTD | PMID:24780913 and PMID:25825206 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of PXDC1 mRNA | CTD | PMID:31881176 | acrylamide | affects expression | EXP | | 6480464 | Acrylamide affects the expression of PXDC1 mRNA | CTD | PMID:28959563 | acrylamide | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of PXDC1 mRNA | CTD | PMID:32763439 | Aflatoxin B2 alpha | increases methylation | ISO | PXDC1 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of PXDC1 intron | CTD | PMID:30157460 | atrazine | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | Atrazine results in increased expression of PXDC1 mRNA | CTD | PMID:22378314 | azathioprine | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | Azathioprine results in increased expression of PXDC1 mRNA | CTD | PMID:22623647 | benzo[a]pyrene | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of PXDC1 mRNA | CTD | PMID:21632981 and PMID:26238291 | benzo[a]pyrene | decreases methylation | ISO | PXDC1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of PXDC1 promoter | CTD | PMID:27901495 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PXDC1 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PXDC1 mRNA | CTD | PMID:34947998 | bisphenol A | increases expression | ISO | Pxdc1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of PXDC1 mRNA | CTD | PMID:32156529 more ... | bisphenol A | affects expression | ISO | PXDC1 (Homo sapiens) | 6480464 | bisphenol A affects the expression of PXDC1 mRNA | CTD | PMID:30903817 | buta-1,3-diene | increases expression | ISO | Pxdc1 (Mus musculus) | 6480464 | 1 and 3-butadiene results in increased expression of PXDC1 mRNA | CTD | PMID:29038090 | butan-1-ol | multiple interactions | ISO | PXDC1 (Homo sapiens) | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of PXDC1 mRNA | CTD | PMID:29432896 | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of PXDC1 promoter | CTD | PMID:22457795 | cadmium dichloride | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of PXDC1 mRNA | CTD | PMID:26472689 | carbon nanotube | decreases expression | ISO | Pxdc1 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in decreased expression of PXDC1 mRNA | CTD | PMID:25554681 | carbon nanotube | increases expression | ISO | Pxdc1 (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of PXDC1 mRNA | CTD | PMID:25554681 | chlorpyrifos | increases expression | ISO | Pxdc1 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of PXDC1 mRNA | CTD | PMID:37019170 | cisplatin | multiple interactions | ISO | PXDC1 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of PXDC1 mRNA | CTD | PMID:27392435 | cisplatin | decreases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of PXDC1 mRNA | CTD | PMID:27392435 | copper atom | multiple interactions | ISO | PXDC1 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of PXDC1 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | PXDC1 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of PXDC1 mRNA | CTD | PMID:20971185 | crocidolite asbestos | decreases expression | ISO | Pxdc1 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of PXDC1 mRNA | CTD | PMID:29279043 | cyclosporin A | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of PXDC1 mRNA | CTD | PMID:20106945 more ... | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of PXDC1 mRNA | CTD | PMID:21266533 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of PXDC1 mRNA | CTD | PMID:25152437 | dorsomorphin | multiple interactions | ISO | PXDC1 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | entinostat | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | entinostat results in increased expression of PXDC1 mRNA | CTD | PMID:26272509 and PMID:27188386 | entinostat | multiple interactions | ISO | PXDC1 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PXDC1 mRNA | CTD | PMID:27188386 | fluoranthene | multiple interactions | ISO | Pxdc1 (Mus musculus) | 6480464 | [1-methylanthracene co-treated with fluoranthene] results in increased expression of PXDC1 mRNA | CTD | PMID:28329830 | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of PXDC1 mRNA | CTD | PMID:24136188 | genistein | decreases expression | ISO | Pxdc1 (Mus musculus) | 6480464 | Genistein results in decreased expression of PXDC1 mRNA | CTD | PMID:32186404 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PXDC1 mRNA | CTD | PMID:33387578 | indometacin | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | Indomethacin results in increased expression of PXDC1 mRNA | CTD | PMID:16984733 | leflunomide | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | leflunomide results in increased expression of PXDC1 mRNA | CTD | PMID:28988120 | Licochalcone B | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | licochalcone