Il17a (interleukin 17A) - Rat Genome Database

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Gene: Il17a (interleukin 17A) Rattus norvegicus
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Symbol: Il17a
Name: interleukin 17A
RGD ID: 2888
Description: Predicted to enable cytokine activity; protein heterodimerization activity; and protein homodimerization activity. Involved in cellular response to glucocorticoid stimulus; positive regulation of transcription by RNA polymerase II; and response to amino acid. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; congestive heart failure; myocarditis; pleurisy; and uveitis. Biomarker of several diseases, including acute necrotizing pancreatitis; inflammatory bowel disease (multiple); lung disease (multiple); myocardial infarction (multiple); and periodontal disease (multiple). Human ortholog(s) of this gene implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); macular degeneration; and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A); PARTICIPATES IN interleukin-23 signaling pathway; interleukin-27 signaling pathway; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 2,4,6-trinitrobenzenesulfonic acid; 7,12-dimethyltetraphene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; hypothetical protein LOC301289; IL-17; IL-17A; Il17; interleukin 17; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin-17A; LOC301289; similar to Interleukin-17 precursor (IL-17) (Cytotoxic T lymphocyte-associated antigen 8) (CTLA-8)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8930,640,844 - 30,644,331 (+)NCBIGRCr8
mRatBN7.2923,144,402 - 23,147,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,144,402 - 23,147,889 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx931,641,574 - 31,645,060 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0936,762,293 - 36,765,779 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,077,566 - 35,081,052 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0926,841,299 - 26,844,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl926,841,299 - 26,844,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0925,696,865 - 25,700,352 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4919,454,979 - 19,458,467 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1919,453,469 - 19,455,797 (+)NCBI
Celera920,720,899 - 20,724,386 (+)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
Acute Lung Injury  (ISO)
acute myocardial infarction  (IEP)
acute necrotizing pancreatitis  (IEP)
Acute Otitis Media  (IEP)
acute promyelocytic leukemia  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Animal Toxoplasmosis  (ISO)
ankylosing spondylitis  (ISO)
anti-basement membrane glomerulonephritis  (IDA)
Arterial Thrombosis  (ISO)
asthma  (IEP,ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autoimmune disease  (ISO)
autoimmune thyroiditis  (ISO)
Bacteremia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
brain ischemia  (IEP,ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis  (ISO)
bronchiolitis obliterans  (ISO)
cardiovascular system disease  (ISO)
central nervous system disease  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chemically-Induced Disorders  (ISO)
chlamydia  (ISO)
chronic obstructive pulmonary disease  (IEP,ISO)
Chronic Rhinosinusitis  (ISO)
colitis  (IEP,ISO)
congestive heart failure  (IEP,IMP)
corneal neovascularization  (ISO)
COVID-19  (ISO)
Cryopyrin-Associated Periodic Syndromes  (ISO)
cutaneous leishmaniasis  (ISO)
cutaneous lupus erythematosus  (ISO)
cystic fibrosis  (ISO)
Delayed Hypersensitivity  (IMP)
Discoid Lupus Erythematosus  (ISO)
Drug Eruptions  (ISO)
Emphysema  (ISO)
Experimental Arthritis  (IDA,IEP,IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (IDA,IEP,ISO)
Experimental Autoimmune Neuritis  (IEP,ISO)
Experimental Autoimmune Uveitis  (IDA,IEP,IMP)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (IEP,ISO)
extrinsic allergic alveolitis  (ISO)
graft-versus-host disease  (ISO)
Gram-Negative Bacterial Infections  (ISO)
Graves' disease  (ISO)
histoplasmosis  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (IDA,IMP)
hypertension  (ISO)
Ige Responsiveness, Atopic  (ISO)
ileitis  (IEP)
Inflammation  (ISO)
invasive aspergillosis  (ISO)
kidney disease  (ISO)
leprosy  (ISO)
lipoid nephrosis  (IEP)
lupus nephritis  (ISO)
lymphoproliferative syndrome  (ISO)
macular degeneration  (ISO)
MPTP Poisoning  (ISO)
multiple sclerosis  (ISO)
Mycobacterium avium complex disease  (ISO)
myocardial infarction  (IEP)
Myocardial Reperfusion Injury  (IMP)
myocarditis  (IDA)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Ocular Toxoplasmosis  (ISO)
otitis media  (ISO)
Perennial Allergic Rhinitis  (ISO)
periapical periodontitis  (IEP)
periodontal disease  (IEP)
plague  (IEP)
pleurisy  (IDA)
Pneumococcal Infections  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (IEP,ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
Sepsis  (IMP)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
Spondylarthritis  (IEP)
Staphylococcal Skin Infections  (ISO)
Streptococcal Infections  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
trachoma  (ISO)
Transplant Rejection  (IEP,IMP,ISO)
tularemia  (ISO)
uveitis  (IMP,ISO)
Viral Bronchiolitis  (ISO)
Viral Myocarditis  (ISO)
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (ISO)
(Z)-ligustilide  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
