Il17a (interleukin 17A) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Il17a (interleukin 17A) Rattus norvegicus
Analyze
Symbol: Il17a
Name: interleukin 17A
RGD ID: 2888
Description: Predicted to have protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of necrotic cell death; and positive regulation of transcription by RNA polymerase II. Localizes to cytoplasm and extracellular space. Used to study anti-basement membrane glomerulonephritis; congestive heart failure; myocarditis; pleurisy; and uveitis. Biomarker of several diseases, including brain ischemia; inflammatory bowel disease (multiple); lipoid nephrosis; lung disease (multiple); and periodontal disease (multiple). Human ortholog(s) of this gene implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); macular degeneration; and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A); PARTICIPATES IN interleukin-23 signaling pathway; interleukin-27 signaling pathway; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 2,4,6-trinitrobenzenesulfonic acid; 7,12-dimethyltetraphene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; hypothetical protein LOC301289; IL-17; IL-17A; Il17; interleukin 17; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin-17A; LOC301289; similar to Interleukin-17 precursor (IL-17) (Cytotoxic T lymphocyte-associated antigen 8) (CTLA-8)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2923,144,402 - 23,147,889 (+)NCBI
Rnor_6.0 Ensembl926,841,299 - 26,844,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0926,841,299 - 26,844,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0925,696,865 - 25,700,352 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4919,454,979 - 19,458,467 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1919,453,469 - 19,455,797 (+)NCBI
Celera920,720,899 - 20,724,386 (+)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
Acute Lung Injury  (ISO)
Acute Necrotizing Pancreatitis  (IEP)
Acute Otitis Media  (IEP)
acute promyelocytic leukemia  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Animal Toxoplasmosis  (ISO)
ankylosing spondylitis  (ISO)
anti-basement membrane glomerulonephritis  (IDA)
Arterial Thrombosis  (ISO)
asthma  (IEP,ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autoimmune disease  (ISO)
autoimmune thyroiditis  (ISO)
Bacteremia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
brain ischemia  (IEP,ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis  (ISO)
bronchiolitis obliterans  (ISO)
cardiovascular system disease  (ISO)
central nervous system disease  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chlamydia  (ISO)
chronic obstructive pulmonary disease  (IEP,ISO)
Chronic Rhinosinusitis  (ISO)
colitis  (IEP,ISO)
congestive heart failure  (IEP,IMP)
corneal neovascularization  (ISO)
COVID-19  (ISO)
Cryopyrin-Associated Periodic Syndromes  (ISO)
cutaneous leishmaniasis  (ISO)
cutaneous lupus erythematosus  (ISO)
cystic fibrosis  (ISO)
Delayed Hypersensitivity  (IMP)
Discoid Lupus Erythematosus  (ISO)
Drug Eruptions  (ISO)
Experimental Arthritis  (IDA,IEP,IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (IDA,IEP,ISO)
Experimental Autoimmune Neuritis  (IEP,ISO)
Experimental Autoimmune Uveitis  (IDA,IEP,IMP)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
extrinsic allergic alveolitis  (ISO)
Graft vs Host Disease  (ISO)
Gram-Negative Bacterial Infections  (ISO)
Graves' disease  (ISO)
histoplasmosis  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (IDA,IMP)
Ige Responsiveness, Atopic  (ISO)
ileitis  (IEP)
Inflammation  (ISO)
invasive aspergillosis  (ISO)
leprosy  (ISO)
lipoid nephrosis  (IEP)
lupus nephritis  (ISO)
lymphoproliferative syndrome  (ISO)
macular degeneration  (ISO)
MPTP Poisoning  (ISO)
multiple sclerosis  (ISO)
Mycobacterium avium complex disease  (ISO)
myocardial infarction  (IEP)
Myocardial Reperfusion Injury  (IMP)
myocarditis  (IDA)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Ocular Toxoplasmosis  (ISO)
otitis media  (ISO)
Perennial Allergic Rhinitis  (ISO)
