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GENE - TERM ANNOTATION REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: DOID:3083
Term: chronic obstructive pulmonary disease
Definition: An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both. (DO)
Definition Source(s): https://pubmed.ncbi.nlm.nih.gov/28513453/ "DO" "DO", https://pubmed.ncbi.nlm.nih.gov/32745458/ "DO" "DO", https://pubmed.ncbi.nlm.nih.gov/32800196/ "DO" "DO", https://www.nhlbi.nih.gov/health-topics/copd "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnf ISOTNF (Homo sapiens)4143270RGDprotein:increased expression:sputum 
Tnf ISOTNF (Homo sapiens)4143272RGDprotein:increased expression:serum 
Tnf ISOTNF (Homo sapiens)4143273RGDDNA:SNPs:promoter 
Tnf ISOTNF (Homo sapiens)4143421RGDDNA:polymorphism: :c. 489G>A (human) 
Tnf ISOTNF (Homo sapiens)4143424RGDDNA:polymorphism:promoter 
Tnfdisease_progressionISOTNF (Homo sapiens)4143391RGDDNA;polymorphism: :rs361525 (human) 
Tnfno_associationISOTNF (Homo sapiens)4145714RGDDNA:SNP:promoter:c.-308 G>A (human) 
Tnf ISOTNF (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:15337792 PMID:29497291 PMID:34652871
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