IL10 (interleukin 10) - Rat Genome Database

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Gene: IL10 (interleukin 10) Homo sapiens
Symbol: IL10
Name: interleukin 10
RGD ID: 735591
Description: Enables protein dimerization activity. Involved in several processes, including negative regulation of cellular catabolic process; regulation of gene expression; and regulation of signal transduction. Acts upstream of or within several processes, including negative regulation of B cell proliferation; positive regulation of B cell apoptotic process; and positive regulation of signaling receptor activity. Located in extracellular space. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Biomarker of several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); eye disease (multiple); female reproductive organ cancer (multiple); and hematologic cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CSIF; cytokine synthesis inhibitory factor; GVHDS; IL-10; IL10A; interleukin-10; MGC126450; MGC126451; T-cell growth inhibitory factor; TGIF
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1206,767,602 - 206,774,541 (-)EnsemblGRCh38hg38GRCh38
GRCh381206,767,602 - 206,772,494 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371206,940,947 - 206,945,839 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,007,571 - 205,012,462 (-)NCBINCBI36hg18NCBI36
Build 341203,329,342 - 203,334,234NCBI
Celera1180,192,396 - 180,197,294 (-)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1177,639,274 - 177,644,165 (-)NCBIHuRef
CHM1_11208,213,574 - 208,218,465 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Actinic Cheilitis  (IEP)
Acute Experimental Pancreatitis  (ISO)
acute kidney failure  (EXP)
Acute Liver Failure  (IAGP)
Acute Lung Injury  (IAGP,ISO)
acute lymphoblastic leukemia  (IEP)
acute myeloid leukemia  (IEP)
acute pancreatitis  (IAGP)
adult respiratory distress syndrome  (ISO)
adult T-cell leukemia  (EXP,IEP)
aggressive periodontitis  (IAGP,IEP)
Airway Obstruction  (IAGP)
allergic conjunctivitis  (IEP,ISO)
allergic contact dermatitis  (EXP,ISO)
allergic rhinitis  (IEP,ISO)
Alveolar Bone Loss  (ISO)
Alzheimer's disease  (IAGP,ISO)
anemia  (IEP)
Animal Disease Models  (EXP)
anogenital venereal wart  (IEP)
anti-basement membrane glomerulonephritis  (ISO)
aphthous stomatitis  (IAGP)
appendicitis  (EXP)
arteriosclerosis  (IAGP,ISO)
Asthenopia  (ISO)
asthma  (EXP,IAGP,IEP,ISO)
atopic dermatitis  (EXP,ISO)
autistic disorder  (EXP,IAGP)
autoimmune hemolytic anemia  (ISO)
autoimmune hepatitis  (EXP)
autoimmune thrombocytopenic purpura  (IAGP)
B-Cell Chronic Lymphocytic Leukemia  (IAGP,IEP)
bacterial infectious disease  (IEP)
bacterial pneumonia  (ISO)
Behcet's disease  (EXP,IAGP,IEP,ISO)
Brain Injuries  (EXP,IEP,ISO)
Breast Neoplasms  (EXP)
Bronchial Hyperreactivity  (IEP)
bronchus carcinoma  (IEP)
Burns  (EXP,ISO)
carotid artery disease  (IEP)
carotid stenosis  (IAGP)
celiac disease  (IEP)
central nervous system lymphoma  (IAGP)
cervical cancer  (IEP)
Chagas Cardiomyopathy  (ISO)
choroid disease  (IAGP)
Choroidal Neovascularization  (ISO)
Chronic Bronchitis  (ISO)
Chronic Hepatitis C  (IAGP,IEP)
chronic myeloid leukemia  (IAGP)
Chronic Periodontitis  (IAGP)
colitis  (EXP,ISO)
colon cancer  (IAGP)
common cold  (IDA)
congestive heart failure  (IEP,ISO)
coronary artery disease  (IAGP,IEP)
Coronavirus infectious disease  (ISO)
Crohn's disease  (EXP,IDA,ISO)
cutaneous leishmaniasis  (EXP,IEP)
cytomegalovirus retinitis  (ISO)
decubitus ulcer  (ISO)
diabetes mellitus  (IEP)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (IAGP)
diabetic retinopathy  (IAGP,IEP)
diffuse scleroderma  (IEP)
dilated cardiomyopathy  (ISO)
disseminated intravascular coagulation  (IEP)
drug allergy  (EXP)
Drug-Related Side Effects and Adverse Reactions  (EXP)
dry eye syndrome  (IEP)
Dysbiosis  (ISO)
Dyspepsia  (IAGP)
Eales Disease  (IAGP)