periapical periodontitis  (IEP)
periodontal disease  (IEP)
plague  (IEP)
pleurisy  (IDA)
Pneumococcal Infections  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (IEP,ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
Sepsis  (IMP)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
Spondylarthritis  (IEP)
Staphylococcal Skin Infections  (ISO)
Streptococcal Infections  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
trachoma  (ISO)
Transplant Rejection  (IEP,IMP,ISO)
tularemia  (ISO)
uveitis  (IMP,ISO)
Viral Bronchiolitis  (ISO)
Viral Myocarditis  (ISO)
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(R)-mevalonic acid  (ISO)
(S)-nicotine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (EXP)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
alloxan  (ISO)
alpha-galactosylceramide  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antigen  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
biochanin A  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (EXP)
calciol  (ISO)
carbamazepine  (EXP)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
corosolic acid  (ISO)
cortisol  (ISO)
cyanidin cation  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP,ISO)
digoxigenin  (ISO)
diiodine  (EXP)
dimethylarsinic acid  (ISO)
enilconazole  (ISO)
ethanol  (ISO)
ferulic acid  (ISO)
flucloxacillin  (ISO)
formaldehyde  (EXP)
formononetin  (ISO)
fragrance  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
geraniol  (ISO)
glucose  (ISO)
halothane  (ISO)
hexaconazole  (ISO)
hydroquinone  (EXP)
imiquimod  (ISO)
indometacin  (EXP)
ionomycin  (ISO)
irinotecan  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
levamisole  (ISO)
lipopolysaccharide  (ISO)
luteolin  (EXP)
LY294002  (ISO)
maslinic acid  (ISO)
mercury dichloride  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methyl salicylate  (ISO)
methylene blue  (EXP)
methylmercury chloride  (EXP)
Methysticin  (ISO)
metyrapone  (EXP)
mifepristone  (ISO)
ML-7  (ISO)
morin  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
paroxetine  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosmet  (ISO)
phytoestrogen  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
propionic acid  (ISO)
pyrrolidine dithiocarbamate  (ISO)
resveratrol  (ISO)
Rhein  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
strophanthidin  (ISO)
sulfasalazine  (EXP)
sulfur dioxide  (ISO)
tamibarotene  (ISO)
tetrachloromethane  (ISO)
tetraconazole  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (ISO)
triflumizole  (ISO)
Triptolide  (ISO)
vitamin K  (EXP)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Adamopoulos IE, etal., Ann Rheum Dis. 2014 Feb 23. doi: 10.1136/annrheumdis-2013-204782.
2. Agak GW, etal., J Invest Dermatol. 2014 Feb;134(2):366-73. doi: 10.1038/jid.2013.334. Epub 2013 Aug 7.
3. Ai S, etal., Clin Exp Nephrol. 2013 Feb;17(1):24-31. doi: 10.1007/s10157-012-0662-y. Epub 2012 Jul 7.
4. Avalos AM, etal., Biol Res. 2012;45(2):193-200. doi: 10.4067/S0716-97602012000200012.
5. Avelino MA, etal., Braz J Otorhinolaryngol. 2013 Sep-Oct;79(5):616-9. doi: 10.5935/1808-8694.20130110.
6. Baeten D, etal., Lancet. 2013 Nov 23;382(9906):1705-13. doi: 10.1016/S0140-6736(13)61134-4. Epub 2013 Sep 13.
7. Bai H, etal., J Immunol. 2009 Nov 1;183(9):5886-95. Epub 2009 Oct 7.
8. Barczyk A, etal., Respir Med. 2003 Jun;97(6):726-33.
9. Barry SP, etal., Int J Cardiol. 2013 Mar 10;163(3):326-34. doi: 10.1016/j.ijcard.2011.08.849. Epub 2011 Oct 24.
10. Braun RK, etal., Inflammation. 2008 Jun;31(3):167-79. Epub 2008 Mar 13.
11. Brodlie M, etal., Eur Respir J. 2010 Nov 25.
12. Burton MJ, etal., Infect Immun. 2011 Dec;79(12):4977-83. doi: 10.1128/IAI.05718-11. Epub 2011 Sep 12.
13. Chang H, etal., Circ J. 2008 May;72(5):813-9.
14. Chao CC, etal., Autoimmunity. 2010 Oct 7.
15. Chen J, etal., J Clin Immunol. 2010 Jul;30(4):539-45. Epub 2010 May 2.
16. Chen K, etal., J Leukoc Biol. 2007 Jan;81(1):306-14. Epub 2006 Oct 17.
17. Cheng X, etal., Atherosclerosis. 2011 Apr;215(2):471-4. doi: 10.1016/j.atherosclerosis.2010.12.034. Epub 2011 Jan 19.
