TNF (tumor necrosis factor) - Rat Genome Database

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Gene: TNF (tumor necrosis factor) Canis lupus familiaris
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Symbol: TNF
Name: tumor necrosis factor
RGD ID: 12373160
Description: ENCODES a protein that exhibits tumor necrosis factor receptor binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); acute inflammatory response (ortholog); animal organ morphogenesis (ortholog); PARTICIPATES IN ceramide signaling pathway; Fc epsilon receptor mediated signaling pathway; interleukin-23 signaling pathway; ASSOCIATED WITH acne (ortholog); acquired immunodeficiency syndrome (ortholog); Acute Coronary Syndrome (ortholog); FOUND IN cytoplasm (ortholog); external side of plasma membrane (ortholog); extracellular region (ortholog); INTERACTS WITH amphotericin B; arsenite(3-); lipopolysaccharide
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cachectin; cTNF; TNF-a; TNF-alpha; TNFA; TNLG1F; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha; tumour necrosis factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,074,561 - 1,076,425 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,074,552 - 1,076,425 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,211,002 - 1,212,867 (+)NCBI
ROS_Cfam_1.0121,219,807 - 1,221,672 (+)NCBI
ROS_Cfam_1.0 Ensembl121,219,798 - 1,221,672 (+)Ensembl
UMICH_Zoey_3.1121,078,543 - 1,080,407 (+)NCBI
UNSW_CanFamBas_1.0121,146,468 - 1,148,336 (+)NCBI
UU_Cfam_GSD_1.0121,213,251 - 1,215,120 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
acquired immunodeficiency syndrome  (ISO)
Acute Coronary Syndrome  (ISO)
Acute Experimental Pancreatitis  (ISO)
Acute Hepatitis  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
adult respiratory distress syndrome  (ISO)
Aggressive Fibromatosis  (ISO)
Albuminuria  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic hepatitis  (ISO)
alcoholic liver cirrhosis  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
Alveolar Bone Loss  (ISO)
Alzheimer's disease  (ISO)
Amebic Liver Abscess  (ISO)
amyloidosis  (ISO)
amyotrophic lateral sclerosis  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
anemia  (ISO)
Angina, Stable  (ISO)
Animal Disease Models  (ISO)
anogenital venereal wart  (ISO)
Anorexia  (ISO)
anterior uveitis  (ISO)
anthracosis  (ISO)
anthrax disease  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
anxiety disorder  (ISO)
aplastic anemia  (ISO)
Arsenic Poisoning  (ISO)
asbestosis  (ISO)
aspiration pneumonia  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
atrial fibrillation  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thyroiditis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
beta thalassemia  (ISO)
bilirubin metabolic disorder  (ISO)
brain edema  (ISO)
Brain Injuries  (ISO)
Brain Injuries, Traumatic  (ISO)
brain ischemia  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiectasis  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Burns  (ISO)
Cachexia  (ISO)
calcinosis  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
Cardiovascular Pregnancy Complications  (ISO)
Cardiovirus Infections  (ISO)
cerebral infarction  (ISO)
cervical cancer  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chlamydia  (ISO)
cholestasis  (ISO)
cholesteatoma of middle ear  (ISO)
chorioamnionitis  (ISO)
Chronic Allograft Dysfunction  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
cicatricial pemphigoid  (ISO)
cochlear disease  (ISO)
colitis  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
Cor pulmonale  (ISO)
corneal ulcer  (ISO)
coronary artery disease  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
Cough  (ISO)
COVID-19  (ISO)
Coxsackievirus Infections  (ISO)
Crohn's disease  (ISO)
cryoglobulinemia  (ISO)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
cystitis  (ISO)
Cytomegalovirus Infections  (ISO)
cytomegalovirus retinitis  (ISO)
degenerative disc disease  (ISO)
demyelinating disease  (ISO)
dermatitis  (ISO)
dermatitis herpetiformis  (ISO)
dermatomyositis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1H  (ISO)
disease by infectious agent  (ISO)
Disease Progression  (ISO)
disseminated intravascular coagulation  (ISO)
drug allergy  (ISO)
Drug Eruptions  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Eales Disease  (ISO)
Edema  (ISO)
Emphysema  (ISO)
encephalitis  (ISO)
encephalomyelitis  (ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
endophthalmitis  (ISO)
Endotoxemia  (ISO)
epididymitis  (ISO)
epilepsy  (ISO)
erythema nodosum  (ISO)
Escherichia Coli Infections  (ISO)
esophagitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
