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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621237
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfrsf1a
Name: TNF receptor superfamily member 1A
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDCarbon Tetrachloride affects the expression of TNFRSF1A mRNA

PMID:15963342
increases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of TNFRSF1A mRNA, Carbon Tetrachloride results in increased expression of TNFRSF1A protein

PMID:17522070, PMID:24389507, PMID:27623180
multiple interactionsEXP 6480464CTD[Carbon Tetrachloride co-treated with TM4SF4 protein] results in increased expression of TNFRSF1A mRNA, [Carbon Tetrachloride co-treated with TM4SF4 protein] results in increased expression of TNFRSF1A protein, almond oil inhibits the reaction [Carbon Tetrachloride results in increased expression of TNFRSF1A mRNA]

PMID:17069928, PMID:27623180
increases expressionISORGD:7342476480464CTDCarbon Tetrachloride results in increased expression of TNFRSF1A protein

PMID:29987408
multiple interactionsISORGD:7342476480464CTDPANX1 protein affects the reaction [Carbon Tetrachloride results in increased expression of TNFRSF1A protein]

PMID:29987408
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.