Tnfrsf1a (TNF receptor superfamily member 1A) - Rat Genome Database

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Gene: Tnfrsf1a (TNF receptor superfamily member 1A) Rattus norvegicus
Symbol: Tnfrsf1a
Name: TNF receptor superfamily member 1A
RGD ID: 621237
Description: Enables protease binding activity; tumor necrosis factor binding activity; and tumor necrosis factor receptor activity. Involved in several processes, including cellular response to estradiol stimulus; regulation of apoptotic process; and regulation of cytokine production. Located in axon; cell surface; and extracellular space. Part of protein-containing complex. Used to study ischemia (multiple); middle cerebral artery infarction; myocardial infarction; uveitis; and visual epilepsy. Biomarker of several diseases, including root resorption; sciatic neuropathy; transient cerebral ischemia; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; ceramide signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
Previously known as: MGC105478; p55; p60; TNF-R1; TNF-RI; TNFR-1; TNFR-I; Tnfr1; Tumor necrosis factor receptor; tumor necrosis factor receptor 1; tumor necrosis factor receptor superfamily member 1A; tumor necrosis factor receptor superfamily, member 1a; tumor necrosis factor receptor type I
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   BN   LEW   DA   ACI/N   F344/NRrrc  
Candidate Gene For: Ciaa4 Cia24
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr84159,837,119 - 159,849,817 (+)NCBIGRCr8
mRatBN7.24158,150,815 - 158,163,592 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4158,150,820 - 158,163,591 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4164,380,489 - 164,393,199 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04160,163,415 - 160,176,125 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,802,250 - 158,814,961 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,864,905 - 157,877,634 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,864,969 - 157,877,633 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,881,368 - 224,894,089 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44162,172,563 - 162,185,252 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14162,417,498 - 162,430,188 (+)NCBI
Celera4146,886,949 - 146,899,646 (+)NCBICelera
RH 3.4 Map41000.9RGD
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
acquired immunodeficiency syndrome  (ISO)
Acute Experimental Pancreatitis  (IEP)
acute kidney failure  (ISO)
adult respiratory distress syndrome  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
amyloidosis  (ISO)
anemia  (ISO)
Anorexia  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
autoimmune disease  (ISO)
autosomal dominant familial periodic fever  (ISO,ISS)
autosomal recessive pseudohypoaldosteronism type 1  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (IEP,ISO)
brain ischemia  (IDA,ISO)
bronchiectasis 1  (ISO)
Cachexia  (IEP,ISO)
CHARGE syndrome  (ISO)
Chediak-Higashi syndrome  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon carcinoma  (ISO)
colorectal adenoma  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (IEP)
cryptogenic organizing pneumonia  (ISO)
cystic fibrosis  (ISO)
cytomegalovirus retinitis  (ISO)
Diabetic Nephropathies  (ISO)
Embryo Loss  (ISO)
End Stage Liver Disease  (IMP)
end stage renal disease  (ISO)
endometrial cancer  (ISO)
Enterovirus Infections  (ISO)
Experimental Arthritis  (IDA,IEP,ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Colitis  (IMP)
Experimental Diabetes Mellitus  (IEP,ISO)
extrinsic allergic alveolitis  (ISO)
familial Mediterranean fever  (ISO)
Febrile Seizures  (ISO)
Fever  (ISO)
fibrosarcoma  (ISO)
focal segmental glomerulosclerosis  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (IEP,IMP,ISO)
Hyperoxia  (ISO)
Hyperphosphatemic Familial Tumoral Calcinosis 1  (ISO)
IgA glomerulonephritis  (ISO)
Insulin Resistance  (ISO)
ischemia  (IDA)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Legionnaires' disease  (ISO)
Liver Reperfusion Injury  (IEP)
Lung Injury  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
lymphoproliferative syndrome 2  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (IMP)
multiple sclerosis  (ISO)
Muscle Weakness  (ISO)
myocardial infarction  (IDA,IEP,IMP)
Nasal Polyps  (ISO)
Nematode Infections  (IEP)
Neurogenic Inflammation  (IDA)
obesity  (ISO)
obstructive sleep apnea  (ISO)
Optic Nerve Injuries  (IEP,ISO)
ovarian cancer  (ISO)
Pain  (IEP)
peroxisome biogenesis disorder 2B  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
primary biliary cholangitis  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
Radiation Pneumonitis  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
Reperfusion Injury  (IEP)
retinal detachment  (ISO)
rheumatoid arthritis  (ISO)
root resorption  (IEP)
sciatic neuropathy  (IEP,ISO)
silicosis  (ISO)
Spinal Cord Compression  (IEP)
Spinal Cord Injuries  (IEP)
squamous cell carcinoma  (ISO)
systemic lupus erythematosus  (ISO)
Temtamy syndrome  (ISO)
transient cerebral ischemia  (IEP)
type 2 diabetes mellitus  (IEP,ISO)
ureteral obstruction  (IEP)
uveitis  (IMP,ISO)
visual epilepsy  (IDA)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-methylcholine  (ISO)
2-naphthylamine  (ISO)
3,3'-diindolylmethane  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-tert-butylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
[des-Arg(9)]-bradykinin  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
AH23848  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
aminoguanidine  (ISO)
amphetamine  (EXP)
amphibole asbestos  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
asperentin  (ISO)
atorvastatin calcium  (ISO)
azathioprine  (ISO)
Bandrowski's base  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
Beta-Solamarine  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
Brevianamide A  (ISO)
butylated hydroxyanisole  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calphostin C  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
cefaloridine  (EXP)
CGP 52608  (ISO)
