TNF (tumor necrosis factor) - Rat Genome Database

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Gene: TNF (tumor necrosis factor) Sus scrofa
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Symbol: TNF
Name: tumor necrosis factor
RGD ID: 14181661
Description: ENCODES a protein that exhibits tumor necrosis factor receptor binding (ortholog); INVOLVED IN positive regulation of endothelial cell apoptotic process; positive regulation of estradiol secretion; regulation of fat cell differentiation; PARTICIPATES IN ceramide signaling pathway; Fc epsilon receptor mediated signaling pathway; interleukin-23 signaling pathway; ASSOCIATED WITH acne (ortholog); acquired immunodeficiency syndrome (ortholog); Acute Coronary Syndrome (ortholog); FOUND IN cytoplasm (ortholog); external side of plasma membrane (ortholog); extracellular region (ortholog); INTERACTS WITH (-)-epigallocatechin 3-gallate; 1,3-thiazolidine-2,4-dione; 2,3-dimethoxynaphthalene-1,4-dione
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cachectin; TNF-a; TNF-alpha; TNFa; TNFSF2; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,699,628 - 23,702,416 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,699,635 - 23,702,393 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,549,619 - 27,552,377 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7p11-q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
acquired immunodeficiency syndrome  (ISO)
Acute Coronary Syndrome  (ISO)
Acute Experimental Pancreatitis  (ISO)
Acute Hepatitis  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
adult respiratory distress syndrome  (ISO)
Aggressive Fibromatosis  (ISO)
Albuminuria  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic hepatitis  (ISO)
alcoholic liver cirrhosis  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
Alveolar Bone Loss  (ISO)
Alzheimer's disease  (ISO)
Amebic Liver Abscess  (ISO)
amyloidosis  (ISO)
amyotrophic lateral sclerosis  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
anemia  (ISO)
Animal Disease Models  (ISO)
anogenital venereal wart  (ISO)
Anorexia  (ISO)
anterior uveitis  (ISO)
anthracosis  (ISO)
anthrax disease  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
anxiety disorder  (ISO)
aortic valve stenosis  (ISO)
aplastic anemia  (ISO)
Arsenic Poisoning  (ISO)
asbestosis  (ISO)
aspiration pneumonia  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
atrial fibrillation  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thyroiditis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
beta thalassemia  (ISO)
bilirubin metabolic disorder  (ISO)
brain edema  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiectasis  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Burns  (ISO)
Cachexia  (ISO)
calcinosis  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
Cardiovascular Pregnancy Complications  (ISO)
Cardiovirus Infections  (ISO)
cerebral infarction  (ISO)
cervical cancer  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chlamydia  (ISO)
cholestasis  (ISO)
cholesteatoma of middle ear  (ISO)
chorioamnionitis  (ISO)
Chronic Allograft Dysfunction  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
cicatricial pemphigoid  (ISO)
cochlear disease  (ISO)
colitis  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
Cor pulmonale  (ISO)
corneal ulcer  (ISO)
coronary artery disease  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
Cough  (ISO)
COVID-19  (ISO)
Coxsackievirus Infections  (ISO)
Crohn's disease  (ISO)
cryoglobulinemia  (ISO)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
cystitis  (ISO)
Cytomegalovirus Infections  (ISO)
cytomegalovirus retinitis  (ISO)
degenerative disc disease  (ISO)
demyelinating disease  (ISO)
dermatitis  (ISO)
dermatitis herpetiformis  (ISO)
dermatomyositis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1H  (ISO)
disease by infectious agent  (ISO)
Disease Progression  (ISO)
disseminated intravascular coagulation  (ISO)
drug allergy  (ISO)
Drug Eruptions  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Eales Disease  (ISO)
Edema  (ISO)
Emphysema  (ISO)
encephalitis  (ISO)
