RGD Reference Report - Effects of probucol on hepatic tumor necrosis factor-alpha, interleukin-6 and adiponectin receptor-2 expression in diabetic rats. - Rat Genome Database

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Effects of probucol on hepatic tumor necrosis factor-alpha, interleukin-6 and adiponectin receptor-2 expression in diabetic rats.

Authors: Zhang, X  Li, Z  Liu, D  Xu, X  Shen, W  Mei, Z 
Citation: Zhang X, etal., J Gastroenterol Hepatol. 2009 Jun;24(6):1058-63. Epub 2009 Feb 9.
RGD ID: 2312478
Pubmed: PMID:19220660   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1440-1746.2008.05719.x   (Journal Full-text)

BACKGROUND AND AIMS: Probucol is a lipid-lowering agent with anti-oxidant effects. Oxidative stress and inflammation are important in the pathophysiology of insulin resistance. We aimed to evaluate the effects of probucol on liver histological changes, serum and hepatic levels of adipokines in rats with high fat-induced type 2 diabetes (T2D). METHODS: Thirty-six rats were divided into a normal control group, a high fat-induced T2D group and a probucol treatment group. After six weeks of treatment with probucol, we evaluated liver histological changes and measured homeostasis model assessment index (HOMA-IR), serum superoxide dismutase (SOD), alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, adiponectin and hepatic TNF-alpha, IL-6 and adiponectin receptor-2 (adipoR2) mRNA. RESULTS: The degree of hepatic steatosis and inflammation, HOMA-IR, serum ALT, TNF-alpha and IL-6 concentrations, and hepatic TNF-alpha and IL-6 mRNA expression in diabetic rats were significantly higher compared with normal controls. Serum SOD and adiponectin concentrations and hepatic adipoR2 mRNA expression in diabetic rats were significantly lower compared with normal controls. Probucol significantly reduced the degree of hepatic steatosis, HOMA-IR, serum ALT, TNF-alpha and IL-6 concentrations, and hepatic TNF-alpha and IL-6 mRNA expression. Probucol significantly raised serum SOD and adiponectin concentrations and hepatic adipoR2 mRNA expression. CONCLUSIONS: In rats with high fat-induced T2D, treatment with probucol improved insulin sensitivity, hepatic steatosis by raising circulating adiponectin and hepatic adipoR2 levels, in addition to reducing pro-inflammatory cytokines in the circulation and liver.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADIPOR2HumanExperimental Diabetes Mellitus  ISOAdipor2 (Rattus norvegicus)High fat induced diabetesRGD 
Adipor2RatExperimental Diabetes Mellitus  IDA  RGD 
Adipor2MouseExperimental Diabetes Mellitus  ISOAdipor2 (Rattus norvegicus)High fat induced diabetesRGD 
TNFHumanExperimental Diabetes Mellitus treatmentISOTnf (Rattus norvegicus) RGD 
TnfRatExperimental Diabetes Mellitus treatmentIEP  RGD 
TnfMouseExperimental Diabetes Mellitus treatmentISOTnf (Rattus norvegicus) RGD 

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TNFHumanprobucol decreases expressionISOTnf (Rattus norvegicus)Probucol decreases expression of Tnf mRNA in liver and protein in serumRGD 
TnfRatprobucol decreases expressionEXP Probucol decreases expression of Tnf mRNA in liver and protein in serumRGD 
TnfMouseprobucol decreases expressionISOTnf (Rattus norvegicus)Probucol decreases expression of Tnf mRNA in liver and protein in serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Adipor2  (adiponectin receptor 2)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Adipor2  (adiponectin receptor 2)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
ADIPOR2  (adiponectin receptor 2)
TNF  (tumor necrosis factor)


Additional Information