B results in increased expression of PXDC1 mRNA | CTD | PMID:33647349 | lipopolysaccharide | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | Lipopolysaccharides results in increased expression of PXDC1 mRNA | CTD | PMID:35811015 | lipopolysaccharide | multiple interactions | ISO | PXDC1 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of PXDC1 mRNA | CTD | PMID:35811015 | mercury dibromide | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | mercuric bromide results in increased expression of PXDC1 mRNA | CTD | PMID:26272509 | mercury dibromide | multiple interactions | ISO | PXDC1 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PXDC1 mRNA | CTD | PMID:27188386 | methylmercury chloride | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of PXDC1 mRNA | CTD | PMID:28001369 | Muraglitazar | decreases expression | EXP | | 6480464 | muraglitazar results in decreased expression of PXDC1 mRNA | CTD | PMID:21515302 | nickel sulfate | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of PXDC1 mRNA | CTD | PMID:18651567 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of PXDC1 mRNA | CTD | PMID:25729387 | oxaliplatin | increases expression | EXP | | 6480464 | oxaliplatin results in increased expression of PXDC1 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | Pxdc1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of PXDC1 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of PXDC1 mRNA | CTD | PMID:34911549 | p-chloromercuribenzoic acid | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in increased expression of PXDC1 mRNA | CTD | PMID:26272509 | p-chloromercuribenzoic acid | multiple interactions | ISO | PXDC1 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PXDC1 mRNA | CTD | PMID:27188386 | panobinostat | multiple interactions | ISO | PXDC1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PXDC1 mRNA | CTD | PMID:27188386 | panobinostat | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | panobinostat results in increased expression of PXDC1 mRNA | CTD | PMID:26272509 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of PXDC1 mRNA | CTD | PMID:33387578 | perfluorohexanesulfonic acid | decreases expression | ISO | Pxdc1 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of PXDC1 mRNA | CTD | PMID:37995155 | perfluorononanoic acid | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in increased expression of PXDC1 mRNA | CTD | PMID:32588087 | phenylmercury acetate | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of PXDC1 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | PXDC1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PXDC1 mRNA | CTD | PMID:27188386 | potassium chromate | decreases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of PXDC1 mRNA | CTD | PMID:22714537 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | PXDC1 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of PXDC1 mRNA | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | PXDC1 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of PXDC1 mRNA | CTD | PMID:25895662 | sodium arsenate | decreases expression | ISO | Pxdc1 (Mus musculus) | 6480464 | sodium arsenate results in decreased expression of PXDC1 mRNA | CTD | PMID:30953684 | sodium arsenite | decreases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of PXDC1 mRNA | CTD | PMID:34032870 | sunitinib | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PXDC1 mRNA | CTD | PMID:31533062 | tetrachloromethane | increases expression | ISO | Pxdc1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of PXDC1 mRNA | CTD | PMID:31919559 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of PXDC1 mRNA | CTD | PMID:23411599 | titanium dioxide | decreases expression | ISO | Pxdc1 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of PXDC1 mRNA | CTD | PMID:23557971 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of PXDC1 mRNA | CTD | PMID:25729387 | topotecan | increases expression | EXP | | 6480464 | Topotecan results in increased expression of PXDC1 mRNA | CTD | PMID:25729387 | triptonide | decreases expression | ISO | Pxdc1 (Mus musculus) | 6480464 | triptonide results in decreased expression of PXDC1 mRNA | CTD | PMID:33045310 | urethane | decreases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | Urethane results in decreased expression of PXDC1 mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | ISO | PXDC1 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of PXDC1 gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | PXDC1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PXDC1 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | PXDC1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PXDC1 mRNA | CTD | PMID:27188386 | |