encephalomyelitis  (ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
endophthalmitis  (ISO)
Endotoxemia  (ISO)
epididymitis  (ISO)
epilepsy  (ISO)
erythema nodosum  (ISO)
Escherichia Coli Infections  (ISO)
esophagitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
extrahepatic cholestasis  (ISO)
extrinsic allergic alveolitis  (ISO)
eye disease  (ISO)
Fanconi anemia  (ISO)
farmer's lung  (ISO)
fatty liver disease  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Fungal Lung Diseases  (ISO)
gastric ulcer  (ISO)
gastritis  (ISO)
Gaucher's disease  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hearing Loss  (ISO)
Hearing Loss, Noise-Induced  (ISO)
heart valve disease  (ISO)
Heat Stroke  (ISO)
hemochromatosis  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhagic Shock  (ISO)
hepatic encephalopathy  (ISO)
hepatitis A  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
hepatopulmonary syndrome  (ISO)
hepatorenal syndrome  (ISO)
hereditary hemorrhagic telangiectasia  (ISO)
herpes simplex virus keratitis  (ISO)
herpes zoster  (ISO)
hidradenitis suppurativa  (ISO)
high grade glioma  (ISO)
High-Frequency Hearing Loss  (ISO)
HIV Wasting Syndrome  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hypercalcemia  (ISO)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
hypochromic microcytic anemia  (ISO)
hypoglycemia  (ISO)
Hypotension  (ISO)
Hypothermia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
IgA glomerulonephritis  (ISO)
impotence  (ISO)
inclusion body myopathy with Paget disease of bone and frontotemporal dementia  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
Insulin Resistance  (ISO)
intermediate uveitis  (ISO)
interstitial cystitis  (ISO)
Intervertebral Disc Displacement  (ISO)
intracranial aneurysm  (ISO)
Intracranial Hemorrhages  (ISO)
intrahepatic cholestasis of pregnancy  (ISO)
iron deficiency anemia  (ISO)
Kawasaki disease  (ISO)
keratoconjunctivitis sicca  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
labyrinthitis  (ISO)
leishmaniasis  (ISO)
leprosy  (ISO)
listeriosis  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Liver Neoplasms  (ISO)
Liver Reperfusion Injury  (ISO)
localized scleroderma  (ISO)
low tension glaucoma  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
lupus nephritis  (ISO)
lymphopenia  (ISO)
malaria  (ISO)
Manganese Poisoning  (ISO)
megacolon  (ISO)
melanoma  (ISO)
Meningeal Tuberculosis  (ISO)
Metabolic Syndrome  (ISO)
mevalonic aciduria  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
middle cerebral artery infarction  (ISO)
Middle East respiratory syndrome  (ISO)
migraine  (ISO)
migraine without aura  (ISO)
mitochondrial myopathy  (ISO)
mixed connective tissue disease  (ISO)
mucocutaneous leishmaniasis  (ISO)
mucopolysaccharidosis VI  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (ISO)
multiple sclerosis  (ISO)
muscular atrophy  (ISO)
muscular dystrophy  (ISO)
Mycobacterium avium complex disease  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
myelodysplastic syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocardial stunning  (ISO)
myocarditis  (ISO)
myositis  (ISO)
Nasal Polyps  (ISO)
Nausea  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
Neuralgia  (ISO)
neuroblastoma  (ISO)
Neurogenic Inflammation  (ISO)
neutropenia  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
occupational asthma  (ISO)
open-angle glaucoma  (ISO)
oral squamous cell carcinoma  (ISO)
oral submucous fibrosis  (ISO)
Osteolysis  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
ovarian cancer  (ISO)
Oxygen-Induced Retinopathy  (ISO)
Pain  (ISO)
Painful Neuropathy  (ISO)
pancreatic cancer  (ISO)
paracoccidioidomycosis  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
Pediatric Crohn's Disease  (ISO)
Penetrating Wounds  (ISO)
peptic esophagitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
periodontitis  (ISO)
Peripheral Nerve Injuries  (ISO)
peritonitis  (ISO)
periventricular leukomalacia  (ISO)
Picornaviridae Infections  (ISO)
placenta disease  (ISO)
plasmacytoma  (ISO)
Plasmodium falciparum malaria  (ISO)
Pleural Effusion  (ISO)
pleurisy  (ISO)
Pneumococcal Meningitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