extrinsic allergic alveolitis  (ISO)
eye disease  (ISO)
Fanconi anemia  (ISO)
farmer's lung  (ISO)
fatty liver disease  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Fungal Lung Diseases  (ISO)
gastric ulcer  (ISO)
gastritis  (ISO)
Gaucher's disease  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hearing Loss  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Heat Stroke  (ISO)
hemochromatosis  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhagic Shock  (ISO)
hepatic encephalopathy  (ISO)
hepatitis A  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
hepatopulmonary syndrome  (ISO)
hepatorenal syndrome  (ISO)
hereditary hemorrhagic telangiectasia  (ISO)
herpes simplex virus keratitis  (ISO)
herpes zoster  (ISO)
hidradenitis suppurativa  (ISO)
high grade glioma  (ISO)
High-Frequency Hearing Loss  (ISO)
HIV Wasting Syndrome  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hypercalcemia  (ISO)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
hypochromic microcytic anemia  (ISO)
hypoglycemia  (ISO)
Hypotension  (ISO)
Hypothermia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
IgA glomerulonephritis  (ISO)
impotence  (ISO)
inclusion body myopathy with Paget disease of bone and frontotemporal dementia  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
Insulin Resistance  (ISO)
intermediate uveitis  (ISO)
interstitial cystitis  (ISO)
Intervertebral Disc Displacement  (ISO)
intracranial aneurysm  (ISO)
Intracranial Hemorrhages  (ISO)
intrahepatic cholestasis of pregnancy  (ISO)
iron deficiency anemia  (ISO)
Kawasaki disease  (ISO)
keratoconjunctivitis sicca  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
labyrinthitis  (ISO)
leishmaniasis  (ISO)
leprosy  (ISO)
listeriosis  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Liver Neoplasms  (ISO)
Liver Reperfusion Injury  (ISO)
localized scleroderma  (ISO)
low tension glaucoma  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
lupus nephritis  (ISO)
lymphopenia  (ISO)
malaria  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Manganese Poisoning  (ISO)
megacolon  (ISO)
melanoma  (ISO)
Meningeal Tuberculosis  (ISO)
Metabolic Syndrome  (ISO)
mevalonic aciduria  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
middle cerebral artery infarction  (ISO)
Middle East respiratory syndrome  (ISO)
migraine  (ISO)
migraine without aura  (ISO)
mitochondrial myopathy  (ISO)
mixed connective tissue disease  (ISO)
mucocutaneous leishmaniasis  (ISO)
mucopolysaccharidosis VI  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (ISO)
multiple sclerosis  (ISO)
muscular atrophy  (ISO)
muscular dystrophy  (ISO)
Mycobacterium avium complex disease  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
myelodysplastic syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocardial stunning  (ISO)
myocarditis  (ISO)
myositis  (ISO)
Nasal Polyps  (ISO)
Nausea  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
Neuralgia  (ISO)
neuroblastoma  (ISO)
Neurogenic Inflammation  (ISO)
neutropenia  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
occupational asthma  (ISO)
open-angle glaucoma  (ISO)
oral squamous cell carcinoma  (ISO)
oral submucous fibrosis  (ISO)
Osteolysis  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
ovarian cancer  (ISO)
Oxygen-Induced Retinopathy  (ISO)
Pain  (ISO)
Painful Neuropathy  (ISO)
pancreatic cancer  (ISO)
paracoccidioidomycosis  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
Pediatric Crohn's Disease  (ISO)
peptic esophagitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
periodontitis  (ISO)
Peripheral Nerve Injuries  (ISO)
peritonitis  (ISO)
periventricular leukomalacia  (ISO)
Picornaviridae Infections  (ISO)
placenta disease  (ISO)
plasmacytoma  (ISO)
Plasmodium falciparum malaria  (ISO)
Pleural Effusion  (ISO)
pleurisy  (ISO)
Pneumococcal Meningitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
portal hypertension  (ISO)
Postmenopausal Osteoporosis  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Premature Birth  (ISO)
primary biliary cholangitis  (ISO)
Primary Graft Dysfunction  (ISO)
primary open angle glaucoma  (ISO)
primary sclerosing cholangitis  (ISO)
prostate cancer  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
pustulosis of palm and sole  (ISO)
Radiation Injuries, Experimental  (ISO)
Radiation Pneumonitis  (ISO)
radiculopathy  (ISO)
Refractory Anemia  (ISO)
relapsing polychondritis  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
respiratory syncytial virus infectious disease  (ISO)
respiratory system disease  (ISO)
Respiratory Tract Infections  (ISO)
Retina Reperfusion Injury  (ISO)
retinal artery occlusion  (ISO)
retinal detachment  (ISO)