chloroform  (EXP)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dihydroxyacetone  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
dioscin  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenamidone  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
furosemide  (EXP)
gadolinium trichloride  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glutathione  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
isoflurane  (EXP)
isoprenaline  (EXP,ISO)
ketoconazole  (ISO)
L-mimosine  (ISO)
lead nitrate  (ISO)
leflunomide  (ISO)
lenalidomide  (ISO)
lignan  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
magnesium atom  (EXP)
magnesium oxide  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
metformin  (ISO)
methacholine chloride  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
mifepristone  (ISO)
Mitotane  (EXP)
monodansylcadaverine  (ISO)
motexafin gadolinium  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naloxone  (EXP)
nefazodone  (EXP)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotine  (EXP,ISO)
nimesulide  (EXP)
nitrates  (EXP)
Nonidet P-40  (ISO)
notoginsenoside R1  (ISO)
o-anisidine  (ISO)
ochratoxin A  (EXP,ISO)
octreotide  (EXP)
osthole  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentobarbital  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphoramide mustard  (EXP)
Phytolaccoside E  (ISO)
prochloraz  (EXP)
progesterone  (EXP,ISO)
propylparaben  (ISO)
prostaglandin E2  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quercitrin  (ISO)
quinidine  (EXP)
resiniferatoxin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 203580  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
sesquiterpene  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium stibogluconate  (ISO)
Soman  (EXP)
sterigmatocystin  (ISO)
sulfasalazine  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thalidomide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
tolcapone  (EXP)
Tomentosin  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (EXP,ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
WR-1065  (ISO)
zerumbone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc molecular entity  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve development  (ISO)
apoptotic process  (IEA)
cell surface receptor signaling pathway  (ISO,ISS)
cellular response to estradiol stimulus  (IEP)
cellular response to mechanical stimulus  (IEA,ISO)
cytokine-mediated signaling pathway  (ISO,ISS)
defense response  (ISO,ISS)
defense response to bacterium  (ISO)
inflammatory response  (IBA,IEA,ISO,ISS)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of cardiac muscle hypertrophy  (ISO)
negative regulation of extracellular matrix constituent secretion  (ISO)
negative regulation of gene expression  (IDA)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of interleukin-6 production  (IDA)
positive regulation of amide metabolic process  (ISO)
positive regulation of angiogenesis  (IMP)
positive regulation of apoptotic process involved in morphogenesis  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of execution phase of apoptosis  (ISO)
positive regulation of gene expression  (IMP)
positive regulation of inflammatory response  (ISO,ISS)
positive regulation of lipid metabolic process  (ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of protein import into nucleus  (IMP)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
positive regulation of tumor necrosis factor production  (IMP)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO)
programmed cell death  (ISO)
prostaglandin metabolic process  (IEA)
protein localization to plasma membrane  (IEA,ISO)
pulmonary valve development  (ISO)
regulation of apoptotic process  (IMP)
regulation of establishment of endothelial barrier  (IEA,ISO)
regulation of membrane lipid metabolic process  (ISO)
regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
response to alkaloid  (IEP)
response to amino acid  (IEP)
response to ethanol  (IEP)
response to hypoxia  (IEP)
response to lipopolysaccharide  (IEP)
transcription by RNA polymerase II  (ISO)
tumor necrosis factor-mediated signaling pathway  (IEA,IMP,ISO)

Cellular Component
axon  (IDA)
cell surface  (IDA,ISO)
extracellular space  (IDA,IEA,ISO)
Golgi membrane  (IEA,ISO,ISS)
membrane raft  (IBA,IEA,ISO)
plasma membrane  (IEA,ISO)
protein-containing complex  (IDA)
receptor complex  (IBA,IEA,ISO)

Molecular Function


References - curated
# Reference Title Reference Citation
1. Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus. Aderka D, etal., Arthritis Rheum. 1993 Aug;36(8):1111-20.
2. Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients. Aderka D, etal., Cancer Res. 1991 Oct 15;51(20):5602-7.
3. Time course profiling of the retinal transcriptome after optic nerve transection and optic nerve crush. Agudo M, etal., Mol Vis. 2008 Jun 3;14:1050-63.
4. Tumor necrosis factor receptor (TNFR) 1, but not TNFR2, mediates tumor necrosis factor-alpha-induced interleukin-6 and RANTES in human airway smooth muscle cells: role of p38 and p42/44 mitogen-activated protein kinases. Amrani Y, etal., Mol Pharmacol 2001 Oct;60(4):646-55.
5. A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis. Arntz OJ, etal., Arthritis Res Ther. 2010;12(2):R61. doi: 10.1186/ar2974. Epub 2010 Apr 6.
6. Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis. Aten J, etal., J Am Soc Nephrol. 2000 Aug;11(8):1426-38.
7. Enhancement of the survival of engrafted mesenchymal stem cells in the ischemic heart by TNFR gene transfection. Bao C, etal., Biochem Cell Biol. 2010 Aug;88(4):629-34.
8. Moxibustion inhibits apoptosis and tumor necrosis factor-alpha/tumor necrosis factor receptor 1 in the colonic epithelium of Crohn's disease model rats. Bao CH, etal., Dig Dis Sci. 2012 Sep;57(9):2286-95. doi: 10.1007/s10620-012-2161-0. Epub 2012 Apr 25.
9. TNFR2 interposes the proliferative and NF-kappaB-mediated inflammatory response by podocytes to TNF-alpha. Bruggeman LA, etal., Lab Invest. 2011 Mar;91(3):413-25. doi: 10.1038/labinvest.2010.199. Epub 2011 Jan 10.
10. Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury. Calfee CS, etal., Crit Care Med. 2011 Jan 28.
11. Expression of tumour necrosis factor receptors by bronchoalveolar cells in hypersensitivity pneumonitis. Chen B, etal., Eur Respir J. 2005 Jun;25(6):1039-43.
12. The effect of intra-articular injection of different concentrations of ozone on the level of TNF-alpha, TNF-R1, and TNF-R2 in rats with rheumatoid arthritis. Chen H, etal., Rheumatol Int. 2013 May;33(5):1223-7. doi: 10.1007/s00296-012-2529-7. Epub 2012 Oct 2.
13. Tumor Necrosis Factor-Alpha Antagonist Reduces Apoptosis of Neurons and Oligodendroglia in Rat Spinal Cord Injury. Chen KB, etal., Spine (Phila Pa 1976). 2011 Jan 8.
14. TNF-alpha enhances the currents of voltage gated sodium channels in uninjured dorsal root ganglion neurons following motor nerve injury. Chen X, etal., Exp Neurol. 2011 Feb;227(2):279-86. Epub 2010 Dec 9.
15. Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer's disease and non-demented patients. Cheng X, etal., J Alzheimers Dis. 2010;19(2):621-30. doi: 10.3233/JAD-2010-1253.
16. TNF-alpha is a key regulator of MUC1, an anti-inflammatory molecule, during airway Pseudomonas aeruginosa infection. Choi S, etal., Am J Respir Cell Mol Biol. 2011 Feb;44(2):255-60. Epub 2010 May 6.
17. Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. Constantin CE, etal., J Neurosci. 2008 May 7;28(19):5072-81.
18. Contribution of TNF receptor 1 to retinal neural cell death induced by elevated glucose. Costa GN, etal., Mol Cell Neurosci. 2012 May;50(1):113-23. doi: 10.1016/j.mcn.2012.04.003. Epub 2012 Apr 10.
19. Tumor necrosis factor receptor 1 expression is upregulated in dendritic cells in patients with chronic HCV who respond to therapy. Cubillas R, etal., Hepat Res Treat. 2010;2010:429243. doi: 10.1155/2010/429243. Epub 2010 Aug 3.
20. Protein and gene expression of tumour necrosis factor receptors I and II and their promoter gene polymorphisms in Alzheimer's disease. Culpan D, etal., Exp Gerontol. 2007 Jun;42(6):538-44. doi: 10.1016/j.exger.2006.12.001. Epub 2007 Jan 30.
21. Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney. Cunningham PN, etal., J Immunol. 2002 Jun 1;168(11):5817-23.
22. The presence of TNF-alpha and TNFR1 in aseptic root resorption. A preliminary study. Curl L and Sampson W, Aust Orthod J. 2011 Nov;27(2):102-9.
23. Exercise preconditioning reduces brain damage and inhibits TNF-alpha receptor expression after hypoxia/reoxygenation: an in vivo and in vitro study. Ding YH, etal., Curr Neurovasc Res. 2006 Nov;3(4):263-71.
24. Circulating levels of TNF-alpha and its soluble receptors in the plasma of patients with epithelial ovarian cancer. Dobrzycka B, etal., Eur Cytokine Netw. 2009 Sep;20(3):131-4.
25. A novel missense mutation (C30S) in the gene encoding tumor necrosis factor receptor 1 linked to autosomal-dominant recurrent fever with localized myositis in a French family. Dode C, etal., Arthritis Rheum. 2000 Jul;43(7):1535-42.
26. Sources of alveolar soluble TNF receptors during acute lung injury of different etiologies. Dorr AD, etal., J Appl Physiol. 2011 Apr 21.
27. Cytokine inhibitors: soluble tumor necrosis factor receptor 1 and interleukin-1 receptor antagonist in Behcet's disease. Duzgun N, etal., Rheumatol Int. 2005 Jan;25(1):1-5. Epub 2003 Nov 5.
28. Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study. Eagan TM, etal., Eur Respir J. 2010 Mar;35(3):540-8. Epub 2009 Jul 30.
29. Characterization of DISC formation and TNFR1 translocation to mitochondria in TNF-alpha-treated hepatocytes. Eum HA, etal., Am J Pathol. 2011 Sep;179(3):1221-9. doi: 10.1016/j.ajpath.2011.05.046. Epub 2011 Jul 8.
30. An atherogenic lipid profile with low serum paraoxonase-1 activity during nematode infection in rats. Farid AS, etal., Eur J Clin Invest. 2010 Nov;40(11):984-93. doi: 10.1111/j.1365-2362.2010.02352.x.
31. Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways. Fernandes A, etal., Glia. 2011 Jan;59(1):14-25. doi: 10.1002/glia.21072. Epub 2010 Oct 21.
32. Structural damage in diabetic nephropathy is associated with TNF-alpha system activity. Fernandez-Real JM, etal., Acta Diabetol. 2012 Aug;49(4):301-5. doi: 10.1007/s00592-011-0349-y. Epub 2011 Nov 1.
33. Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus. Fernandez-Real JM, etal., Am J Physiol Endocrinol Metab. 2002 Apr;282(4):E952-9.
34. Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissue. Figueras M, etal., Int J Oncol. 2005 Sep;27(3):855-60.
35. TNF receptor 1 and 2 contribute in different ways to resistance to Legionella pneumophila-induced mortality in mice. Fujita M, etal., Cytokine. 2008 Nov;44(2):298-303. Epub 2008 Oct 5.
36. Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci Furuya T, etal., Hum Mol Genet 2000 Sep 22;9(15):2241-50
37. Polymorphisms of the tumor necrosis factor receptor type 1 locus among autoimmune susceptible and resistant inbred rat strains. Furuya T, etal., Immunogenetics 2001 Jul;53(5):427-9.
38. Serum levels of soluble receptors for tumor necrosis factor (p55 and p75 sTNFr) in endometrial cancer. Gadducci A, etal., Anticancer Res. 1996 Sep-Oct;16(5B):3125-8.
39. Upregulation of TNF-alpha and Receptors Contribute to Endothelial Dysfunction in Zucker Diabetic Rats. Gao X, etal., Am J Biomed Sci. 2010;2(1):1-12.
40. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
41. Evoked pain behavior and spinal glia activation is dependent on tumor necrosis factor receptor 1 and 2 in a mouse model of bone cancer pain. Geis C, etal., Neuroscience. 2010 Aug 11;169(1):463-74. doi: 10.1016/j.neuroscience.2010.04.022. Epub 2010 Apr 24.
42. TNF/TNFR1 signaling mediates doxorubicin-induced diaphragm weakness. Gilliam LA, etal., Am J Physiol Lung Cell Mol Physiol. 2011 Feb;300(2):L225-31. Epub 2010 Nov 19.
43. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
44. S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: involvement of TNF signaling and NF-kappaB pathway in rats. Gong QH, etal., Brain Behav Immun. 2011 Jan;25(1):110-9. Epub 2010 Sep 7.
45. Circulating TNF-alpha and its soluble receptors during experimental acute pancreatitis. Granell S, etal., Cytokine. 2004 Feb 21;25(4):187-91.
46. TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis. Gregory AP, etal., Nature. 2012 Aug 23;488(7412):508-11. doi: 10.1038/nature11307.
47. Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. Guo G, etal., Am J Physiol. 1999 Nov;277(5 Pt 2):F766-72.
48. Shedding of tumor necrosis factor type 1 receptor after experimental spinal cord injury. Harrington JF, etal., J Neurotrauma. 2005 Aug;22(8):919-28.
49. Expression of tumor necrosis factor receptors on granulocytes in patients with myeloperoxidase anti-neutrophil cytoplasmic autoantibody-associated vasculitis. Hasegawa M, etal., Nephron Clin Pract. 2009;113(3):c222-33. doi: 10.1159/000235242. Epub 2009 Aug 18.
50. Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice. He P, etal., J Cell Biol. 2007 Aug 27;178(5):829-41. doi: 10.1083/jcb.200705042.
51. Molecular cloning and expression of human and rat tumor necrosis factor receptor chain (p60) and its soluble derivative, tumor necrosis factor-binding protein. Himmler A, etal., DNA Cell Biol 1990 Dec;9(10):705-15.
52. Increased tumor necrosis factor receptor 1 expression in human colorectal adenomas. Hosono K, etal., World J Gastroenterol. 2012 Oct 14;18(38):5360-8. doi: 10.3748/wjg.v18.i38.5360.
53. Increased susceptibility to acute kidney injury due to endoplasmic reticulum stress in mice lacking tumor necrosis factor-alpha and its receptor 1. Huang L, etal., Kidney Int. 2011 Mar;79(6):613-23. doi: 10.1038/ki.2010.469. Epub 2010 Dec 8.
54. Urinary excretion of soluble tumour necrosis factor receptor 1 as a marker of increased risk of progressive kidney function deterioration in patients with primary chronic glomerulonephritis. Idasiak-Piechocka I, etal., Nephrol Dial Transplant. 2010 Dec;25(12):3948-56. doi: 10.1093/ndt/gfq310. Epub 2010 Jun 4.
55. Elevated serum levels of the type I and type II receptors for tumor necrosis factor-alpha as predictive factors for ARF in patients with septic shock. Iglesias J, etal., Am J Kidney Dis. 2003 Jan;41(1):62-75.
56. Tumor necrosis factor alpha pathways develops liver apoptosis in type 1 diabetes mellitus. Ingaramo PI, etal., Mol Immunol. 2011 Apr 8.
57. Differences between tumor necrosis factor-alpha receptors types 1 and 2 in the modulation of spinal glial cell activation and mechanical allodynia in a rat sciatic nerve injury model. Ishikawa T, etal., Spine (Phila Pa 1976). 2013 Jan 1;38(1):11-6. doi: 10.1097/BRS.0b013e3182610fa9.
58. Exercise training increases membrane bound form of tumor necrosis factor-alpha receptors with decreases in the secretion of soluble forms of receptors in rat adipocytes. Ito Y, etal., Life Sci 2002 Jun 21;71(5):601-9.
59. Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway. Jacob N, etal., J Immunol. 2009 Feb 15;182(4):2532-41. doi: 10.4049/jimmunol.0802948.
60. Expression of monocyte chemoattractant protein-1 and its induction by tumor necrosis factor receptor 1 in sensory neurons in the ventral rhizotomy model of neuropathic pain. Jeon SM, etal., Neuroscience. 2011 Sep 8;190:354-66. doi: 10.1016/j.neuroscience.2011.06.036. Epub 2011 Jun 25.
61. Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease. Jiang H, etal., Mol Neurodegener. 2011 Oct 6;6:69. doi: 10.1186/1750-1326-6-69.
62. Role of heme oxygenase 1 in TNF/TNF receptor-mediated apoptosis after hepatic ischemia/reperfusion in rats. Kim SJ, etal., Shock. 2013 Apr;39(4):380-8. doi: 10.1097/SHK.0b013e31828aab7f.