portal hypertension  (ISO)
Postmenopausal Osteoporosis  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Premature Birth  (ISO)
primary biliary cholangitis  (ISO)
Primary Graft Dysfunction  (ISO)
primary open angle glaucoma  (ISO)
primary sclerosing cholangitis  (ISO)
prostate cancer  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
pustulosis of palm and sole  (ISO)
Radiation Pneumonitis  (ISO)
radiculopathy  (ISO)
Refractory Anemia  (ISO)
relapsing polychondritis  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
respiratory syncytial virus infectious disease  (ISO)
respiratory system disease  (ISO)
Respiratory Tract Infections  (ISO)
Retina Reperfusion Injury  (ISO)
retinal artery occlusion  (ISO)
retinal detachment  (ISO)
retinal disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
root resorption  (ISO)
SAPHO syndrome  (ISO)
sarcoma  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
scleritis  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
septic arthritis  (ISO)
severe acute respiratory syndrome  (ISO)
Shock  (ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
skin disease  (ISO)
small cell carcinoma  (ISO)
Soft Tissue Neoplasms  (ISO)
Spinal Cord Compression  (ISO)
Spinal Cord Injuries  (ISO)
Spine Osteoarthritis  (ISO)
spondyloarthropathy  (ISO)
Stable Angina  (ISO)
status epilepticus  (ISO)
Stevens-Johnson syndrome  (ISO)
Stomach Neoplasms  (ISO)
Streptococcal Infections  (ISO)
Streptococcus pneumonia  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Sudden Hearing Loss  (ISO)
Systemic Candidiasis  (ISO)
systemic lupus erythematosus  (ISO)
Tachycardia  (ISO)
Temporomandibular Joint Disorders  (ISO)
thalassemia  (ISO)
thrombocytopenia  (ISO)
thrombosis  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
toxic shock syndrome  (ISO)
trachoma  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
Traumatic Brain Injuries  (ISO)
trichinosis  (ISO)
trigeminal neuralgia  (ISO)
tuberculosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
typhoid fever  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
urticaria  (ISO)
uveitis  (ISO)
vascular dementia  (ISO)
vascular disease  (ISO)
Vascular System Injuries  (ISO)
Venous Thromboembolism  (ISO)
Ventricular Dysfunction  (ISO)
Viral Bronchiolitis  (ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)
visual epilepsy  (ISO)
vitiligo  (ISO)
Vogt-Koyanagi-Harada disease  (ISO)
Vulvar Vestibulitis  (ISO)
Weight Gain  (ISO)
Weill-Marchesani syndrome  (ISO)
Wilson disease  (ISO)
Wounds and Injuries  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA,ISO)
acute inflammatory response  (ISO)
animal organ morphogenesis  (IEA,ISO)
apoptotic process  (ISO)
apoptotic signaling pathway  (IEA,ISO)
calcium-mediated signaling  (ISO)
cell activation  (ISO)
cellular extravasation  (IEA,ISO)
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to amyloid-beta  (ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to molecule of bacterial origin  (ISO)
cellular response to nicotine  (IEA)
cellular response to organic cyclic compound  (IEA)
cellular response to retinoic acid  (ISO)
cellular response to toxic substance  (ISO)
cellular response to type II interferon  (ISO)
chronic inflammatory response to antigenic stimulus  (IEA)
circadian rhythm  (ISO)
cortical actin cytoskeleton organization  (IEA)
defense response  (IEA,ISO)
defense response to bacterium  (IEA,ISO)
defense response to Gram-positive bacterium  (IEA,ISO)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
embryonic digestive tract development  (IEA)
endothelial cell apoptotic process  (IEA)
epithelial cell proliferation involved in salivary gland morphogenesis  (IEA,ISO)
extracellular matrix organization  (IEA,ISO)
extrinsic apoptotic signaling pathway  (IEA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IBA,IEA,ISO)
glucose metabolic process  (IEA,ISO)
humoral immune response  (IEA,ISO)
I-kappaB kinase/NF-kappaB signaling  (IEA,ISO)
immune response  (IEA)
inflammatory response  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
JNK cascade  (IEA,ISO)
leukocyte migration  (IEA,ISO)
leukocyte migration involved in inflammatory response  (ISO)
