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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621237
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfrsf1a
Name: TNF receptor superfamily member 1A
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7342476480464CTDAcetaminophen affects the expression of TNFRSF1A mRNA

PMID:17562736
affects response to substanceISORGD:7342476480464CTDTNFRSF1A protein affects the susceptibility to Acetaminophen

PMID:22461450
decreases expressionISORGD:7372886480464CTDAcetaminophen results in decreased expression of TNFRSF1A mRNA

PMID:21420995, PMID:29067470
decreases response to substanceISORGD:7342476480464CTDTNFRSF1A protein results in decreased susceptibility to Acetaminophen

PMID:14550746
increases expressionISORGD:7342476480464CTDAcetaminophen results in increased expression of TNFRSF1A mRNA, Acetaminophen results in increased expression of TNFRSF1A protein

PMID:12540782, PMID:14557383, PMID:22461450, PMID:22575169
increases response to substanceISORGD:7342476480464CTDTNFRSF1A protein results in increased susceptibility to Acetaminophen

PMID:14557383
multiple interactionsISORGD:7342476480464CTDLGALS3 protein affects the reaction [Acetaminophen results in increased expression of TNFRSF1A mRNA], MST1R protein affects the reaction [Acetaminophen results in increased expression of TNFRSF1A protein], O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1, 2-diolate inhibits the reaction [Acetaminophen results in increased expression of TNFRSF1A mRNA], TNFRSF1A protein affects the reaction [Acetaminophen results in increased expression of CCN2 mRNA], TNFRSF1A protein affects the reaction [Acetaminophen results in increased expression of LGALS3 mRNA], TNFRSF1A protein affects the reaction [Acetaminophen results in increased expression of MMP9 mRNA], TNFRSF1A protein affects the reaction [Acetaminophen results in increased expression of SLC3A2 mRNA], TNFRSF1A protein affects the reaction [Acetaminophen results in increased expression of TNF mRNA], TNFRSF1A protein affects the reaction [Acetaminophen results in increased expression of TNF protein], TNFRSF1A protein affects the reaction [pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]], TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of CCL2 mRNA], TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of CCL2 protein], TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of CCL3 mRNA], TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of CCL3 protein], TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of CXCL2 mRNA], TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of CXCL2 protein], TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of ICAM1 mRNA], TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of IFNG mRNA], TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of IL10 mRNA], TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of IL1A mRNA], TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of IL1B mRNA], TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of IL6 mRNA], TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of NOS2 mRNA], TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of SELE mRNA], TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of VCAM1 mRNA], TNFRSF1A protein results in decreased susceptibility to [Acetaminophen results in increased expression of NOS2 protein]

PMID:12540782, PMID:14550746, PMID:14557383, PMID:22461450, PMID:22575169
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.