Il6 (interleukin 6) - Rat Genome Database

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Gene: Il6 (interleukin 6) Rattus norvegicus
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Symbol: Il6
Name: interleukin 6
RGD ID: 2901
Description: Enables cytokine activity and interleukin-6 receptor binding activity. Involved in several processes, including cellular response to lipid; positive regulation of cell communication; and response to peptide hormone. Located in extracellular space. Used to study several diseases, including acute necrotizing pancreatitis; disseminated intravascular coagulation; hypertension (multiple); impotence; and steatotic liver disease. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); auditory system disease (multiple); iron deficiency anemia; and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Orthologous to human IL6 (interleukin 6); PARTICIPATES IN interleukin-6 signaling pathway; pro-inflammatory cytokine mediated pathway; interleukin-23 signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-sesamin; (+)-taxifolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ifnb2; IL-6; ILg6; Interleukin 6 (interferon beta 2); Interleukin 6 (interferon, beta 2); interleukin-6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SHR.BN-(Il6-Npy)   BN.SHR-(Il6-Cd36)/Cub  
QTLs:   Bp33   Scl23   Bp79   Plsm1   Stl2   Bp330  
Candidate Gene For: Plsm1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr845,889,999 - 5,894,575 (-)NCBIGRCr8
mRatBN7.245,214,602 - 5,219,178 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl45,213,394 - 5,219,178 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx410,211,864 - 10,216,458 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.046,026,101 - 6,030,695 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.044,372,235 - 4,376,829 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.043,043,231 - 3,047,807 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl43,043,231 - 3,047,807 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.043,095,536 - 3,100,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44456,799 - 461,376 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14456,798 - 461,376 (-)NCBI
Celera45,093,593 - 5,098,169 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (IEP,ISO)
Acute Hepatitis  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (IDA)
Acute Lung Injury  (IEP,ISO)
acute myeloid leukemia  (ISO)
acute myocardial infarction  (IEP)
acute necrotizing pancreatitis  (IDA,IEP)
Acute-Phase Reaction  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
aggressive periodontitis  (ISO)
Albuminuria  (ISO)
alcoholic liver cirrhosis  (ISO)
allergic disease  (ISO)
Alveolar Bone Loss  (IEP)
Alzheimer's disease  (IDA)
amnestic disorder  (ISO)
anemia  (ISO)
Animal Toxoplasmosis  (ISO)
ankylosing spondylitis  (ISO)
anogenital venereal wart  (ISO)
aortic valve disease 1  (ISO)
arteriovenous malformations of the brain  (ISO)
Ascorbic Acid Deficiency  (IEP)
aseptic meningitis  (ISO)
asthma  (IEP,ISO)
ataxia telangiectasia  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thyroiditis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial pneumonia  (ISO)
basal cell carcinoma  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
beta thalassemia  (ISO)
Bile Duct Neoplasms  (ISO)
biliary tract benign neoplasm  (ISO)
Brain Concussion  (IDA)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (IEP,ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (ISO)
Burns  (ISO)
Cachexia  (IEP,ISO)
Cadmium Poisoning  (IEP)
Cardiomegaly  (IEP)
cardiomyopathy  (ISO)
Cardiovascular Pregnancy Complications  (ISO)
Castleman disease  (ISO)
celiac disease  (ISO)
central nervous system disease  (ISO)
Cerebral Hemorrhage  (IEP)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
Chemical Burns  (ISO)
Chemically-Induced Disorders  (ISO)
cholangiocarcinoma  (ISO)
cholestasis  (ISO)
cholesteatoma of middle ear  (ISO)
chorioamnionitis  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
cochlear disease  (IEP)
colitis  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (IEP)
congestive heart failure  (IDA,IEP,ISO)
conjunctival disease  (ISO)
corneal ulcer  (ISO)
coronary artery disease  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
Coxsackievirus Infections  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
depressive disorder  (IEP,ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IDA,ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
diffuse scleroderma  (ISO)
disseminated intravascular coagulation  (IDA,IEP,ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Eales Disease  (ISO)
eclampsia  (IDA)
Edema  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IDA,IEP)
Entamoebiasis  (ISO)
epididymitis  (IEP)
epilepsy  (IEP)
Experimental Arthritis  (IDA,IEP,IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (IEP,ISO)
Experimental Autoimmune Myocarditis  (IDA)
Experimental Colitis  (IDA,IEP,ISO)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
Experimental Liver Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
familial mediterranean fever  (ISO)
Femoral Fractures  (IEP)
Fetal Inflammatory Response Syndrome  (ISO)
Fever  (IEP,ISO)
Foot Injuries  (IEP)
gastric adenocarcinoma  (ISO)
gastric dilatation  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
gingivitis  (ISO)
glomerulonephritis  (ISO)
glucosephosphate dehydrogenase deficiency  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
Headache  (ISO)
Hearing Loss, Noise-Induced  (IEP)
Heart Injuries  (ISO)
Heat Stress Disorders  (IEP)
Heat Stroke  (ISO)
Helicobacter Infections  (ISO)
hemarthrosis  (ISO)
Hemifacial Spasm  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhagic Shock  (IEP,ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
HIV Wasting Syndrome  (ISO)
Hodgkin's lymphoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (IEP,ISO)
hypercalcemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperoxaluria  (ISO)
Hyperoxia  (IEP)
hypertension  (ISO)
Hypoalbuminemia  (ISO)
hypogonadism  (ISO)
hypomyelinating leukodystrophy 5  (ISO)
Hypotension  (ISO)
idiopathic interstitial pneumonia  (IEP)
impotence  (IEP,IMP)
Inflammation  (IDA,ISO)
inflammatory bowel disease  (ISO)
Insulin Resistance  (IDA,IEP)
Intestinal Reperfusion Injury  (IDA,IEP)
intracranial aneurysm  (ISO)
Intracranial Hemorrhages  (ISO)
Intraventricular Hemorrhage  (ISO)
iron deficiency anemia  (IEP)
ischemia  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kaposi's sarcoma  (ISO)
keratitis  (ISO)
keratoconjunctivitis sicca  (ISO)
Kidney Reperfusion Injury  (ISO)
Klebsiella Infections  (IDA)
Kuhnt-Junius degeneration  (ISO)
learning disability  (ISO)
leishmaniasis  (ISO)
lichen disease  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (IDA,IEP)
Liver Reperfusion Injury  (IDA,ISO)
lung disease  (IDA,IEP,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (ISO)
lymphoplasmacytic lymphoma  (ISO)
macular retinal edema  (ISO)
major depressive disorder  (ISO)
malignant mesothelioma  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (IEP,ISO)
Middle East respiratory syndrome  (ISO)
mitochondrial myopathy  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IDA,IEP)
myocarditis  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
neovascular glaucoma  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
neurodegenerative disease  (ISO)
neuromyelitis optica  (ISO)
nodular goiter  (ISO)
obesity  (IEP,ISO)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (ISO)
oral submucous fibrosis  (ISO)
osteoporosis  (ISO)
otitis media  (IEP,ISO)
ovarian hyperstimulation syndrome  (ISO)
Ovarian Neoplasms  (ISO)
pancreas disease  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (IEP)