retinal disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
root resorption  (ISO)
SAPHO syndrome  (ISO)
sarcoma  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
scleritis  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
septic arthritis  (ISO)
severe acute respiratory syndrome  (ISO)
Shock  (ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
skin disease  (ISO)
small cell carcinoma  (ISO)
Soft Tissue Neoplasms  (ISO)
Spinal Cord Compression  (ISO)
Spinal Cord Injuries  (ISO)
Spine Osteoarthritis  (ISO)
status epilepticus  (ISO)
Stevens-Johnson syndrome  (ISO)
Stomach Neoplasms  (ISO)
Streptococcal Infections  (ISO)
Streptococcus pneumonia  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Sudden Hearing Loss  (ISO)
Systemic Candidiasis  (ISO)
systemic lupus erythematosus  (ISO)
Tachycardia  (ISO)
Temporomandibular Joint Disorders  (ISO)
thalassemia  (ISO)
thrombocytopenia  (ISO)
thrombosis  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
toxic shock syndrome  (ISO)
trachoma  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
trichinosis  (ISO)
trigeminal neuralgia  (ISO)
tuberculosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
typhoid fever  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
urticaria  (ISO)
uveitis  (ISO)
vascular dementia  (ISO)
vascular disease  (ISO)
Vascular System Injuries  (ISO)
Venous Thromboembolism  (ISO)
Ventricular Dysfunction  (ISO)
Viral Bronchiolitis  (ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)
visual epilepsy  (ISO)
vitiligo  (ISO)
Vogt-Koyanagi-Harada disease  (ISO)
Vulvar Vestibulitis  (ISO)
Weight Gain  (ISO)
Weill-Marchesani syndrome  (ISO)
Wilson disease  (ISO)
Wounds and Injuries  (ISO)
Wounds, Penetrating  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA,ISO)
acute inflammatory response  (ISO)
animal organ morphogenesis  (IEA,ISO)
apoptotic process  (ISO)
apoptotic signaling pathway  (IEA,ISO)
calcium-mediated signaling  (ISO)
cell activation  (ISO)
cellular extravasation  (IEA,ISO)
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to amyloid-beta  (ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to molecule of bacterial origin  (ISO)
cellular response to nicotine  (IEA)
cellular response to organic cyclic compound  (IEA)
cellular response to retinoic acid  (ISO)
cellular response to toxic substance  (ISO)
cellular response to type II interferon  (ISO)
chronic inflammatory response to antigenic stimulus  (IEA)
circadian rhythm  (ISO)
cortical actin cytoskeleton organization  (IEA)
defense response  (IEA,ISO)
defense response to bacterium  (IEA,ISO)
defense response to Gram-positive bacterium  (IEA,ISO)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
embryonic digestive tract development  (IEA)
endothelial cell apoptotic process  (IEA)
epithelial cell proliferation involved in salivary gland morphogenesis  (IEA,ISO)
extracellular matrix organization  (IEA,ISO)
extrinsic apoptotic signaling pathway  (IEA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IBA,IEA,ISO)
glucose metabolic process  (IEA,ISO)
humoral immune response  (IEA,ISO)
I-kappaB kinase/NF-kappaB signaling  (IEA,ISO)
immune response  (IEA)
inflammatory response  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
JNK cascade  (IEA,ISO)
leukocyte migration  (IEA,ISO)
leukocyte migration involved in inflammatory response  (ISO)
leukocyte tethering or rolling  (IEA)
lipopolysaccharide-mediated signaling pathway  (IEA)
liver regeneration  (ISO)
MAPK cascade  (IEA)
microglial cell activation  (IEA)
necroptotic signaling pathway  (IEA,ISO,ISS)
negative regulation of alkaline phosphatase activity  (IEA)
negative regulation of amyloid-beta clearance  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (IEA,ISO)
negative regulation of bicellular tight junction assembly  (IEA)
negative regulation of bile acid secretion  (ISO)
negative regulation of blood vessel endothelial cell migration  (IEA)
negative regulation of branching involved in lung morphogenesis  (IEA)
negative regulation of cell population proliferation  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA,ISO)
negative regulation of cytokine production involved in immune response  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of endothelial cell proliferation  (IEA)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IEA)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of glucose import  (IEA,ISO)
negative regulation of heart rate  (ISO)
negative regulation of interleukin-6 production  (IEA)
negative regulation of L-glutamate import across plasma membrane  (ISO)
negative regulation of lipid catabolic process  (IEA)
