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Differences in serum cytokine levels between influenza virus A and B infections in children.

Authors: Sato, M  Hosoya, M  Wright, PF 
Citation: Sato M, etal., Cytokine. 2009 Jul;47(1):65-8. Epub 2009 Jun 3.
Pubmed: (View Article at PubMed) PMID:19497758
DOI: Full-text: DOI:10.1016/j.cyto.2009.05.003

OBJECTIVE: To investigate differences in cytokine production between influenza A and B. MATERIALS AND METHODS: thirty one patients with influenza A and 16 with influenza B were enrolled in this study. We measured soluble tumor necrosis factor receptor (sTNFR) 1, interleukin (IL)-6, interferon (IFN)-gamma and IL-4 concentrations in serum obtained from all patients during the acute and convalescence phases of their illnesses. RESULTS: the sTNFR1 and IL-6 serum concentrations of patients with influenza A and B were equivalently elevated in the acute phase of their illness. However, the acute phase concentrations of IFN-gamma and IL-4 were significantly higher in patients with influenza A than in patients with influenza B. The concentration of all cytokines in influenza A and sTNFR1 in influenza B significantly decreased from the acute to convalescent phase. Plotted from the onset of symptoms it appeared that all of the cytokines peaked within 24h after onset. DISCUSSION: the production pattern of the inflammatory cytokines - TNF and IL-6 - were the same between influenza A and B. However, a Th2 predominant cytokine pattern was induced after natural influenza virus A infection, notably IL-4 that differed from that to influenza B.

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RGD Object Information
RGD ID: 5131432
Created: 2011-04-27
Species: All species
Last Modified: 2011-04-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.