Gria1 (glutamate ionotropic receptor AMPA type subunit 1) - Rat Genome Database

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Gene: Gria1 (glutamate ionotropic receptor AMPA type subunit 1) Rattus norvegicus
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Symbol: Gria1
Name: glutamate ionotropic receptor AMPA type subunit 1
RGD ID: 621531
Description: Enables several functions, including enzyme binding activity; signaling receptor binding activity; and transmitter-gated monoatomic ion channel activity. Involved in several processes, including cellular response to organonitrogen compound; central nervous system development; and modulation of chemical synaptic transmission. Located in several cellular components, including dendrite; endosome membrane; and neuronal cell body membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic active zone membrane. Used to study hyperhomocysteinemia. Biomarker of epilepsy; hepatic encephalopathy; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and autosomal recessive intellectual developmental disorder 76. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; amyotrophic lateral sclerosis pathway; INTERACTS WITH (+)-pilocarpine; (S)-AMPA; 1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AMPA-selective glutamate receptor 1; GluA1; gluR-1; gluR-A; gluR-K1; GluR1; glutamate receptor 1; glutamate receptor A; glutamate receptor subunit GluR1; glutamate receptor, ionotropic, AMPA 1; glutamate receptor, ionotropic, AMPA1 (alpha 1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21041,210,713 - 41,527,283 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1041,210,713 - 41,527,283 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1045,861,160 - 46,177,214 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01045,351,373 - 45,667,433 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01040,855,030 - 41,171,065 (+)NCBIRnor_WKY
Rnor_6.01042,441,723 - 42,760,200 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1042,614,713 - 42,760,200 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01042,257,736 - 42,571,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41042,613,359 - 42,616,610 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1040,506,762 - 40,822,664 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-AMPA  (EXP)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-bromopropane  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
2-tert-butylhydroquinone  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP)
6-Cyano-7-nitroquinoxaline-2,3-dione  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenic acid  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
azoxystrobin  (EXP)
Bay-K-8644  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzoates  (EXP)
beta-naphthoflavone  (EXP)
bicuculline  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
capsaicin  (EXP)
carbon nanotube  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chaetocin  (EXP)
chlorpyrifos  (EXP)
citalopram  (ISO)
Citreoviridin  (ISO)
cocaine  (EXP,ISO)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cypermethrin  (ISO)
decabromodiphenyl ether  (EXP)
Diacetoxyscirpenol  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dichloroacetic acid  (ISO)
dieldrin  (EXP)
dizocilpine maleate  (EXP)
domoic acid  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
excitatory amino acid agonist  (EXP)
flavonoids  (EXP)
fluoxetine  (EXP,ISO)
genistein  (EXP,ISO)
glycine  (EXP)
glyphosate  (EXP)
haloperidol  (EXP)
imidacloprid  (EXP)
istradefylline  (EXP)
kainic acid  (EXP,ISO)
ketamine  (ISO)
KN-93  (EXP)
L-ascorbic acid  (ISO)
lactacystin  (EXP)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
maleic acid  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
minocycline  (EXP)
morphine  (EXP,ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (EXP)
nifedipine  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
Ondansetron  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
panobinostat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (EXP)
pirinixic acid  (ISO)
poly(cytidylic acid)  (EXP)
progesterone  (ISO)
quinpirole  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sterigmatocystin  (EXP)
sulfur dioxide  (EXP)
tadalafil  (ISO)
tetrachloromethane  (EXP)
tetrodotoxin  (EXP)
thiabendazole  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
triazolam  (ISO)
tributylstannane  (EXP)
trichostatin A  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vorinostat  (ISO)
WIN 55212-2  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amine stimulus  (IEP)
cellular response to amino acid stimulus  (IEP)
cellular response to ammonium ion  (IEA,ISO)
cellular response to brain-derived neurotrophic factor stimulus  (IDA)
cellular response to dsRNA  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to organic cyclic compound  (IEP)
cellular response to peptide hormone stimulus  (IEP)
cerebral cortex development  (IEP)
chemical synaptic transmission  (IEA,ISO)
chemical synaptic transmission, postsynaptic  (ISO)
ionotropic glutamate receptor signaling pathway  (IEA)
long-term memory  (IEA,IMP,ISO)
long-term synaptic depression  (IEA,ISO)
modulation of chemical synaptic transmission  (IDA)
monoatomic ion transmembrane transport  (IEA,ISO)
neuronal action potential  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of membrane potential  (IMP)
positive regulation of synaptic transmission  (IMP)
receptor internalization  (IDA,IEA,ISO)
regulation of postsynaptic cytosolic calcium ion concentration  (IEA)
regulation of postsynaptic membrane potential  (IEA,ISO)
regulation of presynaptic membrane potential  (IEA)
regulation of receptor recycling  (IMP)
regulation of synaptic plasticity  (IMP,NAS)
response to arsenic-containing substance  (IEP)
response to cocaine  (IEP)
response to electrical stimulus  (IEP)
response to estradiol  (IEP)
response to fungicide  (IEP)
response to lithium ion  (IEP)
response to organic cyclic compound  (IEP)
response to peptide hormone  (IEP)
response to toxic substance  (IMP)
response to xenobiotic stimulus  (IEP)
spinal cord development  (IEP)
synapse assembly  (ISO)
synaptic transmission, glutamatergic  (NAS)

References

References - curated
# Reference Title Reference Citation
1. Co-localization of AMPA receptor subunits in the nucleus of the solitary tract in the rat. Aicher SA, etal., Brain Res 2002 Dec 27;958(2):454-8.