periodontal disease  (ISO)
periodontitis  (ISO)
Peripheral Nerve Injuries  (IEP)
peripheral nervous system disease  (ISO)
peripheral vascular disease  (ISO)
peritonitis  (ISO)
Plaque, Atherosclerotic  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
pleural disease  (ISO)
pleurisy  (ISO)
Pneumococcal Meningitis  (IDA,IEP,IMP)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
polyneuropathy  (ISO)
Postmenopausal Osteoporosis  (ISO)
Postoperative Atrial Fibrillation  (ISO)
Postoperative Cognitive Dysfunction  (IEP)
pre-eclampsia  (IEP)
pre-malignant neoplasm  (ISO)
prediabetes syndrome  (ISO)
Premature Birth  (ISO)
Premature Obstetric Labor  (ISO)
primary ciliary dyskinesia  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
Pulmonary Contusion  (IEP)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IDA,ISO)
pulmonary tuberculosis  (ISO)
quadriplegia  (ISO)
rectum cancer  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (IEP)
Reperfusion Injury  (IEP,ISO)
respiratory allergy  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retina Reperfusion Injury  (IEP)
retinal artery occlusion  (ISO)
retinal detachment  (ISO)
retinal vasculitis  (ISO)
retinal vein occlusion  (IEP)
rheumatoid arthritis  (ISO)
Right Ventricular Hypertrophy  (IEP)
Sarcopenia  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (IEP)
secondary hyperparathyroidism  (ISO)
Sepsis  (IAGP,IDA,IEP,ISO)
Septic Peritonitis  (IEP)
severe acute respiratory syndrome  (IEP,ISO)
Shwartzman phenomenon  (ISO)
Sjogren's syndrome  (ISO)
skin disease  (ISO)
small cell carcinoma  (ISO)
Spinal Cord Compression  (IEP)
spinal cord disease  (ISO)
Spinal Cord Injuries  (IDA,IEP)
Spine Osteoarthritis  (ISO)
spondyloarthropathy  (ISO)
Spontaneous Abortions  (ISO)
squamous cell carcinoma  (ISO)
steatotic liver disease  (IAGP,ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Streptococcus pneumonia  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Subretinal Fibrosis  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Hearing Loss  (ISO)
Systemic Juvenile Rheumatoid Arthritis  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombocytopenia  (ISO)
Thyroid Neoplasms  (ISO)
Tobacco Use Disorder  (ISO)
toxic shock syndrome  (ISO)
Toxoplasma Chorioretinitis  (ISO)
transverse myelitis  (ISO)
Tympanic Membrane Perforation  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
uveitis  (IEP,ISO)
Ventricular Dysfunction, Left  (ISO)
Viral Bronchiolitis  (ISO)
Viral Myocarditis  (ISO)
visceral leishmaniasis  (ISO)
Wilson disease  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-isoborneol  (ISO)
(+)-pilocarpine  (EXP)
(+)-sesamin  (EXP,ISO)
(+)-syringaresinol beta-D-glucoside  (ISO)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (ISO)
(-)-Arctigenin  (ISO)
(-)-cotinine  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-hinokiresinol  (ISO)
(-)-matairesinol  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(2E,4E)-hexa-2,4-dienoic acid  (EXP)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(E)-roxithromycin  (ISO)
(E)-thiamethoxam  (EXP)
(R)-adrenaline  (EXP,ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(R)-pantothenic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2,3,4-tetrahydroisoquinoline  (EXP,ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (EXP,ISO)
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,4-benzoquinone  (ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1,4-phenylenediamine  (ISO)
1,7-dimethylxanthine  (ISO)
1,8-cineole  (EXP)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-hydroxy-2-naphthoic acid  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
11-dehydrocorticosterone  (ISO)
11-deoxycorticosterone  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-acetyldeoxynivalenol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
15-oxo-ETE  (ISO)
17-hydroxyjolkinolide B  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-imidazole  (ISO)
1H-pyrazole  (ISO)
2''-galloylhyperin  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-bipyridine  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,6-dichlorobenzonitrile  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-acetamidofluorene  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-aminopurine  (ISO)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
2-chloroethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-methylserotonin  (ISO)
2-palmitoylglycerol  (ISO)
2-pyridylethylamine  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
23-epi-26-deoxyactein  (ISO)
25-hydroxycholesterol  (EXP,ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (EXP)
3'-O-(4-Benzoyl)benzoyl ATP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
4',5,7-trihydroxy-3'-methoxyflavone  (ISO)
4',5,7-Trimethoxyflavone  (ISO)
4'-epidoxorubicin  (ISO)
4'-hydroxydiclofenac  (ISO)
4'-Methoxychalcone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-nitro-m-cresol  (ISO)
4-nitrophenol  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-octylphenol  (ISO)
4-phenylbutyric acid  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5,6,7-trimethoxyflavone  (ISO)
5-aminoimidazole-4-carboxamide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-formyltetrahydrofolic acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
5-methoxypsoralen  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-aminonicotinamide  (ISO)
6-anilino-5,8-quinolinedione  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP,ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-dihydroxycoumarin  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-ketocholesterol  (ISO)
8-Br-cAMP  (EXP,ISO)
8-OH-DPAT  (ISO)
9-cis-retinoic acid  (ISO)
abamectin  (EXP)
acalabrutinib  (ISO)
acetaldehyde  (EXP,ISO)
acetate ester  (ISO)
acetic acid  (EXP,ISO)
acetic anhydride  (ISO)
acetoacetic acid  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylic acid  (EXP)
acrylonitrile  (ISO)
acteoside  (ISO)
actinomycin D  (ISO)
adenine  (ISO)
ADP  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
Aflatoxin G1  (ISO)
agathisflavone  (EXP)
agmatine  (ISO)
AICA ribonucleotide  (EXP,ISO)
albuterol  (EXP,ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
alendronic acid  (ISO)
Alisol B  (ISO)
Alkannin  (ISO)
all-trans-retinoic acid  (ISO)
allantoin  (EXP,ISO)
allopurinol  (EXP,ISO)
alloxan  (EXP,ISO)
allyl alcohol  (EXP)
allyl methyl disulfide  (ISO)
alpha-Chaconine  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (EXP)
alpha-methylhistamine  (ISO)
alpha-methylserotonin  (ISO)
alpha-naphthoflavone  (EXP,ISO)
alpha-pinene  (EXP)
Alternaramide  (ISO)
alternariol  (ISO)
aluminium atom  (EXP,ISO)
aluminium hydroxide  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (EXP,ISO)
amifostine  (ISO)
aminoguanidine  (EXP,ISO)
amiodarone  (EXP,ISO)
amitrole  (ISO)
amlexanox  (ISO)
ammonia  (EXP)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (EXP,ISO)
amosite asbestos  (ISO)
amphetamine  (EXP)
amphibole asbestos  (EXP,ISO)
amphotericin B  (ISO)
ampicillin  (ISO)
anandamide  (ISO)
andrographolide  (EXP,ISO)
Anemoside B4  (ISO)
anethole  (EXP)
angiotensin II  (ISO)
Angoline  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracene-1,8,9-triol  (ISO)
antigen  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
apomorphine  (ISO)
arachidonic acid  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
Archazolid B  (ISO)
Arctiin  (EXP)
arecoline  (EXP,ISO)
aripiprazole  (ISO)
aristolochic acid A  (EXP,ISO)
Arkin (TN)  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (EXP)
asarone  (ISO)
asbestos  (ISO)
asiatic acid  (ISO)
aspalathin  (ISO)
aspartame  (ISO)
asperentin  (ISO)
asperuloside  (ISO)
astaxanthin  (ISO)
astilbin  (ISO)
astragaloside IV  (EXP,ISO)
