RGD Reference Report - Tumor necrosis factor-alpha-mediated severity of idiopathic retinal periphlebitis in young adults (Eales' disease): implication for anti-TNF-alpha therapy. - Rat Genome Database

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Tumor necrosis factor-alpha-mediated severity of idiopathic retinal periphlebitis in young adults (Eales' disease): implication for anti-TNF-alpha therapy.

Authors: Saxena, S  Pant, AB  Khanna, VK  Singh, K  Shukla, RK  Meyer, CH  Singh, VK 
Citation: Saxena S, etal., J Ocul Biol Dis Infor. 2010 Jul 16;3(1):35-8. doi: 10.1007/s12177-010-9053-3.
RGD ID: 7387277
Pubmed: PMID:21139707   (View Abstract at PubMed)
PMCID: PMC2956454   (View Article at PubMed Central)
DOI: DOI:10.1007/s12177-010-9053-3   (Journal Full-text)

Tumor necrosis factor-alpha (TNF-alpha) is a pleiotropic inflammatory cytokine. Tumor necrosis factor-alpha was evaluated in the serum samples of patients with idiopathic retinal periphlebitis in young adults (Eales' disease). Retinal periphlebitis was graded according to a new grading system based on severity of inflammation (grade 1-4). Quantification of the TNF-alpha levels was carried out using ELISA kit in the serum samples of young adults with idiopathic retinal periphlebitis (n = 17) and healthy controls (n = 17) of similar age. Tumor necrosis factor-alpha level was found to be significantly raised in cases with retinal periphlebitis as compared with controls (p < 0.001). Higher levels of TNF-alpha were found to be associated with increased severity of retinal periphlebitis. Tumor necrosis factor-alpha represents a novel target for controlling inflammatory activity in idiopathic retinal periphlebitis. Higher levels of TNF-alpha, in association with the increased severity of retinal periphlebitis, have implications for early anti-TNF-alpha therapy.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
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Original Reference(s)
TNFHumanEales Disease severityIEP protein:increased expression:serum:RGD 
TnfRatEales Disease severityISOTNF (Homo sapiens)protein:increased expression:serum:RGD 
TnfMouseEales Disease severityISOTNF (Homo sapiens)protein:increased expression:serum:RGD 


Genes (Rattus norvegicus)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
TNF  (tumor necrosis factor)