RGD Reference Report - Uveitis and erythema nodosum in inflammatory bowel disease: clinical features and the role of HLA genes. - Rat Genome Database

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Uveitis and erythema nodosum in inflammatory bowel disease: clinical features and the role of HLA genes.

Authors: Orchard, TR  Chua, CN  Ahmad, T  Cheng, H  Welsh, KI  Jewell, DP 
Citation: Orchard TR, etal., Gastroenterology. 2002 Sep;123(3):714-8.
RGD ID: 7364926
Pubmed: PMID:12198697   (View Abstract at PubMed)

BACKGROUND & AIMS: There are few systematic studies on the natural history or immunogenetic associations of erythema nodosum (EN) or ocular inflammation in inflammatory bowel disease (IBD), but they are reportedly more common in patients with other extraintestinal manifestations (EIMs), particularly arthritis. Immunogenetic associations have previously been described in IBD arthritis and in EN associated with sarcoidosis. This study examined the clinical features and HLA-B, DR, and tumor necrosis factor alpha (TNF-alpha) associations of ocular inflammation and EN and their clinical and immunogenetic relationship to arthritis in IBD. METHODS: Details of EN and ocular inflammation were gathered by case-note review and questionnaire in 976 ulcerative colitis patients and 483 Crohn's patients. Sequence-specific PCR typing for polymorphisms in HLA-B, DR, and TNF-alpha was performed in 39 EN and 40 ocular patients. Results were compared with 490 IBD controls without EIMs, 38 patients with type 1 and 31 with type 2 peripheral arthritis, and 16 AS patients. RESULTS: EN and ocular inflammation were more common in women, were associated with IBD relapse, and recurred in approximately 30% of patients. They occurred more commonly with arthritis and AS than expected by chance. Ocular inflammation was strongly associated with HLA-B*27, B*58, and HLA-DRB1*0103. There is a weak association between EN and HLA-B*15 but a strong association with the -1031 TNF-alpha. CONCLUSIONS: EN, uveitis, and arthritis associated with IBD occur together commonly. They are associated with genes in the HLA region, and linkage disequilibrium between these genes may account for the clinical picture of overlapping but independent clinical manifestations.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HLA-BHumanAcute Anterior Uveitis  IAGP associated with Inflammatory Bowel Diseases;DNA:polymorphisms:cds:HLA-B*27, HLA-B*58 (human)RGD 
H2-Q4Mouseerythema nodosum  ISOHLA-B (Homo sapiens)associated with Inflammatory Bowel Diseases; DNA:polymorphisms:cds:multiple (human) RGD 
HLA-BHumanerythema nodosum  IAGP associated with Inflammatory Bowel Diseases; DNA:polymorphisms:cds:multiple (human) RGD 
RT1-CE13Raterythema nodosum  ISOHLA-B (Homo sapiens)associated with Inflammatory Bowel Diseases; DNA:polymorphisms:cds:multiple (human) RGD 
TNFHumanerythema nodosum susceptibilityIAGP associated with Inflammatory Bowel Diseases;DNA:polymorphisms: :-1031T>C(human)RGD 
TnfRaterythema nodosum susceptibilityISOTNF (Homo sapiens)associated with Inflammatory Bowel Diseases;DNA:polymorphisms: :-1031T>C(human)RGD 
TnfMouseerythema nodosum susceptibilityISOTNF (Homo sapiens)associated with Inflammatory Bowel Diseases;DNA:polymorphisms: :-1031T>C(human)RGD 
H2-Eb1Mouseuveitis susceptibilityISOHLA-DRB1 (Homo sapiens)associated with Inflammatory Bowel Diseases;DNA:polymorphism: :HLA-DRB1*0103(human)RGD 
H2-Q4Mouseuveitis  ISOHLA-B (Homo sapiens)associated with Inflammatory Bowel Diseases; DNA:polymorphisms:cds:HLA-B*27, HLA-B*58 (human)RGD 
HLA-DRB1Humanuveitis susceptibilityIAGP associated with Inflammatory Bowel Diseases;DNA:polymorphism: :HLA-DRB1*0103(human)RGD 
RT1-CE13Ratuveitis  ISOHLA-B (Homo sapiens)associated with Inflammatory Bowel Diseases; DNA:polymorphisms:cds:HLA-B*27, HLA-B*58 (human)RGD 
RT1-Db1Ratuveitis susceptibilityISOHLA-DRB1 (Homo sapiens)associated with Inflammatory Bowel Diseases;DNA:polymorphism: :HLA-DRB1*0103(human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HLA-BHumanErythematous papule  IAGP associated with Inflammatory Bowel Diseases;DNA:polymorphisms:cds:multipleRGD 
HLA-BHumanInflammatory abnormality of the eye  IAGP associated with Inflammatory Bowel Diseases;DNA:polymorphisms:cds:HLA-B*27, HLA-B*58RGD 
Objects Annotated

Genes (Rattus norvegicus)
RT1-CE13  (RT1 class I, locus CE13)
RT1-Db1  (RT1 class II, locus Db1)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
H2-Eb1  (histocompatibility 2, class II antigen E beta)
H2-Q4  (histocompatibility 2, Q region locus 4)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
HLA-B  (major histocompatibility complex, class I, B)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)
TNF  (tumor necrosis factor)


Additional Information