2. Control of synaptic strength by glial TNFalpha. Beattie EC, etal., Science. 2002 Mar 22;295(5563):2282-5.
3. Modification of ionotropic glutamate receptor-mediated processes in the rat hippocampus following repeated, brief seizures. Borbely S, etal., Neuroscience. 2009 Mar 3;159(1):358-68. Epub 2008 Dec 27.
4. A four PDZ domain-containing splice variant form of GRIP1 is localized in GABAergic and glutamatergic synapses in the brain. Charych EI, etal., J Biol Chem. 2004 Sep 10;279(37):38978-90. doi: 10.1074/jbc.M405786200. Epub 2004 Jun 29.
5. Control of excitatory and inhibitory synapse formation by neuroligins. Chih B, etal., Science. 2005 Feb 25;307(5713):1324-8. Epub 2005 Jan 27.
6. Involvement of microglial P2X7 receptors and downstream signaling pathways in long-term potentiation of spinal nociceptive responses. Chu YX, etal., Brain Behav Immun. 2010 Oct;24(7):1176-89. Epub 2010 Jun 8.
7. Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. Colledge M, etal., Neuron. 2000 Jul;27(1):107-19.
8. Fast, quantitative in situ hybridization of rare mRNAs using 14C-standards and phosphorus imaging. Cremer CM, etal., J Neurosci Methods. 2009 Dec 15;185(1):56-61. Epub 2009 Sep 15.
9. PICK1-mediated glutamate receptor subunit 2 (GluR2) trafficking contributes to cell death in oxygen/glucose-deprived hippocampal neurons. Dixon RM, etal., J Biol Chem. 2009 May 22;284(21):14230-5. doi: 10.1074/jbc.M901203200. Epub 2009 Mar 25.
10. Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression. Du J, etal., J Neurosci. 2004 Jul 21;24(29):6578-89.
11. A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. Du J, etal., Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11573-8. doi: 10.1073/pnas.0913138107. Epub 2010 Jun 7.
12. Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors. Essmann CL, etal., Nat Neurosci. 2008 Sep;11(9):1035-43. doi: 10.1038/nn.2171.
13. PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity. Esteban JA, etal., Nat Neurosci. 2003 Feb;6(2):136-43.
14. Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Evers DM, etal., Nat Neurosci. 2010 Oct;13(10):1199-207. doi: 10.1038/nn.2624. Epub 2010 Aug 29.
15. Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic density. Feligioni M, etal., J Neurochem. 2006 Oct;99(2):549-60. Epub 2006 Aug 11.
16. Glutamatergic reinnervation and assembly of glutamatergic synapses in adult rat skeletal muscle occurs at cholinergic endplates. Francolini M, etal., J Neuropathol Exp Neurol. 2009 Oct;68(10):1103-15.
17. Electrical stimulation of the lateral habenula produces enduring inhibitory effect on cocaine seeking behavior. Friedman A, etal., Neuropharmacology. 2010 Jun 22.
18. Early exposure of cultured hippocampal neurons to excitatory amino acids protects from later excitotoxicity. Friedman LK and Segal M, Int J Dev Neurosci. 2010 Apr;28(2):195-205. Epub 2009 Nov 11.
19. Presynaptic localization of an AMPA-type glutamate receptor in corticostriatal and thalamostriatal axon terminals. Fujiyama F, etal., Eur J Neurosci. 2004 Dec;20(12):3322-30. doi: 10.1111/j.1460-9568.2004.03807.x.
20. Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats. Galic MA, etal., Neurobiol Dis. 2009 Nov;36(2):343-51. Epub 2009 Aug 4.
21. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
22. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
23. Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability. Hamdan FF, etal., Am J Hum Genet. 2011 Mar 11;88(3):306-16. doi: 10.1016/j.ajhg.2011.02.001. Epub 2011 Mar 3.
24. Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction. Hayashi Y, etal., Science. 2000 Mar 24;287(5461):2262-7. doi: 10.1126/science.287.5461.2262.
25. Glutamate receptor GluR-K1: structure, function, and expression in the brain. Hollmann M, etal., Cold Spring Harb Symp Quant Biol 1990;55:41-55.
26. Cloning by functional expression of a member of the glutamate receptor family. Hollmann M, etal., Nature 1989 Dec 7;342(6250):643-8.
27. The potential role of phrenic nucleus glutamate receptor subunits in mediating spontaneous crossed phrenic activity in neonatal rat. Huang Y and Goshgarian HG, Int J Dev Neurosci. 2009 Aug;27(5):477-83. Epub 2009 May 13.
28. Sorting Nexin 27 regulates basal and activity-dependent trafficking of AMPARs. Hussain NK, etal., Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11840-5. doi: 10.1073/pnas.1412415111. Epub 2014 Jul 28.
29. Direct association of the unique C-terminal tail of transmembrane AMPA receptor regulatory protein gamma-8 with calcineurin. Itakura M, etal., FEBS J. 2014 Mar;281(5):1366-78. doi: 10.1111/febs.12708. Epub 2014 Jan 27.
30. Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity. Jang S, etal., Nat Neurosci. 2016 Jan;19(1):84-93. doi: 10.1038/nn.4176. Epub 2015 Nov 23.
31. CaMKII-dependent dendrite ramification and spine generation promote spatial training-induced memory improvement in a rat model of sporadic Alzheimer's disease. Jiang X, etal., Neurobiol Aging. 2015 Feb;36(2):867-76. doi: 10.1016/j.neurobiolaging.2014.10.018. Epub 2014 Oct 16.
32. Crystal structure and association behaviour of the GluR2 amino-terminal domain. Jin R, etal., EMBO J. 2009 Jun 17;28(12):1812-23. doi: 10.1038/emboj.2009.140. Epub 2009 May 21.
33. Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling. Joiner ML, etal., EMBO J. 2010 Jan 20;29(2):482-95. Epub 2009 Nov 26.
34. Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions: implications for sustained AMPA receptor expression. Jourdi H and Kabbaj M, PLoS One. 2013;8(2):e57124. doi: 10.1371/journal.pone.0057124. Epub 2013 Feb 27.
35. Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons. Jourdi H, etal., Dev Biol. 2003 Nov 15;263(2):216-30. doi: 10.1016/j.ydbio.2003.07.008.
36. AMPA receptor and GEF-H1/Lfc complex regulates dendritic spine development through RhoA signaling cascade. Kang MG, etal., Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3549-54. doi: 10.1073/pnas.0812861106. Epub 2009 Feb 10.
37. Regulation of AMPA receptor trafficking by O-glycosylation. Kanno T, etal., Neurochem Res. 2010 May;35(5):782-8. Epub 2010 Feb 18.
38. AMPA receptor subunit-specific regulation by a distinct family of type II TARPs. Kato AS, etal., Neuron. 2008 Sep 25;59(6):986-96. doi: 10.1016/j.neuron.2008.07.034.
39. Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression. Kawashima H, etal., Neuroscience. 2010 Feb 17;165(4):1301-11. Epub 2009 Dec 1.
40. A family of AMPA-selective glutamate receptors. Keinanen K, etal., Science 1990 Aug 3;249(4968):556-60.
41. Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. Ko J, etal., EMBO J. 2009 Oct 21;28(20):3244-55. doi: 10.1038/emboj.2009.249. Epub 2009 Sep 3.
42. Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting. Ko J, etal., J Neurosci. 2003 Mar 1;23(5):1667-77.
43. Electrophysiological properties of AMPA receptors are differentially modulated depending on the associated member of the TARP family. Kott S, etal., J Neurosci. 2007 Apr 4;27(14):3780-9.
44. SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit. Leonard AS, etal., J Biol Chem. 1998 Jul 31;273(31):19518-24.
45. The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene. Levenson JM, etal., Biochim Biophys Acta. 2008 Aug;1779(8):422-31. Epub 2008 Jan 12.
46. Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex. Levy RB and Aoki C, J Neurosci. 2002 Jun 15;22(12):5001-15.
47. Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization. Lin JW, etal., Nat Neurosci. 2000 Dec;3(12):1282-90.
