RGD Reference Report - [Expressions of receptor-interacting protein and caspase-8 in oral squamous cell carcinoma and oral precancerous lesions]. - Rat Genome Database

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[Expressions of receptor-interacting protein and caspase-8 in oral squamous cell carcinoma and oral precancerous lesions].

Authors: Shi, YJ  Shen, LJ  Yin, C 
Citation: Shi YJ, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2009 Sep;29(9):1802-5.
RGD ID: 7777170
Pubmed: PMID:19778795   (View Abstract at PubMed)

OBJECTIVE: To detect the expressions of receptor-interacting protein (RIP) and caspase-8 and investigate their roles in oral squamous cell carcinoma (OSCC) and oral precancerous lesions. METHODS: SABC immunohistochemical methods were used to detect the expressions of RIP and caspase-8 in 22 specimens of OSCC, 14 specimens of oral lichen planus (OLP), 14 specimens of oral leukoplakia (OLK) and 10 specimens of normal oral mucosa (NOM). RESULTS: The rate of weak or negative expression of RIP in normal mucosa was 50% (5/10). The rates of weak and positive expression of RIP in OLP, OLK and OSCC were 75% (36/50), and the rate of positive and strong expression of RIP was 63.7% (14/22) in OSCC, significantly higher that in the others groups (P<0.05). The rates of weak, positive and strong positive expression of caspase-8 in NOM, OLP, OLK and OSCC were 80% (8/10), 100% (14/14), 85.7% (12/14), and 100% (22/22), respectively. CONCLUSION: Both RIP and caspase-8 may play important roles in the occurrence and progression of OSCC and oral precancerous lesions.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
squamous cell carcinoma  IEP 7777170 RGD 
squamous cell carcinoma  ISORIPK1 (Homo sapiens)7777170; 7777170 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ripk1  (receptor interacting serine/threonine kinase 1)

Genes (Mus musculus)
Ripk1  (receptor (TNFRSF)-interacting serine-threonine kinase 1)

Genes (Homo sapiens)
RIPK1  (receptor interacting serine/threonine kinase 1)


Additional Information