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Strain Registration

Strain: ACI/N

Symbol: ACI/N
Strain: ACI
Substrain: N
Full Name: A X C 9935, Irish
RGD ID: 10000
Citation ID: RRID:RRRC_00142
Ontology ID: RS:0000023
Alleles: Tnfrsf1a
Also Known As: MDC-04-48; ACI
Type: inbred
Available Source: Rat Resource and Research Center
Origination: Rat Resource and Research Center
Description: Curtiss and Dunning 1926 at the Columbia University Institute for Cancer Research. To Heston 1945 at F30, to National Institutes of Health 1950 at F41. Subsequent sublines from Dunning or NIH. Donated to RRRC from NIH Animal Genetic Resource Bank (NIHAGR)
Genetic Markers: a, hi
Coat Color: Agouti with white belly and feet.
Inbred Generations: F147
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery
Research Usage spontaneous tumors; chronic renal disease; congenital malformations





References

References - curated
# Reference Title Reference Citation
1. Heterogeneous stock rat: a unique animal model for mapping genes influencing bone fragility. Alam I, etal., Bone. 2011 May 1;48(5):1169-77. Epub 2011 Feb 18.
2. Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Brown DM, etal., Nat Genet 1996 Jan;12(1):44-51
3. Linkage analysis of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the rat identifies a locus controlling demyelination on chromosome 18. Dahlman I, etal., Hum Mol Genet 1999 Nov;8(12):2183-90.
4. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
5. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
6. Chromosomal mapping of genetic loci controlling absence epilepsy phenotypes in the WAG/Rij rat. Gauguier D, etal., Epilepsia 2004 Aug;45(8):908-15.
7. Mapping autoimmunity genes. Griffiths MM, etal., Curr Opin Immunol. 1999 Dec;11(6):689-700.
8. Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats. Gulko PS, etal., Arthritis Rheum 1998 Dec;41(12):2122-31
9. A genetic linkage map of the laboratory rat, Rattus norvegicus. Jacob HJ, etal., Nat Genet 1995 Jan;9(1):63-9
10. Rat Strain List M. Festing Rat Strain List
11. NIH Rat Strain Data NIH Rat Strain Data
12. RGD Strain RSO annotation pipeline RGD Automated Pipelines
13. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
14. Evidence of gene-gene interactions in the genetic susceptibility to renal impairment after unilateral nephrectomy. Shiozawa M, etal., J Am Soc Nephrol 2000 Nov;11(11):2068-78.
15. Fine-mapping a locus for glucose tolerance using heterogeneous stock rats. Solberg Woods L, etal., Physiol Genomics. 2010 Jan 12.
16. Fine-mapping diabetes-related traits, including insulin resistance, in heterogeneous stock rats. Solberg Woods LC, etal., Physiol Genomics. 2012 Sep 4.
17. A high density integrated genetic linkage and radiation hybrid map of the laboratory rat Steen RG, Kwitek-Black AE, etal., Genome Research, 1999, 6:1-8
18. New target regions for human hypertension via comparative genomics. Stoll M, etal., Genome Res 2000 Apr;10(4):473-82.
19. Chromosomal mapping of genes controlling development, histological grade, depth of invasion, and size of rat stomach carcinomas. Ushijima T, etal., Cancer Res 2000 Feb 15;60(4):1092-6.
20. Altered renal hemodynamics and impaired myogenic responses in the fawn-hooded rat. van Dokkum RP, etal., Am J Physiol 1999 Mar;276(3 Pt 2):R855-63
21. Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases. Wilder RL, etal., Transplant Proc 1999 May;31(3):1585-8

Region

Strain QTL Data
Symbol Name Trait
Bp197 Blood pressure QTL 197 arterial blood pressure trait   (VT:2000000)    
Bp283 Blood pressure QTL 283 arterial blood pressure trait   (VT:2000000)    
BpQTLcluster14 Blood pressure QTL cluster 14 arterial blood pressure trait   (VT:2000000)    
Cia10 Collagen induced arthritis QTL 10 joint integrity trait   (VT:0010548)    
Cia9 Collagen induced arthritis QTL 9 joint integrity trait   (VT:0010548)    
Eae12 Experimental allergic encephalomyelitis QTL 12 nervous system integrity trait   (VT:0010566)    
Eae13 Experimental allergic encephalomyelitis QTL 13 nervous system integrity trait   (VT:0010566)    
Eae14 Experimental allergic encephalomyelitis QTL 14 nervous system integrity trait   (VT:0010566)    
Eae15 Experimental allergic encephalomyelitis QTL 15 nervous system integrity trait   (VT:0010566)    
Gcr1 Gastric cancer resistance QTL 1 stomach morphology trait   (VT:0000470)    
Gcr2 Gastric cancer resistance QTL 2 stomach morphology trait   (VT:0000470)    
Gcr3 Gastric cancer resistance QTL 3 stomach morphology trait   (VT:0000470)    
Gcs1 Gastric cancer susceptibility QTL1 stomach morphology trait   (VT:0000470)    
Rf1 Renal disease susceptibility QTL 1 urine protein amount   (VT:0005160)    
Rf2 Renal disease susceptibility QTL 2 urine protein amount   (VT:0005160)    
Rf3 Renal disease susceptibility QTL 3 urine albumin amount   (VT:0002871)    
Rf4 Renal disease susceptibility QTL 4 urine total protein amount   (VT:0000032)    
Rf5 Renal disease susceptibility QTL 5 urine total protein amount   (VT:0000032)    
Swd1 Spike wave discharge measurement QTL 1 brain electrophysiology trait   (VT:0010557)    
Swd2 Spike wave discharge measurement QTL 2 brain electrophysiology trait   (VT:0010557)    
Strain Samples in RGD with Damaging Variants (Polyphen)
AssemblySample 
RGSC_v3.4 ACI/N (KNAW) View Damaging Variants
Rnor_5.0 ACI/N (KNAW) View Damaging Variants
Rnor_6.0 ACI/N (MCW) View Damaging Variants
Rnor_6.0 ACI/N (2020) View Damaging Variants
mRatBN7.2 ACI/N (2020) View Damaging Variants