18. Cho CG, etal., Int J Pediatr Otorhinolaryngol. 2016 Sep;88:146-52. doi: 10.1016/j.ijporl.2016.07.001. Epub 2016 Jul 6.
19. Chong DL, etal., Immunology. 2012 Jul;136(3):325-33. doi: 10.1111/j.1365-2567.2012.03584.x.
20. Comer JE, etal., Infect Immun. 2010 Dec;78(12):5086-5098. Epub 2010 Sep 27.
21. Crowe CR, etal., J Immunol. 2009 Oct 15;183(8):5301-10. Epub 2009 Sep 25.
22. da Motta-Passos I, etal., Eur J Dermatol. 2012 Jul-Aug;22(4):488-94. doi: 10.1684/ejd.2012.1741.
23. Deepe GS Jr and Gibbons RS, J Infect Dis. 2009 Jul 1;200(1):142-51. doi: 10.1086/599333.
24. Di Stefano A, etal., Clin Exp Immunol. 2009 Aug;157(2):316-24.
25. Ding FM, etal., Exp Lung Res. 2015 Feb;41(1):44-55. doi: 10.3109/01902148.2014.964351. Epub 2014 Nov 14.
26. Du JT, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 Mar;41(2):235-8.
27. Dufresne V, etal., Am J Respir Crit Care Med. 2009 Jul 15;180(2):153-8. Epub 2009 Apr 2.
28. Espigol-Frigole G, etal., Ann Rheum Dis. 2013 Sep 1;72(9):1481-7. doi: 10.1136/annrheumdis-2012-201836. Epub 2012 Sep 19.
