RGD Reference Report - Correlation of serum cytokine levels with haematological abnormalities in human immunodeficiency virus infection. - Rat Genome Database

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Correlation of serum cytokine levels with haematological abnormalities in human immunodeficiency virus infection.

Authors: Maury, CP  Lahdevirta, J 
Citation: Maury CP and Lahdevirta J, J Intern Med. 1990 Apr;227(4):253-7.
RGD ID: 10450888
Pubmed: PMID:2324681   (View Abstract at PubMed)

Mononuclear phagocyte-derived cytokines are important regulators of haemopoiesis in inflammatory conditions. By means of radioimmunoassay we measured the levels of two cytokines, tumour necrosis factor-alpha and interleukin 1 beta in sera from subjects infected with human immunodeficiency virus, and related the levels to the presence and severity of haematological abnormalities. The levels of tumour necrosis factor-alpha were significantly higher in patients with anaemia (142 +/- 17 (SE) pg ml-1), lymphopenia (107 +/- 20 pg ml-1) or both (137 +/- 21 pg ml-1) than in individuals without anaemia (18 +/- 5 pg ml-1; P less than 0.001), without lymphopenia (16 +/- 7 pg ml-1; P less than 0.001) or without either disorder (19 +/- 7 pg ml-1; P less than 0.001). A strong negative correlation was found between tumour necrosis factor-alpha and haemoglobin values (r = -0.83, P less than 0.001) and absolute lymphocyte count (r = -0.66, P less than 0.001) in human immunodeficiency virus infection. The changes in the levels of serum interleukin 1 beta were less pronounced but followed the same general trend as the changes in tumour necrosis factor-alpha. The results show that the production of mononuclear phagocyte-derived cytokines is enhanced in acquired immunodeficiency syndrome, and that the levels of these factors are correlated with the presence of certain haematological abnormalities.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TNFHumananemia  IEP associated with HIV Infections and protein:increased expression:serumRGD 
TnfRatanemia  ISOTNF (Homo sapiens)associated with HIV Infections and protein:increased expression:serumRGD 
TnfMouseanemia  ISOTNF (Homo sapiens)associated with HIV Infections and protein:increased expression:serumRGD 
TNFHumanlymphopenia  IEP associated with HIV Infections and protein:increased expression:serumRGD 
TnfRatlymphopenia  ISOTNF (Homo sapiens)associated with HIV Infections and protein:increased expression:serumRGD 
TnfMouselymphopenia  ISOTNF (Homo sapiens)associated with HIV Infections and protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
TNF  (tumor necrosis factor)


Additional Information