Nfkbia (NFKB inhibitor alpha) - Rat Genome Database

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Gene: Nfkbia (NFKB inhibitor alpha) Rattus norvegicus
Symbol: Nfkbia
Name: NFKB inhibitor alpha
RGD ID: 3171
Description: Enables NF-kappaB binding activity and heat shock protein binding activity. Involved in several processes, including cytoplasmic sequestering of NF-kappaB; leukocyte migration involved in inflammatory response; and liver regeneration. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in cytosol and nucleus. Part of protein-containing complex. Used to study gastritis; pulmonary emphysema; and sciatic neuropathy. Biomarker of several diseases, including acute necrotizing pancreatitis; alcoholic hepatitis; artery disease (multiple); middle cerebral artery infarction; and toxic shock syndrome. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; ectodermal dysplasia and immunodeficiency 2; hematologic cancer (multiple); hepatitis B; and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; interleukin-23 signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-Tetrandrine; (20S)-ginsenoside Rg3.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: I-kappa-B-alpha; ikappaBalpha; ikB-alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha; NF-kappa-B inhibitor alpha; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; RL/IF-1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2672,858,713 - 72,861,941 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl672,858,712 - 72,861,941 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx673,278,856 - 73,282,085 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0673,585,214 - 73,588,443 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0673,013,851 - 73,017,079 (-)NCBIRnor_WKY
Rnor_6.0676,267,227 - 76,270,457 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,267,228 - 76,270,457 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0685,803,990 - 85,807,223 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4675,729,302 - 75,732,475 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1675,732,430 - 75,735,531 (-)NCBI
Celera671,699,196 - 71,702,411 (-)NCBICelera
Cytogenetic Map6q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute necrotizing pancreatitis  (IEP)
Adenoviridae Infections  (ISO)
alcoholic hepatitis  (IEP)
arteriosclerosis  (ISO)
atopic dermatitis  (ISS)
brain ischemia  (ISO)
Brain-Lung-Thyroid Syndrome  (ISO)
Breast Neoplasms  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Cardiac Fibrosis  (IEP)
Cerebral Hemorrhage  (IDA)
childhood-onset asthma  (ISO)
Chronic Hepatitis B  (ISO)
cryptorchidism  (ISO)
Cytomegalovirus Infections  (ISO)
Deficiency of Interleukin-1 Receptor Antagonist  (ISO)
diarrhea  (ISO)
diffuse large B-cell lymphoma  (ISO)
ectodermal dysplasia and immunodeficiency 2  (ISO)
encephalitis  (IEP)
endometriosis  (IEP)
Endotoxemia  (ISO)
Experimental Colitis  (IDA)
Experimental Diabetes Mellitus  (IDA,IEP)
Experimental Liver Cirrhosis  (ISO)
gastritis  (IDA)
glioblastoma  (ISO)
Hemorrhagic Shock  (IEP)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Hodgkin's lymphoma  (ISO)
hypertension  (IEP)
lung cancer  (ISO)
Lung Injury  (IEP)
melanoma  (ISO)
middle cerebral artery infarction  (IEP)
multiple myeloma  (ISO)
Murine Acquired Immunodeficiency Syndrome  (ISO)
myocardial infarction  (IEP)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IDA)
Neoplasm Metastasis  (ISO)
nephrotic syndrome  (ISO)
pancreatic cancer  (ISO)
Pneumococcal Infections  (ISO)
pneumonia  (ISO)
pre-malignant neoplasm  (IEP)
Pregnancy Complications  (ISO)
primary immunodeficiency disease  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (IDA)
pulmonary tuberculosis  (ISO)
Sarcopenia  (IEP)
sciatic neuropathy  (IDA)
Sepsis  (IEP)
Sjogren's syndrome  (ISO,ISS)
Spinal Cord Injuries  (IEP)
toxic shock syndrome  (IEP)
toxoplasmosis  (ISO)
Transplant Rejection  (IEP,ISO)
vasculitis  (ISO)
Ventilator-Induced Lung Injury  (IEP)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-catechin  (ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-Tetrandrine  (EXP)
(-)-alpha-phellandrene  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (EXP)
(20S)-ginsenoside Rh2  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(R)-mevalonic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,2-naphthoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1,7-dimethylxanthine  (ISO)
1,8-cineole  (ISO)
1-bromopropane  (ISO)
1-hydroxy-2-naphthoic acid  (ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
15-oxo-ETE  (ISO)
17-hydroxyjolkinolide B  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2''-galloylhyperin  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-acetamidofluorene  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-acetyloxy-4-(trifluoromethyl)benzoic acid  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-aminopurine  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-butoxyethanol  (ISO)
2-Hydroxy-4-trifluoromethyl benzoic acid  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5'-triiodothyronine  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-(1H-indol-3-yl)propanoic acid  (ISO)
3-aminobenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-mercaptopropanoic acid  (ISO)
3-methylcatechol  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4'-epidoxorubicin  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (ISO)
5,6,7-trimethoxyflavone  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7-ketocholesterol  (EXP)
[6]-Shogaol  (ISO)
acetaldehyde  (EXP,ISO)
acetic acid  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (EXP,ISO)
Aciculatin  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
alachlor  (ISO)
albuterol  (ISO)
alcohol  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldehydo-D-ribose  (ISO)
Alkannin  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
alpha-phellandrene  (ISO)
alvocidib  (ISO)
amifostine  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP,ISO)
amorolfine  (ISO)
amphetamine  (EXP)
amphibole asbestos  (ISO)
andrographolide  (ISO)
anethole  (ISO)
aniline  (EXP)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
antroquinonol  (ISO)
apigenin  (EXP,ISO)
apocynin  (ISO)
aprepitant  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (ISO)
arjunolic acid  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asarone  (ISO)
astilbin  (ISO)
astragaloside IV  (EXP,ISO)
Atractylodin  (ISO)
atrazine  (ISO)
auranofin  (ISO)
aureusidin  (ISO)
azadirachtin A  (ISO)
B 581  (ISO)
baicalein  (ISO)
baicalin  (EXP)
Bardoxolone methyl  (ISO)
bathocuproine disulfonic acid  (ISO)
belinostat  (ISO)
benazepril  (EXP)
benzamide  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Berbamine  (ISO)
berberine  (ISO)
Bergenin  (EXP,ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-Elemonic acid  (ISO)
beta-endorphin  (ISO)
beta-naphthoflavone  (EXP,ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
brazilein  (ISO)
bromoacetate  (ISO)
butenafine  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
capsiate  (ISO)
carbon atom  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (ISO)
carmustine  (EXP,ISO)
carnosic acid  (ISO)
carnosine  (EXP)
Carnosol  (ISO)
carrageenan  (ISO)
casticin  (ISO)
catechol  (ISO)
cefaloridine  (EXP)
celastrol  (EXP)
celecoxib  (ISO)
ceritinib  (ISO)
ceruletide  (EXP)
CGP 52608  (ISO)
chalcone  (ISO)
chelerythrine  (ISO)
Chikusetsusaponin-IV  (ISO)
chlorobenzene  (ISO)
chlorogenic acid  (EXP,ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP)
cholic acid  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cilostazol  (ISO)
cisplatin  (EXP,ISO)
citronellol  (EXP,ISO)
clenbuterol  (ISO)
clofibrate  (ISO)
cobalt atom  (EXP)