29. Fang CB, etal., PLoS One. 2013 Apr 23;8(4):e62071. doi: 10.1371/journal.pone.0062071. Print 2013.
30. Farfariello V, etal., Pediatr Allergy Immunol. 2011 Jun;22(4):419-23. doi: 10.1111/j.1399-3038.2010.01116.x.
31. Feng W and Li W, Exp Mol Pathol. 2010 Apr;88(2):299-304. Epub 2009 Nov 10.
32. Feng W, etal., Exp Mol Pathol. 2009 Dec;87(3):212-8. Epub 2009 Jun 13.
33. Glatigny S, etal., Arthritis Rheum. 2012 Jan;64(1):110-20. doi: 10.1002/art.33321.
34. GOA data from the GO Consortium
35. Gorbacheva V, etal., Am J Pathol. 2010 Sep;177(3):1265-73. doi: 10.2353/ajpath.2010.091106. Epub 2010 Jul 22.
36. Hagau N, etal., Crit Care. 2010;14(6):R203. Epub 2010 Nov 9.
37. Hamada H, etal., J Immunol. 2009 Mar 15;182(6):3469-81.
38. Hamzaoui K, etal., Med Sci Monit. 2011 Apr;17(4):CR227-34.
39. Horvat JC, etal., J Immunol. 2010 Apr 15;184(8):4159-69. Epub 2010 Mar 12.
40. Hou WK, etal., J Zhejiang Univ Sci B. 2011 Jan;12(1):40-6. doi: 10.1631/jzus.B1000078.
41. Hu MH, etal., Clin Exp Immunol. 2014 Feb;175(2):268-84. doi: 10.1111/cei.12219.
42. Hu XD, etal., J Int Med Res. 2013 Jun;41(3):777-84. doi: 10.1177/0300060513478089. Epub 2013 Apr 18.
43. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
44. Huang C, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Apr;30(4):366-70.
45. Hueber W, etal., Sci Transl Med. 2010 Oct 6;2(52):52ra72. doi: 10.1126/scitranslmed.3001107.
46. Janssen R, etal., J Infect Dis. 2007 Sep 15;196(6):826-34. Epub 2007 Aug 10.
47. Jia X, etal., Mol Vis. 2011;17:1493-507. Epub 2011 Jun 7.
48. Johnston A, etal., J Immunol. 2013 Mar 1;190(5):2252-62. doi: 10.4049/jimmunol.1201505. Epub 2013 Jan 28.
49. Joshi AD, etal., Am J Respir Crit Care Med. 2009 Apr 15;179(8):705-16. Epub 2009 Jan 16.
50. Khan R, etal., J Am Acad Dermatol. 2012 Mar;66(3):510-1. doi: 10.1016/j.jaad.2011.07.018.
51. Koga C, etal., J Invest Dermatol. 2008 Nov;128(11):2625-30. doi: 10.1038/jid.2008.111. Epub 2008 Apr 24.
52. Komiyama Y, etal., J Immunol. 2006 Jul 1;177(1):566-73.
53. Larranaga CL, etal., Pediatr Infect Dis J. 2009 Oct;28(10):867-73.
54. Lasiglie D, etal., PLoS One. 2011;6(5):e20014. doi: 10.1371/journal.pone.0020014. Epub 2011 May 26.
55. Li GZ, etal., Scand J Immunol. 2005 Nov;62(5):481-6.
56. Lim A, etal., Clin Immunol. 2010 Nov;137(2):296-302. Epub 2010 Aug 24.
57. Liu B, etal., J Transl Med. 2011 Jul 15;9:1-12. doi: 10.1186/1479-5876-9-111.
58. Liu T, etal., Clin Exp Immunol. 2010 Nov 22. doi: 10.1111/j.1365-2249.2010.04278.x.
59. Lo Re S, etal., J Immunol. 2010 Jun 1;184(11):6367-77. Epub 2010 Apr 26.
60. Lopez-Posadas R, etal., J Nutr. 2010 Nov;140(11):2014-9. Epub 2010 Sep 29.
61. Ma J, etal., Infect Immun. 2010 Feb;78(2):830-7. Epub 2009 Dec 7.
62. Maione F, etal., Int J Inflam. 2014;2014:247503. doi: 10.1155/2014/247503. Epub 2014 Apr 3.
63. Markel G, etal., PLoS One. 2010 Jun 18;5(6):e11176.
64. Markovic M, etal., Mol Immunol. 2009 Nov;47(1):141-6. Epub 2009 Feb 23.