leukocyte tethering or rolling  (IEA)
lipopolysaccharide-mediated signaling pathway  (IEA)
liver regeneration  (ISO)
MAPK cascade  (IEA)
microglial cell activation  (IEA)
necroptotic signaling pathway  (IEA,ISO,ISS)
negative regulation of alkaline phosphatase activity  (IEA)
negative regulation of amyloid-beta clearance  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (IEA,ISO)
negative regulation of bicellular tight junction assembly  (IEA)
negative regulation of bile acid secretion  (ISO)
negative regulation of blood vessel endothelial cell migration  (IEA)
negative regulation of branching involved in lung morphogenesis  (IEA)
negative regulation of cell population proliferation  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA,ISO)
negative regulation of cytokine production involved in immune response  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of endothelial cell proliferation  (IEA)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IEA)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of glucose import  (IEA,ISO)
negative regulation of heart rate  (ISO)
negative regulation of interleukin-6 production  (IEA)
negative regulation of L-glutamate import across plasma membrane  (ISO)
negative regulation of lipid catabolic process  (IEA)
negative regulation of miRNA maturation  (IEA,ISO)
negative regulation of mitotic cell cycle  (IEA)
negative regulation of myelination  (ISO)
negative regulation of myoblast differentiation  (IEA,ISO)
negative regulation of myosin-light-chain-phosphatase activity  (IEA)
negative regulation of osteoblast differentiation  (IEA)
negative regulation of oxidative phosphorylation  (ISO)
negative regulation of protein-containing complex disassembly  (IEA)
negative regulation of signaling receptor activity  (IEA,ISO)
negative regulation of systemic arterial blood pressure  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of vascular wound healing  (IEA)
negative regulation of viral genome replication  (IEA)
osteoclast differentiation  (IEA,ISO)
positive regulation of action potential  (ISO)
positive regulation of amyloid-beta formation  (IEA)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of blood microparticle formation  (IEA)
positive regulation of calcidiol 1-monooxygenase activity  (IEA)
positive regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
positive regulation of cell adhesion  (IEA)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IEA)
positive regulation of chemokine production  (IEA)
positive regulation of chronic inflammatory response to antigenic stimulus  (IEA,ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA)
positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis  (ISO)
positive regulation of cytokine production  (IEA)
positive regulation of cytokine production involved in inflammatory response  (IEA,ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of DNA-binding transcription factor activity  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of endothelial cell apoptotic process  (IMP)
positive regulation of estradiol secretion  (IDA)
positive regulation of extrinsic apoptotic signaling pathway  (IBA)
positive regulation of fever generation  (IEA)
positive regulation of fractalkine production  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glial cell proliferation  (IEA)
positive regulation of hair follicle development  (IEA)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of heterotypic cell-cell adhesion  (IEA)
positive regulation of humoral immune response mediated by circulating immunoglobulin  (IEA,ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IBA,IEA,ISO)
positive regulation of I-kappaB phosphorylation  (IEA,ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of interleukin-18 production  (ISO)
positive regulation of interleukin-33 production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of JUN kinase activity  (IEA)
positive regulation of leukocyte adhesion to arterial endothelial cell  (IEA)
positive regulation of leukocyte adhesion to vascular endothelial cell  (IEA)
