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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621237
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfrsf1a
Name: TNF receptor superfamily member 1A
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfrsf1aaffects response to substanceISOTnfrsf1a (Mus musculus)6480464CTDTNFRSF1A protein affects the susceptibility to OxygenPMID:10781441
Tnfrsf1adecreases expressionISOTnfrsf1a (Mus musculus)6480464CTDOxygen deficiency results in decreased expression of TNFRSF1A mRNAPMID:24205000
Tnfrsf1aincreases expressionISOTNFRSF1A (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of TNFRSF1A mRNAPMID:23452621
Tnfrsf1amultiple interactionsISOTnfrsf1a (Mus musculus)6480464CTDTNFRSF1A protein affects the reaction [Oxygen results in increased expression of ICAM1 mRNA]; TNFRSF1A protein affects the reaction [Oxygen results in increased expression of SOD2 mRNA]PMID:10781441
Tnfrsf1amultiple interactionsISOTNFRSF1A (Homo sapiens)6480464CTD3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF1A mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF1A mRNA]; Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF1A mRNA]; resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF1A mRNA]PMID:23452621
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