Serpinb6b (serine (or cysteine) peptidase inhibitor, clade B, member 6b) - Rat Genome Database

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Gene: Serpinb6b (serine (or cysteine) peptidase inhibitor, clade B, member 6b) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Serpinb6b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6b
RGD ID: 1310452
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in nucleus. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 91. Orthologous to human SERPINB6 (serpin family B member 6); PARTICIPATES IN Entamoebiasis pathway; .
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC364705; serine (or cysteine) proteinase inhibitor, clade B, member 6b
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,666,587 - 31,684,222 (-)NCBIGRCr8
mRatBN7.21731,455,092 - 31,475,460 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1731,457,834 - 31,475,176 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1731,293,094 - 31,311,814 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01732,896,865 - 32,915,583 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01731,288,855 - 31,307,575 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01732,770,488 - 32,787,835 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,770,739 - 32,783,427 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01734,662,694 - 34,680,041 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41737,816,548 - 37,834,299 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11737,819,393 - 37,837,140 (-)NCBI
Celera1731,020,008 - 31,037,355 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16778019  


Genomics

Variants

.
Variants in Serpinb6b
120 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:111
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000059921
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172702794936146731Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat

Markers in Region
D17Got43  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21731,463,183 - 31,463,308 (+)MAPPERmRatBN7.2
Rnor_6.01732,775,845 - 32,775,967NCBIRnor6.0
Rnor_5.01734,668,051 - 34,668,173UniSTSRnor5.0
RGSC_v3.41737,821,904 - 37,822,027RGDRGSC3.4
RGSC_v3.41737,821,905 - 37,822,027UniSTSRGSC3.4
RGSC_v3.11737,824,745 - 37,824,868RGD
Celera1731,025,365 - 31,025,487UniSTS
RH 3.4 Map17363.9UniSTS
RH 3.4 Map17363.9RGD
RH 2.0 Map17253.5RGD
Cytogenetic Map17p12UniSTS
RH141133  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21731,458,033 - 31,458,245 (+)MAPPERmRatBN7.2
Rnor_6.01732,770,695 - 32,770,906NCBIRnor6.0
Rnor_5.01734,662,901 - 34,663,112UniSTSRnor5.0
RGSC_v3.41737,816,755 - 37,816,966UniSTSRGSC3.4
Celera1731,020,215 - 31,020,426UniSTS
RH 3.4 Map17359.3UniSTS
Cytogenetic Map17p12UniSTS
Serpinb6c  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21730,978,000 - 30,978,060 (+)MAPPERmRatBN7.2
Rnor_6.01732,197,843 - 32,197,902NCBIRnor6.0
Rnor_5.01734,091,165 - 34,091,224UniSTSRnor5.0
RGSC_v3.41737,323,431 - 37,323,490UniSTSRGSC3.4
RGSC_v3.41737,826,272 - 37,826,332UniSTSRGSC3.4
Celera1731,029,328 - 31,029,388UniSTS
Celera1730,542,150 - 30,542,209UniSTS
Cytogenetic Map17p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 10 2 19 2 17 11
Low 1 43 47 39 39 8 8 74 35 24 8
Below cutoff 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000059921   ⟹   ENSRNOP00000056665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1731,457,834 - 31,475,176 (-)Ensembl
Rnor_6.0 Ensembl1732,770,739 - 32,783,427 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094444   ⟹   ENSRNOP00000080262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1731,457,834 - 31,475,176 (-)Ensembl
RefSeq Acc Id: NM_001012214   ⟹   NP_001012214
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,666,587 - 31,683,934 (-)NCBI
mRatBN7.21731,457,827 - 31,475,176 (-)NCBI
Rnor_6.01732,770,488 - 32,787,835 (-)NCBI
Rnor_5.01734,662,694 - 34,680,041 (-)NCBI
RGSC_v3.41737,816,548 - 37,834,299 (-)RGD
Celera1731,020,008 - 31,037,355 (-)RGD
Sequence:
RefSeq Acc Id: XM_039095971   ⟹   XP_038951899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,666,751 - 31,684,222 (-)NCBI
mRatBN7.21731,455,092 - 31,475,460 (-)NCBI
RefSeq Acc Id: XM_039095972   ⟹   XP_038951900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,666,751 - 31,680,683 (-)NCBI
mRatBN7.21731,455,092 - 31,471,925 (-)NCBI
RefSeq Acc Id: XM_039095973   ⟹   XP_038951901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,666,751 - 31,679,498 (-)NCBI
mRatBN7.21731,455,092 - 31,470,744 (-)NCBI
RefSeq Acc Id: XM_039095974   ⟹   XP_038951902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,666,751 - 31,674,032 (-)NCBI
mRatBN7.21731,455,092 - 31,465,269 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001012214   ⟸   NM_001012214
- UniProtKB: Q68FX2 (UniProtKB/TrEMBL),   F7F6T5 (UniProtKB/TrEMBL),   A0A9K3Y788 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000056665   ⟸   ENSRNOT00000059921
RefSeq Acc Id: XP_038951899   ⟸   XM_039095971
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZQA7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951900   ⟸   XM_039095972
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZQA7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951901   ⟸   XM_039095973
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038951902   ⟸   XM_039095974
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000080262   ⟸   ENSRNOT00000094444
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7F6T5-F1-model_v2 AlphaFold F7F6T5 1-376 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310452 AgrOrtholog
BioCyc Gene G2FUF-9577 BioCyc
Ensembl Genes ENSRNOG00000016420 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059921 ENTREZGENE
  ENSRNOT00000059921.5 UniProtKB/TrEMBL
  ENSRNOT00000094444.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7125468 IMAGE-MGC_LOAD
InterPro Protease_inhib_I4_serpin UniProtKB/TrEMBL
  Protease_inhib_I4_serpin_CS UniProtKB/TrEMBL
  Sepin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report rno:364705 UniProtKB/TrEMBL
MGC_CLONE MGC:94100 IMAGE-MGC_LOAD
NCBI Gene 364705 ENTREZGENE
PANTHER NK13-RELATED UniProtKB/TrEMBL
  Prot_inh_serpin UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpinb6b PhenoGen
PROSITE SERPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016420 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt A0A8I5ZQA7 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y788 ENTREZGENE, UniProtKB/TrEMBL
  F7F6T5 ENTREZGENE
  Q68FX2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F7F6T5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Serpinb6b  serine (or cysteine) peptidase inhibitor, clade B, member 6b  Serpinb6b  serine (or cysteine) proteinase inhibitor, clade B, member 6b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Serpinb6b  serine (or cysteine) proteinase inhibitor, clade B, member 6b  Serpinb6b_predicted  serine (or cysteine) proteinase inhibitor, clade B, member 6b (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Serpinb6b_predicted  serine (or cysteine) proteinase inhibitor, clade B, member 6b (predicted)      Symbol and Name status set to approved 70820 APPROVED