63. Interaction of 5-hydroxytryptamine and tumor necrosis factor-alpha to pain-related behavior by nucleus pulposus applied on the nerve root in rats. Kobayashi H, etal., Spine (Phila Pa 1976). 2011 Feb 1;36(3):210-8.
64. Roles of TNF-alpha and its receptors in the beneficial effects of vagal stimulation after myocardial infarction in rats. Kong SS, etal., Clin Exp Pharmacol Physiol. 2011 Mar 1. doi: 10.1111/j.1440-1681.2011.05505.x.
65. Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by beta-naphthoflavone involving TNFalpha-signaling due to oxidative cellular stress in rats. Kuwata K, etal., Toxicology. 2011 Apr 28;283(1):8-17. Epub 2011 Feb 2.
66. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
67. Soluble tumour necrosis factor receptors as prognostic factors in cancer patients. Langkopf F and Atzpodien J, Lancet. 1994 Jul 2;344(8914):57-8.
68. Polymorphisms in apoptosis-related genes and survival of patients with early-stage non-small-cell lung cancer. Lee EB, etal., Ann Surg Oncol. 2010 Oct;17(10):2608-18. Epub 2010 Apr 27.
69. Cell-specific expression and lipopolysaccharide-induced regulation of tumor necrosis factor alpha (TNFalpha) and TNF receptors in rat dorsal root ganglion. Li Y, etal., J Neurosci. 2004 Oct 27;24(43):9623-31.
70. Inhibitory effects of Dendrobium alkaloids on memory impairment induced by lipopolysaccharide in rats. Li Y, etal., Planta Med. 2011 Jan;77(2):117-21. Epub 2010 Aug 17.
71. Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-kappaB inhibition. Lind MH, etal., Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4972-7. Epub 2004 Mar 25.
72. Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Liu KD, etal., Crit Care Med. 2007 Dec;35(12):2755-61.
73. Therapeutic hypothermia modulates TNFR1 signaling in the traumatized brain via early transient activation of the JNK pathway and suppression of XIAP cleavage. Lotocki G, etal., Eur J Neurosci. 2006 Oct;24(8):2283-90.
74. Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain. Lotocki G, etal., J Neurosci. 2004 Dec 8;24(49):11010-6.
75. Tumor necrosis factor alpha, its soluble receptor I, and -308 gene promoter polymorphism in patients with rheumatoid arthritis with or without amyloidosis: implications for the pathogenesis of nephropathy and anemia of chronic disease in reactive amyloidosis. Maury CP, etal., Arthritis Rheum. 2003 Nov;48(11):3068-76.
76. Polymorphism A36G of the tumor necrosis factor receptor 1 gene is associated with PAI-1 levels in obese women. Mavri A, etal., Thromb Haemost. 2007 Jan;97(1):62-6.
77. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
78. Decrease in tumor necrosis factor-alpha receptor-associated death domain results from ubiquitin-dependent degradation in obstructive renal injury in rats. Misaki T, etal., Am J Pathol. 2009 Jul;175(1):74-83. doi: 10.2353/ajpath.2009.080884. Epub 2009 Jun 18.
79. Insulin resistance, leptin and TNF-alpha system in morbidly obese women after gastric bypass. Molina A, etal., Obes Surg. 2003 Aug;13(4):615-21.
80. TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Morioka S, etal., Blood. 2012 Nov 1;120(18):3846-57. doi: 10.1182/blood-2012-03-416198. Epub 2012 Sep 12.
81. CXCR2 is required for neutrophilic airway inflammation and hyperresponsiveness in a mouse model of human rhinovirus infection. Nagarkar DR, etal., J Immunol. 2009 Nov 15;183(10):6698-707. Epub 2009 Oct 28.
82. Tumor necrosis factor-alpha mediates photoreceptor death in a rodent model of retinal detachment. Nakazawa T, etal., Invest Ophthalmol Vis Sci. 2011 Mar 14;52(3):1384-91. Print 2011 Mar.
83. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
84. Lack of soluble tumor necrosis factor alpha receptor 1 and 2 and interleukin-1beta compartmentalization in lungs of mice after a single intratracheal inoculation with live Porphyromonas gingivalis. Nemec A, etal., Exp Lung Res. 2009 Sep;35(7):605-20.
85. Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes. Niewczas MA, etal., Clin J Am Soc Nephrol. 2009 Jan;4(1):62-70. Epub 2008 Dec 10.
86. Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. Niewczas MA, etal., J Am Soc Nephrol. 2012 Mar;23(3):507-15. doi: 10.1681/ASN.2011060627. Epub 2012 Jan 19.
87. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
88. Tumor necrosis factor receptor deficiency alters matrix metalloproteinase 13/tissue inhibitor of metalloproteinase 1 expression in murine silicosis. Ortiz LA, etal., Am J Respir Crit Care Med. 2001 Jan;163(1):244-52.
89. Tumor necrosis factor receptor type-1 in sensory neurons contributes to induction of chronic enhancement of inflammatory hyperalgesia in rat. Parada CA, etal., Eur J Neurosci. 2003 May;17(9):1847-52.
90. Enhancement of a multianalyte serum biomarker panel to identify lymph node metastases in non-small cell lung cancer with circulating autoantibody biomarkers. Patel K, etal., Int J Cancer. 2010 Sep 7.
91. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
92. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
93. TNFR1 upregulation mediates tolerance after brain ischemic preconditioning. Pradillo JM, etal., J Cereb Blood Flow Metab. 2005 Feb;25(2):193-203. doi: 10.1038/sj.jcbfm.9600019.
