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Gene: Il17a (interleukin 17A) Rattus norvegicus
Symbol: Il17a
Name: interleukin 17A
Description: Predicted to have cytokine activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of necrotic cell death; and positive regulation of transcription by RNA polymerase II. Localizes to cytoplasm and extracellular space. Used to study anti-basement membrane glomerulonephritis; congestive heart failure; myocarditis; pleurisy; and uveitis. Biomarker of several diseases, including brain ischemia; inflammatory bowel disease (multiple); lipoid nephrosis; lung disease (multiple); and periodontal disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; Mycobacterium avium complex disease; bone inflammation disease (multiple); bronchial disease (multiple); and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A); PARTICIPATES IN interleukin-23 signaling pathway; interleukin-27 signaling pathway; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 2,4,6-trinitrobenzenesulfonic acid; ammonium chloride.
Type: protein-coding
Also known as: CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; hypothetical protein LOC301289; IL-17; IL-17A; Il17; interleukin 17; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin-17A; LOC301289; similar to Interleukin-17 precursor (IL-17) (Cytotoxic T lymphocyte-associated antigen 8) (CTLA-8)
Homo sapiens (human) : IL17A (interleukin 17A)  HGNC  Alliance
Mus musculus (house mouse) : Il17a (interleukin 17A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il17a (interleukin 17A)
Pan paniscus (bonobo/pygmy chimpanzee) : IL17A (interleukin 17A)
Canis lupus familiaris (dog) : IL17A (interleukin 17A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il17a (interleukin 17A)
Sus scrofa (pig) : IL17A (interleukin 17A)
Chlorocebus sabaeus (African green monkey) : IL17A (interleukin 17A)
Heterocephalus glaber (naked mole-rat) : Il17a (interleukin 17A)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0926,841,299 - 26,844,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl926,841,299 - 26,844,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0925,696,865 - 25,700,352 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4919,454,979 - 19,458,467 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1919,453,469 - 19,455,797 (+)NCBI
Celera920,720,899 - 20,724,386 (+)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Il17a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2888
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.