astressin 2B  (EXP)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP,ISO)
Atractylodin  (ISO)
atrazine  (EXP,ISO)
atropine  (ISO)
aucubin  (ISO)
auranofin  (ISO)
aurantio-obtusin  (ISO)
aureusidin  (ISO)
Aurin  (ISO)
azathioprine  (ISO)
azetidine  (ISO)
aziridines  (ISO)
azithromycin  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
baicalin  (EXP,ISO)
Bardoxolone methyl  (ISO)
barium chloride  (EXP)
barium sulfate  (ISO)
barium(0)  (EXP)
Bavachinin  (ISO)
BAY 60-6583  (ISO)
bazedoxifene  (ISO)
beclomethasone  (ISO)
belinostat  (ISO)
benazepril  (EXP)
benzalkonium chloride  (ISO)
benzbromarone  (ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
benzoates  (ISO)
benzofurans  (ISO)
benzoic acid  (ISO)
Benzoyl peroxide  (ISO)
benzylpenicillin  (ISO)
berberine  (EXP,ISO)
Bergenin  (ISO)
beryllium sulfate  (ISO)
Besigomsin  (ISO)
beta-amyrin  (ISO)
beta-D-glucan  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-naphthoflavone  (EXP,ISO)
betalain  (ISO)
betulinic acid  (EXP)
bezafibrate  (EXP,ISO)
bicalutamide  (ISO)
bifenthrin  (EXP,ISO)
bilirubin IXalpha  (ISO)
biliverdin  (ISO)
biochanin A  (ISO)
biotin  (EXP)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP,ISO)
boric acid  (EXP,ISO)
boron atom  (EXP)
bortezomib  (EXP,ISO)
bosentan  (ISO)
Botulinum toxin type A  (ISO)
BQ 123  (ISO)
brefeldin A  (ISO)
Brevetoxin B  (ISO)
bromoacetate  (ISO)
bucladesine  (ISO)
budesonide  (EXP,ISO)
buspirone  (EXP)
butanal  (ISO)
butane-2,3-dione  (EXP,ISO)
butein  (ISO)
butylated hydroxyanisole  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
Calcimycin  (ISO)
calciol  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
Calcium propionate  (EXP)
calcium silicate  (ISO)
calcium(0)  (ISO)
Calphostin C  (ISO)
calycosin  (EXP)
candesartan  (EXP)
cannabidiol  (EXP,ISO)
Cannabidivarin  (ISO)
cannabigerol  (EXP)
capecitabine  (ISO)
capillarisin  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
captan  (ISO)
captopril  (EXP)
carbamate ester  (ISO)
carbamazepine  (ISO)
carbendazim  (EXP,ISO)
CARBENOXOLONE  (ISO)
carbon atom  (ISO)
carbon disulfide  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP,ISO)
carboplatin  (ISO)
Cardamonin  (ISO)
carmustine  (EXP,ISO)
carnosine  (EXP,ISO)
carrageenan  (EXP,ISO)
carteolol  (ISO)
carvedilol  (EXP)
carveol  (ISO)
casticin  (ISO)
catalpol  (ISO)
cefoxitin  (ISO)
celastrol  (EXP,ISO)
celecoxib  (ISO)
ceric oxide  (EXP,ISO)
cerium trichloride  (ISO)
cerivastatin  (EXP,ISO)
ceruletide  (EXP,ISO)
cetrorelix  (ISO)
CGP 52608  (ISO)
chaetoglobosin A  (ISO)
chalcone  (ISO)
chalcones  (EXP)
chelerythrine  (ISO)
chenodeoxycholic acid  (ISO)
Chikusetsusaponin-IV  (ISO)
chitosan  (ISO)
chloral hydrate  (EXP)
chloroethene  (ISO)
chlorogenic acid  (EXP,ISO)
chloromethylisothiazolinone  (ISO)
chloroquine  (EXP,ISO)
chlorothalonil  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
choline  (EXP,ISO)
chromium atom  (ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
chrysin  (EXP,ISO)
chrysin 5,7-dimethyl ether  (ISO)
ciglitazone  (ISO)
cilostazol  (EXP,ISO)
ciprofloxacin  (EXP,ISO)
cirsilineol  (ISO)
Cirsimarin  (ISO)
cis-caffeic acid  (EXP,ISO)
cisplatin  (EXP,ISO)
citral  (ISO)
citronellol  (EXP)
clarithromycin  (EXP,ISO)
clenbuterol  (EXP)
clodronic acid  (EXP,ISO)
clomipramine  (ISO)
clopidogrel  (ISO)
cloxacillin  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
colistin  (EXP)
Concanamycin B  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP)
cordycepin  (EXP,ISO)
corilagin  (EXP,ISO)
corticosterone  (EXP,ISO)
cortisol  (ISO)
cortisone  (ISO)
coumarin  (EXP,ISO)
coumarins  (ISO)
coumermycin A1  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP,ISO)
crotonaldehyde  (EXP,ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cyanocob(III)alamin  (EXP)
cyclizine  (ISO)
cycloastragenol  (EXP)
cycloheximide  (ISO)
Cyclopamine  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
cyprodinil  (ISO)
cyproheptadine  (EXP)
cytarabine  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
D-penicillamine  (EXP,ISO)
dabrafenib  (ISO)
dacarbazine  (ISO)
daidzein  (ISO)
danazol  (EXP)
dantrolene  (ISO)
DAPT  (EXP,ISO)
DDT  (EXP,ISO)
decabromodiphenyl ether  (ISO)
decane  (ISO)
Decursin  (ISO)
deguelin  (EXP)
dehydrocostus lactone  (ISO)
dehydroepiandrosterone  (EXP)
Delta(9)-tetrahydrocannabinolic acid  (ISO)
delta-tocotrienol  (ISO)
demeclocycline  (ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (EXP,ISO)
Deoxynivalenol 3-glucoside  (ISO)
desferrioxamine B  (EXP,ISO)
desipramine  (ISO)
devazepide  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP,ISO)
dextran sulfate  (EXP,ISO)
dextromethorphan  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
diazoxide  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
dibutylstannane  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
dichlorvos  (EXP)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
Dictamnine  (ISO)
Didecyldimethylammonium  (ISO)
dieckol  (ISO)
dieldrin  (EXP)
dienogest  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diflorasone  (ISO)
diflunisal  (EXP)
Dihydrotanshinone I  (ISO)
dihydroxyacetone  (ISO)
diiodine  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (EXP,ISO)
Dimaprit  (ISO)
dimethoate  (ISO)
Dimethyl phthalate  (EXP)
dimethyl sulfoxide  (EXP,ISO)
dimethylarsinous acid  (ISO)
diminazene diaceturate  (EXP,ISO)
dinitrogen  (ISO)
Diosbulbin B  (ISO)
dioscin  (EXP,ISO)
diosgenin  (EXP,ISO)
diosmin  (ISO)
dioxygen  (EXP,ISO)
diphenhydramine  (ISO)
dipyridamole  (ISO)
diquat  (EXP)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
diuron  (ISO)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (EXP)
dobutamine  (EXP,ISO)
docebenone  (ISO)
dodecane  (EXP,ISO)
domperidone  (ISO)
donepezil hydrochloride  (ISO)
dopexamine  (ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
dydrogesterone  (ISO)
ebselen  (EXP)
EC 3.1.1.4 (phospholipase A2) inhibitor  (ISO)
edaravone  (EXP)
efavirenz  (ISO)
elemental boron  (EXP)
elemental carbon  (ISO)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP)
emamectin benzoate  (ISO)
embelin  (EXP)
emodin  (EXP,ISO)
enalapril  (EXP,ISO)
endosulfan  (ISO)
enilconazole  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
epalrestat  (ISO)
epinastine  (ISO)
eplerenone  (EXP)
eptifibatide  (ISO)
erdosteine  (EXP,ISO)
ergothioneine  (EXP)
eriodictyol  (ISO)
erlotinib hydrochloride  (EXP,ISO)
erythromycin A  (ISO)
esculetin  (ISO)
estriol  (ISO)
estrone  (ISO)
estrone 3-sulfate  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
ethionamide  (EXP)
Ethyl pyruvate  (ISO)
ethylene glycol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
ethylenediaminetetraacetic acid  (ISO)
ethylmalonic acid  (EXP)
etoposide  (EXP,ISO)
eugenol  (EXP,ISO)
eumelanin  (ISO)
eupatilin  (ISO)
euxanthone  (ISO)
excitatory amino acid agonist  (EXP)
ezogabine  (EXP)
famotidine  (EXP)
Fargesin  (ISO)
farnesol  (ISO)
farrerol  (EXP)
fasudil  (EXP,ISO)
fenbendazole  (ISO)
fenitrothion  (EXP)
fenofibrate  (ISO)
fentin chloride  (ISO)
fenvalerate  (EXP)
ferric ammonium citrate  (ISO)
ferric oxide  (ISO)
ferroheme b  (ISO)
ferrosoferric oxide  (EXP,ISO)
ferrostatin-1  (ISO)
ferruginol  (EXP)
ferulic acid  (ISO)
Fexaramine  (ISO)
Fexofenadine hydrochloride  (ISO)
Fidarestat  (ISO)
finasteride  (EXP)
fingolimod hydrochloride  (ISO)
fisetin  (ISO)
Flavokawain A  (ISO)
flavonoids  (EXP,ISO)
flucloxacillin  (ISO)
flufenamic acid  (EXP,ISO)
fluoranthene  (ISO)
fluorene  (ISO)
fluorometholone  (ISO)
fluoxetine  (ISO)
flurbiprofen  (ISO)
flutamide  (EXP,ISO)
fluticasone  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
formoterol fumarate  (EXP)
fragrance  (ISO)
fraxetin  (ISO)
Fraxinellone  (ISO)
fructose  (EXP,ISO)
fucoidan  (EXP)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
