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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:68657
Term: zingerone
Definition: A methyl ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at positions 3 and 4 by methoxy and hydroxy groups respectively. The major pungent component in ginger.
Chemical ID: MESH:C013738
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases expressionEXP 6480464CTDzingerone results in decreased expression of TNF mRNAPMID:36822304
Tnfmultiple interactionsEXP 6480464CTDzingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of TNF protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TNF mRNA]PMID:30720227 PMID:36822304
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDzingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]PMID:29289488
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