65. Marquez A, etal., Ann Rheum Dis. 2014 Sep;73(9):1742-5. doi: 10.1136/annrheumdis-2014-205261. Epub 2014 Jun 11.
66. McInnes IB, etal., Ann Rheum Dis. 2014 Feb;73(2):349-56. doi: 10.1136/annrheumdis-2012-202646. Epub 2013 Jan 29.
67. Meng X, etal., Pain. 2013 Feb;154(2):294-305. doi: 10.1016/j.pain.2012.10.022. Epub 2012 Nov 5.
68. MGD data from the GO Consortium
69. Miljkovic Z, etal., J Neuroinflammation. 2009 Dec 11;6:37.
70. Montgomery CP, etal., Infect Immun. 2014 May;82(5):2125-34. doi: 10.1128/IAI.01491-14. Epub 2014 Mar 10.
71. Murdoch JR and Lloyd CM, Am J Respir Crit Care Med. 2010 Aug 15;182(4):464-76. Epub 2010 Apr 22.
72. Nabavi NS, etal., Parasite Immunol. 2018 Jan;40(1). doi: 10.1111/pim.12507. Epub 2017 Dec 17.
73. Nakagiri T, etal., Transplantation. 2010 Jun 15;89(11):1312-9.
74. Nguyen CQ, etal., Arthritis Res Ther. 2010;12(6):R220. doi: 10.1186/ar3207. Epub 2010 Dec 23.
75. Ni J, etal., Inflammation. 2013 Feb;36(1):53-65. doi: 10.1007/s10753-012-9519-5.
76. Ogawa A, etal., Clin Immunol. 2004 Jan;110(1):55-62.
77. Okamoto Y, etal., Arthritis Rheum. 2012 Nov;64(11):3726-35. doi: 10.1002/art.34643.
78. Park H, etal., Nat Immunol. 2005 Nov;6(11):1133-41. Epub 2005 Oct 2.
79. Park SJ, etal., Eur Respir J. 2010 Mar 29.
80. Pelidou SH, etal., Exp Neurol. 2000 May;163(1):165-72.
81. Priebe GP, etal., J Immunol. 2008 Oct 1;181(7):4965-75.
82. Qin Y, etal., Asian Pac J Trop Med. 2014 Oct;7(10):792-5. doi: 10.1016/S1995-7645(14)60138-3.
83. Requena P, etal., Br J Pharmacol. 2008 Jun;154(4):825-32. Epub 2008 Apr 21.
84. RGD automated data pipeline
85. RGD automated import pipeline for gene-chemical interactions
86. RGD comprehensive gene curation
87. Rice L, etal., J Infect Dis. 2005 Apr 15;191(8):1368-76. Epub 2005 Mar 3.
88. Richter F, etal., Arthritis Rheum. 2012 Dec;64(12):4125-34. doi: 10.1002/art.37695.
89. Rizzo HL, etal., J Immunol. 2011 Feb 1;186(3):1495-502. doi: 10.4049/jimmunol.1001001. Epub 2010 Dec 20.
90. Roy LD, etal., BMC Cancer. 2014 Mar 27;14:225. doi: 10.1186/1471-2407-14-225.
91. Saitoh T, etal., Int Arch Allergy Immunol. 2010;151(1):8-16. Epub 2009 Aug 6.
92. Sauer A, etal., J Infect Dis. 2012 Oct;206(8):1319-29. Epub 2012 Aug 22.
93. Semik-Orzech A, etal., Ann Allergy Asthma Immunol. 2009 Nov;103(5):418-24.
94. Shen F, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2004 Oct;27(10):654-8.
95. Shen F, etal., Zhonghua Nei Ke Za Zhi. 2004 Dec;43(12):888-90.
96. Shen H, etal., Scand J Rheumatol. 2013;42(1):48-51. doi: 10.3109/03009742.2012.704391. Epub 2012 Oct 26.
97. Silva JA, etal., J Cell Physiol. 2012 Jun;227(6):2441-50. doi: 10.1002/jcp.22979.
98. Song C, etal., J Immunol. 2008 Nov 1;181(9):6117-24.
99. Song SS, etal., Acta Pharmacol Sin. 2013 Mar;34(3):414-23. doi: 10.1038/aps.2012.171. Epub 2013 Feb 4.
100. Sonnenberg GF, etal., J Exp Med. 2010 Jun 7;207(6):1293-305. Epub 2010 May 24.
101. Sun J, etal., Immunopharmacol Immunotoxicol. 2014 Feb;36(1):17-24. doi: 10.3109/08923973.2013.862542. Epub 2013 Nov 29.