Fulvic acid  (EXP)
fumonisin B1  (ISO)
furan  (EXP,ISO)
furosemide  (ISO)
Fusarenone X  (ISO)
gadodiamide hydrate  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (EXP,ISO)
galactose  (EXP,ISO)
galangin  (EXP,ISO)
galaxolide  (ISO)
gallic acid  (EXP,ISO)
gallocatechin  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-Oryzanol (TN)  (EXP)
Ganoderic acid A  (ISO)
Garcinol  (ISO)
Gastrodin  (EXP,ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
gemfibrozil  (EXP)
Genipin  (ISO)
genistein  (EXP,ISO)
genkwanin  (ISO)
gentamycin  (EXP,ISO)
geranial  (ISO)
Geraniin  (ISO)
geraniol  (EXP,ISO)
ghrelin  (ISO)
Gingerenone A  (ISO)
gingerol  (ISO)
Ginkgolide A  (ISO)
Ginkgolide C  (EXP)
ginsenoside C-K  (ISO)
ginsenoside F1  (ISO)
ginsenoside Rb1  (EXP)
ginsenoside Re  (ISO)
ginsenoside Rg1  (EXP,ISO)
glafenine  (EXP)
gliclazide  (EXP)
glucagon  (ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutaraldehyde  (ISO)
glutathione  (ISO)
Gly-His-Lys  (ISO)
glyburide  (EXP,ISO)
glycerol  (ISO)
glycine  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrol  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (EXP,ISO)
glyoxal  (ISO)
glyphosate  (ISO)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (EXP)
GR 113808  (ISO)
granisetron  (ISO)
graphite  (ISO)
guggulsterone  (ISO)
GW 3965  (EXP,ISO)
GW 4064  (ISO)
GW 501516  (ISO)
GW 7647  (ISO)
gypenoside LXXV  (ISO)
haloperidol  (ISO)
halothane  (ISO)
Harpagide  (ISO)
helenalin  (ISO)
heme b  (ISO)
hemin  (ISO)
heparin  (EXP,ISO)
hesperetin  (EXP,ISO)
hesperidin  (EXP,ISO)
hexachlorobenzene  (EXP)
hexadecane  (ISO)
hexadecanoic acid  (EXP,ISO)
Hexadimethrine bromide  (EXP)
hexane  (ISO)
hinokiflavone  (ISO)
histamine  (ISO)
homoeriodictyol  (ISO)
Honokiol  (ISO)
hopane  (ISO)
HU-308  (EXP,ISO)
hyaluronic acid  (ISO)
hydralazine  (ISO)
hydrocortisone succinate  (ISO)
hydrogen chloride  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP,ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP)
hydroxamic acid  (EXP,ISO)
hydroxychloroquine  (ISO)
hydroxyflutamide  (ISO)
hydroxysafflor yellow A  (EXP,ISO)
hydroxytyrosol  (EXP,ISO)
hypochlorous acid  (ISO)
hypoxanthine  (ISO)
Ibotenic acid  (EXP)
ibrutinib  (ISO)
ibuprofen  (EXP,ISO)
IC-87114  (ISO)
icariin  (EXP)
icatibant  (EXP)
ICI 118551  (EXP)
icosanoid  (EXP)
idelalisib  (ISO)
ifosfamide  (EXP)
Iguratimod  (EXP)
Ile(5)-angiotensin II  (ISO)
iloprost  (ISO)
imidacloprid  (EXP)
imidazopyrazole  (ISO)
imidurea  (ISO)
imiquimod  (ISO)
immunological adjuvant  (ISO)
indinavir  (ISO)
indirubin  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (EXP,ISO)
indoline  (EXP)
indometacin  (EXP,ISO)
indoprofen  (ISO)
ionomycin  (EXP,ISO)
irbesartan  (ISO)
irinotecan  (EXP,ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP,ISO)
iron trichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (EXP,ISO)
isocyanates  (ISO)
isoeugenol  (ISO)
isoflurane  (EXP,ISO)
isoliquiritigenin  (ISO)
isoniazide  (EXP,ISO)
isoorientin  (EXP)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP,ISO)
isothiocyanate  (ISO)
isotretinoin  (EXP,ISO)
isovitexin  (EXP)
ivermectin  (ISO)
JTE-013  (ISO)
kaempferol  (EXP,ISO)
kaempferol 3-O-beta-D-glucoside  (ISO)
kainic acid  (EXP,ISO)
kenpaullone  (ISO)
ketamine  (EXP,ISO)
ketanserin  (ISO)
ketoconazole  (EXP,ISO)
ketoprofen  (ISO)
ketotifen  (EXP)
KN-93  (ISO)
kojic acid  (ISO)
KT 5823  (ISO)
kuwanone G  (ISO)
kynurenic acid  (ISO)
L-365260  (ISO)
L-arginine  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (EXP,ISO)
L-proline betaine  (ISO)
L-serine  (EXP)
lactacystin  (ISO)
lactulose  (EXP)
lansoprazole  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (EXP,ISO)
leflunomide  (ISO)
Leonurine  (ISO)
leptomycin B  (ISO)
letrozole  (EXP)
leukotriene D4  (ISO)
leupeptin  (ISO)
leuprolide  (EXP)
levamisole  (ISO)
levofloxacin  (ISO)
Licochalcone B  (ISO)
lidocaine  (ISO)
lignan  (ISO)
limonene  (ISO)
limonin  (ISO)
linagliptin  (EXP)
linoleic acid  (EXP,ISO)
linsidomine  (ISO)
linuron  (ISO)
lipid As  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
lipoxin A4  (ISO)
liquiritigenin  (EXP,ISO)
liquiritin  (EXP,ISO)
liraglutide  (EXP)
lithium atom  (ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
LLY-507  (ISO)
loganin  (EXP,ISO)
lopinavir  (ISO)
lorcaserin  (ISO)
lornoxicam  (ISO)
losartan  (EXP,ISO)
lovastatin  (EXP,ISO)
lucanthone  (ISO)
lupeol  (EXP,ISO)
luteolin  (EXP,ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
lycorine  (ISO)
Macrosphelide B  (ISO)
madecassoside  (ISO)
malathion  (EXP,ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
manganese(II) sulfate  (ISO)
mangiferin  (EXP,ISO)
masoprocol  (ISO)
mastoparan  (ISO)
MC1568  (ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
mefenamic acid  (ISO)
meglumine amidotrizoate  (EXP)
melamine  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
meloxicam  (ISO)
melphalan  (ISO)
menadione  (ISO)
mepanipyrim  (ISO)
mephedrone  (EXP)
mercury atom  (EXP,ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
mesalamine  (EXP,ISO)
metam  (ISO)
metamizole sodium  (EXP)
metformin  (EXP,ISO)
methadone  (EXP)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (EXP,ISO)
methotrexate  (EXP,ISO)
methoxyacetic acid  (EXP)
methoxychlor  (ISO)
methyl methacrylate  (ISO)
methyl methanesulfonate  (ISO)
methyl salicylate  (ISO)
methylene blue  (EXP)
methylglyoxal  (EXP,ISO)
methylisothiazolinone  (ISO)
methyllycaconitine  (ISO)
methylmalonic acid  (EXP)
methylmercury chloride  (EXP,ISO)
methylphenidate  (EXP,ISO)
Methylthiouracil  (ISO)
metoprolol  (EXP)
metronidazole  (ISO)
metyrapone  (EXP)
mevalonic acid  (ISO)
mexiletine  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (EXP,ISO)
Miglitol  (ISO)
milrinone  (ISO)
minocycline  (ISO)
miquelianin  (ISO)
mirtazapine  (EXP)
mitogen  (EXP)
mitomycin C  (ISO)
MJN110  (ISO)
MK-2206  (EXP,ISO)
mocetinostat  (ISO)
molybdenum trichloride  (ISO)
monascin  (ISO)
monensin A  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP,ISO)
Monocyte locomotion inhibitory factor  (ISO)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (ISO)
montelukast  (ISO)
morin  (EXP,ISO)
morphine  (EXP,ISO)
Morroniside  (EXP,ISO)
muramyl dipeptide  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (EXP,ISO)
myricitrin  (ISO)
myxothiazol  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP,ISO)
N,N-dimethylacetamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylnicotinate  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nafcillin  (ISO)
naloxone  (ISO)
naphthalenes  (EXP)
naproxen  (EXP)
Narciclasine  (ISO)
naringin  (EXP,ISO)
Neferine  (EXP)
nelfinavir  (ISO)
neoastilbin  (ISO)
neocuproine  (ISO)
neoechinulin A  (ISO)
neohesperidin dihydrochalcone  (ISO)
neomycin  (ISO)
nerolidol  (EXP)
nevirapine  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicorandil  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP,ISO)
nifuroxazide  (ISO)
nilotinib  (EXP)
nimesulide  (EXP,ISO)
nitric oxide  (EXP,ISO)
nitrofen  (EXP)
nitrogen dioxide  (EXP,ISO)
nitroglycerin  (EXP,ISO)
nitrososulfamethoxazole  (ISO)
nobiletin  (EXP)
nonane  (EXP,ISO)
Nonidet P-40  (ISO)
nonivamide  (ISO)
Nonylphenol  (EXP,ISO)
norlaudanosoline  (ISO)
nortriptyline  (ISO)
notoginsenoside R1  (EXP,ISO)
NS-398  (ISO)
NSC 23766  (ISO)
nystatin  (ISO)
O-acetyl-L-carnitine  (EXP)
o-anisidine  (ISO)
Obacunone  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
oleuropein  (ISO)
olmesartan  (ISO)
Olmesartan medoxomil  (EXP)
omeprazole  (EXP)
oridonin  (EXP,ISO)
orlistat  (ISO)
oroxylin A  (EXP,ISO)
oseltamivir  (ISO)
osimertinib  (ISO)
ospemifene  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
oxidopamine  (ISO)
oxymetholone  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-tolualdehyde  (ISO)
