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Gene: IL10 (interleukin 10) Homo sapiens

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Symbol:

IL10

Name:

interleukin 10

RGD ID:

735591

HGNC Page

HGNC:5962

Description:

Enables cytokine activity and protein dimerization activity. Involved in several processes, including interleukin-10-mediated signaling pathway; regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including negative regulation of B cell proliferation; positive regulation of B cell apoptotic process; and positive regulation of signaling receptor activity. Is active in extracellular space. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Biomarker of several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple).

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

CSIF; cytokine synthesis inhibitory factor; GVHDS; IL-10; IL10A; interleukin-10; MGC126450; MGC126451; T-cell growth inhibitory factor; TGIF

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Il10 (interleukin 10)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Il10 (interleukin 10)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Il10 (interleukin 10)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	IL10 (interleukin 10)	NCBI	Ortholog
Canis lupus familiaris (dog):	IL10 (interleukin 10)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Il10 (interleukin 10)	NCBI	Ortholog
Sus scrofa (pig):	IL10 (interleukin 10)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Treefam
Chlorocebus sabaeus (green monkey):	IL10 (interleukin 10)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Il10 (interleukin 10)	NCBI	Ortholog
Other homologs ²
Rattus norvegicus (Norway rat):	Adgra3 (adhesion G protein-coupled receptor A3)	HGNC	OMA
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Il10 (interleukin 10)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Il10 (interleukin 10)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	il10 (interleukin 10)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid\|ZFIN)
Xenopus laevis (African clawed frog):	il10.S	Alliance	DIOPT (Xenbase)
Xenopus tropicalis (tropical clawed frog):	il10	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus laevis (African clawed frog):	il10.L	Alliance	DIOPT (Xenbase)

Allele / Splice:

See ClinVar data

Candidate Gene For:

BW132_H

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

NCBI Annotation Information:

Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	206,767,602 - 206,772,494 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	206,767,602 - 206,774,541 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	206,940,947 - 206,945,839 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	205,007,571 - 205,012,462 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	203,329,342 - 203,334,234	NCBI
Celera	1	180,192,396 - 180,197,294 (-)	NCBI		Celera
Cytogenetic Map	1	q32.1	NCBI
HuRef	1	177,639,274 - 177,644,165 (-)	NCBI		HuRef
CHM1_1	1	208,213,574 - 208,218,465 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	206,031,803 - 206,036,695 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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