RGD Reference Report - Cosegregation of the Tnfalpha locus with cardiovascular phenotypes in the F2 generation of a New Zealand genetically hypertensive and Brown Norway cross. - Rat Genome Database

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Cosegregation of the Tnfalpha locus with cardiovascular phenotypes in the F2 generation of a New Zealand genetically hypertensive and Brown Norway cross.

Authors: Harris, EL  Grigor, MR  Thompson, CM 
Citation: Harris EL, etal., Clin Exp Pharmacol Physiol 1998 Mar-Apr;25(3-4):204-7.
RGD ID: 1357163
Pubmed: PMID:9590569   (View Abstract at PubMed)

1. The association of the Tnfalpha locus with several cardiovascular phenotypes and body mass has been studied in the F2 generation of a reciprocal cross between rats of the New Zealand genetically hypertensive (GH) and the normotensive Brown Norway (BN) strains. In the total F2 population the GH allele of Tnfalpha cosegregated with increased intra-arterial blood pressure (BP) in a recessive manner. A similar but weaker effect was observed for tail BP. 2. An association between genotype and body mass in females with GH grandfathers was also detected. 3. An association between genotype and pulse rate was observed for females. 4. This work supports other evidence pointing to an association of a gene (or genes) on rat chromosome 20 with hypertension.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  ISOTnf (Rattus norvegicus)1357163; 1357163 RGD 
hypertension  IAGP 1357163 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
decreased heart rate  IAGP 1357163 RGD 
increased body weight  IAGP 1357163 RGD 
increased systemic arterial blood pressure  IAGP 1357163 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
TNF  (tumor necrosis factor)

Objects referenced in this article
Strain BN/Elh null Rattus norvegicus
Strain GH/Omr Genetically Hypertensive Rattus norvegicus

Additional Information