positive regulation of MAP kinase activity  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of membrane protein ectodomain proteolysis  (IEA)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of neuron apoptotic process  (IEA,ISO)
positive regulation of neutrophil activation  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IBA,IEA,ISO,ISS)
positive regulation of NIK/NF-kappaB signaling  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of nitrogen compound metabolic process  (IEA)
positive regulation of osteoclast differentiation  (IEA)
positive regulation of oxidative stress-induced neuron death  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA)
positive regulation of phagocytosis  (IEA)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of podosome assembly  (IEA)
positive regulation of programmed cell death  (IEA)
positive regulation of protein catabolic process  (IEA)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein kinase B signaling  (IEA,ISO)
positive regulation of protein localization to cell surface  (IEA)
positive regulation of protein localization to plasma membrane  (IEA)
positive regulation of protein phosphorylation  (IEA)
positive regulation of protein transport  (IEA,ISO)
positive regulation of protein-containing complex assembly  (IEA)
positive regulation of protein-containing complex disassembly  (IEA)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of smooth muscle cell proliferation  (IEA)
positive regulation of superoxide dismutase activity  (IEA)
positive regulation of synaptic transmission  (IEA,ISO)
positive regulation of synoviocyte proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
positive regulation of translational initiation by iron  (IEA,ISO)
positive regulation of type II interferon production  (IEA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA)
positive regulation of vitamin D biosynthetic process  (IEA)
protein kinase B signaling  (IEA,ISO)
protein localization to plasma membrane  (IEA)
regulation of biological quality  (IEA)
regulation of branching involved in salivary gland morphogenesis  (IEA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of developmental process  (IEA)
regulation of endothelial cell apoptotic process  (IEA)
regulation of establishment of endothelial barrier  (IEA)
regulation of fat cell differentiation  (IGI)
regulation of I-kappaB kinase/NF-kappaB signaling  (IEA)
regulation of immunoglobulin production  (IEA,ISO)
regulation of inflammatory response  (IEA,ISO)
regulation of insulin secretion  (IEA)
regulation of multicellular organismal process  (IEA)
regulation of osteoclast differentiation  (IEA,ISO)
regulation of protein phosphorylation  (IEA,ISO)
regulation of protein secretion  (IEA,ISO)
regulation of reactive oxygen species metabolic process  (IEA,ISO)
regulation of secretion  (IEA)
regulation of synapse organization  (IEA)
regulation of transcription by RNA polymerase II  (ISO)
response to 3,3',5-triiodo-L-thyronine  (ISO)
response to activity  (ISO)
response to bacterium  (ISO)
response to ethanol  (ISO)
response to fructose  (ISO)
response to glucocorticoid  (IEA)
response to gold nanoparticle  (ISO)
response to Gram-negative bacterium  (ISO)
response to hypoxia  (ISO)
response to isolation stress  (ISO)
response to lipopolysaccharide  (ISO)
response to macrophage colony-stimulating factor  (ISO)
response to mechanical stimulus  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (IEA,ISO)
response to paracetamol  (ISO)
response to radiation  (ISO)
response to virus  (IEA)
response to xenobiotic stimulus  (ISO)
sequestering of triglyceride  (IEA)
signal transduction  (ISO)
skeletal muscle contraction  (ISO)
toll-like receptor 3 signaling pathway  (ISO)
tumor necrosis factor-mediated signaling pathway  (IBA,IEA,ISO)
vascular endothelial growth factor production  (IEA,ISS)
vasodilation  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:1503261   PMID:1680808   PMID:1874444   PMID:2216741   PMID:2478420   PMID:11169259   PMID:16034134   PMID:16365405   PMID:16606437   PMID:16857205   PMID:17098266   PMID:17170366  
PMID:17903420   PMID:19261619   PMID:19324350   PMID:19520150   PMID:19558791   PMID:19605905   PMID:19642909   PMID:20027315   PMID:20701940   PMID:21152396   PMID:21205430   PMID:21314908  
