Serpinb1a (serpin family B member 1A)

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Gene: Serpinb1a (serpin family B member 1A) Rattus norvegicus

Analyze

Symbol:

Serpinb1a

Name:

serpin family B member 1A

RGD ID:

1306203

Description:

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including inflammatory response; negative regulation of interleukin-1 beta production; and type B pancreatic cell proliferation. Predicted to act upstream of or within regulation of protein catabolic process. Predicted to be located in cytoplasmic ribonucleoprotein granule and extracellular region. Predicted to be active in extracellular space. Orthologous to human SERPINB1 (serpin family B member 1); PARTICIPATES IN Entamoebiasis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

leukocyte elastase inhibitor A; LOC291091; MGC112650; serine (or cysteine) proteinase inhibitor, clade B, member 1a; serine protease inhibitor EIA; serpin B1a; serpin family B member 1; Serpinb1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SERPINB1 (serpin family B member 1)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Serpinb1a (serine (or cysteine) peptidase inhibitor, clade B, member 1a)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Serpinb1 (serpin family B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SERPINB1 (serpin family B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SERPINB1 (serpin family B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Serpinb1 (serpin family B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SERPINB1 (serpin family B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SERPINB1 (serpin family B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Serpinb1 (serpin family B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SERPINB1 (serpin family B member 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Serpinb1a (serine (or cysteine) peptidase inhibitor, clade B, member 1a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	serpinb1 (serpin peptidase inhibitor, clade B (ovalbumin), member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	serpinb1l2 (serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Spn27A	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	srp-1	Alliance	DIOPT (InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-3	Alliance	DIOPT (Hieranoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn28B	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	srp-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn28Da	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	srp-8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn28F	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	Spn38F	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Spn42Dc	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	Spn42Dd	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Spn43Aa	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Spn55B	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn88Ea	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	Spn88Eb	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	Spn100A	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	serpinb1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	31,590,695 - 31,599,102 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	31,590,677 - 31,599,102 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	31,425,819 - 31,434,247 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	33,029,593 - 33,038,021 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	31,421,586 - 31,430,014 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	32,903,089 - 32,911,498 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	32,904,119 - 32,911,495 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	34,795,295 - 34,803,704 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	37,950,875 - 37,959,284 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	37,905,219 - 37,962,230 (+)	NCBI
Celera	17	31,153,059 - 31,161,466 (+)	NCBI		Celera
Cytogenetic Map	17	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3-dimethoxynaphthalene-1,4-dione (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-(N,N-hexamethylene)amiloride (ISO)

acetamide (EXP)

acetylsalicylic acid (ISO)

acrylamide (EXP)

aflatoxin B1 (EXP)

all-trans-retinoic acid (ISO)

amiodarone (ISO)

antimony(0) (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

atrazine (EXP)

belinostat (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

beta-naphthoflavone (EXP)

bilirubin IXalpha (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butan-1-ol (ISO)

cadmium atom (EXP,ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

carmustine (ISO)

chlordecone (ISO)

chromium atom (ISO)

chrysene (ISO)

copper atom (EXP)

copper(0) (EXP)

cortisol (EXP,ISO)

coumestrol (ISO)

cyclosporin A (ISO)

dexamethasone (EXP,ISO)

dexamethasone phosphate (EXP,ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

ferric oxide (ISO)

flavone (ISO)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP,ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

indole-3-methanol (EXP)

inulin (ISO)

isobutanol (ISO)

ivermectin (ISO)

ketamine (EXP)

ketoconazole (ISO)

menadione (ISO)

mercury atom (ISO)

mercury dibromide (ISO)

mercury(0) (ISO)

methotrexate (ISO)

methylmercury chloride (ISO)

morphine (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (ISO)

nickel atom (ISO)

nickel dichloride (ISO)

nicotine (ISO)

nitrofen (EXP)

oxaliplatin (EXP)

p-chloromercuribenzoic acid (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

phytoestrogen (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

pravastatin (EXP,ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

quercetin (ISO)

quinoline (ISO)

resveratrol (EXP)

rifampicin (ISO)

SB 431542 (ISO)

silicon dioxide (EXP,ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium fluoride (EXP)

Soman (EXP)

sulindac (ISO)

sunitinib (ISO)

tamibarotene (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (EXP,ISO)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP,ISO)

triamcinolone acetonide (EXP,ISO)

tributylstannane (ISO)

trichloroethene (ISO)

troglitazone (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular homeostasis (ISO)

inflammatory response (ISO)

negative regulation of interleukin-1 beta production (IBA,ISO)

regulation of innate immune response (ISO)

regulation of protein catabolic process (ISO)

type B pancreatic cell proliferation (ISO)

