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Serum tumor necrosis factor-alpha and interleukin-10 levels as markers to predict outcome of patients with chronic lymphocytic leukemia in different risk groups defined by the IGHV mutation status.

Authors: Lech-Maranda, E  Grzybowska-Izydorczyk, O  Wyka, K  Mlynarski, W  Borowiec, M  Antosik, K  Cebula-Obrzut, B  Makuch-Lasica, H  Nowak, G  Klimkiewicz-Wojciechowska, G  Wawrzyniak, E  Bilinski, P  Robak, T  Warzocha, K 
Citation: Lech-Maranda E, etal., Arch Immunol Ther Exp (Warsz). 2012 Dec;60(6):477-86. doi: 10.1007/s00005-012-0197-7. Epub 2012 Sep 4.
Pubmed: (View Article at PubMed) PMID:22945689
DOI: Full-text: DOI:10.1007/s00005-012-0197-7

Tumor necrosis factor (TNF)-alpha and interleukin (IL)-10 are cytokines involved in the balance between cell-mediated and humoral immunity. We investigated whether serum TNF-alpha and IL-10 levels have any impact on clinical outcome of patients with chronic lymphocytic leukemia (CLL). TNF-alpha and IL-10 levels were determined in the serum of 160 CLL patients at the time of diagnosis. The cytokine low-risk group consisted of patients with either TNF-alpha and IL-10 levels below their medians or those with only one elevated parameter. Both TNF-alpha and IL-10 levels greater than or equal to their medians defined the cytokine high-risk group. The high-risk patients presented a shorter 3-year treatment-free survival (TFS) than low-risk subjects (15 vs. 69.6 %; p < 0.0001). The high-risk group (p = 0.0002) along with high leukocyte count (p < 0.0001) and unmutated immunoglobulin heavy-chain variable region genes (p < 0.0001) independently predict the risk of progression in patients with Rai stage 0-II. Furthermore, the high-risk group had an independent prognostic impact on shorter TFS both in patients with mutated (24.3 vs. 78.2 %; p < 0.0001) and unmutated (8.2 vs. 49 %; p = 0.004) immunoglobulin heavy-chain variable region genes (IGHV) as compared to the low-risk group. The estimated 5-year overall survival (OS) of high-risk patients was shorter than those in the low-risk group (83.3 vs. 97.1 %; p = 0.003). Multivariate analysis demonstrated the cytokine high-risk group (p = 0.02) followed by Rai stage III-IV (p = 0.048) to be independent factors predicting shorter OS. At diagnosis, TNF-alpha and IL-10 may predict the outcome of patients with CLL.

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RGD Object Information
RGD ID: 11041895
Created: 2016-04-01
Species: All species
Last Modified: 2016-04-01
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.