alloxan  (ISO)
alpha-galactosylceramide  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antigen  (ISO)
apilimod  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
Bardoxolone methyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
budesonide  (ISO)
cadmium atom  (EXP,ISO)
calciol  (ISO)
cannabidiol  (ISO)
carbamazepine  (EXP)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chrysin  (ISO)
corosolic acid  (ISO)
cortisol  (ISO)
curcumin  (ISO)
cyanidin cation  (ISO)
cycloastragenol  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP,ISO)
digoxigenin  (ISO)
dihydroouabain  (ISO)
diiodine  (EXP,ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
doxorubicin  (EXP)
enilconazole  (ISO)
ethanol  (ISO)
ferric oxide  (ISO)
ferulic acid  (ISO)
flucloxacillin  (ISO)
fluorescein 5-isothiocyanate  (ISO)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
fragrance  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
geraniol  (ISO)
glucose  (ISO)
glyburide  (EXP)
gossypin  (EXP)
halothane  (ISO)
hexaconazole  (ISO)
hydroquinone  (EXP)
hydroxysafflor yellow A  (ISO)
imiquimod  (ISO)
indometacin  (EXP)
ionomycin  (ISO)
irinotecan  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP)
lead(0)  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
levamisole  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (EXP)
LY294002  (ISO)
maslinic acid  (ISO)
melatonin  (ISO)
mercury dichloride  (ISO)
mesalamine  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methyl salicylate  (ISO)
methylene blue  (EXP)
methylmercury chloride  (EXP)
Methysticin  (ISO)
metyrapone  (EXP)
mevalonic acid  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
ML-7  (ISO)
morin  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
paroxetine  (ISO)
pentachlorophenol  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosmet  (ISO)
phytoestrogen  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
prednisolone  (ISO)
procymidone  (ISO)
progesterone  (ISO)
propionic acid  (ISO)
pyrrolidine dithiocarbamate  (ISO)
pyrvinium  (EXP)
resveratrol  (ISO)
Rhein  (ISO)
rosmarinic acid  (ISO)
ruxolitinib  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
SB-239063  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium taurocholate  (EXP)
streptozocin  (EXP)
strophanthidin  (ISO)
sulfasalazine  (EXP)
sulfur dioxide  (ISO)
tamibarotene  (ISO)
tetrachloromethane  (ISO)
tetraconazole  (ISO)
thymoquinone  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
tributyrin  (ISO)
trichloroethene  (ISO)
triflumizole  (ISO)
Triptolide  (ISO)
Tryptanthrine  (ISO)
vitamin K  (EXP)
wogonin  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
cellular response to glucocorticoid stimulus  (IMP)
cellular response to interleukin-1  (IEA,ISO)
defense response to fungus  (IEA,ISO)
defense response to Gram-negative bacterium  (IEA,ISO)
defense response to Gram-positive bacterium  (IEA,ISO)
fibroblast activation  (IEA,ISO)
gene expression  (IEA,ISO)
granulocyte migration  (IEA,ISO)
inflammatory response  (IEA)
innate immune response  (IEA)
interleukin-17-mediated signaling pathway  (IEA,ISO)
interleukin-17A-mediated signaling pathway  (IEA,ISO)
intestinal epithelial structure maintenance  (IEA,ISO)
keratinocyte differentiation  (IEA,ISO)
keratinocyte proliferation  (IEA,ISO)
negative regulation of inflammatory response to wounding  (IEA,ISO)
Notch signaling pathway  (IEA,ISO)
positive regulation of antimicrobial peptide production  (IEA,ISO)
positive regulation of bicellular tight junction assembly  (IEA,ISO)
positive regulation of cellular process  (IDA)
positive regulation of chemokine (C-X-C motif) ligand 1 production  (IEA,ISO)
positive regulation of cytokine production involved in inflammatory response  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of interleukin-16 production  (IEA,ISO)
positive regulation of interleukin-23 production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of osteoclast differentiation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
response to amino acid  (IEP)
response to wounding  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis. Adamopoulos IE, etal., Ann Rheum Dis. 2014 Feb 23. doi: 10.1136/annrheumdis-2013-204782.
2. Propionibacterium acnes Induces an IL-17 Response in Acne Vulgaris that Is Regulated by Vitamin A and Vitamin D. Agak GW, etal., J Invest Dermatol. 2014 Feb;134(2):366-73. doi: 10.1038/jid.2013.334. Epub 2013 Aug 7.
3. Proteomic analysis indicates altered expression of plasma proteins in a rat nephropathy model. Ai S, etal., Clin Exp Nephrol. 2013 Feb;17(1):24-31. doi: 10.1007/s10157-012-0662-y. Epub 2012 Jul 7.
4. IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction. Avalos AM, etal., Biol Res. 2012;45(2):193-200. doi: 10.4067/S0716-97602012000200012.
5. Interleukin-17A expression in patients presenting with nasal polyposis. Avelino MA, etal., Braz J Otorhinolaryngol. 2013 Sep-Oct;79(5):616-9. doi: 10.5935/1808-8694.20130110.
6. Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial. Baeten D, etal., Lancet. 2013 Nov 23;382(9906):1705-13. doi: 10.1016/S0140-6736(13)61134-4. Epub 2013 Sep 13.
7. IL-17/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function. Bai H, etal., J Immunol. 2009 Nov 1;183(9):5886-95. Epub 2009 Oct 7.
8. Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Barczyk A, etal., Respir Med. 2003 Jun;97(6):726-33.
