RGD Reference Report - Serum levels of soluble receptors for tumor necrosis factor (p55 and p75 sTNFr) in endometrial cancer. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Serum levels of soluble receptors for tumor necrosis factor (p55 and p75 sTNFr) in endometrial cancer.

Authors: Gadducci, A  Ferdeghini, M  Fanucchi, A  Annicchiarico, C  Prato, B  Prontera, C  Facchini, V  Genazzani, AR 
Citation: Gadducci A, etal., Anticancer Res. 1996 Sep-Oct;16(5B):3125-8.
RGD ID: 5131439
Pubmed: PMID:8920779   (View Abstract at PubMed)

The pretreatment serum levels of the soluble receptors for tumor necrosis factor (p55 and p75 sTNFr) were retrospectively measured in 38 patients with endometrial cancer and 55 patients with benign uterine diseases as controls. Serum p55 and p75 sTNFr levels were significantly higher in patients with endometrial cancer (median = 2.4 ng/ml, range = 1.4-6.8 ng/ml, and median = 7.1 ng/ml, range = 2.5-19.5 ng/ml, respectively) than in controls (median = 1.7 ng/ml, range = 0.5-4.0 ng/ml, p < 0.0001, and median = 5.2 ng/ml, range = 2.6-21.9 ng/ml, p = 0.03, respectively). In the former, serum p55 and p75 sTNFr values correlated with the extent of disease (stage III-IV versus I-II: p = 0.04 and p = 0.03, respectively). Among the 23 patients with stage I endometrial cancer who underwent initial surgery, the preoperative serum levels of both receptors correlated with the histologic grade and myometrial invasion but not with the clinical outcome. In conclusion, a stage-dependent release of the soluble receptors for TNF into the bloodstream occurs in patients with endometrial cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
endometrial cancer  IEP 5131439; 5131439protein:increased expression:serum (human)RGD 
endometrial cancer  ISOTNFRSF1A (Homo sapiens)5131439; 5131439protein:increased expression:serum (human)RGD 
endometrial cancer  ISOTNFRSF1B (Homo sapiens)5131439; 5131439protein:increased expression:serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnfrsf1a  (TNF receptor superfamily member 1A)
Tnfrsf1b  (TNF receptor superfamily member 1B)

Genes (Mus musculus)
Tnfrsf1a  (tumor necrosis factor receptor superfamily, member 1a)
Tnfrsf1b  (tumor necrosis factor receptor superfamily, member 1b)

Genes (Homo sapiens)
TNFRSF1A  (TNF receptor superfamily member 1A)
TNFRSF1B  (TNF receptor superfamily member 1B)


Additional Information