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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:32269
Term: tropisetron
Definition: An indolyl carboxylate ester obtained by formal condensation of the carboxy group of indole-3-carboxylic acid with the hydroxy group of tropine.
Chemical ID: MESH:C045504
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases expressionEXP 6480464CTDtropisetron results in decreased expression of TNF proteinPMID:23285267
Tnfmultiple interactionsEXP 6480464CTDchromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of TNF protein]; tropisetron inhibits the reaction [Vincristine results in increased expression of TNF protein]PMID:23285267 PMID:24374478
Tnfmultiple interactionsISORGD:13441926480464CTDtropisetron inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]PMID:24374478
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