9. Enhanced IL-17 signalling following myocardial ischaemia/reperfusion injury. Barry SP, etal., Int J Cardiol. 2013 Mar 10;163(3):326-34. doi: 10.1016/j.ijcard.2011.08.849. Epub 2011 Oct 24.
10. IL-17 producing gammadelta T cells are required for a controlled inflammatory response after bleomycin-induced lung injury. Braun RK, etal., Inflammation. 2008 Jun;31(3):167-79. Epub 2008 Mar 13.
11. Raised interleukin-17 is immuno-localised to neutrophils in cystic fibrosis lung disease. Brodlie M, etal., Eur Respir J. 2010 Nov 25.
12. Active trachoma is associated with increased conjunctival expression of IL17A and profibrotic cytokines. Burton MJ, etal., Infect Immun. 2011 Dec;79(12):4977-83. doi: 10.1128/IAI.05718-11. Epub 2011 Sep 12.
13. Alteration of IL-17 related protein expressions in experimental autoimmune myocarditis and inhibition of IL-17 by IL-10-Ig fusion gene transfer. Chang H, etal., Circ J. 2008 May;72(5):813-9.
14. Anti-IL-17A therapy protects against bone erosion in experimental models of rheumatoid arthritis. Chao CC, etal., Autoimmunity. 2010 Oct 7.
15. The polymorphism of IL-17 G-152A was associated with childhood asthma and bacterial colonization of the hypopharynx in bronchiolitis. Chen J, etal., J Clin Immunol. 2010 Jul;30(4):539-45. Epub 2010 May 2.
16. Decreasing TNF-alpha results in less fibrosis and earlier resolution of granulomatous experimental autoimmune thyroiditis. Chen K, etal., J Leukoc Biol. 2007 Jan;81(1):306-14. Epub 2006 Oct 17.
17. Inhibition of IL-17A in atherosclerosis. Cheng X, etal., Atherosclerosis. 2011 Apr;215(2):471-4. doi: 10.1016/j.atherosclerosis.2010.12.034. Epub 2011 Jan 19.
18. Role of group 3 innate lymphoid cells during experimental otitis media in a rat model. Cho CG, etal., Int J Pediatr Otorhinolaryngol. 2016 Sep;88:146-52. doi: 10.1016/j.ijporl.2016.07.001. Epub 2016 Jul 6.
19. The nature of innate and adaptive interleukin-17A responses in sham or bacterial inoculation. Chong DL, etal., Immunology. 2012 Jul;136(3):325-33. doi: 10.1111/j.1365-2567.2012.03584.x.
20. Transcriptomic and Innate Immune Responses to Yersinia pestis in the Lymph Node during Bubonic Plague. Comer JE, etal., Infect Immun. 2010 Dec;78(12):5086-5098. Epub 2010 Sep 27.
21. Critical role of IL-17RA in immunopathology of influenza infection. Crowe CR, etal., J Immunol. 2009 Oct 15;183(8):5301-10. Epub 2009 Sep 25.
22. Decreased RNA expression of interleukin 17A in skin of leprosy. da Motta-Passos I, etal., Eur J Dermatol. 2012 Jul-Aug;22(4):488-94. doi: 10.1684/ejd.2012.1741.
23. Interleukins 17 and 23 influence the host response to Histoplasma capsulatum. Deepe GS Jr and Gibbons RS, J Infect Dis. 2009 Jul 1;200(1):142-51. doi: 10.1086/599333.
24. T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. Di Stefano A, etal., Clin Exp Immunol. 2009 Aug;157(2):316-24.
25. Regulatory T cell activity is partly inhibited in a mouse model of chronic Pseudomonas aeruginosa lung infection. Ding FM, etal., Exp Lung Res. 2015 Feb;41(1):44-55. doi: 10.3109/01902148.2014.964351. Epub 2014 Nov 14.
26. [The expression of interleukin-17 in blood and nasal tissue of patients with allergic rhinltis and nasal polyps] Du JT, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 Mar;41(2):235-8.
27. Effect of systemic inflammation on inspiratory and limb muscle strength and bulk in cystic fibrosis. Dufresne V, etal., Am J Respir Crit Care Med. 2009 Jul 15;180(2):153-8. Epub 2009 Apr 2.
28. Increased IL-17A expression in temporal artery lesions is a predictor of sustained response to glucocorticoid treatment in patients with giant-cell arteritis. Espigol-Frigole G, etal., Ann Rheum Dis. 2013 Sep 1;72(9):1481-7. doi: 10.1136/annrheumdis-2012-201836. Epub 2012 Sep 19.
29. Amelioration of experimental autoimmune uveitis by leflunomide in Lewis rats. Fang CB, etal., PLoS One. 2013 Apr 23;8(4):e62071. doi: 10.1371/journal.pone.0062071. Print 2013.
30. IL-22 mRNA in peripheral blood mononuclear cells from allergic rhinitic and asthmatic pediatric patients. Farfariello V, etal., Pediatr Allergy Immunol. 2011 Jun;22(4):419-23. doi: 10.1111/j.1399-3038.2010.01116.x.
31. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, etal., PLoS One. 2018 Oct 22;13(10):e0206130. doi: 10.1371/journal.pone.0206130. eCollection 2018.
32. The study of ISO induced heart failure rat model. Feng W and Li W, Exp Mol Pathol. 2010 Apr;88(2):299-304. Epub 2009 Nov 10.
