TNF (tumor necrosis factor) - Rat Genome Database

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Gene: TNF (tumor necrosis factor) Homo sapiens
Symbol: TNF
Name: tumor necrosis factor
RGD ID: 1344192
HGNC Page HGNC:11892
Description: Enables several functions, including identical protein binding activity; receptor ligand activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including regulation of apoptotic process; regulation of cellular biosynthetic process; and regulation of protein localization. Acts upstream of or within several processes, including positive regulation of I-kappaB phosphorylation; regulation of gene expression; and regulation of signal transduction. Located in cell surface; membrane raft; and plasma membrane. Is active in extracellular space. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Biomarker of several diseases, including anemia (multiple); autoimmune disease (multiple); eye disease (multiple); kidney disease (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: APC1 protein; cachectin; DIF; TNF superfamily, member 2; TNF, macrophage-derived; TNF, monocyte-derived; TNF-a; TNF-alpha; TNFA; TNFSF2; TNLG1F; tumor necrosis factor alpha; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha; tumor necrotic factor alpha
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Candidate Gene For: BW325_H BMD5_H BW111_H
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38631,575,565 - 31,578,336 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,575,565 - 31,578,336 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,543,342 - 31,546,113 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,651,329 - 31,654,091 (+)NCBINCBI36Build 36hg18NCBI36
Build 34631,651,328 - 31,654,091NCBI
Celera633,141,565 - 33,144,327 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,330,078 - 31,332,847 (+)NCBIHuRef
CHM1_1631,545,476 - 31,548,245 (+)NCBICHM1_1
T2T-CHM13v2.0631,428,617 - 31,431,388 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)