TNF (tumor necrosis factor) - Rat Genome Database

Name: TNF
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: TNF (tumor necrosis factor) Homo sapiens

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Symbol:

TNF

Name:

tumor necrosis factor

RGD ID:

1344192

HGNC Page

HGNC:11892

Description:

Enables several functions, including identical protein binding activity; protease binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of cellular component organization; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including negative regulation of apoptotic process; positive regulation of intracellular signal transduction; and regulation of gene expression. Located in several cellular components, including cell surface; extracellular space; and membrane raft. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Biomarker of several diseases, including anemia (multiple); autoimmune disease (multiple); eye disease (multiple); kidney disease (multiple); and lung disease (multiple).

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

APC1 protein; cachectin; DIF; TNF superfamily, member 2; TNF, macrophage-derived; TNF, monocyte-derived; TNF-a; TNF-alpha; TNFA; TNFSF2; TNLG1F; tumor necrosis factor alpha; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha; tumor necrotic factor alpha

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Tnf (tumor necrosis factor)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Tnf (tumor necrosis factor)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Tnf (tumor necrosis factor)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	TNF (tumor necrosis factor)	NCBI	Ortholog
Canis lupus familiaris (dog):	TNF (tumor necrosis factor)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tnf (tumor necrosis factor)	NCBI	Ortholog
Sus scrofa (pig):	TNF (tumor necrosis factor)	HGNC	Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	TNF (tumor necrosis factor)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Tnf (tumor necrosis factor)	NCBI	Ortholog
Other homologs ²
Rattus norvegicus (Norway rat):	Nhs (NHS actin remodeling regulator)	HGNC	OMA
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Tnf (tumor necrosis factor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tnf (tumor necrosis factor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tnfb (tumor necrosis factor b (TNF superfamily, member 2))	Alliance	DIOPT (PANTHER\|SonicParanoid\|ZFIN)
Danio rerio (zebrafish):	tnfa (tumor necrosis factor a (TNF superfamily, member 2))	Alliance	DIOPT (PANTHER\|SonicParanoid\|ZFIN)
Xenopus tropicalis (tropical clawed frog):	tnf	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Xenopus laevis (African clawed frog):	tnf.S	Alliance	DIOPT (Xenbase)
Xenopus laevis (African clawed frog):	tnf.L	Alliance	DIOPT (Xenbase)

Allele / Splice:

See ClinVar data

Candidate Gene For:

BW325_H BMD5_H BW111_H

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

NCBI Annotation Information:

Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	31,575,565 - 31,578,336 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	6	31,575,565 - 31,578,336 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	31,543,342 - 31,546,113 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	31,651,329 - 31,654,091 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	31,651,328 - 31,654,091	NCBI
Celera	6	33,141,565 - 33,144,327 (+)	NCBI		Celera
Cytogenetic Map	6	p21.33	NCBI
HuRef	6	31,330,078 - 31,332,847 (+)	NCBI		HuRef
CHM1_1	6	31,545,476 - 31,548,245 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	31,428,617 - 31,431,388 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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