33. IL-17 induces myocardial fibrosis and enhances RANKL/OPG and MMP/TIMP signaling in isoproterenol-induced heart failure. Feng W, etal., Exp Mol Pathol. 2009 Dec;87(3):212-8. Epub 2009 Jun 13.
34. Proinflammatory Th17 cells are expanded and induced by dendritic cells in spondylarthritis-prone HLA-B27-transgenic rats. Glatigny S, etal., Arthritis Rheum. 2012 Jan;64(1):110-20. doi: 10.1002/art.33321.
35. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
36. Interleukin-17 promotes early allograft inflammation. Gorbacheva V, etal., Am J Pathol. 2010 Sep;177(3):1265-73. doi: 10.2353/ajpath.2010.091106. Epub 2010 Jul 22.
37. Clinical aspects and cytokine response in severe H1N1 influenza A virus infection. Hagau N, etal., Crit Care. 2010;14(6):R203. Epub 2010 Nov 9.
38. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. Hamada H, etal., J Immunol. 2009 Mar 15;182(6):3469-81.
39. Expression of Th-17 and RORgammat mRNA in Behcet's Disease. Hamzaoui K, etal., Med Sci Monit. 2011 Apr;17(4):CR227-34.
40. Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease. Horvat JC, etal., J Immunol. 2010 Apr 15;184(8):4159-69. Epub 2010 Mar 12.
41. Methotrexate ameliorates pristane-induced arthritis by decreasing IFN-gamma and IL-17A expressions. Hou WK, etal., J Zhejiang Univ Sci B. 2011 Jan;12(1):40-6. doi: 10.1631/jzus.B1000078.
42. Neuroprotection effect of interleukin (IL)-17 secreted by reactive astrocytes is emerged from a high-level IL-17-containing environment during acute neuroinflammation. Hu MH, etal., Clin Exp Immunol. 2014 Feb;175(2):268-84. doi: 10.1111/cei.12219.
43. Interleukin-17A expression in patients with chronic rhinosinusitis and its relationship with clinical features. Hu XD, etal., J Int Med Res. 2013 Jun;41(3):777-84. doi: 10.1177/0300060513478089. Epub 2013 Apr 18.
44. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
45. [IL-17A promotes pulmonary inflammation in rats with pulmonary fibrosis induced by bleomycin]. Huang C, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Apr;30(4):366-70.
46. Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis. Hueber W, etal., Sci Transl Med. 2010 Oct 6;2(52):52ra72. doi: 10.1126/scitranslmed.3001107.
47. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. Janssen R, etal., J Infect Dis. 2007 Sep 15;196(6):826-34. Epub 2007 Aug 10.
48. Coordinated gene expression of Th17- and Treg-associated molecules correlated with resolution of the monophasic experimental autoimmune uveitis. Jia X, etal., Mol Vis. 2011;17:1493-507. Epub 2011 Jun 7.
49. Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation. Johnston A, etal., J Immunol. 2013 Mar 1;190(5):2252-62. doi: 10.4049/jimmunol.1201505. Epub 2013 Jan 28.
50. Interleukin-17-mediated immunopathogenesis in experimental hypersensitivity pneumonitis. Joshi AD, etal., Am J Respir Crit Care Med. 2009 Apr 15;179(8):705-16. Epub 2009 Jan 16.
51. Circulatory levels of T-cell cytokines (interleukin -2, IL-4, IL-17, and transforming growth factor-beta) in patients with vitiligo. Khan R, etal., J Am Acad Dermatol. 2012 Mar;66(3):510-1. doi: 10.1016/j.jaad.2011.07.018.
52. Possible pathogenic role of Th17 cells for atopic dermatitis. Koga C, etal., J Invest Dermatol. 2008 Nov;128(11):2625-30. doi: 10.1038/jid.2008.111. Epub 2008 Apr 24.
53. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. Komiyama Y, etal., J Immunol. 2006 Jul 1;177(1):566-73.
54. Impaired immune response in severe human lower tract respiratory infection by respiratory syncytial virus. Larranaga CL, etal., Pediatr Infect Dis J. 2009 Oct;28(10):867-73.
55. Role of IL-1 beta in the development of human T(H)17 cells: lesson from NLPR3 mutated patients. Lasiglie D, etal., PLoS One. 2011;6(5):e20014. doi: 10.1371/journal.pone.0020014. Epub 2011 May 26.
56. Expression of interleukin-17 in ischemic brain tissue. Li GZ, etal., Scand J Immunol. 2005 Nov;62(5):481-6.
57. Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency. Lim A, etal., Clin Immunol. 2010 Nov;137(2):296-302. Epub 2010 Aug 24.
58. Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration. Liu B, etal., J Transl Med. 2011 Jul 15;9:1-12. doi: 10.1186/1479-5876-9-111.
59. Forkhead box P3(+) T cells express interleukin-17 in nasal mucosa of patients with both allergic rhinitis and polyposis. Liu T, etal., Clin Exp Immunol. 2010 Nov 22. doi: 10.1111/j.1365-2249.2010.04278.x.
60. IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis. Lo Re S, etal., J Immunol. 2010 Jun 1;184(11):6367-77. Epub 2010 Apr 26.
61. Bovine glycomacropeptide has intestinal antiinflammatory effects in rats with dextran sulfate-induced colitis. Lopez-Posadas R, etal., J Nutr. 2010 Nov;140(11):2014-9. Epub 2010 Sep 29.
