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Gene: Tnfrsf1a (TNF receptor superfamily member 1A) Rattus norvegicus
Symbol: Tnfrsf1a
Name: TNF receptor superfamily member 1A
RGD ID: 621237
Description: Exhibits protease binding activity; tumor necrosis factor binding activity; and tumor necrosis factor-activated receptor activity. Involved in several processes, including cellular response to estradiol stimulus; regulation of apoptotic process; and regulation of cytokine production. Localizes to several cellular components, including cell surface; membrane raft; and mitochondrion. Used to study ischemia (multiple); middle cerebral artery infarction; myocardial infarction; uveitis; and visual epilepsy. Biomarker of several diseases, including colon carcinoma; root resorption; sciatic neuropathy; transient cerebral ischemia; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; ceramide signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
Also known as: MGC105478; p55; p60; TNF-R1; TNF-RI; TNFR-1; TNFR-I; Tnfr1; Tumor necrosis factor receptor; tumor necrosis factor receptor 1; tumor necrosis factor receptor superfamily member 1A; tumor necrosis factor receptor superfamily, member 1a; tumor necrosis factor receptor type I
Homo sapiens (human) : TNFRSF1A (TNF receptor superfamily member 1A)  HGNC  Alliance
Mus musculus (house mouse) : Tnfrsf1a (tumor necrosis factor receptor superfamily, member 1a)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnfrsf1a (TNF receptor superfamily member 1A)
Pan paniscus (bonobo/pygmy chimpanzee) : TNFRSF1A (TNF receptor superfamily member 1A)
Canis lupus familiaris (dog) : TNFRSF1A (TNF receptor superfamily member 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnfrsf1a (TNF receptor superfamily member 1A)
Sus scrofa (pig) : TNFRSF1A (TNF receptor superfamily member 1A)
Chlorocebus sabaeus (African green monkey) : TNFRSF1A (TNF receptor superfamily member 1A)
Heterocephalus glaber (naked mole-rat) : Tnfrsf1a (TNF receptor superfamily member 1A)
more info ...
Is Marker For: Strains:   BN   LEW   DA   ACI/N   F344/NRrrc  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04157,864,905 - 157,877,634 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,864,969 - 157,877,633 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,881,368 - 224,894,089 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44162,172,563 - 162,185,252 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14162,417,498 - 162,430,188 (+)NCBI
Celera4146,886,949 - 146,899,646 (+)NCBICelera
Cytogenetic Map4q42NCBI
RH 3.4 Map41000.9RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Tnfrsf1a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621237
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.