paclitaxel  (EXP,ISO)
paeoniflorin  (EXP,ISO)
Paeonol  (EXP,ISO)
palmatine  (ISO)
Palmitic acid(d3)  (ISO)
palmitoleic acid  (ISO)
palmitoyl ethanolamide  (ISO)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (EXP,ISO)
parathion-methyl  (ISO)
paricalcitol  (ISO)
parthenolide  (EXP,ISO)
patchouli alcohol  (EXP,ISO)
pefloxacin  (ISO)
pelargonidin  (ISO)
penconazole  (ISO)
pentachlorobenzene  (ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
pentobarbital  (EXP,ISO)
Pentoxifylline  (EXP,ISO)
peptidoglycan  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
perindopril  (EXP,ISO)
permethrin  (EXP,ISO)
pevonedistat  (ISO)
phenanthrene  (EXP,ISO)
Phenelzine  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phentermine  (ISO)
phenyl benzoate  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phloretin  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosalone  (EXP)
phosphatidic acid  (ISO)
phosphatidylcholine  (ISO)
phosphatidylinositol dimannoside  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
phoxim  (EXP)
phthalic anhydride  (ISO)
phylloquinone  (EXP)
physostigmine  (ISO)
phytoestrogen  (ISO)
Phytolaccoside E  (ISO)
picolinic acid  (ISO)
picropodophyllotoxin  (ISO)
pimobendan  (ISO)
pinitol  (EXP,ISO)
pinostrobin  (EXP)
pioglitazone  (EXP,ISO)
piperine  (ISO)
piperonyl butoxide  (ISO)
pipoxolan  (ISO)
Pirarubicin  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
platycodin D  (EXP,ISO)
pluronic P-123  (ISO)
Poloxamer  (ISO)
Polpunonic acid  (ISO)
poly(ethylene)  (ISO)
poly(I:C)  (EXP,ISO)
poly(methyl methacrylate) macromolecule  (ISO)
polymyxin B2  (EXP,ISO)
polyphosphates  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
prednisolone  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prilocaine  (ISO)
Primycin  (ISO)
proanthocyanidin  (EXP)
probucol  (EXP)
procaterol  (ISO)
procyanidin B2  (EXP)
procyanidin B3  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
promethazine  (EXP)
propacetamol  (ISO)
propamocarb  (ISO)
propan-2-ol  (ISO)
propanal  (ISO)
propane-1,2-diol  (ISO)
propanil  (ISO)
propionic acid  (EXP)
propofol  (ISO)
propranolol  (EXP)
prostaglandin D2  (ISO)
prostaglandin E1  (EXP,ISO)
prostaglandin E2  (EXP,ISO)
prostaglandins E  (ISO)
protein kinase inhibitor  (EXP,ISO)
prunetin  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
Punicalagin  (EXP,ISO)
pyocyanine  (ISO)
pyridaben  (EXP)
Pyridostigmine bromide  (EXP,ISO)
pyrimethamine  (ISO)
pyrimethanil  (ISO)
pyrogallol  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quinapril hydrochloride  (EXP)
quinazolines  (ISO)
quinine  (ISO)
quinolinic acid  (EXP)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (EXP,ISO)
ramipril  (EXP)
ranitidine  (EXP)
raspberry ketone  (EXP,ISO)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (EXP)
remdesivir  (ISO)
Repaglinide  (EXP)
resiquimod  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
Rhein  (ISO)
Rhynchophylline  (EXP)
ribavirin  (EXP)
riboflavin  (ISO)
rifampicin  (EXP,ISO)
Riluzole  (ISO)
rimonabant  (ISO)
ritonavir  (ISO)
Ro 31-8220  (ISO)
rofecoxib  (ISO)
roflumilast  (EXP)
rolipram  (ISO)
Roridin A  (ISO)
rosmarinic acid  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rucaparib  (ISO)
Rutecarpine  (ISO)
ruthenium red  (ISO)
rutin  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (EXP,ISO)
S-adenosyl-L-methionine  (EXP,ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
salicylic acid  (EXP,ISO)
Salidroside  (ISO)
salsalate  (EXP)
salubrinal  (ISO)
Salvianolic acid A  (EXP,ISO)
salvianolic acid B  (EXP)
Sanggenon C  (EXP)
saquinavir  (ISO)
sarin  (EXP)
sarpogrelate  (ISO)
SB 203580  (EXP,ISO)
SB 206553  (ISO)
SB 290157  (ISO)
SB 415286  (ISO)
SB 431542  (ISO)
SB-239063  (ISO)
SCH772984  (EXP)
scoparone  (ISO)
scopolamine  (EXP,ISO)
scopoletin  (EXP)
selenium atom  (EXP,ISO)
serotonin  (ISO)
serpentine asbestos  (EXP,ISO)
Sesamol  (ISO)
sesquiterpene  (ISO)
sevoflurane  (EXP,ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sincalide  (EXP)
sirolimus  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium aurothiosulfate  (ISO)
sodium benzoate  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
sodium nitrite  (EXP,ISO)
sodium perchlorate  (EXP)
sodium propionate  (ISO)
Sodium salicylate  (ISO)
sodium sulfide (anhydrous)  (EXP)
Soman  (ISO)
Sophocarpine  (ISO)
sophoraflavanone B  (ISO)
Sophoricoside  (ISO)
sorafenib  (ISO)
sorbinil  (ISO)
soyasaponin I  (ISO)
sphingosine 1-phosphate  (ISO)
spironolactone  (EXP,ISO)
stattic  (ISO)
stavudine  (ISO)
sterigmatocystin  (EXP)
stigmasterol  (ISO)
streptozocin  (EXP,ISO)
styrene  (ISO)
succimer  (EXP)
sucrose  (ISO)
sulfadiazine  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (EXP,ISO)
sulfoxaflor  (EXP)
sulfur dioxide  (EXP,ISO)
sulindac  (EXP)
Sulpyrine  (EXP)
sumatriptan  (EXP)
sunitinib  (EXP,ISO)
Sunset Yellow FCF  (ISO)
suramin  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
synephrine  (ISO)
syringic acid  (EXP,ISO)
syringin  (ISO)
T-2 toxin  (EXP,ISO)
tacrine  (ISO)
tacrolimus hydrate  (EXP,ISO)
tadalafil  (ISO)
Talc  (ISO)
tamibarotene  (EXP,ISO)
tamoxifen  (EXP,ISO)
tangeretin  (EXP)
tannic acid  (EXP)
Tanshinone I  (ISO)
taurine  (EXP,ISO)
taurocholic acid  (EXP,ISO)
taurolithocholic acid sulfate  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
tepoxalin  (ISO)
terameprocol  (ISO)
terbutaline  (EXP)
Terfenadine  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
Testosterone propionate  (ISO)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetradecane  (ISO)
tetralin  (ISO)
tetramethylpyrazine  (ISO)
Tetramethylthiourea  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (EXP,ISO)
thapsigargin  (EXP,ISO)
theophylline  (ISO)
thiacloprid  (EXP)
thiamethoxam  (EXP)
thiazoles  (EXP)
thiazolidinediones  (ISO)
thiazolidines  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
thiophenes  (ISO)
thiourea  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
thymoquinone  (EXP,ISO)
thyroxine  (EXP)
tigecycline  (ISO)
Timosaponin b ii  (ISO)
Tiron  (ISO)
titanium atom  (EXP,ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (ISO)
tofacitinib  (EXP,ISO)
Tolmetin glucuronide  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (EXP,ISO)
Tomentosin  (ISO)
topotecan  (EXP)
Trachelogenin  (ISO)
trans-anethole  (EXP)
trans-caffeic acid  (EXP,ISO)
trans-chalcone  (ISO)
trans-cinnamic acid  (ISO)
trans-isoeugenol  (ISO)
trans-piceid  (ISO)
trelagliptin  (ISO)
tremolite asbestos  (ISO)
triamcinolone acetonide  (EXP)
tributylstannane  (EXP,ISO)
trichloroacetic acid  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclocarban  (EXP,ISO)
triclosan  (ISO)
tridecane  (ISO)
trilobatin  (ISO)
trimellitic anhydride  (ISO)
trimethoprim  (ISO)
trimethyltin  (EXP,ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tropisetron  (EXP)
trovafloxacin  (ISO)
Tryptanthrine  (ISO)
tungsten  (EXP)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
tyloxapol  (ISO)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
ubiquinones  (ISO)
UDP  (ISO)
umbelliferone  (EXP)
undecan-2-one  (EXP,ISO)
undecane  (EXP)
urethane  (EXP,ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
usnic acid  (ISO)
UTP  (ISO)
vadimezan  (EXP,ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vanadium atom  (EXP,ISO)
vanadium(0)  (EXP,ISO)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
vanillin  (ISO)
verapamil  (EXP,ISO)
verrucarin A  (ISO)
verteporfin  (ISO)
vincaleukoblastine  (ISO)
vincristine  (EXP,ISO)
Vinpocetine  (EXP)
vitamin D  (EXP,ISO)
vitamin E  (EXP,ISO)
vitamin K  (EXP)
vorinostat  (ISO)
VX-745  (ISO)
warfarin  (EXP,ISO)
wedelolactone  (EXP,ISO)
WIN 55212-2  (ISO)
withaferin A  (EXP,ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (ISO)
xanthone  (EXP)
xyloglucan  (ISO)