negative regulation of miRNA maturation  (IEA,ISO)
negative regulation of mitotic cell cycle  (IEA)
negative regulation of myelination  (ISO)
negative regulation of myoblast differentiation  (IEA,ISO)
negative regulation of myosin-light-chain-phosphatase activity  (IEA)
negative regulation of osteoblast differentiation  (IEA)
negative regulation of oxidative phosphorylation  (ISO)
negative regulation of protein-containing complex disassembly  (IEA,ISS)
negative regulation of signaling receptor activity  (IEA,ISO)
negative regulation of systemic arterial blood pressure  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of vascular wound healing  (IEA)
negative regulation of viral genome replication  (IEA)
osteoclast differentiation  (IEA,ISO)
positive regulation of action potential  (ISO)
positive regulation of amyloid-beta formation  (IEA)
positive regulation of apoptotic process  (IEA,ISO,ISS)
positive regulation of blood microparticle formation  (IEA)
positive regulation of calcidiol 1-monooxygenase activity  (IEA)
positive regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
positive regulation of cell adhesion  (IEA)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IEA)
positive regulation of chemokine production  (IEA)
positive regulation of chronic inflammatory response to antigenic stimulus  (IEA,ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA)
positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis  (ISO)
positive regulation of cytokine production  (IEA)
positive regulation of cytokine production involved in inflammatory response  (IEA,ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of DNA-binding transcription factor activity  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of estradiol secretion  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IBA)
positive regulation of fever generation  (IEA)
positive regulation of fractalkine production  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glial cell proliferation  (IEA)
positive regulation of hair follicle development  (IEA)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of heterotypic cell-cell adhesion  (IEA)
positive regulation of humoral immune response mediated by circulating immunoglobulin  (IEA,ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IBA,IEA,ISO)
positive regulation of I-kappaB phosphorylation  (IEA,ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of interleukin-18 production  (ISO)
positive regulation of interleukin-33 production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of JUN kinase activity  (IEA,ISS)
positive regulation of leukocyte adhesion to arterial endothelial cell  (IEA)
positive regulation of leukocyte adhesion to vascular endothelial cell  (IEA)
positive regulation of MAP kinase activity  (IEA,ISO,ISS)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of membrane protein ectodomain proteolysis  (IEA)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of neuron apoptotic process  (IEA,ISO)
positive regulation of neutrophil activation  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IBA,IEA,ISO,ISS)
positive regulation of NIK/NF-kappaB signaling  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of nitrogen compound metabolic process  (IEA)
positive regulation of osteoclast differentiation  (IEA)
positive regulation of oxidative stress-induced neuron death  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA)
positive regulation of phagocytosis  (IEA)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of podosome assembly  (IEA)
positive regulation of programmed cell death  (IEA)
positive regulation of protein catabolic process  (IEA)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein kinase B signaling  (IEA,ISO)
positive regulation of protein localization to cell surface  (IEA)
positive regulation of protein localization to plasma membrane  (IEA)
positive regulation of protein phosphorylation  (IEA,ISS)
positive regulation of protein transport  (IEA,ISO)
positive regulation of protein-containing complex assembly  (IEA)
positive regulation of protein-containing complex disassembly  (IEA,ISS)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of smooth muscle cell proliferation  (IEA)
positive regulation of superoxide dismutase activity  (IEA)
positive regulation of synaptic transmission  (IEA,ISO)
positive regulation of synoviocyte proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
positive regulation of translational initiation by iron  (IEA,ISO)
positive regulation of type II interferon production  (IEA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA)
positive regulation of vitamin D biosynthetic process  (IEA)
protein kinase B signaling  (IEA,ISO)
