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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:59132
Term: antigen
Definition: Any substance that stimulates an immune response in the body, such as through antibody production or by presentation to a T-cell receptor after binding to a major histocompability complex (MHC).
Chemical ID: MESH:D000941
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDAntigens results in increased expression of TNF mRNAPMID:21958720
Tnfincreases secretionISOTnf (Mus musculus)6480464CTDAntigens results in increased secretion of TNF proteinPMID:21958720
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD[deoxynivalenol results in increased susceptibility to Antigens] which results in increased expression of TNF protein; [ochratoxin A results in increased susceptibility to Antigens] which results in increased expression of TNF protein; Quinoxalines analog inhibits the reaction [Antigens results in increased expression of TNF mRNA]; Quinoxalines analog inhibits the reaction [Antigens results in increased secretion of TNF protein]PMID:21958720 PMID:28935500
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