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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621237
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfrsf1a
Name: TNF receptor superfamily member 1A
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7372886480464CTDQuercetin results in increased expression of TNFRSF1A mRNA

PMID:23727915
multiple interactionsISORGD:7342476480464CTDQuercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein], Quercetin results in decreased expression of and affects the localization of TNFRSF1A protein

PMID:26076811, PMID:27494022
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.