protein localization to plasma membrane  (IEA)
regulation of biological quality  (IEA)
regulation of branching involved in salivary gland morphogenesis  (IEA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of developmental process  (IEA)
regulation of endothelial cell apoptotic process  (IEA)
regulation of establishment of endothelial barrier  (IEA)
regulation of fat cell differentiation  (ISO)
regulation of I-kappaB kinase/NF-kappaB signaling  (IEA)
regulation of immunoglobulin production  (IEA,ISO)
regulation of inflammatory response  (IEA,ISO)
regulation of insulin secretion  (IEA)
regulation of osteoclast differentiation  (IEA,ISO)
regulation of protein phosphorylation  (IEA,ISO)
regulation of protein secretion  (IEA,ISO)
regulation of reactive oxygen species metabolic process  (IEA,ISO)
regulation of secretion  (IEA)
regulation of synapse organization  (IEA)
regulation of transcription by RNA polymerase II  (ISO)
response to 3,3',5-triiodo-L-thyronine  (ISO)
response to activity  (ISO)
response to bacterium  (ISO)
response to ethanol  (ISO)
response to fructose  (ISO)
response to glucocorticoid  (IEA)
response to gold nanoparticle  (ISO)
response to Gram-negative bacterium  (ISO)
response to hypoxia  (ISO)
response to isolation stress  (ISO)
response to lipopolysaccharide  (ISO)
response to macrophage colony-stimulating factor  (ISO)
response to mechanical stimulus  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (IEA,ISO)
response to paracetamol  (ISO)
response to radiation  (ISO)
response to virus  (IEA)
response to xenobiotic stimulus  (ISO)
sequestering of triglyceride  (IEA)
signal transduction  (IEA,ISO)
skeletal muscle contraction  (ISO)
toll-like receptor 3 signaling pathway  (ISO)
tumor necrosis factor-mediated signaling pathway  (IBA,IEA,ISO)
vascular endothelial growth factor production  (IEA,ISS)
vasodilation  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:7948427   PMID:10331940   PMID:11730929   PMID:16022989   PMID:17573384   PMID:18343681   PMID:19254251   PMID:19261619   PMID:19578946   PMID:19605916   PMID:21212278   PMID:22154216  
PMID:22300704   PMID:23978557   PMID:24042337   PMID:25312048   PMID:26646413   PMID:26692319   PMID:26824356  


Genomics

Comparative Map Data
TNF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,074,561 - 1,076,425 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,074,552 - 1,076,425 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,211,002 - 1,212,867 (+)NCBI
ROS_Cfam_1.0121,219,807 - 1,221,672 (+)NCBI
ROS_Cfam_1.0 Ensembl121,219,798 - 1,221,672 (+)Ensembl
UMICH_Zoey_3.1121,078,543 - 1,080,407 (+)NCBI
UNSW_CanFamBas_1.0121,146,468 - 1,148,336 (+)NCBI
UU_Cfam_GSD_1.0121,213,251 - 1,215,120 (+)NCBI
TNF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,575,565 - 31,578,336 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl631,575,565 - 31,578,336 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,543,342 - 31,546,113 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,651,329 - 31,654,091 (+)NCBINCBI36hg18NCBI36
Build 34631,651,328 - 31,654,091NCBI
Celera633,141,565 - 33,144,327 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,330,078 - 31,332,847 (+)NCBIHuRef
CHM1_1631,545,476 - 31,548,245 (+)NCBICHM1_1
T2T-CHM13v2.0631,428,617 - 31,431,388 (+)NCBI
Tnf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,418,343 - 35,420,983 (-)NCBIGRCm39mm39
GRCm39 Ensembl1735,418,357 - 35,420,983 (-)Ensembl
GRCm381735,199,367 - 35,202,007 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,199,381 - 35,202,007 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,336,335 - 35,338,941 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,807,442 - 34,810,048 (-)NCBImm8
Celera1738,296,090 - 38,298,699 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.59NCBI
Tnf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2203,622,011 - 3,624,629 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl203,622,011 - 3,624,629 (+)Ensembl
Rnor_6.0205,189,382 - 5,192,000 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,189,390 - 5,192,000 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,855,829 - 4,858,447 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,936,229 - 6,938,847 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,661,000 - 3,663,618 (+)NCBIRGSC3.4rn4RGSC3.4
Celera204,400,860 - 4,403,478 (-)NCBICelera
RH 3.4 Map20 RGD
Cytogenetic Map20p12NCBI
Tnf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437117,206 - 120,700 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955437117,267 - 119,899 (+)NCBIChiLan1.0ChiLan1.0
