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Gene: Tnfrsf1a (TNF receptor superfamily member 1A) Rattus norvegicus
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Symbol: Tnfrsf1a
Name: TNF receptor superfamily member 1A
Description: Exhibits protease binding activity; tumor necrosis factor binding activity; and tumor necrosis factor-activated receptor activity. Involved in several processes, including cellular response to estradiol stimulus; regulation of apoptotic process; and regulation of gene expression. Localizes to several cellular components, including the cell surface; membrane raft; and mitochondrion. Used to study several diseases, including Legionnaires' disease; ischemia (multiple); middle cerebral artery infarction; uveitis; and visual epilepsy. Biomarker of several diseases, including colon carcinoma; root resorption; sciatic neuropathy; transient cerebral ischemia; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; Legionnaires' disease; acne; allergic bronchopulmonary aspergillosis; and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; ceramide signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC105478; p55; p60; TNF-R1; TNF-RI; TNFR-1; TNFR-I; Tnfr1; Tumor necrosis factor receptor; tumor necrosis factor receptor 1; tumor necrosis factor receptor superfamily member 1A; tumor necrosis factor receptor superfamily, member 1a; tumor necrosis factor receptor type I
Orthologs:
Homo sapiens (human) : TNFRSF1A (TNF receptor superfamily member 1A)  HGNC  Alliance
Mus musculus (house mouse) : Tnfrsf1a (tumor necrosis factor receptor superfamily, member 1a)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnfrsf1a (TNF receptor superfamily member 1A)
Pan paniscus (bonobo/pygmy chimpanzee) : TNFRSF1A (TNF receptor superfamily member 1A)
Canis lupus familiaris (dog) : TNFRSF1A (TNF receptor superfamily member 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnfrsf1a (TNF receptor superfamily member 1A)
Sus scrofa (pig) : TNFRSF1A (TNF receptor superfamily member 1A)
more info ...
Is Marker For: Strains:   BN   LEW   DA   ACI/N   F344/NRrrc  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04157,864,905 - 157,877,634 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,864,969 - 157,877,633 (+)Ensembl
Rnor_5.04224,881,368 - 224,894,089 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44162,172,563 - 162,185,252 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14162,417,498 - 162,430,188 (+)NCBI
Celera4146,886,949 - 146,899,646 (+)NCBICelera
Cytogenetic Map4q42NCBI
RH 3.4 Map41000.9RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Tnfrsf1a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621237
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.