RGD Reference Report - Immunohistochemical expression of tumor necrosis factor alpha in neonatal leukomalacia. - Rat Genome Database

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Immunohistochemical expression of tumor necrosis factor alpha in neonatal leukomalacia.

Authors: Deguchi, K  Mizuguchi, M  Takashima, S 
Citation: Deguchi K, etal., Pediatr Neurol. 1996 Jan;14(1):13-6.
RGD ID: 12904655
Pubmed: PMID:8652010   (View Abstract at PubMed)

The expression of tumor necrosis factor alpha (TNF alpha) was examined in infants with leukomalacia by means of immunohistochemical methods with an antihuman TNF alpha monoclonal antibody. We studied 23 patients with neonatal leukomalacia, classified as having "focal," "widespread," or "diffuse" disease according to the distribution of the lesions, and 18 age-matched controls. TNF alpha immunoreactivity was positive in 19 of the 23 (83%) patients with leukomalacia, and in 7 of the 18 (39%) controls. TNF alpha was expressed mainly in glial cells in the deep white matter in both groups, and was most abundant around the necrotic foci in the focal group. TNF alpha immunoreactivity appeared earlier in patients with leukomalacia than in controls, being first detected at 25 and 29 weeks gestation, respectively. Immunofluorescence double-labeling revealed the TNF alpha -immunoreactive cells were Ricinus communis agglutinin-1 (RCA-1)-positive microglial cells. Thus, our study revealed increasing expression of TNF alpha in the normally developing brain during the late fetal period, and overproduction of TNF alpha by microglial cells associated with the pathogenesis of neonatal leukomalacia.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
periventricular leukomalacia  IEP 12904655 RGD 
periventricular leukomalacia  ISOTNF (Homo sapiens)12904655; 12904655 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
TNF  (tumor necrosis factor)


Additional Information