TNF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1632,126,618 - 32,129,389 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,126,618 - 32,129,381 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0631,236,650 - 31,239,423 (+)NCBIMhudiblu_PPA_v0panPan3
Tnf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,623,427 - 35,626,009 (+)NCBI
SpeTri2.0NW_0049367271,936,066 - 1,937,766 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,699,628 - 23,702,416 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,699,635 - 23,702,393 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,549,619 - 27,552,377 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7p11-q11NCBI
TNF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366604431,477,411 - 31,480,675 (+)NCBIVero_WHO_p1.0
Tnf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,623,425 - 24,625,531 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462475424,623,059 - 24,625,647 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3
Low 4 10 6 3 6 6 1 6 2
Below cutoff 1 5 12 5 11 8 4 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001003244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB819627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB819628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB819629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF103743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF327899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF349537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY423389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ923808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU249361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LN874472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S74068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X94932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z70046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000000804   ⟹   ENSCAFP00000000739
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl121,074,552 - 1,076,273 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000093235   ⟹   ENSCAFP00000065180
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl121,074,561 - 1,076,425 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845018595   ⟹   ENSCAFP00845014504
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl121,219,798 - 1,221,520 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845018639   ⟹   ENSCAFP00845014546
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl121,219,807 - 1,221,672 (+)Ensembl
RefSeq Acc Id: NM_001003244   ⟹   NP_001003244
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1121,074,561 - 1,076,425 (+)NCBI
Dog10K_Boxer_Tasha121,211,002 - 1,212,867 (+)NCBI
ROS_Cfam_1.0121,219,807 - 1,221,672 (+)NCBI
UMICH_Zoey_3.1121,078,543 - 1,080,407 (+)NCBI
UNSW_CanFamBas_1.0121,146,468 - 1,148,336 (+)NCBI
UU_Cfam_GSD_1.0121,213,251 - 1,215,120 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001003244   ⟸   NM_001003244
- UniProtKB: Q28339 (UniProtKB/Swiss-Prot),   P51742 (UniProtKB/Swiss-Prot),   A9LMQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000739   ⟸   ENSCAFT00000000804
RefSeq Acc Id: ENSCAFP00000065180   ⟸   ENSCAFT00000093235
RefSeq Acc Id: ENSCAFP00845014504   ⟸   ENSCAFT00845018595
RefSeq Acc Id: ENSCAFP00845014546   ⟸   ENSCAFT00845018639
Protein Domains
TNF_2

Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
12 1074600 1074601 G A snv Great Lakes Wolf (SRS661486)
12 1074684 1074685 G A snv Portuguese Wolf (SRS661492)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000517 Ensembl
  ENSCAFG00030005072 UniProtKB/Swiss-Prot
  ENSCAFG00040009744 UniProtKB/Swiss-Prot
  ENSCAFG00845010558 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030008206 UniProtKB/Swiss-Prot
  ENSCAFP00040015692 UniProtKB/Swiss-Prot
  ENSCAFP00845014504 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSCAFP00845014546.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030009369 UniProtKB/Swiss-Prot
  ENSCAFT00040018078 UniProtKB/Swiss-Prot
  ENSCAFT00845018595 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSCAFT00845018639.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403922 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene TNF ENTREZGENE
PANTHER PTHR11471:SF23 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TNECROSISFCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TNF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I3N4X6_CANLF UniProtKB/TrEMBL
  A9LMQ0 ENTREZGENE, UniProtKB/TrEMBL
  P51742 ENTREZGENE
  Q28339 ENTREZGENE
  TNFA_CANLF UniProtKB/Swiss-Prot
UniProt Secondary Q006K5 UniProtKB/Swiss-Prot
  Q28339 UniProtKB/Swiss-Prot
VGNC ID VGNC:47647 ENTREZGENE