62. Morphine disrupts interleukin-23 (IL-23)/IL-17-mediated pulmonary mucosal host defense against Streptococcus pneumoniae infection. Ma J, etal., Infect Immun. 2010 Feb;78(2):830-7. Epub 2009 Dec 7.
63. Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid Artery. Maione F, etal., Int J Inflam. 2014;2014:247503. doi: 10.1155/2014/247503. Epub 2014 Apr 3.
64. The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis. Markel G, etal., PLoS One. 2010 Jun 18;5(6):e11176.
65. Strain difference in susceptibility to experimental autoimmune encephalomyelitis in rats correlates with T(H)1 and T(H)17-inducing cytokine profiles. Markovic M, etal., Mol Immunol. 2009 Nov;47(1):141-6. Epub 2009 Feb 23.
66. Influence of the IL17A locus in giant cell arteritis susceptibility. Marquez A, etal., Ann Rheum Dis. 2014 Sep;73(9):1742-5. doi: 10.1136/annrheumdis-2014-205261. Epub 2014 Jun 11.
67. Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial. McInnes IB, etal., Ann Rheum Dis. 2014 Feb;73(2):349-56. doi: 10.1136/annrheumdis-2012-202646. Epub 2013 Jan 29.
68. Spinal interleukin-17 promotes thermal hyperalgesia and NMDA NR1 phosphorylation in an inflammatory pain rat model. Meng X, etal., Pain. 2013 Feb;154(2):294-305. doi: 10.1016/j.pain.2012.10.022. Epub 2012 Nov 5.
69. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
70. Methylprednisolone inhibits IFN-gamma and IL-17 expression and production by cells infiltrating central nervous system in experimental autoimmune encephalomyelitis. Miljkovic Z, etal., J Neuroinflammation. 2009 Dec 11;6:37.
71. Protective immunity against recurrent Staphylococcus aureus skin infection requires antibody and interleukin-17A. Montgomery CP, etal., Infect Immun. 2014 May;82(5):2125-34. doi: 10.1128/IAI.01491-14. Epub 2014 Mar 10.
72. Resolution of allergic airway inflammation and airway hyperreactivity is mediated by IL-17-producing {gamma}{delta}T cells. Murdoch JR and Lloyd CM, Am J Respir Crit Care Med. 2010 Aug 15;182(4):464-76. Epub 2010 Apr 22.
73. Increased Th17 functions are accompanied by Tregs activities in lupoid leishmaniasis. Nabavi NS, etal., Parasite Immunol. 2018 Jan;40(1). doi: 10.1111/pim.12507. Epub 2017 Dec 17.
74. Local IL-17 production and a decrease in peripheral blood regulatory T cells in an animal model of bronchiolitis obliterans. Nakagiri T, etal., Transplantation. 2010 Jun 15;89(11):1312-9.
75. Pathogenic effect of interleukin-17A in induction of Sjogren's syndrome-like disease using adenovirus-mediated gene transfer. Nguyen CQ, etal., Arthritis Res Ther. 2010;12(6):R220. doi: 10.1186/ar3207. Epub 2010 Dec 23.
76. Involvement of interleukin-17A in pancreatic damage in rat experimental acute necrotizing pancreatitis. Ni J, etal., Inflammation. 2013 Feb;36(1):53-65. doi: 10.1007/s10753-012-9519-5.
77. Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Ogawa A, etal., Clin Immunol. 2004 Jan;110(1):55-62.
78. Potential roles of interleukin-17A in the development of skin fibrosis in mice. Okamoto Y, etal., Arthritis Rheum. 2012 Nov;64(11):3726-35. doi: 10.1002/art.34643.
79. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Park H, etal., Nat Immunol. 2005 Nov;6(11):1133-41. Epub 2005 Oct 2.
80. Phosphoinositide 3-kinase {delta} inhibitor suppresses IL-17 expression in a murine asthma model. Park SJ, etal., Eur Respir J. 2010 Mar 29.
81. Enhancement of acute phase and inhibition of chronic phase of experimental autoimmune neuritis in Lewis rats by intranasal administration of recombinant mouse interleukin 17: potential immunoregulatory role. Pelidou SH, etal., Exp Neurol. 2000 May;163(1):165-72.
82. IL-17 is a critical component of vaccine-induced protection against lung infection by lipopolysaccharide-heterologous strains of Pseudomonas aeruginosa. Priebe GP, etal., J Immunol. 2008 Oct 1;181(7):4965-75.
83. Effect of simvastatin on expression of IL17, HMGB1 and TLR4 in LN kidney tissues of rats. Qin Y, etal., Asian Pac J Trop Med. 2014 Oct;7(10):792-5. doi: 10.1016/S1995-7645(14)60138-3.
84. Application quantitative proteomics approach to identify differentially expressed proteins associated with cardiac protection mediated by cycloastragenol in acute myocardial infarction rats. Ren YS, etal., J Proteomics. 2020 Jun 30;222:103691. doi: 10.1016/j.jprot.2020.103691. Epub 2020 Feb 14.
85. Bovine glycomacropeptide ameliorates experimental rat ileitis by mechanisms involving downregulation of interleukin 17. Requena P, etal., Br J Pharmacol. 2008 Jun;154(4):825-32. Epub 2008 Apr 21.