48. Involvement of myosin Vb in glutamate receptor trafficking. Lise MF, etal., J Biol Chem. 2006 Feb 10;281(6):3669-78. Epub 2005 Dec 7.
49. Mechanisms of CaMKII action in long-term potentiation. Lisman J, etal., Nat Rev Neurosci. 2012 Feb 15;13(3):169-82. doi: 10.1038/nrn3192.
50. Synaptic targeting of AMPA receptors is regulated by a CaMKII site in the first intracellular loop of GluA1. Lu W, etal., Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22266-71. doi: 10.1073/pnas.1016289107. Epub 2010 Dec 6.
51. The structure and function of glutamate receptor ion channels. Madden DR Nat Rev Neurosci. 2002 Feb;3(2):91-101.
52. Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs. Martinez-Turrillas R, etal., Biochem Biophys Res Commun. 2007 Feb 16;353(3):750-5. Epub 2006 Dec 19.
53. Selective disruption of stimulus-reward learning in glutamate receptor gria1 knock-out mice. Mead AN and Stephens DN, J Neurosci 2003 Feb 1;23(3):1041-8.
54. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
55. Regulation of synaptic structure and function by palmitoylated AMPA receptor binding protein. Misra C, etal., Mol Cell Neurosci. 2010 Apr;43(4):341-52. Epub 2010 Jan 18.
56. Transport of AMPA receptors during long-term potentiation is impaired in rats with hepatic encephalopathy. Monfort P, etal., Neurochem Int. 2009 Dec;55(7):514-20. Epub 2009 May 18.
57. AMPA receptor down-regulation induced by ischaemia/reperfusion is attenuated by age and blocked by meloxicam. Montori S, etal., Neuropathol Appl Neurobiol. 2010 Apr 8.
58. Leptin regulates AMPA receptor trafficking via PTEN inhibition. Moult PR, etal., J Neurosci. 2010 Mar 17;30(11):4088-101.
59. The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors. Nadif Kasri N, etal., Genes Dev. 2009 Jun 1;23(11):1289-302.
60. Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate. Nakatsu Y, etal., Toxicol Appl Pharmacol. 2009 Oct 15;240(2):292-8. Epub 2009 Jul 7.
61. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
62. Physical exercise improves learning by modulating hippocampal mossy fiber sprouting and related gene expression in a developmental rat model of penicillin-induced recurrent epilepticus. Ni H, etal., Toxicol Lett. 2009 Dec 1;191(1):26-32. Epub 2009 Aug 8.
63. Cortical neurons from intrauterine growth retardation rats exhibit lower response to neurotrophin BDNF. Ninomiya M, etal., Neurosci Lett. 2010 May 31;476(2):104-9. Epub 2010 Apr 14.
64. The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway. Nishizaki T and Matsumura T, Brain Res Mol Brain Res 2002 Jan 31;98(1-2):130-4.
65. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
66. Mutagenesis reveals a role for ABP/GRIP binding to GluR2 in synaptic surface accumulation of the AMPA receptor. Osten P, etal., Neuron. 2000 Aug;27(2):313-25. doi: 10.1016/s0896-6273(00)00039-8.
67. Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory. Pearson-Leary J and McNay EC, J Neurosci. 2016 Nov 23;36(47):11851-11864. doi: 10.1523/JNEUROSCI.1700-16.2016.
68. LTP inhibits LTD in the hippocampus via regulation of GSK3beta. Peineau S, etal., Neuron. 2007 Mar 1;53(5):703-17.
69. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
70. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
71. Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances. Ren Y, etal., J Neurosci. 2009 Nov 25;29(47):14764-9.
72. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
73. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
74. Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers. Rossmann M, etal., EMBO J. 2011 Mar 2;30(5):959-71. doi: 10.1038/emboj.2011.16. Epub 2011 Feb 11.
75. Regulated delivery of AMPA receptor subunits to the presynaptic membrane. Schenk U, etal., EMBO J 2003 Feb 3;22(3):558-68.
76. Actin/alpha-actinin-dependent transport of AMPA receptors in dendritic spines: role of the PDZ-LIM protein RIL. Schulz TW, etal., J Neurosci. 2004 Sep 29;24(39):8584-94.
77. Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Schwenk J, etal., Science. 2009 Mar 6;323(5919):1313-9. doi: 10.1126/science.1167852.
78. Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone. Sears RM, etal., J Neurosci. 2010 Jun 16;30(24):8263-73.
79. S-nitrosylation of stargazin regulates surface expression of AMPA-glutamate neurotransmitter receptors. Selvakumar B, etal., Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16440-5. doi: 10.1073/pnas.0908949106. Epub 2009 Sep 10.
80. Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons. Shi S, etal., Cell. 2001 May 4;105(3):331-43.
81. Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. Shi Y, etal., Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16315-9. doi: 10.1073/pnas.1011706107. Epub 2010 Aug 30.
82. BDNF activates mTOR to regulate GluR1 expression required for memory formation. Slipczuk L, etal., PLoS One. 2009 Jun 23;4(6):e6007.
83. Myo-inositol treatment prevents biochemical changes triggered by kainate-induced status epilepticus. Solomonia R, etal., Neurosci Lett. 2010 Jan 14;468(3):277-81. Epub 2009 Nov 13.
84. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Sommer B, etal., Science 1990 Sep 28;249(4976):1580-5.
85. Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5. Soto D, etal., Nat Neurosci. 2009 Mar;12(3):277-85. doi: 10.1038/nn.2266. Epub 2009 Feb 22.
86. Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a. Spinelli M, etal., Nat Commun. 2017 Dec 8;8(1):2009. doi: 10.1038/s41467-017-02221-9.
87. Interactions between NEEP21, GRIP1 and GluR2 regulate sorting and recycling of the glutamate receptor subunit GluR2. Steiner P, etal., EMBO J. 2005 Aug 17;24(16):2873-84. Epub 2005 Jul 21.
88. Nucleus accumbens neurons exhibit synaptic scaling that is occluded by repeated dopamine pre-exposure. Sun X and Wolf ME, Eur J Neurosci. 2009 Aug;30(4):539-50. Epub 2009 Aug 7.
89. Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. Sutton MA, etal., Nature 2003 Jan 2;421(6918):70-5.
90. SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression. Tuerxun T, etal., Neurosci Lett. 2010 Jan 29;469(3):303-8. Epub 2009 Dec 16.
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96. Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting. Wyszynski M, etal., Neuron 2002 Mar 28;34(1):39-52.
97. Developmentally regulated expression of CaMKII and iGluRs in the rat retina. Xue J, etal., Brain Res Dev Brain Res 2002 Sep 20;138(1):61-70.
98. Crystal structure of the glutamate receptor GluA1 N-terminal domain. Yao G, etal., Biochem J. 2011 Sep 1;438(2):255-63. doi: 10.1042/BJ20110801.
99. Identification of PSD-95 Depalmitoylating Enzymes. Yokoi N, etal., J Neurosci. 2016 Jun 15;36(24):6431-44. doi: 10.1523/JNEUROSCI.0419-16.2016.
100. Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption. Zhao WQ, etal., J Biol Chem. 2010 Mar 5;285(10):7619-32. doi: 10.1074/jbc.M109.057182. Epub 2009 Dec 23.
101. Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM. Zhao Y, etal., Science. 2019 Apr 26;364(6438):355-362. doi: 10.1126/science.aaw8250. Epub 2019 Apr 11.
Additional References at PubMed
PMID:1309749   PMID:2168579   PMID:7877986   PMID:8848293   PMID:9405465   PMID:10688364   PMID:11340067   PMID:11431570   PMID:11891216   PMID:12050163   PMID:12161022   PMID:12368290  
PMID:12379442   PMID:12507773   PMID:12624270   PMID:12628184   PMID:12676337   PMID:12676339   PMID:12687711   PMID:12849753   PMID:12855351   PMID:12909632   PMID:14555717   PMID:14596864  
PMID:14684464   PMID:14706873   PMID:15001777   PMID:15207857   PMID:15260958   PMID:15601948   PMID:15664178   PMID:15673434   PMID:15746389   PMID:15781472   PMID:15854589   PMID:15858065  
PMID:15883194   PMID:15924137   PMID:16000628   PMID:16091361   PMID:16272153   PMID:16443372   PMID:16485113   PMID:16495937   PMID:16606358   PMID:16794574   PMID:16814779   PMID:16980545  
PMID:17093100   PMID:17187855   PMID:17229826   PMID:17335044   PMID:17360685   PMID:17446041   PMID:17460080   PMID:17472959   PMID:17510319   PMID:17719086   PMID:17854777   PMID:17873364  
PMID:17901379   PMID:17923095   PMID:17976577   PMID:18000827   PMID:18031714   PMID:18065236   PMID:18077682   PMID:18174334   PMID:18289517   PMID:18304748   PMID:18341993   PMID:18368037  
PMID:18403705   PMID:18815255   PMID:18819923   PMID:18829953   PMID:18924138   PMID:18957222   PMID:19013221   PMID:19020286   PMID:19073915   PMID:19077125   PMID:19110036   PMID:19120442  
PMID:19238810   PMID:19258522   PMID:19439609   PMID:19503082   PMID:19563786   PMID:19629758   PMID:19657020   PMID:19773551   PMID:19858198   PMID:19886034   PMID:20051515   PMID:20131911  
PMID:20202754   PMID:20417256   PMID:20418887   PMID:20423831   PMID:20434989   PMID:20463192   PMID:20584904   PMID:20826795   PMID:20869354   PMID:20953906   PMID:20963825   PMID:21080412  