Y-27632  (ISO)
Yangonin  (ISO)
zafirlukast  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zidovudine  (ISO)
zileuton  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP,ISO)
ziram  (ISO)
zoledronic acid  (ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEA)
bone remodeling  (IEP)
branching involved in salivary gland morphogenesis  (ISO)
cell redox homeostasis  (IMP)
cellular response to cytokine stimulus  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (IEP,ISO)
cellular response to interleukin-1  (IEP,ISO)
cellular response to interleukin-17  (ISO)
cellular response to lipopolysaccharide  (IEP,ISO)
cellular response to nutrient levels  (IEP)
cellular response to prolactin  (IEP)
cellular response to tumor necrosis factor  (IEP,ISO)
cellular response to virus  (ISO,ISS)
cytokine-mediated signaling pathway  (ISO)
defense response to protozoan  (ISO)
defense response to virus  (ISO)
endocrine pancreas development  (ISO)
epithelial cell proliferation involved in salivary gland morphogenesis  (ISO)
gene expression  (ISO)
germinal center B cell differentiation  (ISO,ISS)
glucagon secretion  (ISO)
glucose homeostasis  (ISO,ISS)
hepatic immune response  (ISO)
hepatocyte proliferation  (ISO,ISS)
inflammatory response  (ISO)
inflammatory response to wounding  (ISO)
interleukin-6-mediated signaling pathway  (ISO,ISS)
liver regeneration  (ISO,ISS)
lymphocyte costimulation  (IEP)
muscle cell cellular homeostasis  (ISO)
myeloid cell homeostasis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of bone resorption  (ISO)
negative regulation of cell population proliferation  (IMP)
negative regulation of chemokine production  (ISO)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IDA)
negative regulation of gluconeogenesis  (IDA)
negative regulation of hormone secretion  (ISO)
negative regulation of interleukin-1-mediated signaling pathway  (ISO)
negative regulation of membrane potential  (IMP)
negative regulation of muscle organ development  (IDA)
negative regulation of neuron apoptotic process  (IDA)
negative regulation of primary miRNA processing  (ISO)
negative regulation of protein kinase activity  (IDA)
neuron projection development  (ISO)
neutrophil apoptotic process  (ISO)
positive regulation of acute inflammatory response  (ISO)
positive regulation of apoptotic DNA fragmentation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of B cell activation  (ISO)
positive regulation of cell population proliferation  (IBA,ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of DNA replication  (IMP)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of estradiol secretion  (ISO)
positive regulation of extracellular matrix disassembly  (ISO)
positive regulation of gene expression  (IDA,ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of gliogenesis  (ISO)
positive regulation of immunoglobulin production  (ISO,ISS)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-17 production  (ISO)
positive regulation of interleukin-21 production  (ISO,ISS)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of multicellular organismal process  (IEA)
positive regulation of neuron differentiation  (IMP)
positive regulation of neuron projection development  (IMP)
positive regulation of nitric oxide biosynthetic process  (IDA)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA)
positive regulation of platelet aggregation  (ISO)
positive regulation of protein import into nucleus  (IDA)
positive regulation of receptor signaling pathway via JAK-STAT  (IBA,IDA,IEA,ISO)
positive regulation of receptor signaling pathway via STAT  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of T-helper 2 cell differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of translation  (ISO)
positive regulation of transmission of nerve impulse  (IDA)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
regulation of apoptotic process  (ISO)
regulation of cell population proliferation  (ISO)
regulation of cell shape  (IDA)
regulation of circadian sleep/wake cycle, non-REM sleep  (IMP)
regulation of glucagon secretion  (ISO,ISS)
regulation of insulin secretion  (ISO,ISS)
regulation of vascular endothelial growth factor production  (ISO)
response to activity  (ISO,ISS)
response to amino acid  (IEP)
response to auditory stimulus  (IEP)
response to bacterium  (IEP)
response to caffeine  (IEP)
response to calcium ion  (IEP)
response to cytokine  (IEP)
response to electrical stimulus  (IEP)
response to glucocorticoid  (ISO)
response to Gram-positive bacterium  (IEP)
response to insulin  (IEP)
response to lipopolysaccharide  (IEP)
response to mechanical stimulus  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to wounding  (ISO)
response to xenobiotic stimulus  (IEP)
response to yeast  (IEP)
signal transduction  (IEA)
T cell activation  (ISO)
T follicular helper cell differentiation  (ISO,ISS)
T-helper 17 cell lineage commitment  (IEA,ISO,ISS)
T-helper 2 cell differentiation  (ISO)
vascular endothelial growth factor production  (ISO,ISS)

Cellular Component

Molecular Function

References

References - curated
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375. Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice. Zhang H, etal., J Nanobiotechnology. 2019 Feb 19;17(1):29. doi: 10.1186/s12951-019-0461-7.
376. Hepatic insulin gene therapy diminishes liver glycogen despite insulin responsive transcriptional effects in diabetic CD-1 mice. Zhang JA, etal., J Gene Med. 2009 May 11.
377. Association of genetic variations in IL-6/IL-6R pathway genes with gastric cancer risk in a Chinese population. Zhang JZ, etal., Gene. 2017 Aug 5;623:1-4. doi: 10.1016/j.gene.2017.04.038. Epub 2017 Apr 23.
378. Exogenous interleukin-6 facilitated the contraction of the colon in a depression rat model. Zhang L, etal., Dig Dis Sci. 2013 Aug;58(8):2187-96. doi: 10.1007/s10620-013-2656-3. Epub 2013 Apr 16.
379. Mechanisms of multiple organ damages in acute necrotizing pancreatitis. Zhang Q, etal., Chin Med J (Engl). 2001 Jul;114(7):738-42.
380. Potassium channel changes of peripheral blood T-lymphocytes from Kazakh hypertensive patients in Northwest China and the inhibition effect towards potassium channels by telmisartan. Zhang Q, etal., Kardiol Pol. 2016;74(5):476-488. doi: 10.5603/KP.a2015.0210. Epub 2015 Oct 27.
381. ANGIOTENSIN CONVERTING ENZYME INHIBITORS IMPROVE HEPATIC STEATOSIS BY MODULATING EXPRESSION OF TUMOR NECROSIS FACTOR-Alpha, INTERLEUKIN-6 AND ADIPONECTIN RECEPTOR-2 IN RATS WITH TYPE 2 DIABETES. Zhang X, etal., Clin Exp Pharmacol Physiol. 2008 Nov 28.
382. Viral and host factors related to the clinical outcome of COVID-19. Zhang X, etal., Nature. 2020 May 20. pii: 10.1038/s41586-020-2355-0. doi: 10.1038/s41586-020-2355-0.
383. Analysis of serum cytokines in patients with severe acute respiratory syndrome. Zhang Y, etal., Infect Immun. 2004 Aug;72(8):4410-5. doi: 10.1128/IAI.72.8.4410-4415.2004.
384. Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Zheng L, etal., Biomed Pharmacother. 2018 Jan;97:481-488. doi: 10.1016/j.biopha.2017.10.153. Epub 2017 Nov 6.
385. Protective Effects of Melatonin Against the Damages of Neuroendocrine-immune Induced by Lipopolysaccharide in Diabetic Rats. Zhong LY, etal., Exp Clin Endocrinol Diabetes. 2009 May 15.
386. Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation. Zhong W, etal., Oncotarget. 2017 Jun 20;8(25):40486-40500. doi: 10.18632/oncotarget.17119.
387. Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population. Zhou F, etal., Oncotarget. 2016 May 10;7(19):28112-23. doi: 10.18632/oncotarget.8492.
388. Can perioperative C-reactive protein and interleukin-6 levels predict atrial fibrillation after coronary artery bypass surgery? Ziabakhsh-Tabari S Saudi Med J. 2008 Oct;29(10):1429-31.