PMID:21471537   PMID:22497732   PMID:22699004   PMID:22768175   PMID:22994292   PMID:23090779   PMID:23102097   PMID:24066302   PMID:24098322   PMID:24139936   PMID:25708177   PMID:26724939  
PMID:27125399   PMID:27408333   PMID:27618228   PMID:27660103   PMID:28683436   PMID:30317108   PMID:30782567   PMID:31213269   PMID:34445450  


Genomics

Comparative Map Data
TNF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,699,628 - 23,702,416 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,699,635 - 23,702,393 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,549,619 - 27,552,377 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7p11-q11NCBI
TNF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,575,565 - 31,578,336 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl631,575,565 - 31,578,336 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,543,342 - 31,546,113 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,651,329 - 31,654,091 (+)NCBINCBI36Build 36hg18NCBI36
Build 34631,651,328 - 31,654,091NCBI
Celera633,141,565 - 33,144,327 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,330,078 - 31,332,847 (+)NCBIHuRef
CHM1_1631,545,476 - 31,548,245 (+)NCBICHM1_1
T2T-CHM13v2.0631,428,617 - 31,431,388 (+)NCBIT2T-CHM13v2.0
Tnf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,418,343 - 35,420,983 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,418,357 - 35,420,983 (-)EnsemblGRCm39 Ensembl
GRCm381735,199,367 - 35,202,007 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,199,381 - 35,202,007 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,336,335 - 35,338,941 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,807,442 - 34,810,048 (-)NCBIMGSCv36mm8
Celera1738,296,090 - 38,298,699 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.59NCBI
Tnf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2203,622,011 - 3,624,629 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,622,011 - 3,624,629 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,321,864 - 4,324,463 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0203,683,924 - 3,686,523 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0204,221,516 - 4,224,112 (+)NCBIRnor_WKY
Rnor_6.0205,189,382 - 5,192,000 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,855,829 - 4,858,447 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,189,390 - 5,192,000 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,936,229 - 6,938,847 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,661,000 - 3,663,618 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera204,400,860 - 4,403,478 (-)NCBICelera
RH 3.4 Map20 RGD
Cytogenetic Map20p12NCBI
Tnf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437117,206 - 120,700 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955437117,267 - 119,899 (+)NCBIChiLan1.0ChiLan1.0
TNF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1632,126,618 - 32,129,389 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,126,618 - 32,129,381 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0631,236,650 - 31,239,423 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TNF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,074,561 - 1,076,425 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,074,552 - 1,076,425 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,211,002 - 1,212,867 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,219,807 - 1,221,672 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,219,798 - 1,221,672 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,078,543 - 1,080,407 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,146,468 - 1,148,336 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,213,251 - 1,215,120 (+)NCBIUU_Cfam_GSD_1.0
Tnf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,623,427 - 35,626,009 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367271,936,066 - 1,937,766 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366604431,477,411 - 31,480,675 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,623,425 - 24,625,531 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,623,059 - 24,625,647 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system nervous system reproductive system respiratory system
