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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:28918
Term: (R)-adrenaline
Definition: The R-enantiomer of adrenaline. It is a hormone secreted by the adrenal glands resulting in the 'fight-or-flight' response.
Chemical ID: MESH:D004837
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases expressionEXP 6480464CTDEpinephrine results in decreased expression of TNF mRNAPMID:12423672
Tnfdecreases secretionEXP 6480464CTDEpinephrine results in decreased secretion of TNF proteinPMID:12423672
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDEpinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]PMID:10588509
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