102. Suryawanshi A, etal., J Immunol. 2012 Apr 1;188(7):3434-46. doi: 10.4049/jimmunol.1102602. Epub 2012 Feb 29.
103. Suzuki T, etal., PLoS One. 2013 Jun 24;8(6):e67475. doi: 10.1371/journal.pone.0067475. Print 2013.
104. Tanasescu C, etal., Eur J Intern Med. 2010 Jun;21(3):202-7. doi: 10.1016/j.ejim.2010.03.004. Epub 2010 Apr 8.
105. Truchetet ME, etal., Arthritis Rheum. 2013 May;65(5):1347-56. doi: 10.1002/art.37860.
106. Wang GQ, etal., Inflammation. 2012 Jun;35(3):822-7.
107. Wang M, etal., Hum Immunol. 2012 Jun;73(6):647-53. doi: 10.1016/j.humimm.2012.03.010. Epub 2012 Apr 13.
108. Wang W, etal., Infect Immun. 2014 Jun;82(6):2368-77. doi: 10.1128/IAI.00006-14. Epub 2014 Mar 24.
109. Wang XF, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2010 Feb;12(2):113-6.
110. Werner JL, etal., Infect Immun. 2011 Oct;79(10):3966-77. doi: 10.1128/IAI.05493-11. Epub 2011 Aug 1.
111. Wilson MS, etal., J Exp Med. 2010 Mar 15;207(3):535-52. Epub 2010 Feb 22.
112. Xie XJ, etal., J Zhejiang Univ Sci B. 2010 Nov;11(11):819-27.
113. Xiong H, etal., J Endod. 2009 Feb;35(2):216-20. Epub 2008 Dec 13.
114. Xiong W, etal., J Huazhong Univ Sci Technolog Med Sci. 2007 Oct;27(5):498-500.
115. Yan N, etal., Autoimmunity. 2012 Nov;45(7):533-9. doi: 10.3109/08916934.2012.702814. Epub 2012 Aug 17.
116. Yang JJ, etal., World J Gastroenterol. 2013 Feb 7;19(5):682-91. doi: 10.3748/wjg.v19.i5.682.
117. Yeh CL, etal., Nutrition. 2012 Oct;28(10):1063-7. doi: 10.1016/j.nut.2012.01.014. Epub 2012 Jun 5.
118. Yu J, etal., PLoS One. 2012;7(7):e39032. doi: 10.1371/journal.pone.0039032. Epub 2012 Jul 27.
119. Zhang H, etal., Am J Reprod Immunol. 2012 Feb;67(2):112-21. doi: 10.1111/j.1600-0897.2011.01065.x. Epub 2011 Sep 19.
120. Zhang R, etal., Curr Eye Res. 2009 Apr;34(4):297-303.
121. Zhang S, etal., Inflammation. 2014 Jul 16.
122. Zhang YY, etal., Life Sci. 2013 Jul 10;92(24-26):1186-94. doi: 10.1016/j.lfs.2013.05.010. Epub 2013 May 20.
123. Zhang Z, etal., J Immunol. 2014 Feb 1;192(3):859-66. doi: 10.4049/jimmunol.1301062. Epub 2013 Dec 13.
124. Zhang ZY, etal., Neuropathol Appl Neurobiol. 2009 Oct;35(5):487-95. Epub 2009 Feb 4.
125. Zhong W, etal., Oncotarget. 2017 Jun 20;8(25):40486-40500. doi: 10.18632/oncotarget.17119.
Additional References at PubMed
PMID:8390535   PMID:8877732   PMID:15642151   PMID:16239543   PMID:16785495   PMID:16982811   PMID:17827167   PMID:17888176   PMID:17969033   PMID:17982105   PMID:18792410   PMID:18997793  
PMID:19666510   PMID:19714651   PMID:19838199   PMID:20554964   PMID:20706986   PMID:21143599   PMID:21145111   PMID:21316418   PMID:21317395   PMID:21693307   PMID:21996014   PMID:21996044  
PMID:22152774   PMID:22355716   PMID:22851861   PMID:23034280   PMID:23147107   PMID:23285072   PMID:23334376   PMID:24026300   PMID:24548428   PMID:24914249   PMID:25231257   PMID:25331672  
PMID:25470037   PMID:25867387   PMID:25955429   PMID:26002979   PMID:26062421   PMID:26153393   PMID:26704184   PMID:27049496   PMID:27055905   PMID:27889748   PMID:27959414   PMID:27980343  
PMID:28104249   PMID:28359934   PMID:28759646   PMID:28916896   PMID:28919411   PMID:29469038   PMID:29734196   PMID:30097894   PMID:30216518   PMID:30401564   PMID:31351185   PMID:32531822  
PMID:33834668  


Genomics

Comparative Map Data
Il17a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2923,144,402 - 23,147,889 (+)NCBI
Rnor_6.0 Ensembl926,841,299 - 26,844,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0926,841,299 - 26,844,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0925,696,865 - 25,700,352 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4919,454,979 - 19,458,467 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1919,453,469 - 19,455,797 (+)NCBI
Celera920,720,899 - 20,724,386 (+)NCBICelera
Cytogenetic Map9q13NCBI
IL17A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl652,186,375 - 52,190,638 (+)EnsemblGRCh38hg38GRCh38
GRCh38652,186,375 - 52,190,638 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37652,051,173 - 52,055,436 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,159,144 - 52,163,395 (+)NCBINCBI36hg18NCBI36
Build 34652,159,143 - 52,163,395NCBI
Celera653,712,308 - 53,716,559 (+)NCBI
Cytogenetic Map6p12.2NCBI
HuRef651,882,254 - 51,886,505 (+)NCBIHuRef
CHM1_1652,053,438 - 52,057,689 (+)NCBICHM1_1
Il17a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39120,801,129 - 20,804,720 (+)NCBIGRCm39mm39
GRCm39 Ensembl120,801,129 - 20,804,720 (+)Ensembl
GRCm38120,730,905 - 20,734,496 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl120,730,905 - 20,734,496 (+)EnsemblGRCm38mm10GRCm38
MGSCv37120,720,986 - 20,724,577 (+)NCBIGRCm37mm9NCBIm37
MGSCv36120,716,056 - 20,719,647 (+)NCBImm8
Celera120,604,456 - 20,608,046 (+)NCBICelera
Cytogenetic Map1A4NCBI
Il17a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554115,896,702 - 5,900,962 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554115,896,435 - 5,899,911 (-)NCBIChiLan1.0ChiLan1.0
IL17A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1653,004,820 - 53,009,074 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl653,004,820 - 53,009,074 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0651,736,269 - 51,740,538 (+)NCBIMhudiblu_PPA_v0panPan3