86. GOA pipeline RGD automated data pipeline
87. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
88. Comprehensive gene review and curation RGD comprehensive gene curation
89. CpG oligodeoxynucleotide protection in polymicrobial sepsis is dependent on interleukin-17. Rice L, etal., J Infect Dis. 2005 Apr 15;191(8):1368-76. Epub 2005 Mar 3.
90. Interleukin-17 sensitizes joint nociceptors to mechanical stimuli and contributes to arthritic pain through neuronal interleukin-17 receptors in rodents. Richter F, etal., Arthritis Rheum. 2012 Dec;64(12):4125-34. doi: 10.1002/art.37695.
91. IL-23-mediated psoriasis-like epidermal hyperplasia is dependent on IL-17A. Rizzo HL, etal., J Immunol. 2011 Feb 1;186(3):1495-502. doi: 10.4049/jimmunol.1001001. Epub 2010 Dec 20.
92. Systemic neutralization of IL-17A significantly reduces breast cancer associated metastasis in arthritic mice by reducing CXCL12/SDF-1 expression in the metastatic niches. Roy LD, etal., BMC Cancer. 2014 Mar 27;14:225. doi: 10.1186/1471-2407-14-225.
93. Role of interleukin-17A in the eosinophil accumulation and mucosal remodeling in chronic rhinosinusitis with nasal polyps associated with asthma. Saitoh T, etal., Int Arch Allergy Immunol. 2010;151(1):8-16. Epub 2009 Aug 6.
94. Interleukin 17A as an effective target for anti-inflammatory and antiparasitic treatment of toxoplasmic uveitis. Sauer A, etal., J Infect Dis. 2012 Oct;206(8):1319-29. Epub 2012 Aug 22.
95. Interleukin 17 and RANTES levels in induced sputum of patients with allergic rhinitis after a single nasal allergen challenge. Semik-Orzech A, etal., Ann Allergy Asthma Immunol. 2009 Nov;103(5):418-24.
96. [The changes and significance of interleukin-17 in rat models of chronic obstructive pulmonary disease and asthma]. Shen F, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2004 Oct;27(10):654-8.
97. [The levels and clinical implications of induced sputum interleukin-17 in chronic obstructive pulmonary disease and asthma] Shen F, etal., Zhonghua Nei Ke Za Zhi. 2004 Dec;43(12):888-90.
98. Elevated levels of interleukin-27 and effect on production of interferon-gamma and interleukin-17 in patients with Behcet's disease. Shen H, etal., Scand J Rheumatol. 2013;42(1):48-51. doi: 10.3109/03009742.2012.704391. Epub 2012 Oct 26.
99. Sequential IL-23 and IL-17 and increased Mmp8 and Mmp14 expression characterize the progression of an experimental model of periodontal disease in type 1 diabetes. Silva JA, etal., J Cell Physiol. 2012 Jun;227(6):2441-50. doi: 10.1002/jcp.22979.
100. IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma. Song C, etal., J Immunol. 2008 Nov 1;181(9):6117-24.
101. BF02, a recombinant TNFR2 fusion protein, alleviates adjuvant arthritis by regulating T lymphocytes in rats. Song SS, etal., Acta Pharmacol Sin. 2013 Mar;34(3):414-23. doi: 10.1038/aps.2012.171. Epub 2013 Feb 4.
102. Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A. Sonnenberg GF, etal., J Exp Med. 2010 Jun 7;207(6):1293-305. Epub 2010 May 24.
103. A comparison of the effects of topical treatment of calcipotriol, camptothecin, clobetasol and tazarotene on an imiquimod-induced psoriasis-like mouse model. Sun J, etal., Immunopharmacol Immunotoxicol. 2014 Feb;36(1):17-24. doi: 10.3109/08923973.2013.862542. Epub 2013 Nov 29.
104. IL-17A differentially regulates corneal vascular endothelial growth factor (VEGF)-A and soluble VEGF receptor 1 expression and promotes corneal angiogenesis after herpes simplex virus infection. Suryawanshi A, etal., J Immunol. 2012 Apr 1;188(7):3434-46. doi: 10.4049/jimmunol.1102602. Epub 2012 Feb 29.
105. Therapeutic effects of human mesenchymal stem cells in Wistar-Kyoto rats with anti-glomerular basement membrane glomerulonephritis. Suzuki T, etal., PLoS One. 2013 Jun 24;8(6):e67475. doi: 10.1371/journal.pone.0067475. Print 2013.
106. IL-17 in cutaneous lupus erythematosus. Tanasescu C, etal., Eur J Intern Med. 2010 Jun;21(3):202-7. doi: 10.1016/j.ejim.2010.03.004. Epub 2010 Apr 8.
107. Interleukin-17A+ cell counts are increased in systemic sclerosis skin and their number is inversely correlated with the extent of skin involvement. Truchetet ME, etal., Arthritis Rheum. 2013 May;65(5):1347-56. doi: 10.1002/art.37860.
108. Anti-inflammation effects of corn silk in a rat model of carrageenin-induced pleurisy. Wang GQ, etal., Inflammation. 2012 Jun;35(3):822-7.
