RGD Reference Report - Polymorphisms in apoptosis-related genes and survival of patients with early-stage non-small-cell lung cancer. - Rat Genome Database

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Polymorphisms in apoptosis-related genes and survival of patients with early-stage non-small-cell lung cancer.

Authors: Lee, EB  Jeon, HS  Yoo, SS  Choi, YY  Kang, HG  Cho, S  Cha, SI  Choi, JE  Park, TI  Lee, BH  Park, RW  Kim, IS  Kang, YM  Kim, CH  Jheon, S  Jung, TH  Park, JY 
Citation: Lee EB, etal., Ann Surg Oncol. 2010 Oct;17(10):2608-18. Epub 2010 Apr 27.
RGD ID: 5131202
Pubmed: PMID:20422457   (View Abstract at PubMed)
DOI: DOI:10.1245/s10434-010-1082-4   (Journal Full-text)

PURPOSE: This study was conducted to determine the association between single-nucleotide polymorphisms (SNPs) in apoptosis-related genes and survival outcomes of patients with early-stage non-small-cell lung cancer (NSCLC). METHODS: Three hundred ten consecutive patients with surgically resected NSCLC were enrolled. Twenty-five SNPs in 17 apoptosis-related genes were genotyped by a sequenome mass spectrometry-based genotyping assay. The genotype associations with overall survival (OS) and disease-free survival (DFS) were analyzed. RESULTS: Three SNPs (TNFRSF10B rs1047266, TNFRSF1A rs4149570, and PPP1R13L rs1005165) were significantly associated with survival outcomes on multivariate analysis. When the three SNPs were combined, OS and DFS were decreased as the number of bad genotypes increased (P (trend) for OS and DFS = 7 x 10(-5) and 1 x 10(-4), respectively). Patients with one bad genotype, and patients with two or three bad genotypes had significantly worse OS and DFS compared with those with no bad genotypes [adjusted hazard ratio (aHR) for OS = 2.27, 95% confidence interval (CI) = 1.22-4.21, P = 0.01, aHR for DFS = 1.74, 95% CI = 1.08-2.81, P = 0.02; aHR for OS = 4.11, 95% CI = 2.03-8.29, P = 8 x 10(-5); and aHR for DFS = 2.89, 95% CI = 1.64-5.11, P = 3 x 10(-4), respectively]. CONCLUSION: Three SNPs in apoptosis-related genes were identified as possible prognostic markers of survival in patients with early-stage NSCLC. The SNPs, and particularly their combined genotypes, can be used to identify patients at high risk for poor disease outcome.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
lung non-small cell carcinoma severityIAGP 5131202DNA:snp:5' utr:g.-329G>T rs4149570 (human)RGD 
lung non-small cell carcinoma severityISOTNFRSF1A (Homo sapiens)5131202; 5131202DNA:snp:5' utr:g.-329G>T rs4149570 (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnfrsf1a  (TNF receptor superfamily member 1A)

Genes (Mus musculus)
Tnfrsf1a  (tumor necrosis factor receptor superfamily, member 1a)

Genes (Homo sapiens)
TNFRSF1A  (TNF receptor superfamily member 1A)


Additional Information