Predicted to have cytokine activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of necrotic cell death; and positive regulation of transcription by RNA polymerase II. Localizes to cytoplasm and extracellular space. Used to study anti-basement membrane glomerulonephritis; congestive heart failure; myocarditis; pleurisy; and uveitis. Biomarker of several diseases, including brain ischemia; inflammatory bowel disease (multiple); lipoid nephrosis; lung disease (multiple); and periodontal disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; Mycobacterium avium complex disease; bone inflammation disease (multiple); bronchial disease (multiple); and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A); PARTICIPATES IN interleukin-23 signaling pathway; interleukin-27 signaling pathway; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 2,4,6-trinitrobenzenesulfonic acid; ammonium chloride.
resveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]], tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]
Estradiol inhibits the reaction [Halothane results in increased expression of IL17A protein], fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL17A protein]]
[Trinitrobenzenesulfonic Acid results in increased susceptibility to [Ionomycin co-treated with Tetradecanoylphorbol Acetate]] which results in increased expression of IL17A protein
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein], Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein]
Trinitrobenzenesulfonic Acid results in increased expression of IL17A mRNA, Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein
Alloxan results in increased expression of and results in increased secretion of IL17A protein, platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL17A protein]
[deoxynivalenol results in increased susceptibility to Antigens] which results in increased expression of IL17A protein, [ochratoxin A results in increased susceptibility to Antigens] which results in increased expression of IL17A protein
[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of IL17A mRNA, Arsenic results in decreased secretion of and results in decreased expression of IL17A protein
[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of IL17A mRNA, Arsenic results in decreased secretion of and results in decreased expression of IL17A protein
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL17A protein
[PTGS2 gene mutant form results in increased susceptibility to [Nanotubes, Carbon co-treated with OVAL protein]] which results in increased expression of IL17A mRNA
[tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL17A protein], tripterine inhibits the reaction [Dextran Sulfate results in increased expression of IL17A protein]
[Dietary Fats co-treated with Choline deficiency] results in increased expression of IL17A protein, PANX1 gene mutant form inhibits the reaction [[Dietary Fats co-treated with Choline deficiency] results in increased expression of IL17A protein]
corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL17A mRNA], corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL17A mRNA]
[cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of and results in increased phosphorylation of STAT3 protein]] which results in increased expression of PIAS3 protein more ...
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL17A protein], Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL17A protein]
[lead chloride results in increased abundance of Lead] promotes the reaction [decabromobiphenyl ether results in increased expression of IL17A protein], decabromobiphenyl ether promotes the reaction [[lead chloride results in increased abundance of Lead] which results in increased expression of IL17A protein]
2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester inhibits the reaction [Dextran Sulfate results in increased expression of IL17A protein] more ...
[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein, pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein]
[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein, pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein]
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA], ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL17A protein]
[IL17A protein co-treated with Floxacillin] results in increased expression of MPO protein, IL17A protein promotes the reaction [Floxacillin results in increased expression of GPT protein]
[morin co-treated with Indomethacin] inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A mRNA], Indomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A mRNA]
[Trinitrobenzenesulfonic Acid results in increased susceptibility to [Ionomycin co-treated with Tetradecanoylphorbol Acetate]] which results in increased expression of IL17A protein
[lead chloride results in increased abundance of Lead] promotes the reaction [decabromobiphenyl ether results in increased expression of IL17A protein] more ...
[lead chloride results in increased abundance of Lead] promotes the reaction [decabromobiphenyl ether results in increased expression of IL17A protein] more ...
[lead chloride results in increased abundance of Lead] promotes the reaction [decabromobiphenyl ether results in increased expression of IL17A protein] more ...
Methotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A mRNA], Methotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein]
[morin co-treated with Indomethacin] inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A mRNA], morin inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A mRNA]
Acetylcysteine inhibits the reaction [Azoxymethane results in increased expression of IL17A protein], Acetylcysteine inhibits the reaction [Trichloroethylene results in increased expression of IL17A mRNA]
[Trinitrobenzenesulfonic Acid results in increased susceptibility to [Ionomycin co-treated with Tetradecanoylphorbol Acetate]] which results in increased expression of IL17A protein
platycodin D inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased expression of and results in increased secretion of IL17A protein], platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL17A protein]
Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of IL17A protein]], Progesterone promotes the reaction [Halothane results in increased expression of IL17A protein]
stannous mesoporphyrin inhibits the reaction [4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased expression of IL17A protein]]
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL17A protein
Carbon Tetrachloride results in increased secretion of and results in decreased expression of IL17A protein, INCB018424 inhibits the reaction [Carbon Tetrachloride results in increased secretion of and results in decreased expression of IL17A protein]
tofacitinib inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of and results in increased secretion of IL17A protein]
[Trichloroethylene co-treated with Dietary Fats] results in increased expression of IL17A mRNA, Acetylcysteine inhibits the reaction [Trichloroethylene results in increased expression of IL17A mRNA]
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Gene-Chemical Interaction Annotations