109. Association between polymorphisms in cytokine genes IL-17A and IL-17F and development of allergic rhinitis and comorbid asthma in Chinese subjects. Wang M, etal., Hum Immunol. 2012 Jun;73(6):647-53. doi: 10.1016/j.humimm.2012.03.010. Epub 2012 Apr 13.
110. Interleukin 17A promotes pneumococcal clearance by recruiting neutrophils and inducing apoptosis through a p38 mitogen-activated protein kinase-dependent mechanism in acute otitis media. Wang W, etal., Infect Immun. 2014 Jun;82(6):2368-77. doi: 10.1128/IAI.00006-14. Epub 2014 Mar 24.
111. [Measurement of eosinophils and interleukin-17 in nasopharyngeal secretions of children under 5 years old with wheezing] Wang XF, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2010 Feb;12(2):113-6.
112. Neutrophils produce interleukin 17A (IL-17A) in a dectin-1- and IL-23-dependent manner during invasive fungal infection. Werner JL, etal., Infect Immun. 2011 Oct;79(10):3966-77. doi: 10.1128/IAI.05493-11. Epub 2011 Aug 1.
113. Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. Wilson MS, etal., J Exp Med. 2010 Mar 15;207(3):535-52. Epub 2010 Feb 22.
114. Th17 promotes acute rejection following liver transplantation in rats. Xie XJ, etal., J Zhejiang Univ Sci B. 2010 Nov;11(11):819-27.
115. Immunohistochemical localization of IL-17 in induced rat periapical lesions. Xiong H, etal., J Endod. 2009 Feb;35(2):216-20. Epub 2008 Dec 13.
116. Expression of interleukin-17 in lung and peripheral blood of asthmatic rats and the influence of dexamethasone. Xiong W, etal., J Huazhong Univ Sci Technolog Med Sci. 2007 Oct;27(5):498-500.
117. Association of interleukin-17A and -17F gene single-nucleotide polymorphisms with autoimmune thyroid diseases. Yan N, etal., Autoimmunity. 2012 Nov;45(7):533-9. doi: 10.3109/08916934.2012.702814. Epub 2012 Aug 17.
118. Interleukin-17 plays a critical role in the acute rejection of intestinal transplantation. Yang JJ, etal., World J Gastroenterol. 2013 Feb 7;19(5):682-91. doi: 10.3748/wjg.v19.i5.682.
119. Effects of supplemental dietary arginine on the exogenous advanced glycosylation end product-induced interleukin-23/interleukin-17 immune response in rats. Yeh CL, etal., Nutrition. 2012 Oct;28(10):1063-7. doi: 10.1016/j.nut.2012.01.014. Epub 2012 Jun 5.
120. Epicutaneous exposure to staphylococcal superantigen enterotoxin B enhances allergic lung inflammation via an IL-17A dependent mechanism. Yu J, etal., PLoS One. 2012;7(7):e39032. doi: 10.1371/journal.pone.0039032. Epub 2012 Jul 27.
121. The Treg/Th17 imbalance in Toxoplasma gondii-infected pregnant mice. Zhang H, etal., Am J Reprod Immunol. 2012 Feb;67(2):112-21. doi: 10.1111/j.1600-0897.2011.01065.x. Epub 2011 Sep 19.
122. Potassium channel changes of peripheral blood T-lymphocytes from Kazakh hypertensive patients in Northwest China and the inhibition effect towards potassium channels by telmisartan. Zhang Q, etal., Kardiol Pol. 2016;74(5):476-488. doi: 10.5603/KP.a2015.0210. Epub 2015 Oct 27.
123. Suppression of experimental autoimmune uveoretinitis by Anti-IL-17 antibody. Zhang R, etal., Curr Eye Res. 2009 Apr;34(4):297-303.
124. Genetic Variants of Interleukin 17A Are Functionally Associated with Increased Risk of Age-Related Macular Degeneration. Zhang S, etal., Inflammation. 2014 Jul 16.
125. Protective effects of losartan in mice with chronic viral myocarditis induced by coxsackievirus B3. Zhang YY, etal., Life Sci. 2013 Jul 10;92(24-26):1186-94. doi: 10.1016/j.lfs.2013.05.010. Epub 2013 May 20.
126. EGFR signaling blunts allergen-induced IL-6 production and Th17 responses in the skin and attenuates development and relapse of atopic dermatitis. Zhang Z, etal., J Immunol. 2014 Feb 1;192(3):859-66. doi: 10.4049/jimmunol.1301062. Epub 2013 Dec 13.
127. FTY720 attenuates lesional interleukin-17(+) cell accumulation in rat experimental autoimmune neuritis. Zhang ZY, etal., Neuropathol Appl Neurobiol. 2009 Oct;35(5):487-95. Epub 2009 Feb 4.
128. Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation. Zhong W, etal., Oncotarget. 2017 Jun 20;8(25):40486-40500. doi: 10.18632/oncotarget.17119.
129. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Zhu S, etal., Nat Med. 2012 Jul;18(7):1077-86. doi: 10.1038/nm.2815.