Cellular Component

cytolytic granule (IEA)

cytoplasmic ribonucleoprotein granule (ISO)

early endosome (IEA)

extracellular region (ISO)

extracellular space (IBA)

Molecular Function

peptidase inhibitor activity (ISO)

protein binding (ISO)

serine-type endopeptidase inhibitor activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

Entamoebiasis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12189154	PMID:12477932	PMID:16502470	PMID:17664292	PMID:19056867	PMID:19946888	PMID:20551380	PMID:21683252	PMID:22344266	PMID:22664934	PMID:23376485	PMID:23533145
PMID:23580065	PMID:24899316	PMID:26701651	PMID:27068509	PMID:27559042	PMID:30692621	PMID:35291946

Genomics

Comparative Map Data

Serpinb1a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	31,590,695 - 31,599,102 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	31,590,677 - 31,599,102 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	31,425,819 - 31,434,247 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	33,029,593 - 33,038,021 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	31,421,586 - 31,430,014 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	32,903,089 - 32,911,498 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	32,904,119 - 32,911,495 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	34,795,295 - 34,803,704 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	37,950,875 - 37,959,284 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	37,905,219 - 37,962,230 (+)	NCBI
Celera	17	31,153,059 - 31,161,466 (+)	NCBI		Celera
Cytogenetic Map	17	p12	NCBI

SERPINB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	2,832,332 - 2,841,863 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	2,832,332 - 2,841,959 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	2,832,566 - 2,842,097 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	2,778,732 - 2,787,080 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	2,778,734 - 2,787,080	NCBI
Celera	6	4,062,686 - 4,071,034 (-)	NCBI		Celera
Cytogenetic Map	6	p25.2	NCBI
HuRef	6	2,705,973 - 2,715,695 (-)	NCBI		HuRef
CHM1_1	6	2,835,084 - 2,844,765 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	2,698,484 - 2,708,154 (-)	NCBI		T2T-CHM13v2.0

Serpinb1a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	33,026,075 - 33,037,189 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	33,026,075 - 33,035,168 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	32,842,092 - 32,853,206 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	32,842,092 - 32,851,185 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	32,933,961 - 32,943,054 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	32,849,591 - 32,858,650 (-)	NCBI		MGSCv36	mm8
Celera	13	33,052,332 - 33,062,299 (-)	NCBI		Celera
Cytogenetic Map	13	A3.2	NCBI
cM Map	13	13.75	NCBI

Serpinb1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955465	10,541,485 - 10,550,290 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955465	10,541,562 - 10,551,417 (+)	NCBI	ChiLan1.0	ChiLan1.0

SERPINB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	6	13,437,056 - 13,459,495 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	2,655,244 - 2,664,074 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	2,758,173 - 2,766,984 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	2,758,173 - 2,766,650 (-)	Ensembl	panpan1.1		panPan2

SERPINB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	3,147,140 - 3,151,747 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	35	3,147,170 - 3,153,915 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	3,154,221 - 3,162,902 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	3,201,536 - 3,210,182 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	35	3,201,544 - 3,211,067 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	35	3,077,400 - 3,086,040 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	3,099,914 - 3,108,812 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	4,432,360 - 4,441,097 (-)	NCBI		UU_Cfam_GSD_1.0

Serpinb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	22,694,570 - 22,703,240 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936633	3,916,572 - 3,926,176 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936633	3,917,430 - 3,926,046 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SERPINB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	1,684,215 - 1,693,299 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	1,684,212 - 1,693,313 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	1,783,253 - 1,792,454 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SERPINB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	69,318,919 - 69,327,733 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	69,319,302 - 69,328,865 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	2,771,546 - 2,781,061 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Serpinb1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624756	21,994,769 - 22,002,065 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624756	21,993,777 - 22,003,715 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Serpinb1a
40 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	88
Count of miRNA genes:	71
Interacting mature miRNAs:	74
Transcripts:	ENSRNOT00000059854
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31701463	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	1	31990913	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	37830672	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	60781592	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2115149	34551001	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	4299130	35837242	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	4299130	60781592	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4528038	49528038	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4528038	49528038	Rat
2303561	Bw91	Body weight QTL 91	2		body mass (VT:0001259)	body weight (CMO:0000012)	17	8868462	53868462	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9991286	40540197	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15330613	55836425	Rat
1354640	Scl32	Serum cholesterol level QTL 32	5.4		blood HDL cholesterol amount (VT:0000184)	blood high density lipoprotein cholesterol level (CMO:0000052)	17	15781592	60781592	Rat
1354659	Scl68	Serum cholesterol level QTL 68	3.9		blood VLDL cholesterol amount (VT:0005144)	blood very low density lipoprotein cholesterol level (CMO:0000648)	17	15781592	60781592	Rat
7394837	Memor18	Memory QTL 18			exploratory behavior trait (VT:0010471)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	17	18640182	63640182	Rat
1354628	Stl13	Serum triglyceride level QTL 13	3.8		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	21293039	60781592	Rat
70157	Niddm32	Non-insulin dependent diabetes mellitus QTL 32	4.34		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	22454924	50909196	Rat
61394	Bp8	Blood pressure QTL 8	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	23080567	59555013	Rat
7488966	Bp370	Blood pressure QTL 370		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	57246843	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23653184	68653184	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23653184	68653184	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23653184	68653184	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23653184	68653184	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	68653184	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23653184	70974005	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	24599340	69599340	Rat
4889891	Eae32	Experimental allergic encephalomyelitis QTL 32	4.8	0.0002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	27027949	36146731	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27027949	56836890	Rat
4889955	Bss93	Bone structure and strength QTL 93	4.4		tibia size trait (VT:0100001)	tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)	17	27027949	60463643	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	27389946	53481766	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	28409147	73409147	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	28409147	73409147	Rat
10450503	Bp386	Blood pressure QTL 386		0.28	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	31368391	62109574	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	31368391	73951021	Rat

