IL10 (interleukin 10) - Rat Genome Database

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Gene: IL10 (interleukin 10) Homo sapiens
Symbol: IL10
Name: interleukin 10
RGD ID: 735591
HGNC Page HGNC:5962
Description: Enables protein dimerization activity. Involved in several processes, including negative regulation of cellular catabolic process; positive regulation of receptor signaling pathway via JAK-STAT; and regulation of macromolecule biosynthetic process. Acts upstream of or within negative regulation of B cell proliferation; positive regulation of B cell apoptotic process; and regulation of gene expression. Located in extracellular space. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Biomarker of several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CSIF; cytokine synthesis inhibitory factor; GVHDS; IL-10; IL10A; interleukin-10; MGC126450; MGC126451; T-cell growth inhibitory factor; TGIF
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Candidate Gene For: BW132_H
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381206,767,602 - 206,772,494 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,767,602 - 206,774,541 (-)EnsemblGRCh38hg38GRCh38
GRCh371206,940,947 - 206,945,839 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,007,571 - 205,012,462 (-)NCBINCBI36Build 36hg18NCBI36
Build 341203,329,342 - 203,334,234NCBI
Celera1180,192,396 - 180,197,294 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,639,274 - 177,644,165 (-)NCBIHuRef
CHM1_11208,213,574 - 208,218,465 (-)NCBICHM1_1
T2T-CHM13v2.01206,031,803 - 206,036,695 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)