PMID:21143596   PMID:21144999   PMID:21147092   PMID:21170339   PMID:21172611   PMID:21185848   PMID:21220022   PMID:21425350   PMID:21439793   PMID:21461922   PMID:21498562   PMID:21539895  
PMID:21558424   PMID:21564097   PMID:21613507   PMID:21700703   PMID:21795692   PMID:21846932   PMID:21876464   PMID:21878564   PMID:21937801   PMID:22108330   PMID:22223644   PMID:22302822  
PMID:22373567   PMID:22405206   PMID:22470488   PMID:22567428   PMID:22632720   PMID:22980744   PMID:23141062   PMID:23160045   PMID:23277581   PMID:23296627   PMID:23303939   PMID:23326329  
PMID:23375774   PMID:23392471   PMID:23395379   PMID:23511975   PMID:23537341   PMID:23545413   PMID:23583340   PMID:23598433   PMID:23676497   PMID:23694703   PMID:23760273   PMID:23844251  
PMID:23884930   PMID:23974710   PMID:24002084   PMID:24023391   PMID:24133208   PMID:24244357   PMID:24259587   PMID:24442866   PMID:24625397   PMID:24966334   PMID:24983627   PMID:25017011  
PMID:25023288   PMID:25126703   PMID:25225098   PMID:25429150   PMID:25472821   PMID:25524891   PMID:25533481   PMID:25609091   PMID:25627107   PMID:25697598   PMID:25746394   PMID:25753037  
PMID:25792422   PMID:25796132   PMID:25918374   PMID:25964356   PMID:26049209   PMID:26055072   PMID:26134564   PMID:26220330   PMID:26260133   PMID:26674878   PMID:26725511   PMID:26773257  
PMID:26839312   PMID:27060412   PMID:27118769   PMID:27601647   PMID:27965425   PMID:28132827   PMID:28263869   PMID:28377502   PMID:28474392   PMID:28630296   PMID:28875935   PMID:28916629  
PMID:29098531   PMID:29107806   PMID:29383693   PMID:29476059   PMID:29490264   PMID:29592780   PMID:30328550   PMID:30575928   PMID:30747310   PMID:30872532   PMID:31146278   PMID:31283924  
PMID:31705923   PMID:31721013   PMID:31794026   PMID:32162577   PMID:32594591   PMID:33022406   PMID:33049318   PMID:33075473   PMID:33244735   PMID:33393454   PMID:35136046   PMID:35227653  
PMID:35820448  


Genomics

Comparative Map Data
Gria1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21041,210,713 - 41,527,283 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1041,210,713 - 41,527,283 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1045,861,160 - 46,177,214 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01045,351,373 - 45,667,433 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01040,855,030 - 41,171,065 (+)NCBIRnor_WKY
Rnor_6.01042,441,723 - 42,760,200 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1042,614,713 - 42,760,200 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01042,257,736 - 42,571,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41042,613,359 - 42,616,610 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1040,506,762 - 40,822,664 (+)NCBICelera
Cytogenetic Map10q22NCBI
GRIA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385153,489,615 - 153,813,869 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5153,489,615 - 153,813,869 (+)EnsemblGRCh38hg38GRCh38
GRCh375152,870,230 - 153,193,429 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365152,850,499 - 153,171,354 (+)NCBINCBI36Build 36hg18NCBI36
Build 345152,850,498 - 153,171,354NCBI
Celera5148,945,616 - 149,268,929 (+)NCBICelera
Cytogenetic Map5q33.2NCBI
HuRef5148,010,721 - 148,334,111 (+)NCBIHuRef
CHM1_15152,302,506 - 152,626,274 (+)NCBICHM1_1
T2T-CHM13v2.05154,023,831 - 154,347,051 (+)NCBIT2T-CHM13v2.0
Gria1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391156,902,342 - 57,221,070 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1156,902,213 - 57,221,070 (+)EnsemblGRCm39 Ensembl
GRCm381157,011,571 - 57,330,244 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1157,011,387 - 57,330,244 (+)EnsemblGRCm38mm10GRCm38
MGSCv371156,825,193 - 57,143,746 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361156,855,379 - 57,146,439 (+)NCBIMGSCv36mm8
Celera1161,935,002 - 62,079,468 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1134.51NCBI
Gria1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554087,912,592 - 8,223,570 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554087,912,223 - 8,226,241 (+)NCBIChiLan1.0ChiLan1.0
