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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:30772
Term: butyric acid
Definition: A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.
Chemical ID: MESH:D020148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDButyric Acid results in increased expression of TNF mRNAPMID:17928716
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD[Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TNF mRNA]; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TNF mRNA]PMID:29751049 PMID:37269894
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDButyric Acid promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of TNF protein]PMID:33130239
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