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Will grow transplantable Morris hepatomas 3924A which can be used as a model for the treatment of liver cancer (Yang et al 1995) 634612
strain_drgs_chems Many tumours induced by ptaquiloside, a carcinogen in the bracken fern (Hirono et al 1987).Caffeine suppresses 2-acetylaminofluorine-induced hepatic tumours (Hosaka et al 1984). Effects of retinoids on tumours of the skin, prostate and endocrine pancreas studied by Ohshina et al(1985). Susceptible to the development of glioblastomas of a mixed oligo-astrocytic type following treatment with N-methyl-N-nitrosourea in the drinking water (Shibutani et al 1993). Like F344, refractory to the development of prostatic hyperplasia induced by citral compared with outbred Wistar and Sprague-Dawley rats (Scolnik et al 1994). Highly sensitive to the development of N-methyl-N-nitrosoguanidine (MNNG) induced gastric cancer though levels of adduct were same as in the resistant BUF strain (Sugimura et al 1995). Susceptible to the induction of tumours of the large intestine and forestomach by 1-hydroxyanthraquinone, though incidence can be reduced by the nonsteroidal anti-inflamatory drug indomethacin (Tanaka et al 1995). High hepatic metabolism of anilene in females (2/10) (Page and Vesell 1969). Absorbs diethylstilboestrol at intermediate rate, leading to a high incidence of mammary tumours (Dunning et al 1947, see also Rothschild et al 1987). High LD50 (120mg/kg) for pentobarbital sodium (1/7) (Shearer et al 1973). Long pentobarbitone sleeping time (1/10 males, 3/10 females), Vieregge et al (1987). Susceptible to the induction of gastric tumours by N-methyl-N-nitro-N- nitrosoguanidine (Ohgaki et al 1983). 634612
strain_life_disease Median survival 113 weeks in males, 108 weeks in females. Spontaneous tumours 46% testes,16% adrenal, 5% pituitary, 6% skin and ear duct and fewer of other types in males; 21%pituitary, 13% uterus, 11% mammary gland, 6% adrenal and fewer of other types in females.Other conditions include 28% of males and 20% of females with absent, hypoplastic or cystic kidneys on one side sometimes associated with an absent or defective uterine horn or atrophictestes on the same side (Maekawa and Odashima 1975). These abnormalities have a polygenic mode of inheritance (Cramer and Gill 1975). Spontaneous adenocarcinomas of ventral prostate seen in 7/41 untreated males at 34-37 months (Shain et al 1975, see also Ward et al 1980, Isaacs1984). This is substantially increased by a high fat diet (Kondo et al 1994). High survival to 2 years of age at 74% (rank 2/5) in males and 70% (rank 1/5) in females. However, a high incidence of relatively mild chronic renal disease and a high incidence of hydronephrosis and the congenital renal agenesis may make the strain unsuitable for long-term toxicological studies(Solleveld and Boorman 1986). Four spontaneous kidney and five bladder tumours found among a cohort of 300 rats maintained for 30 months (Vanmoorsellar et al 1993). Urolithiasis seen in 2/55 rats at an average age of 144 days (Kunstyr et al 1982). A diet deficientin choline and methionine has been used to develop a rat model of fatty liver transplantation (Teramoto et al 1993). 634612
strain_phys_biochem Almost free of spike-wave discharges associated with absence of epilepsy seen in strain WAG/Rij, while BN/Bi, B and G were intermediate (Inoue et al 1990). Low serum thyroxine (5/5) (Esber etal 1974). Low systolic blood pressure (17/17) (Hansen et al 1973). Low blood pressure (18/23), reaching 124_1.1 (SEM) mmHg at 10 weeks of age (Tanase et al 1982). Copper deficiency results in pigment patterns similar to that of the mottled mouse, a model for Menkes kinky hair syndrome (Miranda et al 1992). Liver gangliosides are of the a-type (cf LEA,LEW & BUF) (Kasai et al 1993) 634612
strain_reproduction Poor reproductive performance (9/12) and low litter size (11/12) (Hansen et al 1973). High (11%) early prenatal mortality (2/8) and high (10%) incidence of congenital malformations (Shoji 1977). High in-utero embryo mortality, which depends on maternal genotype (Cramer and Gill 1975). 634612

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-04-05 ACI/N  A X C 9935, Irish  ACI/N  A X C 9935, Irish  Name updated 68913 APPROVED
2003-11-12 ACI/N  A X C 9935, Irish  ACI    Symbol Updated 728213 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00142 RGD