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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases expressionEXP 6480464CTDCyclosporine results in decreased expression of TNF mRNAPMID:24971338
Tnfincreases expressionEXP 6480464CTDCyclosporine results in increased expression of TNF proteinPMID:27596067
Tnfincreases secretionEXP 6480464CTDCyclosporine results in increased secretion of TNF proteinPMID:28886988
Tnfmultiple interactionsEXP 6480464CTD[Ciprofloxacin co-treated with Cyclosporine] results in decreased expression of TNF mRNA; allicin inhibits the reaction [Cyclosporine results in increased expression of TNF protein]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]]PMID:18337667 PMID:26276312 PMID:27596067
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDCyclosporine results in increased expression of TNF mRNA; Cyclosporine results in increased expression of TNF proteinPMID:21292993
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD[Arsenic Trioxide co-treated with Cyclosporine] affects the expression of TNF mRNA; [Cyclosporine co-treated with Thapsigargin] results in increased expression of TNF protein; Cyclosporine inhibits the reaction [Antigen-Antibody Complex results in increased expression of TNF mRNA]; Cyclosporine inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of TNF protein]; Cyclosporine inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of TNF protein]; Cyclosporine promotes the reaction [sodium arsenite results in increased expression of TNF mRNA]PMID:10339586 PMID:19545743 PMID:21381053 PMID:25451590 PMID:36557995 PMID:7871569
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDCyclosporine inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]; Cyclosporine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF protein]; Cyclosporine inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of TNF protein]; Cyclosporine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; Cyclosporine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Cyclosporine inhibits the reaction [TNF protein results in decreased metabolism of Oxygen]PMID:11121130 PMID:11169223 PMID:1371491 PMID:19744167 PMID:36416909
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