Markers in Region

BE100150

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	31,594,543 - 31,594,696 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	32,906,940 - 32,907,092	NCBI	Rnor6.0
Rnor_5.0	17	34,799,146 - 34,799,298	UniSTS	Rnor5.0
RGSC_v3.4	17	37,954,726 - 37,954,878	UniSTS	RGSC3.4
Celera	17	31,156,908 - 31,157,060	UniSTS
RH 3.4 Map	17	324.81	UniSTS
Cytogenetic Map	17	p12	UniSTS

RH132528

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	31,598,727 - 31,598,926 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	32,911,124 - 32,911,322	NCBI	Rnor6.0
Rnor_5.0	17	34,803,330 - 34,803,528	UniSTS	Rnor5.0
RGSC_v3.4	17	37,958,910 - 37,959,108	UniSTS	RGSC3.4
Celera	17	31,161,092 - 31,161,290	UniSTS
RH 3.4 Map	17	356.7	UniSTS
Cytogenetic Map	17	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	2	30	22	19	22	4	4	3	29	19	11	4
Low		41	27	19		19	4	7	71	6	21		4
Below cutoff											1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001031642	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC098686	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000289	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000059854 ⟹ ENSRNOP00000056600

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	31,590,677 - 31,599,102 (+)	Ensembl
Rnor_6.0 Ensembl	17	32,904,119 - 32,911,495 (+)	Ensembl

RefSeq Acc Id:

NM_001031642 ⟹ NP_001026812

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	31,590,695 - 31,599,102 (+)	NCBI
Rnor_6.0	17	32,903,089 - 32,911,498 (+)	NCBI
Rnor_5.0	17	34,795,295 - 34,803,704 (+)	NCBI
RGSC_v3.4	17	37,950,875 - 37,959,284 (+)	RGD
Celera	17	31,153,059 - 31,161,466 (+)	RGD

Sequence:

show sequence

CAGCTAAGCAAGAGCCTTCACCATGGAGCAGCTGAGTTCAGCCAACAGCCTGTTCGCCTTGGAG
CTGTTCCACACCCTGAGTGAAAGCAGCCCCACAGGAAACATCTTCTTCTCTCCCTTCAGCATTT
CTTCTGCCTTGGCCATGGTCTTTCTGGGGACCAAAGGCACCACTGCAGCCCAGCTCTCTAAGAC
TTTTCATTTCGACTCTGTTGAGGACGTTCATTCACGCTTTCAAAGCCTGAATGCTGAAGTGAGC
AAGCGTGGAGCATCTCACACTCTGAAACTTGCCAACAGGCTGTATGGAGAGAAAACCTACAATT
TCCTTCCTGAGTTCTTGACTTCAACTCAGAAGATGTATGGTGCTGACTTGGCCCCTGTGGATTT
TCAGCATGCCTCTGAGGATGCAAGGAAGGAGATAAACCAGTGGGTCAAAGGTCAAACCGAAGGT
AAAATCCCAGAACTGTTGGCTGTGGGTGTGGTGGACAGCATGACCAAACTTGTGCTGGTGAACG
CCATCTACTTCAAGGGGATGTGGGAGGAGAAATTCATGAAACAAGACACAACAGATGCTCCATT
CCGGCTGAATAAGAAAAACACAAAATCTGTGAAGATGATGTATCAAAAGAAAAAATTTTTCTTT
GGCTACATTTCGGATCTGAAGTGCAAGGTGCTGGAGATGCCATACCAGGGTGGAGAACTGAGCA
TGGTCATCCTGCTGCCCGAAGACATTGAGGATGAGTCCACGGGTCTTAAGAAGATTGAGGAGCA
AATAACTTTGGAAAAACTGCGTGAATGGACCAAACGTGAGAACTTGGAAAACATTGATGTCCAT
GTCAAATTGCCCCGGTTCAAGATAGAAGAGAGCTACATCCTCAACTCGAACCTGGGCCGCTTGG
GATTGCAGGATCTCTTTAACAGTAGCAAGGCTGATCTGTCTGGCATGTCAGGATCCAGAGATCT
TTTCATATCAAAAATTGTCCACAAGGCCTTTGTGGAAGTGAATGAGGAGGGAACAGAGGCAGCC
GCTGCCACGGCAGGCATCGCTACATTCTGCATGTTGCTGCCCGAAGAAGAATTCACAGCGGACC
ATCCATTCATTTTCTTCATTCGGCACAACCCCACAGCTAATGTGCTCTTCCTTGGCAGGGTTTG
TTCCCCATAGAAGAAGACTTTACCAATACAAGGCAGAACTTAGAGTTTCATCCCCTGAGATTTT
AACAGTGATTATATTCCTTTGTACTTGACAATAAAACCTCTAACCAGAAAAAAAAAAAAAAAAA
AAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001026812	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98686	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000056600
GenBank Protein	Q4G075	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001026812 ⟸ NM_001031642

- UniProtKB:

Q4G075 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MEQLSSANSLFALELFHTLSESSPTGNIFFSPFSISSALAMVFLGTKGTTAAQLSKTFHFDSVE
DVHSRFQSLNAEVSKRGASHTLKLANRLYGEKTYNFLPEFLTSTQKMYGADLAPVDFQHASEDA
RKEINQWVKGQTEGKIPELLAVGVVDSMTKLVLVNAIYFKGMWEEKFMKQDTTDAPFRLNKKNT
KSVKMMYQKKKFFFGYISDLKCKVLEMPYQGGELSMVILLPEDIEDESTGLKKIEEQITLEKLR
EWTKRENLENIDVHVKLPRFKIEESYILNSNLGRLGLQDLFNSSKADLSGMSGSRDLFISKIVH
KAFVEVNEEGTEAAAATAGIATFCMLLPEEEFTADHPFIFFIRHNPTANVLFLGRVCSP

hide sequence

RefSeq Acc Id:

ENSRNOP00000056600 ⟸ ENSRNOT00000059854

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4G075-F1-model_v2	AlphaFold	Q4G075	1-379	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306203	AgrOrtholog
BioCyc Gene	G2FUF-9573	BioCyc
Ensembl Genes	ENSRNOG00000016581	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000059854	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	2.30.39.10	UniProtKB/Swiss-Prot
	3.30.497.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7385870	IMAGE-MGC_LOAD
InterPro	Serpin_CS	UniProtKB/Swiss-Prot
	Serpin_dom	UniProtKB/Swiss-Prot
	Serpin_fam	UniProtKB/Swiss-Prot
	Serpin_sf	UniProtKB/Swiss-Prot
	Serpin_sf_1	UniProtKB/Swiss-Prot
	Serpin_sf_2	UniProtKB/Swiss-Prot
KEGG Report	rno:291091	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112650	IMAGE-MGC_LOAD
NCBI Gene	291091	ENTREZGENE
PANTHER	PTHR11461	UniProtKB/Swiss-Prot
	PTHR11461:SF180	UniProtKB/Swiss-Prot
Pfam	Serpin	UniProtKB/Swiss-Prot
PhenoGen	Serpinb1a	PhenoGen
PROSITE	SERPIN	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000016581	RatGTEx
SMART	SERPIN	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56574	UniProtKB/Swiss-Prot
UniProt	ILEUA_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-09-09	Serpinb1a	serpin family B member 1A	Serpinb1a	serpin family B member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-08-29	Serpinb1a	serpin family B member 1	Serpinb1	serpin family B member 1a	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-08-23	Serpinb1	serpin family B member 1a	Serpinb1a	serine (or cysteine) proteinase inhibitor, clade B, member 1a	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Serpinb1a	serine (or cysteine) proteinase inhibitor, clade B, member 1a	Serpinb1a_predicted	serine (or cysteine) proteinase inhibitor, clade B, member 1a (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Serpinb1a_predicted	serine (or cysteine) proteinase inhibitor, clade B, member 1a (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)