Additional References at PubMed
PMID:1312474   PMID:1373998   PMID:1577194   PMID:2104886   PMID:2261637   PMID:2444978   PMID:3023045   PMID:3130269   PMID:3264880   PMID:3491322   PMID:7508917   PMID:7595060  
PMID:7749983   PMID:7867561   PMID:7959007   PMID:8043507   PMID:8557680   PMID:9949178   PMID:10443688   PMID:10510402   PMID:10549626   PMID:11016935   PMID:11159963   PMID:11275690  
PMID:11710966   PMID:11781188   PMID:11884027   PMID:11886848   PMID:11894098   PMID:11948286   PMID:12046086   PMID:12100026   PMID:12392281   PMID:12397370   PMID:12419823   PMID:12423624  
PMID:12552091   PMID:12594267   PMID:12639960   PMID:12643274   PMID:12646246   PMID:12661899   PMID:12785009   PMID:12821383   PMID:12824010   PMID:12829785   PMID:12855817   PMID:12865171  
PMID:12925700   PMID:12950323   PMID:12957790   PMID:12960020   PMID:14575314   PMID:14606087   PMID:14654230   PMID:14688199   PMID:14715528   PMID:14754894   PMID:14764707   PMID:15019946  
PMID:15031602   PMID:15085088   PMID:15240714   PMID:15256805   PMID:15272006   PMID:15292196   PMID:15298985   PMID:15316242   PMID:15316244   PMID:15328477   PMID:15342195   PMID:15345694  
PMID:15385469   PMID:15475534   PMID:15551000   PMID:15575898   PMID:15692051   PMID:15781751   PMID:15843532   PMID:15905211   PMID:15920760   PMID:16033193   PMID:16034137   PMID:16150725  
PMID:16189509   PMID:16236719   PMID:16272873   PMID:16275384   PMID:16330325   PMID:16381797   PMID:16406266   PMID:16427158   PMID:16484300   PMID:16606666   PMID:16732314   PMID:16809219  
PMID:16809483   PMID:16815050   PMID:16877563   PMID:16888221   PMID:16940225   PMID:16946298   PMID:16988192   PMID:16990136   PMID:17009398   PMID:17109471   PMID:17133350   PMID:17133487  
PMID:17170234   PMID:17204394   PMID:17277142   PMID:17303338   PMID:17313958   PMID:17314490   PMID:17322172   PMID:17324931   PMID:17327367   PMID:17328769   PMID:17340223   PMID:17341596  
PMID:17385713   PMID:17395896   PMID:17433709   PMID:17556393   PMID:17567751   PMID:17582939   PMID:17665433   PMID:17693256   PMID:17822789   PMID:17875732   PMID:18056981   PMID:18162526  
PMID:18214944   PMID:18223607   PMID:18255192   PMID:18261938   PMID:18270592   PMID:18280640   PMID:18299267   PMID:18299269   PMID:18303626   PMID:18344939   PMID:18345501   PMID:18348986  
PMID:18358738   PMID:18401835   PMID:18406623   PMID:18500730   PMID:18511508   PMID:18535404   PMID:18541141   PMID:18559975   PMID:18563316   PMID:18593633   PMID:18636982   PMID:18677579  
PMID:18679050   PMID:18686625   PMID:18700232   PMID:18716207   PMID:18719127   PMID:18782534   PMID:18782543   PMID:18792410   PMID:18821705   PMID:18848809   PMID:18938092   PMID:18973594  
PMID:19041259   PMID:19047410   PMID:19074435   PMID:19084916   PMID:19136380   PMID:19139201   PMID:19168699   PMID:19192484   PMID:19207862   PMID:19211730   PMID:19220679   PMID:19326443  
PMID:19330444   PMID:19342597   PMID:19363165   PMID:19383497   PMID:19390056   PMID:19396873   PMID:19404405   PMID:19497205   PMID:19500508   PMID:19551494   PMID:19563340   PMID:19567205  
PMID:19647022   PMID:19653339   PMID:19666510   PMID:19695174   PMID:19710104   PMID:19723085   PMID:19748527   PMID:19751774   PMID:19817504   PMID:19907006   PMID:19921094   PMID:19955433  
PMID:19955834   PMID:19961020   PMID:20035858   PMID:20122990   PMID:20150963   PMID:20180411   PMID:20373517   PMID:20411395   PMID:20420568   PMID:20458762   PMID:20519077   PMID:20519080  
PMID:20529813   PMID:20607388   PMID:20643563   PMID:20655350   PMID:20658183   PMID:20702406   PMID:20717763   PMID:20926198   PMID:20945380   PMID:20969918   PMID:20970480   PMID:21030786  
PMID:21048959   PMID:21069809   PMID:21072211   PMID:21109592   PMID:21116112   PMID:21173340   PMID:21192080   PMID:21192292   PMID:21193288   PMID:21199478   PMID:21216156   PMID:21245987  
PMID:21265103   PMID:21294755   PMID:21439977   PMID:21470923   PMID:21494199   PMID:21528066   PMID:21565410   PMID:21599899   PMID:21606371   PMID:21640816   PMID:21643979   PMID:21882482  
PMID:21914363   PMID:21945087   PMID:22133515   PMID:22144718   PMID:22152774   PMID:22157761   PMID:22164858   PMID:22201020   PMID:22326661   PMID:22426572   PMID:22432126   PMID:22480838  
PMID:22507133   PMID:22554223   PMID:22561097   PMID:22578249   PMID:22634718   PMID:22697788   PMID:22761278   PMID:22851861   PMID:22856259   PMID:22884876   PMID:22911046   PMID:22956308  
PMID:22992031   PMID:23018187   PMID:23034271   PMID:23086831   PMID:23218517   PMID:23261764   PMID:23294974   PMID:23379983   PMID:23395675   PMID:23438872   PMID:23451164   PMID:23460747  
PMID:23520526   PMID:23608380   PMID:23610142   PMID:23634725   PMID:23639820   PMID:23685388   PMID:23692924   PMID:23695883   PMID:23700204   PMID:23764358   PMID:23776175   PMID:23802625  
PMID:23846262   PMID:23869758   PMID:23870461   PMID:23892723   PMID:23948778   PMID:24037056   PMID:24048027   PMID:24091940   PMID:24139936   PMID:24210203   PMID:24311225   PMID:24332041  
PMID:24338258   PMID:24344329   PMID:24379062   PMID:24431453   PMID:24463741   PMID:24467743   PMID:24489578   PMID:24584780   PMID:24623002   PMID:24667246   PMID:24706318   PMID:24763697  
PMID:24845382   PMID:24865534   PMID:24913911   PMID:24961501   PMID:24965599   PMID:25084278   PMID:25096025   PMID:25129106   PMID:25150005   PMID:25200151   PMID:25260633   PMID:25262023  
PMID:25362566   PMID:25682689   PMID:25752645   PMID:25809226   PMID:25863030   PMID:25916550   PMID:26102301   PMID:26134658   PMID:26191141   PMID:26205888   PMID:26390417   PMID:26523620  
PMID:26527061   PMID:26583134   PMID:26587789   PMID:26591203   PMID:26760196   PMID:26825317   PMID:26846568   PMID:26914683   PMID:26927369   PMID:26927377   PMID:27009340   PMID:27038016  
PMID:27049312   PMID:27180201   PMID:27214337   PMID:27252421   PMID:27348628   PMID:27383646   PMID:27529541   PMID:27534878   PMID:27539920   PMID:27619517   PMID:27764704   PMID:27993875  
PMID:28091942   PMID:28141871   PMID:28258441   PMID:28319508   PMID:28387444   PMID:28433754   PMID:28573530   PMID:28592636   PMID:28698251   PMID:28713893   PMID:28759646   PMID:28776758  
PMID:29018960   PMID:29222114   PMID:29306260   PMID:29397206   PMID:29402223   PMID:29486618   PMID:29547593   PMID:29580751   PMID:29674256   PMID:29848725   PMID:30221360   PMID:30670152  
PMID:30974824   PMID:31077169   PMID:31144562   PMID:31200316   PMID:31252000   PMID:31335655   PMID:31507089   PMID:31703282   PMID:31886314   PMID:32024466   PMID:32026477   PMID:32039828  
PMID:32196570   PMID:32279611   PMID:32329820   PMID:32382539   PMID:32704142   PMID:32791212   PMID:32908484   PMID:33099553   PMID:33126892   PMID:33189652   PMID:33220932   PMID:33577025  
PMID:33741073   PMID:33770644   PMID:33893246   PMID:33920198   PMID:33945195   PMID:33971931   PMID:34023825   PMID:34407316   PMID:34423720   PMID:35583060   PMID:35655056   PMID:35853948  
PMID:36631456   PMID:36794521   PMID:37629166   PMID:37914358  


Genomics

Comparative Map Data
Il6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr845,889,999 - 5,894,575 (-)NCBIGRCr8
mRatBN7.245,214,602 - 5,219,178 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl45,213,394 - 5,219,178 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx410,211,864 - 10,216,458 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.046,026,101 - 6,030,695 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.044,372,235 - 4,376,829 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.043,043,231 - 3,047,807 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl43,043,231 - 3,047,807 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.043,095,536 - 3,100,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44456,799 - 461,376 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14456,798 - 461,376 (-)NCBI
Celera45,093,593 - 5,098,169 (+)NCBICelera
Cytogenetic Map4q11NCBI
IL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38722,727,200 - 22,731,998 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl722,725,884 - 22,732,002 (+)EnsemblGRCh38hg38GRCh38
GRCh37722,766,819 - 22,771,617 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36722,733,343 - 22,738,145 (+)NCBINCBI36Build 36hg18NCBI36
Build 34722,540,059 - 22,544,856NCBI
Celera722,752,396 - 22,757,251 (+)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef722,649,846 - 22,654,701 (+)NCBIHuRef
CHM1_1722,767,669 - 22,772,524 (+)NCBICHM1_1
T2T-CHM13v2.0722,861,319 - 22,867,916 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2722,817,875 - 22,822,730 (+)NCBI
