RGD Reference Report - Control of synaptic strength by glial TNFalpha. - Rat Genome Database

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Control of synaptic strength by glial TNFalpha.

Authors: Beattie, EC  Stellwagen, D  Morishita, W  Bresnahan, JC  Ha, BK  Von Zastrow, M  Beattie, MS  Malenka, RC 
Citation: Beattie EC, etal., Science. 2002 Mar 22;295(5563):2282-5.
RGD ID: 1580308
Pubmed: (View Article at PubMed) PMID:11910117
DOI: Full-text: DOI:10.1126/science.1067859

Activity-dependent modulation of synaptic efficacy in the brain contributes to neural circuit development and experience-dependent plasticity. Although glia are affected by activity and ensheathe synapses, their influence on synaptic strength has largely been ignored. Here, we show that a protein produced by glia, tumor necrosis factor alpha (TNFalpha), enhances synaptic efficacy by increasing surface expression of AMPA receptors. Preventing the actions of endogenous TNFalpha has the opposite effects. Thus, the continual presence of TNFalpha is required for preservation of synaptic strength at excitatory synapses. Through its effects on AMPA receptor trafficking, TNFalpha may play roles in synaptic plasticity and modulating responses to neural injury.


Gene Ontology Annotations    

Biological Process

Cellular Component

Objects Annotated

Genes (Rattus norvegicus)
Gria1  (glutamate ionotropic receptor AMPA type subunit 1)
Tnf  (tumor necrosis factor)

Additional Information