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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:31633
Term: formoterol fumarate
Definition: A racemate consisting of equal amounts of arformoterol fumarate (the active enantiomer) and (S,S)-formoterol fumarate (the inactive enantiomer). It is used (particularly in its dihydrate form) as a direct-acting sympathomimetic and bronchodilator for the treatment of chronic obstructive pulmonary disease (any progressive respiratory disease that makes it harder to breathe over time, such as chronic bronchitis and emphysema).
Chemical ID: MESH:D000068759
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfaffects expressionEXP 6480464CTDFormoterol Fumarate affects the expression of TNF mRNA Formoterol Fumarate affects the expression of TNF protein

PMID:10525314
Tnfmultiple interactionsEXP 6480464CTDFormoterol Fumarate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] Formoterol Fumarate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]

PMID:10525314 PMID:11096136
Tnfmultiple interactionsISORGD:114296480464CTD[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Formoterol Fumarate Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Formoterol Fumarate]

PMID:20061444
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