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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621237
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfrsf1a
Name: TNF receptor superfamily member 1A
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDoxorubicin results in increased expression of TNFRSF1A protein

PMID:17651020
affects localizationISORGD:7342476480464CTDDoxorubicin affects the localization of TNFRSF1A protein

PMID:21097524
affects response to substanceISORGD:7342476480464CTDTNFRSF1A protein affects the susceptibility to Doxorubicin

PMID:16618758
increases expressionISORGD:7342476480464CTDDoxorubicin results in increased expression of TNFRSF1A mRNA, Doxorubicin results in increased expression of TNFRSF1A protein

PMID:21097524
increases expressionISORGD:7372886480464CTDDoxorubicin results in increased expression of TNFRSF1A mRNA

PMID:29803840
multiple interactionsISORGD:7342476480464CTDTNFRSF1A protein affects the reaction [Doxorubicin affects the expression of PLCD1 mRNA], TNFRSF1A protein affects the reaction [Doxorubicin affects the expression of PLCD1 protein], TNFRSF1A protein affects the reaction [Doxorubicin results in decreased expression of FAS protein]

PMID:16505099, PMID:16618758
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.