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Gene: TNF (tumor necrosis factor) Sus scrofa
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Symbol: TNF
Name: tumor necrosis factor
Description: ENCODES a protein that exhibits identical protein binding (inferred); protease binding (inferred); transcription regulatory region DNA binding (inferred); INVOLVED IN positive regulation of endothelial cell apoptotic process; positive regulation of estradiol secretion; regulation of fat cell differentiation; PARTICIPATES IN allograft rejection pathway; Alzheimer's disease pathway; amyotrophic lateral sclerosis pathway; ASSOCIATED WITH acne (ortholog); acquired immunodeficiency syndrome (ortholog); Acute Coronary Syndrome (ortholog); FOUND IN external side of plasma membrane (inferred); integral component of plasma membrane (inferred); membrane raft (inferred); INTERACTS WITH (-)-epigallocatechin 3-gallate; 1,3-thiazolidine-2,4-dione; 2,3-dimethoxynaphthalene-1,4-dione
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cachectin; TNF-a; TNF-alpha; TNFa; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2
Orthologs:
Homo sapiens (human) : TNF (tumor necrosis factor)  HGNC  Alliance
Mus musculus (house mouse) : Tnf (tumor necrosis factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tnf (tumor necrosis factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnf (tumor necrosis factor)
Pan paniscus (bonobo/pygmy chimpanzee) : TNF (tumor necrosis factor)
Canis lupus familiaris (dog) : TNF (tumor necrosis factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnf (tumor necrosis factor)
Heterocephalus glaber (naked mole-rat) : Tnf (tumor necrosis factor)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,699,636 - 23,703,655 (+)Ensembl
Sscrofa11.1723,699,635 - 23,702,393 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,549,619 - 27,552,377 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7p11-q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - uncurated

Genomics

Comparative Map Data

Expression


Sequence

Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
 
More on TNF
NCBI Gene
Ensembl Gene
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 14181661
Created: 2019-01-29
Species: Sus scrofa
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.