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Gene: Tnf (tumor necrosis factor) Rattus norvegicus
Symbol: Tnf
Name: tumor necrosis factor
Description: Exhibits tumor necrosis factor receptor binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of cytokine production; and positive regulation of macromolecule metabolic process. Localizes to several cellular components, including external side of plasma membrane; extracellular space; and neuronal cell body. Used to study several diseases, including cerebrovascular disease (multiple); liver disease (multiple); peptic esophagitis; perinatal necrotizing enterocolitis; and periventricular leukomalacia. Biomarker of several diseases, including brain disease (multiple); congestive heart failure (multiple); inflammatory bowel disease (multiple); lung disease (multiple); and non-alcoholic fatty liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to human TNF (tumor necrosis factor); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; tumor necrosis factor mediated signaling pathway; ceramide signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-catechin; (+)-pilocarpine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cachectin; MGC124630; RATTNF; TNF-a; TNF-alpha; Tnfa; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor superfamily member 2; tumor necrosis factor superfamily, member 2; tumor necrosis factor-alpha
Homo sapiens (human) : TNF (tumor necrosis factor)  HGNC  Alliance
Mus musculus (house mouse) : Tnf (tumor necrosis factor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnf (tumor necrosis factor)
Pan paniscus (bonobo/pygmy chimpanzee) : TNF (tumor necrosis factor)
Canis lupus familiaris (dog) : TNF (tumor necrosis factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnf (tumor necrosis factor)
Sus scrofa (pig) : TNF (tumor necrosis factor)
Heterocephalus glaber (naked mole-rat) : Tnf (tumor necrosis factor)
more info ...
Is Marker For: QTLs:   Bp144  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0205,189,382 - 5,192,000 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,189,390 - 5,192,000 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,936,229 - 6,938,847 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,661,000 - 3,663,618 (+)NCBIRGSC3.4rn4RGSC3.4
Celera204,400,860 - 4,403,478 (-)NCBICelera
Cytogenetic Map20p12NCBI
RH 3.4 Map20 RGD
JBrowse: View Region in Genome Browser (JBrowse)