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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:28851
Term: phenanthrene
Definition: A polycyclic aromatic hydrocarbon composed of three fused benzene rings which takes its name from the two terms 'phenyl' and 'anthracene.'
Chemical ID: MESH:C031181
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionEXP 6480464CTDphenanthrene results in increased expression of TNF mRNA; phenanthrene results in increased expression of TNF proteinPMID:31456356
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDphenanthrene results in increased expression of TNF proteinPMID:34453960
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDphenanthrene results in increased expression of TNF mRNA; phenanthrene results in increased expression of TNF proteinPMID:32856796
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTD[fluorene co-treated with phenanthrene] results in increased expression of TNF mRNA; [fluorene co-treated with phenanthrene] results in increased expression of TNF protein; TNF protein promotes the reaction [phenanthrene results in increased expression of CXCL8 mRNA]PMID:18434080 PMID:32856796
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