RGD Reference Report - Lack of association between atopic asthma and the tumor necrosis factor alpha-308 gene polymorphism in a Czech population. - Rat Genome Database

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Lack of association between atopic asthma and the tumor necrosis factor alpha-308 gene polymorphism in a Czech population.

Authors: Buckova, D  Holla, LI  Vasku, A  Znojil, V  Vacha, J 
Citation: Buckova D, etal., J Investig Allergol Clin Immunol. 2002;12(3):192-7.
RGD ID: 4143254
Pubmed: PMID:12530118   (View Abstract at PubMed)

Susceptibility to the development of asthma and other atopic diseases is known to be associated with genetic components. Several investigators have linked the tumor necrosis factor (TNF) genes and nearby markers located on chromosome 6p to atopy and asthma. A recent study has demonstrated that the TNF-alpha*2 allele of a polymorphism in the TNF-alpha gene promoter region (G-308 A) is associated with a higher risk for the development of atopy in Spanish patients. This study evaluates the possible role of two described bi-allelic polymorphisms in the TNF locus [a G to A transition at position-308 in the 5'-promoter region of the TNF-alpha gene and an NcoI restriction fragment length polymorphism (RFLP) in the first intron (+252A/G) of the LT-alpha(TNF-beta) gene] in atopic diseases in a Czech population. We investigated the distribution of these polymorphisms in a case-control study. The genotypes were determined in 151 patients with atopic asthma and 155 randomly sampled control subjects. The genotype frequencies for both polymorphisms were similar in cases and controls. No significant differences in allele frequencies were found between either of the patients groups and the reference subjects. Similarly, there were no associations of any of the examined variants of the TNF genes with total IgE, specific IgE or pulmonary function tests in patients with allergic diseases. We conclude that these polymorphisms of the TNF genes are unlikely to contribute to atopic disease risk in our population. Significant associations that have been reported in other studies may reflect the genetic heterogeneity of these complex diseases.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma no_associationIAGP 4143254DNA:polymorphism:intronRGD 
asthma no_associationISOLTA (Homo sapiens)4143254; 4143254DNA:polymorphism:intronRGD 
asthma no_associationIAGP 4143254DNA:polymorphism:promoter:RGD 
asthma no_associationISOTNF (Homo sapiens)4143254; 4143254DNA:polymorphism:promoter:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Lta  (lymphotoxin alpha)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Lta  (lymphotoxin A)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
LTA  (lymphotoxin alpha)
TNF  (tumor necrosis factor)


Additional Information