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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14181661
Species: Sus scrofa
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of TNF mRNA; Lipopolysaccharides results in increased expression of TNF proteinPMID:21948611 PMID:26180592 PMID:27861533 PMID:28528741 PMID:32877744 PMID:9185964
TNFincreases secretionEXP 6480464CTDLipopolysaccharides results in increased secretion of TNF proteinPMID:12406900
TNFmultiple interactionsEXP 6480464CTD3',4',5'-trimethoxyflavone analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; [deoxynivalenol co-treated with Lipopolysaccharides co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with Lipopolysaccharides co-treated with fumonisin B1] results in increased expression of TNF protein; [laminaran co-treated with fucoidan co-treated with Minerals] promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; GH1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; MAP1LC3B protein affects the reaction [deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; picolinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]PMID:21948611 PMID:26180592 PMID:27861533 PMID:28528741 PMID:30708112 PMID:32877744 PMID:9185964
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