High
Medium
Low 7 2 5 1 1 3
Below cutoff 3 8 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000001533   ⟹   ENSSSCP00000001491
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl723,699,636 - 23,703,655 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000067500   ⟹   ENSSSCP00000062245
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl723,699,817 - 23,703,655 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000096809   ⟹   ENSSSCP00000079669
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl723,699,817 - 23,702,416 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000104535   ⟹   ENSSSCP00000075411
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl723,699,628 - 23,702,407 (+)Ensembl
RefSeq Acc Id: NM_214022   ⟹   NP_999187
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1723,699,635 - 23,702,393 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_999187   ⟸   NM_214022
- UniProtKB: A5D9N8 (UniProtKB/Swiss-Prot),   P23563 (UniProtKB/Swiss-Prot),   B3GDZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000001491   ⟸   ENSSSCT00000001533
RefSeq Acc Id: ENSSSCP00000062245   ⟸   ENSSSCT00000067500
RefSeq Acc Id: ENSSSCP00000079669   ⟸   ENSSSCT00000096809
RefSeq Acc Id: ENSSSCP00000075411   ⟸   ENSSSCT00000104535
Protein Domains
TNF_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001404 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00000060860 Ensembl, ENTREZGENE
  ENSSSCG00005032154 UniProtKB/Swiss-Prot
  ENSSSCG00015057632 UniProtKB/Swiss-Prot
  ENSSSCG00025077751 UniProtKB/Swiss-Prot
  ENSSSCG00030065721 UniProtKB/Swiss-Prot
  ENSSSCG00035019345 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00040070661 UniProtKB/Swiss-Prot
  ENSSSCG00045038014 UniProtKB/Swiss-Prot
  ENSSSCG00050005898 UniProtKB/Swiss-Prot
  ENSSSCG00055028741 UniProtKB/Swiss-Prot
  ENSSSCG00060043262 UniProtKB/Swiss-Prot
  ENSSSCG00065026040 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00070024118 UniProtKB/Swiss-Prot
Ensembl Protein ENSSSCP00000001491 UniProtKB/Swiss-Prot
  ENSSSCP00000062245.1 UniProtKB/TrEMBL
  ENSSSCP00000075411 ENTREZGENE
  ENSSSCP00005031803 UniProtKB/Swiss-Prot
  ENSSSCP00015031063 UniProtKB/Swiss-Prot
  ENSSSCP00025048968 UniProtKB/Swiss-Prot
  ENSSSCP00030042263 UniProtKB/Swiss-Prot
  ENSSSCP00035009452 UniProtKB/Swiss-Prot
  ENSSSCP00035009460.1 UniProtKB/TrEMBL
  ENSSSCP00040043236 UniProtKB/Swiss-Prot
  ENSSSCP00045046558 UniProtKB/Swiss-Prot
  ENSSSCP00050003415 UniProtKB/Swiss-Prot
  ENSSSCP00055045643 UniProtKB/Swiss-Prot
  ENSSSCP00060025133 UniProtKB/Swiss-Prot
  ENSSSCP00065014573 UniProtKB/Swiss-Prot
  ENSSSCP00065014577.1 UniProtKB/TrEMBL
  ENSSSCP00070040652 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000001533 UniProtKB/Swiss-Prot
  ENSSSCT00000067500.1 UniProtKB/TrEMBL
  ENSSSCT00000104535 ENTREZGENE
  ENSSSCT00005051419 UniProtKB/Swiss-Prot
  ENSSSCT00015077176 UniProtKB/Swiss-Prot
  ENSSSCT00025108213 UniProtKB/Swiss-Prot
  ENSSSCT00030091837 UniProtKB/Swiss-Prot
  ENSSSCT00035025057 UniProtKB/Swiss-Prot
  ENSSSCT00035025067.1 UniProtKB/TrEMBL
  ENSSSCT00040097071 UniProtKB/Swiss-Prot
  ENSSSCT00045065761 UniProtKB/Swiss-Prot
  ENSSSCT00050008020 UniProtKB/Swiss-Prot
  ENSSSCT00055057060 UniProtKB/Swiss-Prot
  ENSSSCT00060058688 UniProtKB/Swiss-Prot
  ENSSSCT00065034958 UniProtKB/Swiss-Prot
  ENSSSCT00065034964.1 UniProtKB/TrEMBL
  ENSSSCT00070048157 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397086 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene TNF ENTREZGENE
PANTHER PTHR11471:SF23 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TNECROSISFCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TNF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5G2QEW4_PIG UniProtKB/TrEMBL
  A0A8D0Z2F8_PIG UniProtKB/TrEMBL
  A5D9N8 ENTREZGENE
  B3GDZ6 ENTREZGENE, UniProtKB/TrEMBL
  P23563 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A5D9N8 UniProtKB/Swiss-Prot
VGNC ID VGNC:94249 ENTREZGENE