Il6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39530,218,112 - 30,224,973 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl530,218,112 - 30,224,979 (+)EnsemblGRCm39 Ensembl
GRCm38530,013,114 - 30,019,975 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,013,114 - 30,019,981 (+)EnsemblGRCm38mm10GRCm38
MGSCv37530,339,701 - 30,346,508 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36530,343,948 - 30,350,755 (+)NCBIMGSCv36mm8
Celera527,530,266 - 27,537,070 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map515.7NCBI
Il6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541025,079,835 - 25,084,390 (+)NCBIChiLan1.0ChiLan1.0
IL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2627,593,486 - 27,598,569 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1775,918,460 - 75,923,290 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0723,415,922 - 23,420,767 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1723,027,560 - 23,032,419 (+)NCBIpanpan1.1PanPan1.1panPan2
IL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11436,474,268 - 36,478,519 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1436,473,394 - 36,478,519 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1436,015,351 - 36,019,602 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01436,398,579 - 36,402,833 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1436,397,705 - 36,402,833 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11436,519,712 - 36,523,966 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01436,216,365 - 36,220,619 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01436,553,276 - 36,557,530 (+)NCBIUU_Cfam_GSD_1.0
Il6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213183,842,756 - 183,843,378 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365497,015,595 - 7,016,246 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl991,506,421 - 91,511,263 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1991,506,421 - 91,510,830 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29101,081,042 - 101,085,451 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9q14-q15NCBI
IL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12135,577,513 - 35,582,385 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2135,577,939 - 35,582,237 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604269,001,958 - 69,006,830 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247397,957,674 - 7,962,318 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247397,957,709 - 7,963,414 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il6
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:28
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000013732
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat

Markers in Region
D4Wox27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.245,218,294 - 5,218,392 (-)MAPPERmRatBN7.2
Rnor_6.043,044,017 - 3,044,114NCBIRnor6.0
Rnor_5.043,096,322 - 3,096,419UniSTSRnor5.0
RGSC_v3.44460,493 - 460,590UniSTSRGSC3.4
RGSC_v3.14460,492 - 460,590RGD
Celera45,094,379 - 5,094,476UniSTS
Cytogenetic Map4q11UniSTS
D4Arb14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.245,218,227 - 5,218,417 (-)MAPPERmRatBN7.2
Rnor_6.043,043,992 - 3,044,181NCBIRnor6.0
Rnor_5.043,096,297 - 3,096,486UniSTSRnor5.0
RGSC_v3.44460,426 - 460,615UniSTSRGSC3.4
RGSC_v3.44460,425 - 460,615RGDRGSC3.4
RGSC_v3.14460,425 - 460,615RGD
Celera45,094,354 - 5,094,543UniSTS
SHRSP x BN Map40.0UniSTS
SHRSP x BN Map40.0RGD
FHH x ACI Map40.0501RGD
Cytogenetic Map4q11UniSTS
RH142237  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.245,217,991 - 5,218,160 (-)MAPPERmRatBN7.2
Rnor_6.043,044,249 - 3,044,417NCBIRnor6.0
Rnor_5.043,096,554 - 3,096,722UniSTSRnor5.0
RGSC_v3.44460,190 - 460,358UniSTSRGSC3.4
Celera45,094,611 - 5,094,779UniSTS
Cytogenetic Map4q11UniSTS
PMC209527P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.245,214,895 - 5,215,050 (-)MAPPERmRatBN7.2
Rnor_6.043,047,359 - 3,047,513NCBIRnor6.0
Rnor_5.043,099,664 - 3,099,818UniSTSRnor5.0
RGSC_v3.44457,093 - 457,248UniSTSRGSC3.4
Celera45,097,721 - 5,097,875UniSTS
Cytogenetic Map4q11UniSTS
PMC356028P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.043,097,263 - 3,097,347NCBIRnor5.0
RGSC_v3.44459,565 - 459,648UniSTSRGSC3.4
Cytogenetic Map4q11UniSTS
UniSTS:532119  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.245,214,899 - 5,215,081 (-)MAPPERmRatBN7.2
Rnor_6.043,047,328 - 3,047,509NCBIRnor6.0
Rnor_5.043,099,633 - 3,099,814UniSTSRnor5.0
Celera45,097,690 - 5,097,871UniSTS
Cytogenetic Map4q11UniSTS
UniSTS:532129  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.245,216,376 - 5,217,472 (-)MAPPERmRatBN7.2
Rnor_6.043,044,937 - 3,046,032NCBIRnor6.0
Rnor_5.043,097,242 - 3,098,337UniSTSRnor5.0
Celera45,095,299 - 5,096,394UniSTS
Cytogenetic Map4q11UniSTS


Related Rat Strains
The following Strains have been annotated to Il6


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 5 15 1 1 2
Below cutoff 1 2 5 1 3 1 3 3 17 5 17 8 3

Sequence


RefSeq Acc Id: ENSRNOT00000013732   ⟹   ENSRNOP00000013732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl45,214,602 - 5,219,178 (-)Ensembl
Rnor_6.0 Ensembl43,043,231 - 3,047,807 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103213   ⟹   ENSRNOP00000092021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl45,216,170 - 5,219,178 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104678   ⟹   ENSRNOP00000087590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl45,213,394 - 5,218,961 (-)Ensembl
RefSeq Acc Id: NM_012589   ⟹   NP_036721
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr845,889,999 - 5,894,575 (-)NCBI
mRatBN7.245,214,602 - 5,219,178 (-)NCBI
Rnor_6.043,043,231 - 3,047,807 (+)NCBI
Rnor_5.043,095,536 - 3,100,112 (+)NCBI
RGSC_v3.44456,799 - 461,376 (-)RGD
Celera45,093,593 - 5,098,169 (+)RGD
Sequence:
RefSeq Acc Id: NP_036721   ⟸   NM_012589
- Peptide Label: precursor
- UniProtKB: P20607 (UniProtKB/Swiss-Prot),   A6KJN3 (UniProtKB/TrEMBL),   A0A8I6A641 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013732   ⟸   ENSRNOT00000013732
RefSeq Acc Id: ENSRNOP00000092021   ⟸   ENSRNOT00000103213
RefSeq Acc Id: ENSRNOP00000087590   ⟸   ENSRNOT00000104678

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20607-F1-model_v2 AlphaFold P20607 1-211 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692776
Promoter ID:EPDNEW_R3300
Type:single initiation site
Name:Il6_1
Description:interleukin 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.043,043,236 - 3,043,296EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2901 AgrOrtholog
BioCyc Gene G2FUF-46178 BioCyc
Ensembl Genes ENSRNOG00000010278 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055005535 UniProtKB/Swiss-Prot
  ENSRNOG00060024169 UniProtKB/Swiss-Prot
  ENSRNOG00065004225 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013732 ENTREZGENE
  ENSRNOT00000013732.7 UniProtKB/Swiss-Prot
  ENSRNOT00000103213.1 UniProtKB/TrEMBL
  ENSRNOT00000104678.1 UniProtKB/TrEMBL
  ENSRNOT00055008887 UniProtKB/Swiss-Prot
  ENSRNOT00060041923 UniProtKB/Swiss-Prot
  ENSRNOT00065006164 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-6/GCSF/MGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL6/GCSF/MGF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24498 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24498 ENTREZGENE
PANTHER PTHR10511 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10511:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB IL6 RGD
PhenoGen Il6 PhenoGen
PIRSF IL6_MGF_GCSF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS IL6GCSFMGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERLEUKIN6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INTERLEUKIN_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010278 RatGTEx
  ENSRNOG00055005535 RatGTEx
  ENSRNOG00060024169 RatGTEx
  ENSRNOG00065004225 RatGTEx
SMART IL6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC209798
UniProt A0A8I6A641 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGT8_RAT UniProtKB/TrEMBL
  A6KJN3 ENTREZGENE, UniProtKB/TrEMBL
  IL6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Il6  Interleukin 6 (interferon, beta 2)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA level dramatically increases after cyclophosphamide (CYP)-induced cystitis 625630
gene_regulation expression regulated by the cyclooxygenase 2 cascade 625680
gene_regulation expression and secretion regulated by IL-1beta in primary mixed glial cells 729230