Additional References at PubMed
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Genomics

Comparative Map Data
Il17a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8930,640,844 - 30,644,331 (+)NCBIGRCr8
mRatBN7.2923,144,402 - 23,147,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,144,402 - 23,147,889 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx931,641,574 - 31,645,060 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0936,762,293 - 36,765,779 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,077,566 - 35,081,052 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0926,841,299 - 26,844,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl926,841,299 - 26,844,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0925,696,865 - 25,700,352 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4919,454,979 - 19,458,467 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1919,453,469 - 19,455,797 (+)NCBI
Celera920,720,899 - 20,724,386 (+)NCBICelera
Cytogenetic Map9q13NCBI
IL17A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,186,375 - 52,190,638 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,186,375 - 52,190,638 (+)EnsemblGRCh38hg38GRCh38
GRCh37652,051,173 - 52,055,436 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,159,144 - 52,163,395 (+)NCBINCBI36Build 36hg18NCBI36
Build 34652,159,143 - 52,163,395NCBI
Celera653,712,308 - 53,716,559 (+)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef651,882,254 - 51,886,505 (+)NCBIHuRef
CHM1_1652,053,438 - 52,057,689 (+)NCBICHM1_1
T2T-CHM13v2.0652,025,075 - 52,029,336 (+)NCBIT2T-CHM13v2.0
Il17a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39120,801,129 - 20,804,720 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl120,801,129 - 20,804,720 (+)EnsemblGRCm39 Ensembl
GRCm38120,730,905 - 20,734,496 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl120,730,905 - 20,734,496 (+)EnsemblGRCm38mm10GRCm38
MGSCv37120,720,986 - 20,724,577 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36120,716,056 - 20,719,647 (+)NCBIMGSCv36mm8
Celera120,604,456 - 20,608,046 (+)NCBICelera
Cytogenetic Map1A4NCBI
cM Map16.45NCBI
Il17a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554115,896,702 - 5,900,962 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554115,896,435 - 5,899,911 (-)NCBIChiLan1.0ChiLan1.0
IL17A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2566,651,896 - 66,656,165 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1662,528,730 - 62,532,997 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0651,736,269 - 51,740,538 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1653,004,820 - 53,009,074 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl653,004,820 - 53,009,074 (+)Ensemblpanpan1.1panPan2
IL17A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11219,854,129 - 19,862,521 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1219,854,129 - 19,862,513 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1219,751,596 - 19,759,988 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01220,353,311 - 20,361,254 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11219,859,850 - 19,868,228 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01219,962,726 - 19,971,118 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01220,100,900 - 20,109,292 (+)NCBIUU_Cfam_GSD_1.0
Il17a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494655,335,194 - 55,338,342 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364768,621,860 - 8,625,008 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364768,621,860 - 8,625,008 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL17A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl746,013,584 - 46,017,153 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1746,013,584 - 46,017,161 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,463,736 - 52,467,313 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL17A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11720,314,082 - 20,319,917 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1720,315,773 - 20,318,785 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604452,087,244 - 52,091,712 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il17a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248553,911,349 - 3,913,136 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248553,911,349 - 3,914,214 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il17a
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:43
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000016664
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system reproductive system respiratory system appendage
High
Medium
Low
Below cutoff 2 6 1 11 1 1 1 2 1 1

Sequence


RefSeq Acc Id: ENSRNOT00000016664   ⟹   ENSRNOP00000016664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl923,144,402 - 23,147,889 (+)Ensembl
Rnor_6.0 Ensembl926,841,299 - 26,844,786 (+)Ensembl
RefSeq Acc Id: NM_001106897   ⟹   NP_001100367
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8930,640,844 - 30,644,331 (+)NCBI
mRatBN7.2923,144,402 - 23,147,889 (+)NCBI
Rnor_6.0926,841,299 - 26,844,786 (+)NCBI
Rnor_5.0925,696,865 - 25,700,352 (+)NCBI
RGSC_v3.4919,454,979 - 19,458,467 (+)RGD
Celera920,720,899 - 20,724,386 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100367 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18652 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016664.3
GenBank Protein Q61453 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001100367   ⟸   NM_001106897
- Peptide Label: precursor
- UniProtKB: Q61453 (UniProtKB/Swiss-Prot),   A6JJ80 (UniProtKB/TrEMBL),   G3V7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016664   ⟸   ENSRNOT00000016664

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61453-F1-model_v2 AlphaFold Q61453 1-150 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2888 AgrOrtholog
BioCyc Gene G2FUF-28034 BioCyc
Ensembl Genes ENSRNOG00000012467 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016664.5 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-17_chr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-17_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:301289 UniProtKB/TrEMBL
NCBI Gene Il17a ENTREZGENE
Pfam IL17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il17a PhenoGen
PRINTS INTRLEUKIN17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012467 RatGTEx
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JJ80 ENTREZGENE, UniProtKB/TrEMBL
  G3V7M4 ENTREZGENE, UniProtKB/TrEMBL
  IL17_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-05-26 Il17a  interleukin 17A  LOC301289  similar to Interleukin-17 precursor (IL-17) (Cytotoxic T lymphocyte-associated antigen 8) (CTLA-8)  Data merged from RGD:1587366 737654 APPROVED
2008-02-15 Il17a  interleukin 17A  Il17  interleukin 17  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC301289  similar to Interleukin-17 precursor (IL-17) (Cytotoxic T lymphocyte-associated antigen 8) (CTLA-8)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-11-06 Il17  interleukin 17    Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)  Name updated 625702 APPROVED
2002-06-10 Il17  Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in activated T cells 729041
gene_protein 150 amino acids 729041