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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:7940
Term: patchouli alcohol
Definition: A carbotricyclic compound and sesquiterpenoid tertiary alcohol that is tricyclo[5.3.1.0(3,8)]undecan-3-ol which is substituted at positions 2, 2, 6 and 8 by methyl groups (the 1R,3R,6S,7S,8S-diastereoisomer).
Chemical ID: MESH:C052983
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfmultiple interactionsEXP 6480464CTDpatchouli alcohol inhibits the reaction [Ethanol results in increased expression of TNF protein]

PMID:25168850
Tnfmultiple interactionsISORGD:114296480464CTDpatchouli alcohol inhibits the reaction [TNF protein results in increased expression of MAPK1 protein modified form] patchouli alcohol inhibits the reaction [TNF protein results in increased expression of MAPK3 protein modified form]

PMID:23348408
Tnfmultiple interactionsISORGD:13441926480464CTDpatchouli alcohol inhibits the reaction [TNF protein affects the localization of RELA protein] patchouli alcohol inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] patchouli alcohol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA] patchouli alcohol inhibits the reaction [TNF protein results in increased expression of IL6 protein] patchouli alcohol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA] patchouli alcohol inhibits the reaction [TNF protein results in increased expression of NOS2 protein]

PMID:23348408
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