endometrial cancer  (IEP)
endometriosis  (EXP,ISO)
Endotoxemia  (ISO)
Entamoebiasis  (EXP)
Enterocolitis  (EXP)
Enterovirus Infections  (IAGP)
Experimental Arthritis  (EXP,IDA,ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (EXP,ISO)
Eye Burns  (ISO)
factor VIII deficiency  (IAGP)
Fanconi anemia  (IEP)
fatty liver disease  (ISO)
Femoral Fractures  (ISO)
gallbladder carcinoma  (IAGP)
gastric dilatation  (ISO)
Gastro-Enteropancreatic Neuroendocrine Tumor  (EXP)
gastrointestinal stromal tumor  (IAGP)
Genetic Predisposition to Disease  (EXP)
gestational diabetes  (IEP)
glomerulonephritis  (EXP)
glucosephosphate dehydrogenase deficiency  (IAGP)
Graft vs Host Disease  (IAGP,IDA,IEP)
granulomatosis with polyangiitis  (IAGP)
Graves Ophthalmopathy  (IAGP,IEP)
Graves' disease  (IAGP,IEP)
Hearing Loss  (ISO)
Heat Stroke  (EXP)
Hemorrhagic Shock  (ISO)
Heparin-induced Thrombocytopenia  (IAGP)
hepatitis B  (IAGP)
hepatitis C  (IAGP,IEP)
hepatocellular carcinoma  (IAGP,ISO)
herpes simplex virus keratitis  (ISO)
herpes zoster  (IEP)
high grade glioma  (IAGP)
Hodgkin's lymphoma  (IEP)
human immunodeficiency virus infectious disease  (EXP,IAGP,IEP)
Human Influenza  (ISO)
Human Viral Hepatitis  (IAGP)
Hyperalgesia  (EXP,IMP,ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
hypothyroidism  (ISO)
ileitis  (EXP)
Immediate Hypersensitivity  (EXP)
Inflammation  (EXP,IEP,ISO)
inflammatory bowel disease  (EXP,IAGP,ISO)
intermediate uveitis  (IEP)
intestinal obstruction  (ISO)
irritable bowel syndrome  (EXP)
Kidney Reperfusion Injury  (ISO)
leishmaniasis  (EXP)
lip cancer  (IEP)
liver benign neoplasm  (ISO)
liver cancer  (IEP)
liver carcinoma  (IAGP)
liver cirrhosis  (IAGP)
Liver Reperfusion Injury  (ISO)
lung disease  (IEP,ISO)
Lung Neoplasms  (EXP)
lung non-small cell carcinoma  (EXP)
major depressive disorder  (IAGP)
Malignant Pleural Effusions  (ISO)
Mammary Neoplasms, Experimental  (EXP)
Middle East respiratory syndrome  (ISO)
mitral valve stenosis  (IEP)
mucositis  (EXP)
multiple myeloma  (IAGP,IEP)
Multiple Organ Failure  (EXP)
multiple sclerosis  (EXP)
Murine Acquired Immunodeficiency Syndrome  (ISO)
myocardial infarction  (EXP,IAGP)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (IEP)
Neoplasm Metastasis  (IDA)
Neuralgia  (IMP,ISO)
non-alcoholic fatty liver disease  (IEP)
non-alcoholic steatohepatitis  (IAGP)
obesity  (IEP,ISO)
obstructive sleep apnea  (ISO)
occupational dermatitis  (EXP)
Ocular Toxoplasmosis  (ISO)
ocular tuberculosis  (IEP)
open-angle glaucoma  (IEP)
oral squamous cell carcinoma  (IAGP)
otitis media  (IAGP,IEP,ISO)
ovarian cancer  (IEP)
pancreatic cancer  (IAGP,IEP)
pancreatitis  (ISO)
panuveitis  (IAGP)
parathyroid carcinoma  (IAGP)
pericardial effusion  (IEP)
perinatal necrotizing enterocolitis  (ISO)
periodontitis  (ISO)
plasmacytoma  (ISO)
pleurisy  (EXP)
pneumonia  (IEP)
postpartum depression  (ISO)
Pregnancy-associated Malaria  (IEP)
primary biliary cholangitis  (IEP)
Primary Graft Dysfunction  (ISO)
Prostatic Neoplasms  (EXP)
prostatitis  (EXP,ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (IAGP)
pulmonary eosinophilia  (IEP)
pulmonary hypertension  (IEP)
Radiation Injuries, Experimental  (ISO)
Reperfusion Injury  (EXP,IDA,ISO)
respiratory allergy  (ISO)
respiratory syncytial virus infectious disease  (IEP)
retinal artery occlusion  (IAGP)
retinal disease  (IEP,ISO)
retinopathy of prematurity  (IEP)
Retroviridae Infections  (ISO)
rheumatic heart disease  (IAGP)
rheumatoid arthritis  (EXP,IAGP)
Rhinosinusitis  (IEP)
schizophrenia  (IAGP)
sciatic neuropathy  (ISO)
Seasonal Allergic Rhinitis  (IEP)
Sepsis  (EXP,ISO)
severe acute respiratory syndrome  (IEP,ISO)
shigellosis  (ISO)
Shwartzman phenomenon  (ISO)
sickle cell anemia  (ISO)
Sjogren's syndrome  (IAGP)
skin disease  (IAGP,IEP)
Spinal Cord Injuries  (ISO)
Splenomegaly  (ISO)
Staphylococcal Infections  (ISO)
