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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases expressionEXP 6480464CTDCannabidiol results in decreased expression of TNF mRNAPMID:30793820
Tnfmultiple interactionsEXP 6480464CTDCannabidiol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]PMID:21492165
Tnfdecreases secretionISOTNF (Homo sapiens)6480464CTDCannabidiol results in decreased secretion of TNF proteinPMID:34269108
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDCannabidiol results in increased expression of TNF proteinPMID:31801206
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD[lipopolysaccharide, E coli O55-B5 co-treated with Cannabidiol] results in decreased expression of TNF mRNA; [Plant Extracts results in increased abundance of Cannabidiol] which affects the expression of TNF mRNA; Cannabidiol analog inhibits the reaction [Peptidoglycan results in increased expression of TNF protein]; Cannabidiol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein]; Cannabidiol inhibits the reaction [Croton Oil results in increased expression of TNF protein]; Cannabidiol inhibits the reaction [DMD gene mutant form results in increased expression of TNF mRNA]; Cannabidiol inhibits the reaction [DMD gene mutant form results in increased expression of TNF protein]; Cannabidiol inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of TNF protein]; Cannabidiol inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Cannabidiol inhibits the reaction [Ethanol results in increased expression of TNF protein]; Cannabidiol inhibits the reaction [Haloperidol results in increased expression of TNF mRNA]; Cannabidiol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Cannabidiol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]PMID:28935932 PMID:30074247 PMID:30217539 PMID:30742662 PMID:30796934 PMID:32345916 PMID:32400224
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTD[Cannabidiol co-treated with TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA; Cannabidiol analog inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Cannabidiol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of TRPV1 mRNA]; Cannabidiol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA]; Cannabidiol inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of TNF protein]; Cannabidiol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Cannabidiol inhibits the reaction [TNF protein results in decreased expression of AIMP1 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in decreased expression of C5 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in decreased expression of CCL26 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in decreased expression of CCR6 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in decreased expression of IL13 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in decreased expression of IL1R1 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in decreased expression of IL5 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of BMP2 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CCL1 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CCL20 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CDH1 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of COL3A1 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of COL4A1 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CSF1 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CSF2 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CSF3 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CX3CL1 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CXCL11 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CXCL2 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CXCL3 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CXCL5 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of CXCL9 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of EGF mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of EGFR mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of FGF7 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of IL17C mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of IL7 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of ITGA1 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of ITGA5 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of ITGAV mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of LTB mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of MMP7 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of PLAT mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of PLAUR mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of RAC1 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of RHOA mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of STAT3 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of TNF mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of TNFRSF11B mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased expression of WISP1 mRNA]; Cannabidiol inhibits the reaction [TNF protein results in increased secretion of MMP9 protein]; Cannabidiol promotes the reaction [Imiquimod results in increased secretion of TNF protein]; Cannabidiol promotes the reaction [Pam(3)CSK(4) peptide results in increased secretion of TNF protein]PMID:30796934 PMID:31054246 PMID:31250491 PMID:32345916 PMID:34740670
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