GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | increases expression | EXP | | 6480464 | CTD | Amiodarone results in increased expression of TNF mRNA; Amiodarone results in increased expression of TNF protein | PMID:26781185 PMID:34590760 | Tnf | multiple interactions | EXP | | 6480464 | CTD | [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased expression of TNF protein]; Losartan inhibits the reaction [Amiodarone results in increased expression of TNF protein]; Olmesartan Medoxomil inhibits the reaction [Amiodarone results in increased expression of TNF mRNA]; Prednisolone inhibits the reaction [Amiodarone results in increased expression of TNF protein]; TNF protein affects the susceptibility to [Amiodarone co-treated with Lipopolysaccharides]; Vitamin D inhibits the reaction [Amiodarone results in increased expression of TNF protein] | PMID:21984482 PMID:26781185 PMID:34590760 | Tnf | increases expression | ISO | Tnf (Mus musculus) | 6480464 | CTD | Amiodarone results in increased expression of TNF mRNA | PMID:34259586 | Tnf | increases expression | ISO | TNF (Homo sapiens) | 6480464 | CTD | Amiodarone results in increased expression of TNF mRNA; Amiodarone results in increased expression of TNF protein | PMID:34434487 | Tnf | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | [Amiodarone co-treated with TNF protein] results in increased activity of CASP9 protein | PMID:23042730 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | [Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA; [Amiodarone co-treated with CYP3A4 protein] results in increased secretion of TNF protein; [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Amiodarone; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of TNF mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of TNF protein]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP3 protein]]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP7 protein]]; Amiodarone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TNF protein]; Amiodarone inhibits the reaction [CRP protein results in increased expression of TNF protein]; Amiodarone inhibits the reaction [TNF protein results in increased expression of and results in increased activity of F3 protein]; Amiodarone inhibits the reaction [TNF protein results in increased expression of F3 mRNA]; Amiodarone inhibits the reaction [TNF protein results in increased expression of F3 protein]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of TNF protein]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of TNF mRNA]]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; TNF protein promotes the reaction [Amiodarone results in increased activity of CASP3 protein]; TNF protein promotes the reaction [Amiodarone results in increased activity of CASP7 protein] | PMID:18974383 PMID:19225199 PMID:19362101 PMID:22785256 PMID:23042730 PMID:23305835 PMID:25073960 PMID:34434487 | | ||||||||||||||||||||||
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