Serpinb1b (serine (or cysteine) peptidase inhibitor, clade B, member 1b) - Rat Genome Database

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Gene: Serpinb1b (serine (or cysteine) peptidase inhibitor, clade B, member 1b) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Serpinb1b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 1b
RGD ID: 1560658
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of interleukin-1 beta production. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Orthologous to human SERPINB1 (serpin family B member 1); PARTICIPATES IN Entamoebiasis pathway; .
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leukocyte elastase inhibitor A-like; LOC102553010; LOC306891; RGD1560658; similar to serine (or cysteine) proteinase inhibitor, clade B, member 1b
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,528,880 - 31,538,119 (-)NCBIGRCr8
mRatBN7.21731,320,135 - 31,329,151 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1731,320,556 - 31,327,935 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01732,550,351 - 32,559,423 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,550,801 - 32,558,180 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01734,442,596 - 34,451,533 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41737,679,496 - 37,686,875 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1730,882,641 - 30,891,578 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Serpinb1bRatnegative regulation of interleukin-1 beta production involved_inIBAMGI:1913472 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Serpinb1bRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Serpinb1bRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Serpinb1bRatextracellular space is_active_inIBAFB:FBgn0002930 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Serpinb1bRatextracellular space located_inIEAInterPro:IPR0002151600115GO_REF:0000002InterProGO_REF:0000002

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Serpinb1bRatpeptidase inhibitor activity enablesIEAUniProtKB-KW:KW-06461600115GO_REF:0000043UniProtGO_REF:0000043
Serpinb1bRatserine-type endopeptidase inhibitor activity enablesIEAInterPro:IPR0002151600115GO_REF:0000002InterProGO_REF:0000002
Serpinb1bRatserine-type endopeptidase inhibitor activity enablesIBAMGI:101780 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Serpinb1bRatserine-type endopeptidase inhibitor activity enablesIEAUniProtKB-KW:KW-07221600115GO_REF:0000043UniProtGO_REF:0000043

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Serpinb1bRatEntamoebiasis pathway  IEA 6907045 KEGGrno:05146

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


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Variants in Serpinb1b
108 total Variants

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:19
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000022681
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 41 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat

1 to 10 of 41 rows



alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 1 21 8 11 1 6 1 6 20 13 13 11 10



Ensembl Acc Id: ENSRNOT00000022681   ⟹   ENSRNOP00000022680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1731,320,556 - 31,327,935 (-)Ensembl
Rnor_6.0 Ensembl1732,550,801 - 32,558,180 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000070876   ⟹   ENSRNOP00000067865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1732,009,809 - 32,015,071 (-)Ensembl
RefSeq Acc Id: XM_039096351   ⟹   XP_038952279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,528,880 - 31,538,119 (-)NCBI
mRatBN7.21731,320,135 - 31,329,132 (-)NCBI
RefSeq Acc Id: XM_039096352   ⟹   XP_038952280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,528,886 - 31,536,696 (-)NCBI
mRatBN7.21731,320,135 - 31,329,151 (-)NCBI
Protein RefSeqs XP_038952279 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952280 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022680
  ENSRNOP00000022680.8
Ensembl Acc Id: ENSRNOP00000022680   ⟸   ENSRNOT00000022681
RefSeq Acc Id: XP_038952280   ⟸   XM_039096352
- Peptide Label: isoform X2
- UniProtKB: F8WGA3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952279   ⟸   XM_039096351
- Peptide Label: isoform X1
- UniProtKB: A6J7I6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000067865   ⟸   ENSRNOT00000070876
SERPIN

Name Modeler Protein Id AA Range Protein Structure
AF-M0RE01-F1-model_v2 AlphaFold M0RE01 1-323 view protein structure
AF-F8WGA3-F1-model_v2 AlphaFold F8WGA3 1-378 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-9584 BioCyc
Ensembl Genes ENSRNOG00000034229 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000048358 Ensembl
Ensembl Transcript ENSRNOT00000022681 ENTREZGENE
  ENSRNOT00000022681.8 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Protease_inhib_I4_serpin UniProtKB/TrEMBL
  Protease_inhib_I4_serpin_CS UniProtKB/TrEMBL
  Sepin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
NCBI Gene 306891 ENTREZGENE
PANTHER Prot_inh_serpin UniProtKB/TrEMBL
  PTHR11461:SF180 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpinb1b PhenoGen
PROSITE SERPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000034229 RatGTEx
  ENSRNOG00000048358 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt A6J7I6 ENTREZGENE, UniProtKB/TrEMBL
  F8WGA3 ENTREZGENE, UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Serpinb1b  serine (or cysteine) peptidase inhibitor, clade B, member 1b  LOC102553010  leukocyte elastase inhibitor A-like  Data merged from RGD:7739348 737654 PROVISIONAL
2013-12-18 LOC102553010  leukocyte elastase inhibitor A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-23 Serpinb1b  serine (or cysteine) peptidase inhibitor, clade B, member 1b  RGD1560658  similar to serine (or cysteine) proteinase inhibitor, clade B, member 1b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560658  similar to serine (or cysteine) proteinase inhibitor, clade B, member 1b   RGD1560658_predicted  similar to serine (or cysteine) proteinase inhibitor, clade B, member 1b (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560658_predicted  similar to serine (or cysteine) proteinase inhibitor, clade B, member 1b (predicted)  LOC306891  similar to serine (or cysteine) proteinase inhibitor, clade B, member 1b  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC306891  similar to serine (or cysteine) proteinase inhibitor, clade B, member 1b      Symbol and Name status set to provisional 70820 PROVISIONAL