Staphylococcal Pneumonia  (ISO)
stomach cancer  (IAGP,IEP)
Stroke  (IAGP,ISO)
systemic lupus erythematosus  (EXP,IAGP)
thrombocytopenia  (IDA,IEP)
thrombosis  (ISO)
thyrotoxicosis  (ISO)
tongue squamous cell carcinoma  (ISO)
toxic encephalopathy  (ISO)
toxic shock syndrome  (IDA,IEP,ISO)
Toxoplasma Chorioretinitis  (IAGP)
trachoma  (IAGP,IEP)
transient cerebral ischemia  (ISO)
Transplant Rejection  (IMP,ISO)
trichinosis  (ISO)
type 1 diabetes mellitus  (EXP,IEP)
type 2 diabetes mellitus  (IAGP,IEP)
ulcerative colitis  (EXP,IEP)
uveitis  (IAGP,IEP)
vasculitis  (IEP)
Venous Thrombosis  (IAGP)
Ventilator-Induced Lung Injury  (ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (EXP,IEP)
Waldenstroem's macroglobulinemia  (IAGP)
Weight Loss  (EXP)
Wilson disease  (EXP)
Wounds and Injuries  (ISO)
Wounds, Penetrating  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP,ISO)
(+)-catechin  (EXP)
(+)-pilocarpine  (ISO)
(+)-syringaresinol beta-D-glucoside  (ISO)
(+)-Tetrandrine  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(R)-adrenaline  (EXP)
(R)-carnitine  (ISO)
(R)-lipoic acid  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitrobenzene  (ISO)
1,4-benzoquinone  (EXP)
1,4-phenylenediamine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-chloroethanol  (ISO)
2-naphthylamine  (EXP)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-dihydroxybenzoic acid  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-phenylprop-2-enal  (ISO)
4'-hydroxydiclofenac  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-chloro-m-cresol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-methylhistamine  (EXP)
4-nitroquinoline N-oxide  (ISO)
4-nonylphenol  (EXP)
4-octylphenol  (EXP)
4-tolyl isocyanate  (ISO)
5-(1,4-diazepane-1-sulfonyl)isoquinoline  (ISO)
5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol  (ISO)
5-aminoimidazole-4-carboxamide  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (EXP)
acetaldehyde  (EXP)
acetic acid  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP)
actinomycin D  (ISO)
adapalene  (EXP)
adenosine  (ISO)
adenosine 5'-[gamma-thio]triphosphate  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (ISO)
Aflatoxin G1  (ISO)
agathisflavone  (ISO)
albendazole  (EXP)
albuterol  (ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinyl palmitate  (EXP)
alloxan  (ISO)
alpha-galactosylceramide  (ISO)
alpha-naphthoflavone  (EXP,ISO)
aluminium oxide  (EXP)
amitrole  (ISO)
amlexanox  (ISO)
ammonium chloride  (ISO)
Ammothamnine  (ISO)
amphibole asbestos  (ISO)
amphotericin B  (EXP)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
asbestos  (EXP)
asperentin  (ISO)
atrazine  (EXP)
beclomethasone  (EXP)
benzalkonium chloride  (EXP,ISO)
benzene  (EXP)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzocaine  (ISO)
berberine  (ISO)
Bergenin  (ISO)
beta-D-glucan  (EXP)
biliverdin  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisoprolol  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
boron atom  (ISO)
bortezomib  (EXP)
BQ 123  (ISO)
bryostatin 1  (EXP)
bucladesine  (EXP,ISO)
butan-1-ol  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (EXP)
caffeine  (EXP)
calciol  (EXP,ISO)
calcitriol  (EXP,ISO)
capsaicin  (ISO)
carbachol  (ISO)
carbamate ester  (EXP)
carbon monoxide  (ISO)
carbon nanotube  (EXP,ISO)
carnosine  (ISO)
carrageenan  (ISO)
carvedilol  (EXP,ISO)
catechol  (EXP)
cefotaxime  (EXP)
ceftazidime pentahydrate  (EXP)
cefuroxime  (EXP)
celastrol  (ISO)
celecoxib  (ISO)
cerium trichloride  (ISO)
ceruletide  (ISO)
CGS-21680  (EXP)
chenodeoxycholic acid  (ISO)
chitosan  (EXP)
chloroethene  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium atom  (ISO)
chrysin  (EXP,ISO)
ciprofloxacin  (EXP,ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
citronellol  (ISO)
clenbuterol  (EXP,ISO)
clodronic acid  (ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino fo