GRIA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15154,877,807 - 155,204,660 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5154,879,080 - 155,204,660 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05148,879,996 - 149,206,914 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GRIA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1455,801,269 - 56,103,383 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl455,803,296 - 56,103,669 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha455,639,927 - 55,995,772 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0456,183,572 - 56,538,983 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl456,237,177 - 56,538,754 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1456,012,350 - 56,367,654 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0456,111,546 - 56,466,793 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0456,613,928 - 56,969,631 (-)NCBIUU_Cfam_GSD_1.0
Gria1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213110,488,036 - 110,787,054 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365158,940,009 - 9,083,151 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365158,937,391 - 9,236,438 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1669,332,587 - 69,655,380 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11669,332,786 - 69,654,366 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21675,191,970 - 75,275,696 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRIA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12355,944,128 - 56,265,748 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2356,101,294 - 56,265,849 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603421,402,866 - 21,730,046 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gria1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473335,339,683 - 35,647,349 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473335,337,039 - 35,648,184 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gria1
2306 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:52
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000071615, ENSRNOT00000073148
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat

Markers in Region
D10Rat126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,482,022 - 41,482,228 (+)MAPPERmRatBN7.2
Rnor_6.01042,716,036 - 42,716,241NCBIRnor6.0
Rnor_5.01042,526,318 - 42,526,523UniSTSRnor5.0
Celera1040,777,431 - 40,777,636UniSTS
RH 3.4 Map10452.9UniSTS
RH 3.4 Map10452.9RGD
RH 2.0 Map10470.1RGD
SHRSP x BN Map1038.6199RGD
FHH x ACI Map1035.9499RGD
D10Rat165  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,361,875 - 41,362,094 (+)MAPPERmRatBN7.2
Rnor_6.01042,595,412 - 42,595,630NCBIRnor6.0
Rnor_6.01042,592,183 - 42,592,397NCBIRnor6.0
Rnor_5.01042,408,413 - 42,408,631UniSTSRnor5.0
Celera1040,657,748 - 40,657,974UniSTS
SHRSP x BN Map1038.5499RGD
SHRSP x BN Map1038.5499UniSTS
D10Got68  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,415,826 - 41,416,063 (+)MAPPERmRatBN7.2
Rnor_6.01042,649,802 - 42,650,038NCBIRnor6.0
Rnor_5.01042,460,499 - 42,460,735UniSTSRnor5.0
Celera1040,712,729 - 40,712,953UniSTS
RH 3.4 Map10452.9RGD
RH 3.4 Map10452.9UniSTS
X57497  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,527,211 - 41,527,327 (+)MAPPERmRatBN7.2
Rnor_6.01042,760,129 - 42,760,244NCBIRnor6.0
Rnor_5.01042,571,149 - 42,571,264UniSTSRnor5.0
Celera1040,822,593 - 40,822,708UniSTS
RH138240  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,231,885 - 41,232,036 (+)MAPPERmRatBN7.2
Rnor_6.01042,463,288 - 42,463,438NCBIRnor6.0
Rnor_5.01042,279,301 - 42,279,451UniSTSRnor5.0
RGSC_v3.41042,634,532 - 42,634,682UniSTSRGSC3.4
Celera1040,527,881 - 40,528,031UniSTS
RH 3.4 Map10440.59UniSTS
AU048687  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,239,851 - 41,240,077 (+)MAPPERmRatBN7.2
Rnor_6.01042,471,248 - 42,471,471NCBIRnor6.0
Rnor_5.01042,287,261 - 42,287,484UniSTSRnor5.0
RGSC_v3.41042,642,492 - 42,642,715UniSTSRGSC3.4
Celera1040,535,851 - 40,536,104UniSTS
AU049642  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1040,736,495 - 40,736,651UniSTS
RH143108  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,491,538 - 41,491,644 (+)MAPPERmRatBN7.2
Rnor_6.01042,725,552 - 42,725,657NCBIRnor6.0
Rnor_5.01042,535,834 - 42,535,939UniSTSRnor5.0
Celera1040,786,947 - 40,787,052UniSTS
RH 3.4 Map10452.8UniSTS
RH144075  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,527,332 - 41,527,523 (+)MAPPERmRatBN7.2