IL17A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11219,854,129 - 19,862,521 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1219,854,129 - 19,862,513 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1219,751,596 - 19,759,988 (+)NCBI
ROS_Cfam_1.01220,353,311 - 20,361,254 (+)NCBI
UMICH_Zoey_3.11219,859,850 - 19,868,228 (+)NCBI
UNSW_CanFamBas_1.01219,962,726 - 19,971,118 (+)NCBI
UU_Cfam_GSD_1.01220,100,900 - 20,109,292 (+)NCBI
Il17a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494655,335,194 - 55,338,342 (+)NCBI
SpeTri2.0NW_0049364768,621,860 - 8,625,008 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL17A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl746,013,584 - 46,017,153 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1746,013,584 - 46,017,161 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,463,736 - 52,467,313 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL17A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11720,314,082 - 20,319,917 (-)NCBI
ChlSab1.1 Ensembl1720,315,773 - 20,318,785 (-)Ensembl
Vero_WHO_p1.0NW_02366604452,087,244 - 52,091,712 (+)NCBI
Il17a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248553,911,349 - 3,914,214 (-)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9129467098Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9140383872Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9140383872Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9140383872Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9145029794Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9105522293442944Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9235572247355722Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9235572247355722Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9288097747375681Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9288097747880977Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9498609549986095Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9498609549986095Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)91221677157216771Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)91242546357425463Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)91242546357425463Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91555490147249201Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91952048945029794Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92488509969885099Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92569234292741406Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92569237370692373Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92575432054885226Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:43
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000016664
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system reproductive system respiratory system appendage
High
Medium
Low
Below cutoff 2 6 1 11 1 1 1 2 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016664   ⟹   ENSRNOP00000016664
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl926,841,299 - 26,844,786 (+)Ensembl
RefSeq Acc Id: NM_001106897   ⟹   NP_001100367
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2923,144,402 - 23,147,889 (+)NCBI
Rnor_6.0926,841,299 - 26,844,786 (+)NCBI
Rnor_5.0925,696,865 - 25,700,352 (+)NCBI
RGSC_v3.4919,454,979 - 19,458,467 (+)RGD
Celera920,720,899 - 20,724,386 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100367 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18652 (Get FASTA)   NCBI Sequence Viewer  
  Q61453 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100367   ⟸   NM_001106897
- Peptide Label: precursor
- UniProtKB: G3V7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016664   ⟸   ENSRNOT00000016664

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2888 AgrOrtholog
Ensembl Genes ENSRNOG00000012467 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016664 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016664 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-17_chr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-17_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:301289 UniProtKB/TrEMBL
NCBI Gene 301289 ENTREZGENE
Pfam IL17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il17a PhenoGen
PRINTS INTRLEUKIN17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V7M4 ENTREZGENE, UniProtKB/TrEMBL
  IL17_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-05-26 Il17a  interleukin 17A  LOC301289  similar to Interleukin-17 precursor (IL-17) (Cytotoxic T lymphocyte-associated antigen 8) (CTLA-8)  Data Merged 737654 APPROVED
2008-02-15 Il17a  interleukin 17A  Il17  interleukin 17  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC301289  similar to Interleukin-17 precursor (IL-17) (Cytotoxic T lymphocyte-associated antigen 8) (CTLA-8)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-11-06 Il17  interleukin 17    Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)  Name updated 625702 APPROVED
2002-06-10 Il17  Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in activated T cells 729041
gene_protein 150 amino acids 729041