RGD Reference Report - The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. - Rat Genome Database

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The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α.

Authors: Zhu, Shu  Pan, Wen  Song, Xinyang  Liu, Yan  Shao, Xinrui  Tang, Yuanjia  Liang, Dong  He, Dongyi  Wang, Honglin  Liu, Wenjun  Shi, Yufang  Harley, John B  Shen, Nan  Qian, Youcun 
Citation: Zhu S, etal., Nat Med. 2012 Jul;18(7):1077-86. doi: 10.1038/nm.2815.
RGD ID: 155663483
Pubmed: PMID:22660635   (View Abstract at PubMed)
DOI: DOI:10.1038/nm.2815   (Journal Full-text)

Inflammatory cytokines such as interleukin-17 (IL-17) promote inflammatory autoimmune diseases. Although several microRNAs (miRNAs) have been shown to regulate autoimmune pathogenesis by affecting lymphocyte development and function, the role of miRNAs in resident cells present in inflammatory lesions remains unclear. Here we show that miR-23b is downregulated in inflammatory lesions of humans with lupus or rheumatoid arthritis, as well as in the mouse models of lupus, rheumatoid arthritis or multiple sclerosis. IL-17 downregulates miR-23b expression in human fibroblast-like synoviocytes, mouse primary kidney cells and astrocytes and is essential for the downregulation of miR-23b during autoimmune pathogenesis. In turn, miR-23b suppresses IL-17-, tumor necrosis factor α (TNF-α)- or IL-1β-induced NF-κB activation and inflammatory cytokine expression by targeting TGF-β-activated kinase 1/MAP3K7 binding protein 2 (TAB2), TAB3 and inhibitor of nuclear factor κ-B kinase subunit α (IKK-α) and, consequently, represses autoimmune inflammation. Thus, IL-17 contributes to autoimmune pathogenesis by suppressing miR-23b expression in radio-resident cells and promoting proinflammatory cytokine expression.



1 to 20 of 69 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
MIR146AHumanExperimental Arthritis  ISOMir146 (Mus musculus)mRNA:increased expression:joints (mouse)RGD 
MIR23BHumanExperimental Arthritis  ISOMir23b (Mus musculus)mRNA:decreased expression:joint (mouse)RGD 
Mir146MouseExperimental Arthritis  IEP mRNA:increased expression:joints (mouse)RGD 
Mir146aRatExperimental Arthritis  ISOMir146 (Mus musculus)mRNA:increased expression:joints (mouse)RGD 
Mir23bRatExperimental Arthritis  ISOMir23b (Mus musculus)mRNA:decreased expression:joint (mouse)RGD 
Mir23bMouseExperimental Arthritis  IEP mRNA:decreased expression:joint (mouse)RGD 
Mir23bMouseExperimental Arthritis treatmentIMP  RGD 
MIR146AHumanExperimental Autoimmune Encephalomyelitis  ISOMir146 (Mus musculus)mRNA:increased expression:spinal cord (mouse)RGD 
MIR23BHumanExperimental Autoimmune Encephalomyelitis  ISOMir23b (Mus musculus)mRNA:decreased expression:spinal cord (mouse)RGD 
Mir146MouseExperimental Autoimmune Encephalomyelitis  IEP mRNA:increased expression:spinal cord (mouse)RGD 
Mir146aRatExperimental Autoimmune Encephalomyelitis  ISOMir146 (Mus musculus)mRNA:increased expression:spinal cord (mouse)RGD 
Mir23bRatExperimental Autoimmune Encephalomyelitis  ISOMir23b (Mus musculus)mRNA:decreased expression:spinal cord (mouse)RGD 
Mir23bMouseExperimental Autoimmune Encephalomyelitis  IEP mRNA:decreased expression:spinal cord (mouse)RGD 
Mir23bMouseExperimental Autoimmune Encephalomyelitis treatmentIMP  RGD 
IFNGHumanrheumatoid arthritis  IEP mRNA:increased expression:synovial (human)RGD 
IL17AHumanrheumatoid arthritis  IEP mRNA:increased expression:synovial (human)RGD 
IL1BHumanrheumatoid arthritis  IEP mRNA:increased expression:synovial (human)RGD 
IfngRatrheumatoid arthritis  ISOIFNG (Homo sapiens)mRNA:increased expression:synovial (human)RGD 
IfngMouserheumatoid arthritis  ISOIFNG (Homo sapiens)mRNA:increased expression:synovial (human)RGD 
Il17aRatrheumatoid arthritis  ISOIL17A (Homo sapiens)mRNA:increased expression:synovial (human)RGD 
1 to 20 of 69 rows


Genes (Rattus norvegicus)
Ifng  (interferon gamma) Il17a  (interleukin 17A) Il1b  (interleukin 1 beta)
Mir146a  (microRNA 146a) Mir23b  (microRNA 23b) Tab2  (TGF-beta activated kinase 1/MAP3K7 binding protein 2)
Tab3  (TGF-beta activated kinase 1 (MAP3K7) binding protein 3) Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Ifng  (interferon gamma) Il17a  (interleukin 17A) Il1b  (interleukin 1 beta)
Mir146  (microRNA 146) Mir23b  (microRNA 23b) Tab2  (TGF-beta activated kinase 1/MAP3K7 binding protein 2)
Tab3  (TGF-beta activated kinase 1/MAP3K7 binding protein 3) Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
IFNG  (interferon gamma) IL17A  (interleukin 17A) IL1B  (interleukin 1 beta)
MIR146A  (microRNA 146a) MIR23B  (microRNA 23b) TAB2  (TGF-beta activated kinase 1 (MAP3K7) binding protein 2)
TAB3  (TGF-beta activated kinase 1 (MAP3K7) binding protein 3) TNF  (tumor necrosis factor)