Rnor_6.01042,760,250 - 42,760,440NCBIRnor6.0
Rnor_5.01042,571,270 - 42,571,460UniSTSRnor5.0
Celera1040,822,714 - 40,822,904UniSTS
RH 3.4 Map10452.7UniSTS
BF416798  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,241,330 - 41,241,420 (+)MAPPERmRatBN7.2
Rnor_6.01042,472,725 - 42,472,814NCBIRnor6.0
Rnor_5.01042,288,738 - 42,288,827UniSTSRnor5.0
RGSC_v3.41042,643,969 - 42,644,058UniSTSRGSC3.4
Celera1040,537,358 - 40,537,447UniSTS
RH 3.4 Map10441.0UniSTS
BF390153  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,218,612 - 41,218,784 (+)MAPPERmRatBN7.2
Rnor_6.01042,449,623 - 42,449,794NCBIRnor6.0
Rnor_5.01042,265,636 - 42,265,807UniSTSRnor5.0
RGSC_v3.41042,621,259 - 42,621,430UniSTSRGSC3.4
Celera1040,514,678 - 40,514,849UniSTS
AU049595  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,261,128 - 41,261,344 (+)MAPPERmRatBN7.2
Rnor_6.01042,492,689 - 42,492,906NCBIRnor6.0
Rnor_5.01042,308,480 - 42,308,697UniSTSRnor5.0
RGSC_v3.41042,663,835 - 42,664,052UniSTSRGSC3.4
Celera1040,556,980 - 40,557,203UniSTS
AU049867  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,523,343 - 41,523,566 (+)MAPPERmRatBN7.2
Rnor_6.01042,756,267 - 42,756,489NCBIRnor6.0
Rnor_5.01042,567,294 - 42,567,516UniSTSRnor5.0
Celera1040,818,668 - 40,818,890UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 64 2 4
Low 1 31 14 1 15 1 4 4 6 21 15 11 4
Below cutoff 2 12 15 12 3 12 4 7 4 8 22 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000071615   ⟹   ENSRNOP00000064722
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1041,210,713 - 41,527,283 (+)Ensembl
Rnor_6.0 Ensembl1042,618,487 - 42,760,200 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000073148   ⟹   ENSRNOP00000066072
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1041,380,221 - 41,527,283 (+)Ensembl
Rnor_6.0 Ensembl1042,614,713 - 42,760,129 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081136   ⟹   ENSRNOP00000074119
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1041,210,713 - 41,527,283 (+)Ensembl
Rnor_6.0 Ensembl1042,614,713 - 42,760,129 (+)Ensembl
RefSeq Acc Id: NM_031608   ⟹   NP_113796
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21041,210,713 - 41,527,283 (+)NCBI
Rnor_6.01042,441,723 - 42,760,200 (+)NCBI
Rnor_5.01042,257,736 - 42,571,220 (+)NCBI
RGSC_v3.41042,613,359 - 42,616,610 (+)RGD
Celera1040,506,762 - 40,822,664 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_113796   ⟸   NM_031608
- Peptide Label: precursor
- UniProtKB: P19490 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066072   ⟸   ENSRNOT00000073148
RefSeq Acc Id: ENSRNOP00000074119   ⟸   ENSRNOT00000081136
RefSeq Acc Id: ENSRNOP00000064722   ⟸   ENSRNOT00000071615
Protein Domains
Lig_chan-Glu_bd   PBPe

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19490-F1-model_v2 AlphaFold P19490 1-907 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621531 AgrOrtholog
BioCyc Gene G2FUF-25030 BioCyc
Ensembl Genes ENSRNOG00000045816 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000064722 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOP00000066072.3 UniProtKB/TrEMBL
  ENSRNOP00000074119 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071615 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000073148.3 UniProtKB/TrEMBL
  ENSRNOT00000081136 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50592 UniProtKB/Swiss-Prot
NCBI Gene 50592 ENTREZGENE
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gria1 PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PBPe UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K798_RAT UniProtKB/TrEMBL
  GRIA1_RAT UniProtKB/Swiss-Prot
  M0R5P7_RAT UniProtKB/TrEMBL
  M0R9A7_RAT UniProtKB/TrEMBL
  P19490 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Gria1  glutamate ionotropic receptor AMPA type subunit 1  Gria1  glutamate receptor, ionotropic, AMPA 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-24 Gria1  glutamate receptor, ionotropic, AMPA 1  Gria1  glutamate receptor, ionotropic, AMPA1 (alpha 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Gria1  glutamate receptor, ionotropic, AMPA1 (alpha 1)      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Gria1  glutamate receptor, ionotropic, AMPA1 (alpha 1)      Symbol and Name status set to provisional 70820 PROVISIONAL