RGD Reference Report - Ascitic Fluid Calprotectin and Serum Procalcitonin as Accurate Diagnostic Markers for Spontaneous Bacterial Peritonitis. - Rat Genome Database

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Ascitic Fluid Calprotectin and Serum Procalcitonin as Accurate Diagnostic Markers for Spontaneous Bacterial Peritonitis.

Authors: Abdel-Razik, Ahmed  Mousa, Nasser  Elhammady, Dina  Elhelaly, Rania  Elzehery, Rasha  Elbaz, Sherif  Eissa, Mohamed  El-Wakeel, Niveen  Eldars, Waleed 
Citation: Abdel-Razik A, etal., Gut Liver. 2016 Jul 15;10(4):624-31. doi: 10.5009/gnl15120.
RGD ID: 14975296
Pubmed: PMID:26601826   (View Abstract at PubMed)
PMCID: PMC4933425   (View Article at PubMed Central)
DOI: DOI:10.5009/gnl15120   (Journal Full-text)


BACKGROUND/AIMS: The diagnosis of spontaneous bacterial peritonitis (SBP) is based on a polymorphonuclear leukocytes (PMNs) exceeding 250/μL in ascitic fluid. The aim of the study was to evaluate serum procalcitonin and ascitic fluid calprotectin as accurate diagnostic markers for detecting SBP.
METHODS: Seventy-nine patients with cirrhotic ascites were included. They were divided into a SBP group, including 52 patients, and a non-SBP group of 27 patients. Serum procalcitonin, ascitic calprotectin, and serum and ascitic levels of tumor necrosis factor α (TNF-α) and interleukin 6 (IL- 6) were measured using an enzyme-linked immunosorbent assay.
RESULTS: Serum procalcitonin and ascitic calprotectin were significantly higher in SBP patients than in non-SBP patients. Significant increases in both serum and ascitic levels of TNF-α and IL-6 were observed in SBP patients versus non- SBP patients. At a cutoff value of 0.94 ng/mL, serum procalcitonin had 94.3% sensitivity and 91.8% specificity for detecting SBP. In addition, at a cutoff value of 445 ng/mL, ascitic calprotectin had 95.4% sensitivity and 85.2% specificity for detecting SBP. Both were positively correlated with ascitic fluid proteins, PMN count, TNF-α, and IL-6.
CONCLUSIONS: According to our findings, determination of serum procalcitonin levels and ascitic calprotectin appears to provide satisfactory diagnostic markers for the diagnosis of SBP.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL6Humanperitonitis  IEP  RGD 
Il6Ratperitonitis  ISOIL6 (Homo sapiens) RGD 
Il6Mouseperitonitis  ISOIL6 (Homo sapiens) RGD 
TNFHumanperitonitis  IEP  RGD 
TnfRatperitonitis  ISOTNF (Homo sapiens) RGD 
TnfMouseperitonitis  ISOTNF (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il6  (interleukin 6)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Il6  (interleukin 6)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
IL6  (interleukin 6)
TNF  (tumor necrosis factor)


Additional Information