RGD Reference Report - Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease. - Rat Genome Database

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Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease.

Authors: Culpan, D  MacGowan, SH  Ford, JM  Nicoll, JA  Griffin, WS  Dewar, D  Cairns, NJ  Hughes, A  Kehoe, PG  Wilcock, GK 
Citation: Culpan D, etal., Neurosci Lett. 2003 Oct 16;350(1):61-5.
RGD ID: 1580320
Pubmed: PMID:12962917   (View Abstract at PubMed)

Recent findings suggest that production of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-alpha), is increased in the brains of people with Alzheimer's disease (AD). We used direct sequencing methods on a section of the enhancer/promoter region and on a smaller fragment located 10.5 kb upstream of the TNF-alpha gene to respectively examine TNF-alpha polymorphisms and TNF-a and -b microsatellite alleles in a cohort of 235 post-mortem confirmed AD and 130 control cases. None of the TNF-alpha point mutations or microsatellite alleles investigated proved to be independent risk factors for AD. However, when -308/A, -238/G and TNF-a2 were examined as a 2-1-2 haplotype, we observed that the absence of that haplotype was significantly associated with AD (P = 0.014, Fisher's exact test) suggesting that the 2-1-2 haplotype may be protective against AD.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TNFHumanAlzheimer's disease  IAGP  RGD 
TnfRatAlzheimer's disease  ISOTNF (Homo sapiens) RGD 
TnfMouseAlzheimer's disease  ISOTNF (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
TNF  (tumor necrosis factor)


Additional Information