SERPINB1 (serpin family B member 1) - Rat Genome Database

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Gene: SERPINB1 (serpin family B member 1) Pan paniscus
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Symbol: SERPINB1
Name: serpin family B member 1
RGD ID: 11946239
Description: ENCODES a protein that exhibits peptidase inhibitor activity (inferred); serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN cellular homeostasis (ortholog); inflammatory response (ortholog); regulation of innate immune response (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytoplasmic ribonucleoprotein granule (inferred); extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leukocyte elastase inhibitor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2517,458,189 - 17,467,186 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1613,437,056 - 13,459,495 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v062,655,244 - 2,664,074 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.162,758,173 - 2,766,984 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl62,758,173 - 2,766,650 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SERPINB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2517,458,189 - 17,467,186 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1613,437,056 - 13,459,495 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v062,655,244 - 2,664,074 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.162,758,173 - 2,766,984 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl62,758,173 - 2,766,650 (-)Ensemblpanpan1.1panPan2
SERPINB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3862,832,332 - 2,841,863 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl62,832,332 - 2,841,959 (-)EnsemblGRCh38hg38GRCh38
GRCh3762,832,566 - 2,842,097 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3662,778,732 - 2,787,080 (-)NCBINCBI36Build 36hg18NCBI36
Build 3462,778,734 - 2,787,080NCBI
Celera64,062,686 - 4,071,034 (-)NCBICelera
Cytogenetic Map6p25.2NCBI
HuRef62,705,973 - 2,715,695 (-)NCBIHuRef
CHM1_162,835,084 - 2,844,765 (-)NCBICHM1_1
T2T-CHM13v2.062,698,484 - 2,708,154 (-)NCBIT2T-CHM13v2.0
Serpinb1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391333,026,075 - 33,037,189 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1333,026,075 - 33,035,168 (-)EnsemblGRCm39 Ensembl
GRCm381332,842,092 - 32,853,206 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1332,842,092 - 32,851,185 (-)EnsemblGRCm38mm10GRCm38
MGSCv371332,933,961 - 32,943,054 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361332,849,591 - 32,858,650 (-)NCBIMGSCv36mm8
Celera1333,052,332 - 33,062,299 (-)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.75NCBI
Serpinb1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,799,446 - 31,807,853 (+)NCBIGRCr8
mRatBN7.21731,590,695 - 31,599,102 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1731,590,677 - 31,599,102 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1731,425,819 - 31,434,247 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01733,029,593 - 33,038,021 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01731,421,586 - 31,430,014 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01732,903,089 - 32,911,498 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,904,119 - 32,911,495 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01734,795,295 - 34,803,704 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41737,950,875 - 37,959,284 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11737,905,219 - 37,962,230 (+)NCBI
Celera1731,153,059 - 31,161,466 (+)NCBICelera
Cytogenetic Map17p12NCBI
Serpinb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546510,541,485 - 10,550,290 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546510,541,562 - 10,551,417 (+)NCBIChiLan1.0ChiLan1.0
SERPINB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,147,140 - 3,151,747 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,147,170 - 3,153,915 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha353,154,221 - 3,162,902 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,201,536 - 3,210,182 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,201,544 - 3,211,067 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,077,400 - 3,086,040 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,099,914 - 3,108,812 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0354,432,360 - 4,441,097 (-)NCBIUU_Cfam_GSD_1.0
Serpinb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494622,694,570 - 22,703,240 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366333,916,572 - 3,926,176 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366333,917,430 - 3,926,046 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl71,684,215 - 1,693,299 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.171,684,212 - 1,693,313 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.271,783,253 - 1,792,454 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11769,318,919 - 69,327,733 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1769,319,302 - 69,328,865 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660442,771,546 - 2,781,061 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpinb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475621,994,769 - 22,002,065 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475621,993,777 - 22,003,715 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000059746   ⟹   ENSPPAP00000036852
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl62,758,173 - 2,766,650 (-)Ensembl
RefSeq Acc Id: XM_003805563   ⟹   XP_003805611
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2517,458,189 - 17,467,186 (-)NCBI
NHGRI_mPanPan1613,450,517 - 13,459,488 (-)NCBI
Mhudiblu_PPA_v062,655,244 - 2,664,074 (-)NCBI
PanPan1.162,758,173 - 2,766,984 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008972757   ⟹   XP_008971005
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2517,458,189 - 17,466,972 (-)NCBI
NHGRI_mPanPan1613,450,517 - 13,459,015 (-)NCBI
Mhudiblu_PPA_v062,655,828 - 2,663,752 (-)NCBI
PanPan1.162,758,637 - 2,766,650 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034961357   ⟹   XP_034817248
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2517,458,189 - 17,467,181 (-)NCBI
NHGRI_mPanPan1613,450,517 - 13,459,489 (-)NCBI
Mhudiblu_PPA_v062,655,828 - 2,663,973 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003805611 (Get FASTA)   NCBI Sequence Viewer  
  XP_008971005 (Get FASTA)   NCBI Sequence Viewer  
  XP_034817248 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000036852.1
RefSeq Acc Id: XP_003805611   ⟸   XM_003805563
- Sequence:
RefSeq Acc Id: XP_008971005   ⟸   XM_008972757
- Sequence:
RefSeq Acc Id: XP_034817248   ⟸   XM_034961357
RefSeq Acc Id: ENSPPAP00000036852   ⟸   ENSPPAT00000059746
Protein Domains
SERPIN


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041181 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000059746.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report pps:100995323 UniProtKB/TrEMBL
NCBI Gene SERPINB1 ENTREZGENE
PANTHER PTHR11461 UniProtKB/TrEMBL
  PTHR11461:SF180 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PROSITE SERPIN UniProtKB/TrEMBL
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/TrEMBL
UniProt A0A2R9CF34_PANPA UniProtKB/TrEMBL