94. TNFR1 mediates increased neuronal membrane EAAT3 expression after in vivo cerebral ischemic preconditioning. Pradillo JM, etal., Neuroscience. 2006;138(4):1171-8. Epub 2006 Jan 25.
95. TNFR1-dependent regulation of myeloid cell function in experimental autoimmune uveoretinitis. Raveney BJ, etal., J Immunol. 2009 Aug 15;183(4):2321-9. doi: 10.4049/jimmunol.0901340. Epub 2009 Jul 27.
96. GOA pipeline RGD automated data pipeline
97. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
98. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
99. Neutralizing tumor necrosis factor-alpha activity suppresses activation of infiltrating macrophages in experimental autoimmune uveoretinitis. Robertson M, etal., Invest Ophthalmol Vis Sci. 2003 Jul;44(7):3034-41.
100. Ethanol increases tumor necrosis factor-alpha receptor-1 (TNF-R1) levels in hepatic, intestinal, and cardiac cells. Rodriguez DA, etal., Alcohol. 2004 May;33(1):9-15.
101. Quantification of the mRNA encoding Tumor Necrosis Factor alpha (TNFalpha) and its receptors in human nasal polyps. Rostkowska-Nadolska B, etal., Adv Med Sci. 2008;53(2):263-9.
102. Imbalances in serum proinflammatory cytokines and their soluble receptors: a putative role in the progression of idiopathic IgA nephropathy (IgAN) and Henoch-Schonlein purpura nephritis, and a potential target of immunoglobulin therapy? Rostoker G, etal., Clin Exp Immunol. 1998 Dec;114(3):468-76.
103. 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway. Roy DN, etal., Br J Pharmacol. 2010 Aug;160(7):1823-43.
104. Plasma concentrations of TNF-alpha and its soluble receptors sTNFR1 and sTNFR2 in patients with coronary artery disease. Safranow K, etal., Tissue Antigens. 2009 Nov;74(5):386-92.
105. TNFR1 mRNA expression level and TNFR1 gene polymorphisms are predictive markers for susceptibility to develop invasive pulmonary aspergillosis. Sainz J, etal., Int J Immunopathol Pharmacol. 2010 Apr-Jun;23(2):423-36.
106. Differential cellular expression of tumor necrosis factor-alpha and Type I tumor necrosis factor receptor after transient global forebrain ischemia. Sairanen TR, etal., J Neurol Sci. 2001 May 1;186(1-2):87-99.
107. Contribution of TNF-alpha and nuclear factor-kappaB signaling to type 2 iodothyronine deiodinase activation in the mediobasal hypothalamus after lipopolysaccharide administration. Sanchez E, etal., Endocrinology. 2010 Aug;151(8):3827-35. Epub 2010 May 25.
108. Differences in serum cytokine levels between influenza virus A and B infections in children. Sato M, etal., Cytokine. 2009 Jul;47(1):65-8. Epub 2009 Jun 3.
109. Soluble tumor necrosis factor receptor type I enhances tumor development and persistence in vivo. Selinsky CL and Howell MD, Cell Immunol. 2000 Mar 15;200(2):81-7.
110. Soluble tumor necrosis factor alpha receptor type 1 in psoriasis patients treated with narrowband ultraviolet B. Serwin AB, etal., Photodermatol Photoimmunol Photomed. 2005 Aug;21(4):210-1.
111. Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn's disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2. Shi Y, etal., Chin J Integr Med. 2011 Mar;17(3):212-7. Epub 2011 Feb 27.
112. Elevation of serum soluble tumour necrosis factor receptors in patients with polymyositis and dermatomyositis. Shimizu T, etal., Clin Rheumatol. 2000;19(5):352-9.
113. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Shinoda S, etal., Eur J Neurosci. 2003 May;17(10):2065-76.
114. Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors. Shubayev VI and Myers RR, J Neuroimmunol. 2001 Mar 1;114(1-2):48-56.
115. Increased expression of tumor necrosis factor-alpha receptors in the brains of patients with AIDS. Sippy BD, etal., J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15;10(5):511-21.
116. Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina. Sivakumar V, etal., J Pathol. 2011 Jan 17. doi: 10.1002/path.2858.
117. Hyperalgesia in experimental neuropathy is dependent on the TNF receptor 1. Sommer C, etal., Exp Neurol. 1998 May;151(1):138-42.
118. The association between BMI and plasma cytokine levels in patients with acute lung injury. Stapleton RD, etal., Chest. 2010 Sep;138(3):568-77. Epub 2010 Apr 30.
119. Intramuscular gene transfer of soluble tumor necrosis factor-alpha receptor 1 activates vascular endothelial growth factor receptor and accelerates angiogenesis in a rat model of hindlimb ischemia. Sugano M, etal., Circulation. 2004 Feb 17;109(6):797-802.
120. In vivo transfer of soluble TNF-alpha receptor 1 gene improves cardiac function and reduces infarct size after myocardial infarction in rats. Sugano M, etal., FASEB J. 2004 May;18(7):911-3. Epub 2004 Mar 19.
121. Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. Sunil VR, etal., Toxicol Appl Pharmacol. 2011 Feb 1;250(3):245-55. Epub 2010 Nov 9.
122. Analysis of associations between polymorphisms within genes coding for tumour necrosis factor (TNF)-alpha and TNF receptors and responsiveness to TNF-alpha blockers in patients with rheumatoid arthritis. Swierkot J, etal., Joint Bone Spine. 2015 Mar;82(2):94-9. doi: 10.1016/j.jbspin.2014.08.006. Epub 2014 Oct 11.
123. Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice. Szretter KJ, etal., J Virol. 2007 Mar;81(6):2736-44. Epub 2006 Dec 20.
124. Role of tumor necrosis factor receptor-1 in the death of retinal ganglion cells following optic nerve crush injury in mice. Tezel G, etal., Brain Res. 2004 Jan 23;996(2):202-12.
125. TNFR 2 M196R polymorphism and acne vulgaris in Han Chinese: a case-control study. Tian L, etal., J Huazhong Univ Sci Technolog Med Sci. 2010 Jun;30(3):408-11. doi: 10.1007/s11596-010-0366-z. Epub 2010 Jun 17.
126. Serum cytokine receptor levels in noninfectious uveitis. Torun N, etal., Ophthalmic Res. 2005 Mar-Apr;37(2):112-6. Epub 2005 Mar 3.
127. Effects of ciliary muscle plasmid electrotransfer of TNF-alpha soluble receptor variants in experimental uveitis. Touchard E, etal., Gene Ther. 2009 Jul;16(7):862-73. doi: 10.1038/gt.2009.43. Epub 2009 May 14.
128. Tumor necrosis factor signaling. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
129. Tumor necrosis factor alpha primes cerebral endothelial cells for erythropoietin-induced angiogenesis. Wang L, etal., J Cereb Blood Flow Metab. 2011 Feb;31(2):640-7. Epub 2010 Aug 11.
130. Gene network revealed involvements of Birc2, Birc3 and Tnfrsf1a in anti-apoptosis of injured peripheral nerves. Wang Y, etal., PLoS One. 2012;7(9):e43436. doi: 10.1371/journal.pone.0043436. Epub 2012 Sep 17.
131. Opposing actions of hippocampus TNFalpha receptors on limbic seizure susceptibility. Weinberg MS, etal., Exp Neurol. 2013 Jan 16. pii: S0014-4886(13)00024-1. doi: 10.1016/j.expneurol.2013.01.011.
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134. Amelioration of liver injury by continuously targeted intervention against TNFRp55 in rats with acute-on-chronic liver failure. Xu Y, etal., PLoS One. 2013 Jul 16;8(7):e68757. doi: 10.1371/journal.pone.0068757. Print 2013.
135. Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats. Yan P, etal., Exp Neurol 2003 Oct;183(2):286-97.
136. Intrathecal ultra-low dose naloxone enhances the antihyperalgesic effects of morphine and attenuates tumor necrosis factor-alpha and tumor necrosis factor-alpha receptor 1 expression in the dorsal horn of rats with partial sciatic nerve transection. Yang CP, etal., Anesth Analg. 2013 Dec;117(6):1493-502. doi: 10.1213/ANE.0000000000000020.
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138. Blocking TNF-alpha by combination of TNF-alpha- and TNFR-binding cyclic peptide ameliorates the severity of TNBS-induced colitis in rats. Yin B, etal., Eur J Pharmacol. 2011 Apr 10;656(1-3):119-24. doi: 10.1016/j.ejphar.2011.01.046. Epub 2011 Feb 4.
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Additional References at PubMed
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Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr84159,837,119 - 159,849,817 (+)NCBIGRCr8
mRatBN7.24158,150,815 - 158,163,592 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4158,150,820 - 158,163,591 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4164,380,489 - 164,393,199 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04160,163,415 - 160,176,125 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,802,250 - 158,814,961 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,864,905 - 157,877,634 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,864,969 - 157,877,633 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,881,368 - 224,894,089 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44162,172,563 - 162,185,252 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14162,417,498 - 162,430,188 (+)NCBI
Celera4146,886,949 - 146,899,646 (+)NCBICelera
RH 3.4 Map41000.9RGD
Cytogenetic Map4q42NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38126,328,771 - 6,342,076 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,328,757 - 6,342,114 (-)EnsemblGRCh38hg38GRCh38
GRCh37126,437,937 - 6,451,242 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,308,184 - 6,321,522 (-)NCBINCBI36Build 36hg18NCBI36
Build 34126,308,184 - 6,321,522NCBI
Celera128,054,567 - 8,067,927 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,291,179 - 6,304,533 (-)NCBIHuRef
CHM1_1126,437,153 - 6,450,509 (-)NCBICHM1_1
T2T-CHM13v2.0126,338,163 - 6,351,461 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm396125,326,686 - 125,339,446 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6125,326,325 - 125,339,447 (+)EnsemblGRCm39 Ensembl
GRCm386125,349,723 - 125,362,483 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6125,349,362 - 125,362,484 (+)EnsemblGRCm38mm10GRCm38
MGSCv376125,299,741 - 125,312,501 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366125,315,374 - 125,328,104 (+)NCBIMGSCv36mm8
Celera6127,020,792 - 127,033,747 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map659.32NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554133,981,400 - 3,996,021 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554133,982,670 - 3,996,320 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21011,888,472 - 11,902,332 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11211,885,230 - 11,898,580 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,457,617 - 6,470,969 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,374,256 - 6,387,613 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,374,257 - 6,387,613 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12738,641,837 - 38,654,693 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,638,753 - 38,700,282 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha277,959,778 - 7,972,628 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,997,951 - 39,010,819 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12738,870,492 - 38,883,352 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,911,954 - 38,924,837 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,438,485 - 7,451,382 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404945102,735,979 - 102,753,899 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367091,407,278 - 1,421,921 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367091,407,327 - 1,421,448 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl564,319,051 - 64,331,909 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1564,319,349 - 64,331,876 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,780,726 - 66,793,255 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1116,364,544 - 6,378,880 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,364,330 - 6,378,902 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660631,856,767 - 1,871,090 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248603,111,630 - 3,122,711 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,111,244 - 3,123,041 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Tnfrsf1a
35 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:202
Count of miRNA genes:142
Interacting mature miRNAs:152
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4157680158158841762Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24158,163,236 - 158,163,349 (+)MAPPERmRatBN7.2
Rnor_6.04157,877,279 - 157,877,391NCBIRnor6.0
Rnor_5.04224,893,734 - 224,893,846UniSTSRnor5.0
RGSC_v3.44162,184,898 - 162,185,010UniSTSRGSC3.4
Celera4146,899,292 - 146,899,404UniSTS
RH 3.4 Map41000.9UniSTS
Cytogenetic Map4q42UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24158,163,215 - 158,163,413 (+)MAPPERmRatBN7.2
Rnor_6.04157,877,258 - 157,877,455NCBIRnor6.0
Rnor_5.04224,893,713 - 224,893,910UniSTSRnor5.0
RGSC_v3.44162,184,877 - 162,185,074UniSTSRGSC3.4
Celera4146,899,271 - 146,899,468UniSTS
Cytogenetic Map4q42UniSTS

Related Rat Strains
The following Strains have been annotated to Tnfrsf1a
ACI/N     BN     DA     F344/NRrrc     LEW    


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 37 57 41 19 41 2 5 57 35 34 11 2
Low 6 6 6 17 7 6
Below cutoff


RefSeq Acc Id: ENSRNOT00000048529   ⟹   ENSRNOP00000042371
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4158,150,820 - 158,163,588 (+)Ensembl
Rnor_6.0 Ensembl4157,864,969 - 157,877,633 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102042   ⟹   ENSRNOP00000092064
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4158,150,820 - 158,163,588 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113507   ⟹   ENSRNOP00000080227
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4158,158,214 - 158,163,591 (+)Ensembl
RefSeq Acc Id: NM_013091   ⟹   NP_037223
Rat AssemblyChrPosition (strand)Source
GRCr84159,837,119 - 159,849,816 (+)NCBI
mRatBN7.24158,150,894 - 158,163,591 (+)NCBI
Rnor_6.04157,864,990 - 157,877,633 (+)NCBI
Rnor_5.04224,881,368 - 224,894,089 (+)NCBI
RGSC_v3.44162,172,563 - 162,185,252 (+)RGD
Celera4146,886,949 - 146,899,646 (+)RGD
RefSeq Acc Id: XM_039107128   ⟹   XP_038963056
Rat AssemblyChrPosition (strand)Source
GRCr84159,845,618 - 159,849,817 (+)NCBI
mRatBN7.24158,161,212 - 158,163,592 (+)NCBI
RefSeq Acc Id: NP_037223   ⟸   NM_013091
- Peptide Label: precursor
- UniProtKB: Q91Y93 (UniProtKB/Swiss-Prot),   Q91V30 (UniProtKB/Swiss-Prot),   Q5U1X6 (UniProtKB/Swiss-Prot),   P22934 (UniProtKB/Swiss-Prot),   A0A0G2JSU9 (UniProtKB/TrEMBL),   A6ILU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000042371   ⟸   ENSRNOT00000048529
RefSeq Acc Id: XP_038963056   ⟸   XM_039107128
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000092064   ⟸   ENSRNOT00000102042
RefSeq Acc Id: ENSRNOP00000080227   ⟸   ENSRNOT00000113507
Protein Domains
Death   TNFR-Cys

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22934-F1-model_v2 AlphaFold P22934 1-461 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693412
Promoter ID:EPDNEW_R3937
Type:initiation region
Description:TNF receptor superfamily member 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.04157,864,947 - 157,865,007EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621237 AgrOrtholog
BioCyc Gene G2FUF-42992 BioCyc
Ensembl Genes ENSRNOG00000031312 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048529 ENTREZGENE
  ENSRNOT00000048529.5 UniProtKB/TrEMBL
  ENSRNOT00000102042.1 UniProtKB/TrEMBL
  ENSRNOT00000113507.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Death_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR/NGFR_Cys_rich_reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFRSF1A_death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFRSF1A_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25625 UniProtKB/Swiss-Prot
Pfam Death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_c6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tnfrsf1a PhenoGen
  TNFR_NGFR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_NGFR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031312 RatGTEx
SMART DEATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNR1A_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q5U1X6 UniProtKB/Swiss-Prot
  Q91V30 UniProtKB/Swiss-Prot
  Q91Y93 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-05 Tnfrsf1a  TNF receptor superfamily member 1A  Tnfrsf1a  tumor necrosis factor receptor superfamily, member 1a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Tnfrsf1a  tumor necrosis factor receptor superfamily, member 1a      Symbol and Name updated 629477 APPROVED
2003-03-12 Tnfrsf1a  tumor necrosis factor receptor superfamily, member 1a  Tnfr1  Tumor necrosis factor receptor  Data merged from RGD:3878 628472 PROVISIONAL
2002-08-07 Tnfrsf1a        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Tnfr1  Tumor necrosis factor receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease nucleotide sequence variants between rat strains may be associated with collagen induced arthritis QTL Cia13 619594
gene_process may contribute to collagen induced arthritis severity QTL Cia13 619594
gene_process human homolog induces MAP kinase activation and may mediate inflammatory response in airway muscle cells 730191